Article
Psychiatry
Uzma Zahid, Robert A. A. McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M. M. Nour, Maria Rogdaki, Martin Osugo, Graham K. K. Murray, Pamela Hathway, Robin M. M. Murray, Oliver D. D. Howes
Summary: This study found that baseline glutamatergic levels are unlikely to predict treatment response in patients with first episode psychosis. Antipsychotic treatment also does not significantly affect glutamate levels in the anterior cingulate cortex.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neuroimaging
Yongfeng Yang, Yuqing Sun, Yuliang Zhang, Xueyan Jin, Zheng Li, Minli Ding, Han Shi, Qing Liu, Luwen Zhang, Xi Su, Minglong Shao, Meng Song, Yan Zhang, Wenqiang Li, Weihua Yue, Bing Liu, Luxian Lv
Summary: This study investigated regional activity and functional connectivity alterations in adolescent first-episode SZ, adult first-episode SZ, and adult chronic SZ. Abnormal patterns in the medial frontal gyrus and putamen were found to be common across all stages of SZ. The abnormal functional connectivity between ventromedial prefrontal cortex and dorsolateral prefrontal cortex was also observed in adolescence and adulthood, potentially indicating a shared neurodevelopmental abnormality.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Wei Zhao, Valerie Voon, Kangkang Xue, Chao Xie, Jujiao Kang, Ching-Po Lin, Jijun Wang, Jingliang Cheng, Jianfeng Feng
Summary: This study identifies a common region of functional connectivity disruption in both early-onset and chronic schizophrenia, suggesting the potential of targeting low-order sensory-motor systems for neuromodulation treatment.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Cell Biology
Kai Huang, Yamei Tang, Zhiheng Chen, Shan Ding, Hongtao Zeng, Yuxu Zhao, Qi Yu, Yong Liu
Summary: This study compared hematological parameters and inflammation ratios in anti-NMDAR encephalitis, FES, and healthy control groups. Results showed that inflammatory markers were significantly higher in anti-NMDAR encephalitis patients compared to FES patients, and their serum albumin levels were lower.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Min Tae M. Park, Peter Jeon, Ali R. Khan, Kara Dempster, M. Mallar Chakravarty, Jason P. Lerch, Michael MacKinley, Jean Theberge, Lena Palaniyappan
Summary: The study suggests disrupted serotonergic and glutamatergic signaling play a role in the pathophysiology of schizophrenia, particularly affecting the hippocampus. It found reduced hippocampal volumes and specific subfields in first-episode psychosis (FEP) patients, with gene expression showing correlations between serotonin and glutamate receptor genes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Ling-yin Kong, Yuan-yuan Huang, Bing-ye Lei, Peng-fei Ke, He-hua Li, Jing Zhou, Dong-sheng Xiong, Gui-xiang Li, Jun Chen, Xiao-bo Li, Zhi-ming Xiang, Yu-ping Ning, Feng-chun Wu, Kai Wu
Summary: This study revealed significantly increased SC-FC coupling strength in CSZ patients compared to FeSZ patients, as well as significantly decreased SC-FC coupling strength at the node strength level in FeSZ patients compared to NCs, with the coupling strength positively correlated with negative PANSS scores.
Article
Clinical Neurology
Mar Guasp, Eloi Gine-Serven, Estibaliz Maudes, Mireia Rosa-Justicia, Eugenia Martinez-Hernandez, Ester Boix-Quintana, Miquel Bioque, Virginia Casado, Yasmina Modena-Ouarzi, Nicolau Guanyabens, Desiree Muriana, Gisela Sugranyes, Isabella Pacchiarotti, Eva Davi-Loscos, Cristina Torres-Rivas, Jose Rios, Lidia Sabater, Albert Saiz, Francesc Graus, Josefina Castro-Fornieles, Eduard Parellada, Josep Dalmau
Summary: The study found that NMDAR antibodies were not common in FEP patients without anti-NMDAR encephalitis, and the warning signs and criteria for autoimmune psychosis had limited utility when neurological symptoms were absent or paraclinical tests were normal.
Article
Biochemistry & Molecular Biology
Samantha V. Abram, Brian J. Roach, Susanna L. Fryer, Vince D. Calhoun, Adrian Preda, Theo G. M. van Erp, Juan R. Bustillo, Kelvin O. Lim, Rachel L. Loewy, Barbara K. Stuart, John H. Krystal, Judith M. Ford, Daniel H. Mathalon
Summary: NMDAR hypofunction is a leading pathophysiological model of schizophrenia. Resting-state functional magnetic resonance imaging (rsfMRI) studies demonstrate thalamic dysconnectivity pattern in schizophrenia involving excessive connectivity with sensory regions and deficient connectivity with frontal, cerebellar, and thalamic regions. Ketamine, an NMDAR antagonist, induces schizophrenia-like symptoms and alters rsfMRI thalamic connectivity. This study confirms that ketamine-induced thalamic dysconnectivity resembles the thalamic dysconnectivity observed in schizophrenia, which suggests the contribution of NMDAR hypofunction to the pathophysiology of schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Nina Vanessa Kraguljac, Matthew Carle, Michael A. Frolich, Steve Tran, Michael A. Yassa, David Matthew White, Abhishek Reddy, Adrienne Carol Lahti
Summary: The study found a deficit in mnemonic discrimination performance in patients with first-episode psychosis compared to healthy volunteers, as well as in volunteers during a ketamine challenge compared to baseline. These findings suggest a potential mechanistic link between dentate gyrus dysfunction in first-episode psychosis and NMDA receptor hypofunction.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Psychology, Clinical
Deepak K. Sarpal, Goda Tarcijonas, Finnegan J. Calabro, William Foran, Gretchen L. Haas, Beatriz Luna, Vishnu P. Murty
Summary: This study examined the background connectivity in individuals with first-episode psychosis during executive processing and found that there were impairments in connectivity, potentially undermining cognitive control capacities in these patients.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Clinical Neurology
Anastasia Levinta, Shakila Meshkat, Roger S. McIntyre, Cameron Ho, Leanna M. W. Lui, Yena Lee, Rodrigo B. Mansur, Kayla M. Teopiz, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Felicia Ceban, Joshua D. Rosenblat
Summary: Ketamine has demonstrated antidepressant efficacy in patients with treatment-resistant depression, although its effectiveness may be affected by the level of treatment resistance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Sitong Feng, Sisi Zheng, Haoming Zou, Linrui Dong, Hong Zhu, Shanshan Liu, Dan Wang, Yanzhe Ning, Hongxiao Jia
Summary: Abnormalities in the cerebellum have been linked to schizophrenia, with lower between-network functional connectivity observed in patients with first-episode SCH compared to healthy controls. The between-network FC of cerebellar networks is associated with positive and negative symptoms in patients with first-episode SCH, and a classification model based on these abnormalities shows satisfactory accuracy in identifying SCH patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Ge Yang, Sen Zhang, Youqi Zhou, Yichen Song, Wenyan Hu, Yue Peng, Han Shi, Yan Zhang
Summary: The study found that drug-naive first-episode AOS patients demonstrate abnormalities in interhemispheric functional connectivity, which are not mitigated by short-term antipsychotic treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Zhou Wu, Chun Wang, Yingliang Dai, Chaoyong Xiao, Ning Zhang, Yuan Zhong
Summary: The study found that cognitive behavioral therapy plays a significant role in the treatment of major depressive disorder by improving brain connectivity between the dorsolateral prefrontal cortex (dlPFC) and hippocampus. Further research on the pathophysiology of the dlPFC is needed to better understand these abnormalities in patients with depressive symptoms and the effect of early CBT treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Francisco Reyes-Madrigal, Elisa Guma, Pablo Leon-Ortiz, Gladys Gomez-Cruz, Ricardo Mora-Duran, Ariel Graff-Guerrero, Lawrence S. Kegeles, M. Mallar Chakravarty, Camilo De la Fuente-Sandoval
Summary: This study found that in patients with schizophrenia, non-responders had higher levels of striatal glutamate compared to responders both before and after treatment. Combining anatomic measures with glutamate levels has the potential to improve classification of responders and non-responders to antipsychotic medications, and to provide mechanistic understanding of the interplay between neuroanatomical and neurochemical changes induced by these medications.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Flora Moujaes, Katrin H. Preller, Jie Lisa Ji, John D. Murray, Lucie Berkovitch, Franz X. Vollenweider, Alan Anticevic
Summary: Precision psychiatry aims to predict the right treatment for each patient by identifying markers of interindividual variability. Recent studies show the potential of psychedelics as a promising treatment for psychiatric symptoms. However, a precision medicine approach is essential due to the highly psychoactive nature of these substances.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Takuya Ito, John D. Murray
Summary: The study reveals the computational and functional architectures of human cognition by characterizing the geometry and topography of multitask representations in the human cortex using functional magnetic resonance imaging. The results show that multitask representations are organized along a gradient from sensory to association to motor processing, and the dimensions of these representations undergo compression-then-expansion. Neural network models trained in a rich learning regime replicate the compression-then-expansion organization observed in empirical data, suggesting that optimized representations and noise robustness play a crucial role in multitask cognition.
NATURE NEUROSCIENCE
(2023)
Article
Health Care Sciences & Services
William U. Meyerson, Sarah K. Fineberg, Ye Kyung Song, Adam Faber, Garrett Ash, Fernanda C. Andrade, Philip Corlett, Mark B. Gerstein, Rick H. Hoyle
Summary: Researchers estimated the bedtimes of Reddit users based on their posting times and tested the accuracy using survey data. They developed an R package to apply the model and share with the research community. This model provides a passive way to infer sleep parameters of frequent social media users without the need for active surveys.
JMIR FORMATIVE RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael Bloomfield, Michael Browning, Anthony J. Cleare, Phillip Corlett, J. F. William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver D. Howes, Mario F. Juruena, Raymond W. Lam, Stephen M. Lawrie, Hamish McAllister-Williams, Steven Marwaha, David Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selvaraj, Paul Stokes, Rachel Upthegrove, Nefize Yalin, Lakshmi Yatham, Allan H. Young, Roland Zahn, Philip J. Cowen
Summary: A recent umbrella review found no consistent evidence linking serotonin to the pathophysiology of depression. However, we argue that this conclusion is overstated due to methodological weaknesses, selective reporting of data, oversimplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two most relevant research areas, to support our argument.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Maxwell Shinn, Amber Hu, Laurel Turner, Stephanie Noble, Katrin H. Preller, Jie Lisa Ji, Flora Moujaes, Sophie Achard, Dustin Scheinost, R. Todd Constable, John H. Krystal, Franz X. Vollenweider, Daeyeol Lee, Alan Anticevic, Edward T. Bullmore, John D. Murray
Summary: High-throughput experimental methods in neuroscience have led to a surge in techniques for measuring complex interactions and multi-dimensional patterns. However, it is unclear whether these sophisticated measures can be traced back to simpler low-dimensional statistics. In this study, we examined rs-fMRI data using complex topology measures from network neuroscience, and found that spatial and temporal autocorrelation serve as reliable statistics that explain various network topology measures. These findings have important implications for understanding neurobiology and could help establish a connection between complexity measures and brain function.
NATURE NEUROSCIENCE
(2023)
Article
Psychiatry
James M. Gold, Philip R. Corlett, Molly Erickson, James A. Waltz, Sharon August, Jenna Dutterer, Sonia Bansal
Summary: This study compared the experience of auditory verbal hallucinations (AVH) in nonclinical voice hearers (NCVH) and people with schizophrenia (PSZ). The results showed that the AVH in NCVH and PSZ shared similar sensory features, but NCVH experienced less distress and had greater control over their AVH. NCVH also showed a wider range of unusual beliefs and reported fewer symptoms compared to PSZ such as paranoia, alterations in self-experience, cognitive deficits, and negative symptoms.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Erica L. Karp, Trevor F. Williams, Lauren M. Ellman, Gregory P. Strauss, Elaine F. Walker, Philip R. Corlett, Scott W. Woods, Albert R. Powers, James M. Gold, Jason E. Schiffman, James A. Waltz, Steven M. Silverstein, Vijay A. Mittal
Summary: This study investigated self-reported gesture interpretation and performance in individuals at clinical high risk for psychosis, those with internalizing disorders, and healthy controls. The results showed that the clinical high-risk group had significantly lower scores in self-reported gesture interpretation compared to the other two groups, while there were no differences in gesture performance among the three groups. Within the clinical high-risk group, greater deficits in gesture performance were associated with lower verbal learning and memory, and gesture deficits were also linked to higher cross-sectional risk for conversion to a full psychotic disorder.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
Julia M. Sheffield, Ryan Smith, Praveen Suthaharan, Pantelis Leptourgos, Philip R. Corlett
Summary: This study indicates that decision-making under uncertainty is associated with delusional thinking. However, it is unclear whether these decision-making processes are specific to paranoia or delusional ideation in general, and further investigation into the underlying computational mechanisms is required. By collecting task and self-report data from 88 individuals (46 healthy controls, 42 schizophrenia-spectrum), it was found that reversal learning performance, random exploration, and poor evidence integration in BADE are significantly and independently associated with paranoia. Only self-reported JTC is associated with delusional ideation, controlling for paranoia. Computational parameters increase the proportion of variance explained in paranoia. Overall, decision-making influenced by strong volatility and variability is specifically associated with paranoia, while self-reported hasty decision-making is specifically associated with other themes of delusional ideation. These decision-making processes under uncertainty may represent distinct cognitive processes that, together, have the potential to worsen delusional thinking across the psychosis spectrum.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Praveen Suthaharan, Philip R. Corlett
Summary: Paranoia is the belief in intentional harm from others, which is related to conspiracy theories involving organized groups violating societal norms. Current psychological studies explore individual and social factors in paranoid conspiracy theorizing. This study examines belief updating and social sensing in relation to paranoia and conspiracy theories. The findings suggest that conspiracy believers expect more volatility, assume shared beliefs in their social network, and find comfort and less distress in larger social networks.
SCIENTIFIC REPORTS
(2023)
Article
Mathematical & Computational Biology
Jie Lisa Ji, Jure Demsar, Clara Fonteneau, Zailyn Tamayo, Lining Pan, Aleksij Kraljic, Andraz Matkovic, Nina Purg, Markus Helmer, Shaun Warrington, Anderson Winkler, Valerio Zerbi, Timothy S. Coalson, Matthew F. Glasser, Michael P. Harms, Stamatios N. Sotiropoulos, John D. Murray, Alan Anticevic, Grega Repovs
Summary: Neuroimaging technology has greatly advanced the study of neural mechanisms in health and disease. However, challenges arise due to the variety of neuroimaging tools, hindering method integration across modalities and species. To address this, we developed QuNex, a platform that allows consistent processing and analysis of neuroimaging data with novel functionalities, including seamless integration of community-developed tools and high-performance parallel processing capabilities.
FRONTIERS IN NEUROINFORMATICS
(2023)
Article
Psychology, Biological
Warren Woodrich Pettine, Dhruva Venkita Raman, A. David Redish, John D. Murray
Summary: The study uses three learning tasks to examine how people approximate the complexities of the external world with simplified internal representations that generalize to novel examples or situations. The findings reveal that most participants attend to goal-relevant discriminative features and the covariance of features within a prototype, while a minority rely solely on discriminative features. The behavior of all participants can be captured by a model combining prototype representations with goal-oriented discriminative attention.
NATURE HUMAN BEHAVIOUR
(2023)
Meeting Abstract
Neurosciences
Christina Sarantopoulos, Doah E. Shin, Charles H. Schleifer, Flora Moujaes, Brendan Adkinson, Jie Lisa Ji, Antonija Kolabaric, Morgan Flynn, Nicole Santamauro, John H. Krystal, John D. Murray, Grega Repovs, William J. Martin, Christopher Pittenger, Alan Anticevic, Youngsun Cho
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Christopher Schutte, Masih Rahmati, Clara Fonteneau, Geena Fram, Charles H. Schleifer, Brendan Adkinson, Antonija Kolabaric, Naja Hill, Nicole Santamauro, John D. Murray, Repov S. Grega, Youngsun Cho, Alan Anticevic
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Chenyang Lin, Clara Fonteneau, Kangjoo Lee, Lucie Berkovitch, Lining Pan, Zailyn Tamayo, Xia Wei, Grega Repovs, John D. Murray, Su Lui, Qiyong Gong, Alan Anticevic
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Ally Price, Clara Fonteneau, Kangjoo Lee, Lucie Berkovitch, Jie Lisa Ji, Lining Pan, Zailyn Tamayo, Yvette Afriyie-Agyemang, Amber Howell, Repov S. Grega, John D. Murray, Youngsun Cho, Alan Anticevic
BIOLOGICAL PSYCHIATRY
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)