Article
Cell Biology
Yu-Seon Han, Eui-Yeun Yi, Myeong-Eun Jegal, Yung-Jin Kim
Summary: Mitochondrial dysfunction can transform cancer cells into cancer stem-like cells, as shown by the generation of mitochondria dysfunctional (rho(0)) cells from the Hep3B hepatocellular carcinoma cell line. These rho(0) cells exhibited increased cancer stem-like properties, such as self-renewal, chemotherapy resistance, and angiogenesis. The data suggest that mitochondrial dysfunction plays a significant role in driving the transition of cancer cells towards a stem-like phenotype.
Article
Biochemistry & Molecular Biology
Jurgen Wess
Summary: Beta-arrestins play a dual role as inhibitors of signaling via G protein-coupled receptors and as signaling molecules themselves. Despite their structural and sequence homology, beta-arrestin-1 and -2 have distinct and non-redundant functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Elodie Blondel-Tepaz, Marie Leverve, Badr Sokrat, Justine S. Paradis, Milena Kosic, Kusumika Saha, Cedric Auffray, Evelyne Lima-Fernandes, Alessia Zamborlini, Anne Poupon, Louis Gaboury, Jane Findlay, George S. Baillie, Herve Enslen, Michel Bouvier, Stephane Angers, Stefano Marullo, Mark G. H. Scott
Summary: The protein beta-arrestin2 plays a critical role in regulating the Mdm2-p53 signaling axis by promoting the nuclear-cytoplasmic shuttling of Mdm2 and enhancing p53 signaling. While beta-arrestin2 can be SUMOylated, it is the non-covalent interaction between SUMO and beta-arrestin2, mediated by a SUMO interaction motif (SIM), that is essential for its cytonuclear trafficking function. Depletion of the RanBP2/RanGAP1-SUMO nucleocytoplasmic transport hub leads to defective beta-arrestin2 nuclear entry, inhibiting its ability to displace Mdm2 from the nucleus and enhancing p53 signaling in cancer cells.
Article
Cell & Tissue Engineering
Wei-Min Chung, Ryan D. Molony, Yi-Fen Lee
Summary: This study revealed that EVs derived from NSCCs contain cargo proteins enriched in proteostasis-related functions, significantly impacting the development of CSCs to be more intrinsically chemoresistant and aggressive. This novel communication mechanism between NSCC-EVs and CSCs may promote disease progression and the acquisition of chemoresistance.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Xin Gao, Dachuan Zhang, Chunliang Xu, Huihui Li, Kathleen M. Caron, Paul S. Frenette
Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.
Article
Oncology
Haruka Miyata, Yoshihiko Hirohashi, Shuhei Yamada, Junko Yanagawa, Aiko Murai, Shinichi Hashimoto, Serina Tokita, Kanta Hori, Takashige Abe, Terufumi Kubo, Tomohide Tsukahara, Takayuki Kanaseki, Nobuo Shinohara, Toshihiko Torigoe
Summary: Recent studies have shown that treatment-resistant cancer stem-like cells can be targeted by cytotoxic T lymphocytes, with a specific antigenic peptide (LMYDAVHVV) derived from GRIK2 being identified as a potential novel target for bladder CSC/CIC immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Fotis Nikolos, Kazukuni Hayashi, Xen Ping Hoi, Mark Ellie Alonzo, Qianxing Mo, Armine Kasabyan, Hideki Furuya, Jane Trepel, Dolores Di Vizio, Jlenia Guarnerio, Dan Theodorescu, Charles Rosser, Andrea Apolo, Matthew Galsky, Keith Syson Chan
Summary: Chemoimmunotherapy has shown limited clinical benefit in bladder cancer patients and the reasons for this are not well understood. This study reveals that platinum-based chemotherapy hinders the infiltration and activity of CD8+ T cells in mouse models of muscle-invasive bladder cancer. The release of prostaglandin E-2 (PGE(2)) from dying cancer cells is identified as a mechanism that inhibits dendritic cell maturation. By blocking PGE(2) release, CD8+ T cells regain their tumoricidal activity and infiltrate the tumor site. Blocking PGE(2) release synergizes with chemotherapy and enhances the response to immune checkpoint inhibitor therapy. These findings highlight the potential of targeting the COX-2/PGE2 axis in chemoimmunotherapy for bladder cancer.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Yawei Zhao, Xuehan Yang, Jingtong Zhao, Mohan Gao, Min Zhang, Tongfei Shi, Fan Zhang, Xiao Zheng, Yue Pan, Dan Shao, Jing Li, Kan He, Li Chen
Summary: The study revealed the crucial role of berberine in overcoming chemotherapy-exacerbated ovarian cancer metastasis, by inhibiting the GLI1/BMI1 signaling pathway to reverse EMT and migration, as well as reduce CSC-like characteristics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Bari Aamna, Aritra Kumar Dan, Raghaba Sahu, Santosh Kumar Behera, Sagarika Parida
Summary: beta-Arrestins are intracellular proteins with various functions, playing roles in GPCR desensitization, receptor endocytosis, and ubiquitylation. They also act as adaptor proteins, controlling the recruitment, activation, and scaffolding of signaling complexes, and participate in cellular processes such as proliferation, migration, apoptosis, and transcription. Additionally, their involvement in cancer onset and progression has been recognized.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Nelli S. Lakis, Alexander S. Brodsky, Galina Karashchuk, Amanda J. Audesse, Dongfang Yang, Ashlee Sturtevant, Kara Lombardo, Ian Y. Wong, Ashley E. Webb, Douglas C. Anthony
Summary: A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phenotype which shares certain biological markers with adult neural stem cells. Stratification of GBM by the level of expression of CD133 and SOX2 improved the prognostic power of MGMT promoter methylation status.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Oncology
Zixi Qin, Weiye Liang, Zixuan Zhang, Peiwen Li, Tianyu Wang, Qianyu Chen, Baoyin Guo, Ying Zhong, Hui Kang, Lihui Wang
Summary: The activation of KRAS gene can transform normal NPCs into GSC-like cells and lead to aggressive tumor formation. Additionally, KRAS activation also causes abnormal structure in ESC-derived brain organoids. This study provides a simple cellular model to investigate gliomagenesis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Cell Biology
Nour Zaimia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
Summary: Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors play important roles in glucose homeostasis. This study highlights the distinct roles of ARRB2 in regulating GLP-1R and GIPR signaling, as well as the potential consequences of its decreased expression in pathological conditions such as diabetes.
Article
Multidisciplinary Sciences
Pamela Swiatlowska, Brian Sit, Zhen Feng, Emilie Marhuenda, Ioannis Xanthis, Simona Zingaro, Matthew Ward, Xinmiao Zhou, Qingzhong Xiao, Cathy Shanahan, Gareth E. Jones, Cheng-han Yu, Thomas Iskratsch
Summary: The study shows that vascular smooth muscle cells (VSMCs) undergo a phenotypic switch when exposed to a combination of hypertensive pressure and matrix compliance, which are prevalent during atherosclerosis. The molecular mechanism involves the regulation of the actin cytoskeleton through cofilin via distinct pathways.
Article
Biochemistry & Molecular Biology
Tyson W. Lager, Clay Conner, Claudia R. Keating, Jane N. Warshaw, Athanasia D. Panopoulos
Summary: GRP78 is a heat shock protein that is usually found in the endoplasmic reticulum of normal tissues, but can also be expressed on the cell surface of cancer cells and stem cells. It functions as a signaling molecule with diverse binding partners to regulate various cellular responses. The interaction of GRP78 with Dermcidin (DCD) has been identified as critical for regulating migration in both stem cells and cancer cells, involving the Wnt/beta-catenin signaling pathway.
Article
Multidisciplinary Sciences
Lijun Mo, Bijia Su, Lili Xu, Zhiming Hu, Hongwei Li, Hongyan Du, Jinlong Li
Summary: Bladder cancer stem-like cells (BCSLCs) are in a slow-cycling state with enhanced autophagy and mitophagy. The enhanced autophagy/mitophagy helps BCSLCs maintain mitochondrial respiration, thus inhibiting AMPK activation.
Article
Oncology
Georgios Kallifatidis, Daniel Munoz, Rajendra Kumar Singh, Nicole Salazar, James J. Hoy, Bal L. Lokeshwar
MOLECULAR CANCER RESEARCH
(2016)
Review
Oncology
Georgios Kallifatidis, James J. Hoy, Bal L. Lokeshwar
SEMINARS IN CANCER BIOLOGY
(2016)
Article
Multidisciplinary Sciences
James J. Hoy, Georgios Kallifatidis, Diandra K. Smith, Bal L. Lokeshwar
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Vinata B. Lokeshwar, Daley S. Morera, Sarrah L. Hasanali, Travis J. Yates, Marie C. Hupe, Judith Knapp, Soum D. Lokeshwar, Jiaojiao Wang, Martin J. P. Hennig, Rohitha Baskar, Diogo O. Escudero, Ronny R. Racine, Neetika Dhir, Andre R. Jordan, Kelly Hoye, Ijeoma Azih, Murugesan Manoharan, Zachary Klaassen, Sravan Kavuri, Luis E. Lopez, Santu Ghosh, Bal L. Lokeshwar
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Allison E. Bridges, Sabarish Ramachandran, Rajneesh Pathania, Utkarsh Parwal, Adrienne Lester, Pragya Rajpurohit, Daley S. Morera, Nikhil Patel, Nagendra Singh, Hasan Korkaya, Santhakumar Manicassamy, Puttur D. Prasad, Vinata B. Lokeshwar, Bal L. Lokeshwar, Vadivel Ganapathy, Muthusamy Thangaraju
Article
Oncology
Sarrah L. Hasanali, Daley S. Morera, Ronny R. Racine, Martin Hennig, Santu Ghosh, Luis E. Lopez, Marie C. Hupe, Diogo O. Escudero, Jiaojiao Wang, Huabin Zhu, Semih Sarcan, Ijeoma Azih, Michael Zhou, Andre R. Jordan, Martha K. Terris, Markus A. Kuczyk, Axel S. Merseburger, Vinata B. Lokeshwar
Summary: This study identified that the splice variant V1 of HYAL-4 is upregulated in bladder cancer and drives a malignant phenotype, as well as chemotherapy resistance to gemcitabine. While V1 does not affect gemcitabine influx, it increases drug metabolism and efflux by upregulating CD44-JAK2/STAT3 signaling, leading to resistance.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Allison E. Bridges, Sabarish Ramachandran, Kavin Tamizhmani, Utkarsh Parwal, Adrienne Lester, Pragya Rajpurohit, Daley S. Morera, Sarrah L. Hasanali, Pachiappan Arjunan, Ravirajsinh N. Jedeja, Nikhil Patel, Pamela M. Martin, Hasan Korkaya, Nagendra Singh, Santhakumar Manicassamy, Puttur D. Prasad, Vinata B. Lokeshwar, Bal L. Lokeshwar, Vadivel Ganapathy, Muthusamy Thangaraju
Summary: DNA repair processes have both protective and detrimental effects on colorectal cancer development. RAD51AP1 expression is significantly increased in colorectal cancer and may serve as a novel diagnostic marker and potential therapeutic target for the disease.
MOLECULAR CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Bal L. Lokeshwar, Georgios Kallifatidis, James J. Hoy
GPCR SIGNALING IN CANCER
(2020)
Article
Surgery
Andrew Mitchell, Daley S. Morera, Steven Holsten
Article
Oncology
Daley S. Morera, Martin S. Hennig, Asif Talukder, Soum D. Lokeshwar, Jiaojiao Wang, Michael Garcia-Roig, Nicolas Ortiz, Travis J. Yates, Luis E. Lopez, Georgios Kallifatidis, Mario W. Kramer, Andre R. Jordan, Axel S. Merseburger, Murugesan Manoharan, Mark S. Soloway, Martha K. Terris, Vinata B. Lokeshwar
BRITISH JOURNAL OF CANCER
(2017)
Article
Astronomy & Astrophysics
A. J. Apponi, J. J. Hoy, D. T. Halfen, L. M. Ziurys, M. A. Brewster
ASTROPHYSICAL JOURNAL
(2006)