Article
Psychiatry
Kyle Woisard, Joel L. Steinberg, Liangsuo Ma, Edward Zuniga, Michael Lennon, F. Gerard Moeller
Summary: Resting state functional magnetic resonance imaging (fMRI) has been used to study the functional connectivity of brain networks in addictions. This study assessed the functional and effective connectivity of the executive control network (ECN), default mode network (DMN), and salience network (SN) in cocaine dependent subjects compared to healthy control subjects. The results showed that cocaine dependent subjects had greater effective connectivity in the right ECN to left ECN pathway and negative associations between delay discounting and effective connectivity in DMN to ECN and SN to DMN pathways.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Neurosciences
Yuchao Jiang, Mingjun Duan, Hui He, Dezhong Yao, Cheng Luo
Summary: This study aimed to summarize the brain changes on sMRI and fMRI after ECT in patients with schizophrenia, and explore the relationship between these changes and symptom remission.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Gustavo Deco, Morten L. Kringelbach, Aurina Arnatkeviciute, Stuart Oldham, Kristina Sabaroedin, Nigel C. Rogasch, Kevin M. Aquino, Alex Fornito
Summary: Transcriptional variations in excitatory and inhibitory receptor gene expression play a key role in shaping complex neuronal dynamics, yielding both ignition-like dynamics and a wide variance of regional activity time scales. This study demonstrates the viability of using transcriptomic data to constrain models of large-scale brain function.
Article
Clinical Neurology
Eleftherios Kavroulakis, Nicholas J. Simos, Thomas G. Maris, Ioannis Zaganas, Simeon Panagiotakis, Efrosini Papadaki
Summary: This study found age-related changes in intrinsic functional brain connectivity and hemodynamics in adulthood, with a greater reduction in connectivity and increased hemodynamic lead in frontal regions, while the effects were influenced by concurrent subclinical depression symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Nina Zhang, Binyu Teng, Xinyi Lu, Liangliang Shi, Li Liu, Fan Zhou, Ni Jiang, Xin Zhang, Cong Wang, Shanshan Shen, Ruhua Zheng, Shu Zhang, Yi Wang, Yuzheng Hu, Bing Zhang, Qipeng Zhang, Lei Wang
Summary: Abnormal resting-state functional connectivity and regional brain activity were found in patients with achalasia. This study provides new insights into the pathophysiology of achalasia and highlights the potential of resting-state functional MRI in improving the diagnosis and treatment of this condition.
Article
Neurosciences
Giulia Baracchini, Bratislav Misic, Roni Setton, Laetitia Mwilambwe-Tshilobo, Manesh Girn, Jason S. Nomi, Lucina Q. Uddin, Gary R. Turner, R. Nathan Spreng
Summary: Shared inter-regional BOLD signal variability may underlie macroscale brain network dynamics, as stronger functional connectivity region pairs exhibit similar BOLD signal variability patterns.
Article
Multidisciplinary Sciences
Motoharu Gondo, Keisuke Kawai, Yoshiya Moriguchi, Akio Hiwatashi, Shu Takakura, Kazufumi Yoshihara, Chihiro Morita, Makoto Yamashita, Sanami Eto, Nobuyuki Sudo
Summary: The psychopathology of patients with anorexia nervosa involves inappropriate self-referential processing, disturbed interoceptive awareness, and excessive cognitive control. This study found that the resting-state brain networks may be altered in such patients and that treatment can normalize neural functional connectivity. Treatment improved body mass index and psychometric measurements and increased functional connectivity in default mode and salience networks.
Article
Clinical Neurology
Hui Zheng, Min Wang, Yanbin Zheng, Guang-Heng Dong
Summary: Studies have shown that individuals with Internet gaming disorder (IGD) exhibit abnormal hippocampal connections with various cerebral cortexes, especially in the prefrontal, parietal, and temporal lobes. The right posterior hippocampus (pHIP)-left caudate resting-state functional connectivity (rsFC) was found to be positively correlated with both sleep quality and addiction severity, mediating the relationship between the two. The nucleus accumbens (NAcc) in IGD subjects showed differences in rsFC with the inferior orbitofrontal cortex, suggesting a potential role in understanding the interaction between sleep disturbances and motivational systems in IGD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Siqi Cai, Zhifeng Shi, Chunxiang Jiang, Kai Wang, Liang Chen, Lin Ai, Lijuan Zhang
Summary: The study found that functional remodeling in the contralesional hemisphere is highly predictive of the malignant grade of glioma, showing significant hemispheric specificity. This suggests that functional features in the contralesional hemisphere may serve as efficient predictors for glioma aggressiveness.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Seyma Bayrak, Reinder Vos de Wael, H. Lina Schaare, Meike D. Hettwer, Benoit Caldairou, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt, Sofie L. Valk
Summary: This study used neuroimaging data from twins to investigate the heritability and organization of the hippocampus in healthy adults. The results showed that the functional connectivity between the hippocampus and cortex is heritable, and the microstructure of the hippocampus is genetically correlated with cortical microstructure. Additionally, the functional and microstructural organization can be consistently described by anterior-to-posterior and medial-to-lateral axes across individuals, suggesting an interplay of stability and plasticity within the hippocampus.
Article
Psychology, Clinical
Ben Chen, Mingfeng Yang, Xiaomei Zhong, Qiang Wang, Huarong Zhou, Meiling Liu, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: The slowed information processing speed is the core cause of cognitive impairment in patients with late-life depression (LLD). The hippocampus, which is an important link between depression and dementia, may be involved in the slowing of information processing speed in LLD patients. The study found that the dynamic connectivity and connectivity changes of hippocampal subregions in LLD patients were associated with slowed information processing speed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Herve Lemaitre, Pierre Auge, Ana Saitovitch, Alice Vincon-Leite, Jean-Marc Tacchella, Ludovic Fillon, Raphael Calmon, Volodia Dangouloff-Ros, Raphael Levy, David Grevent, Francis Brunelle, Nathalie Boddaert, Monica Zilbovicius
Summary: The study found that global rest cerebral blood flow significantly increased during the first year of life in infants, with marked regional differences in local functional brain maturation. While the primary sensorimotor cortices and insula showed early maturation, the temporal and prefrontal regions had great rest cerebral blood flow increase across the first year of life. Additionally, a late and synchronous maturation of the prefrontal and posterior superior temporal cortices was highlighted.
Article
Geriatrics & Gerontology
Lidia Glodzik, Henry Rusinek, Tracy Butler, Yi Li, Pippa Storey, Elizabeth Sweeney, Ricardo S. Osorio, Adrienne Biskaduros, Emily Tanzi, Patrick Harvey, Christopher Woldstad, Thomas Maloney, Mony J. de Leon
Summary: Obesity is associated with hippocampal hemodynamic impairment, suggesting that targeting obesity is an important prevention strategy.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Steven M. Weisberg, Arne D. Ekstrom
Summary: The relationship between hippocampal volume and navigation ability is controversial, with some evidence showing a structure-behavior relationship and other experiments showing no correlation. Therefore, the functional connectivity model may be more important, as navigation is dynamic and good navigators can flexibly solve spatial challenges.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Zhen-Gui Xu, Jin-Jing Xu, Yu-Chen Chen, Jinghua Hu, Yuanqing Wu, Yuan Xue
Summary: Chronic tinnitus patients exhibit reduced cerebral blood flow in the auditory and prefrontal cortex, and migraine may facilitate a decrease in cerebral blood flow in the context of tinnitus, underlying the neuropathological mechanisms of chronic tinnitus comorbid with migraine.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Cardiac & Cardiovascular Systems
Houman Khalili, Haekyung Jeon-Slaughter, Ehrin J. Armstrong, Amutharani Baskar, Ishita Tejani, Nicolas W. Shammas, Anand Prasad, Mazen Abu-Fadel, Emmanouil S. Brilakis, Subhash Banerjee
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2019)
Article
Surgery
Haekyung Jeon-Slaughter, Harish Krishnamoorthi, David Timaran, Amanda Wall, Bala Ramanan, Subhash Banerjee, Carlos H. Timaran, J. Gregory Modrall, Shirling Tsai
JOURNAL OF ENDOVASCULAR THERAPY
(2019)
Article
Surgery
Bala Ramanan, Haekyung Jeon-Slaughter, Xiaofei Chen, J. Gregory Modrall, Shirling Tsai
JOURNAL OF VASCULAR SURGERY
(2019)
Article
Surgery
Ehrin J. Armstrong, Haekyung Jeon-Slaughter, Ravi S. Kahlon, Khusrow A. Niazi, Nicolas W. Shammas, Subhash Banerjee
JOURNAL OF ENDOVASCULAR THERAPY
(2020)
Article
Biology
Xiaofei Chen, Daniel F. Heitjan, Gerald Greil, Haekyung Jeon-Slaughter
Summary: Infants with hypoplastic left heart syndrome require initial Norwood operation and later S2P surgery, but the optimal timing for S2P is unknown. Analysis of data from SVRT suggests that the best timing for S2P is at 6 months after Norwood surgery.
Article
Cardiac & Cardiovascular Systems
Xiaofei Chen, Bala Ramanan, Shirling Tsai, Haekyung Jeon-Slaughter
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Haekyung Jeon-Slaughter, Xiaofei Chen, Shirling Tsai, Bala Ramanan, Ramin Ebrahimi
Summary: This study developed an internally validated cardiovascular disease risk score for women military service members and veterans using the Veterans Affairs national electronic health records data. The new VA women CVD risk score performed better in predicting VA women's 10-year atherosclerosis cardiovascular disease risk than the existing American College of Cardiology/American Heart Association risk score.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Hematology
Daniel Welder, Haekyung Jeon-Slaughter, Bilal Ashraf, Sung-Hee Choi, Weina Chen, Ibrahim Ibrahim, Taha Bat
Summary: This study indicates that the level of thrombopoiesis in COVID-19 patients is correlated with disease severity, with elevated IPF and IPC values potentially serving as prognostic biomarkers for disease progression.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Environmental Sciences
Haekyung Jeon-Slaughter, Xiaofei Chen, Bala Ramanan, Shirling Tsai
Summary: The study assessed the performance of VA women CVD risk score in predicting 60-day CVD event risk in women veterans using VA COVID-19 shared cohort data. The VA women CVD risk score showed good accuracy for White and Hispanic women veterans, but poor accuracy for African American women veterans. Future studies are needed to identify non-traditional factors and biomarkers associated with increased CVD risk specific to African American women.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Brian R. Carr, Haekyung Jeon-Slaughter, Timothy W. Neal, Joseph A. Gulko, Nicholas C. Kolar, Richard A. Finn
Summary: The purpose of this study was to compare the incidence of early dental implant failures between implants with insertional torque less than 30 N-cm and those with insertional torque 30 N-cm or greater. The results showed that implants with insertional torque less than 30 N-cm had a significantly higher risk of early failure, indicating an association between insertional torque and early dental implant failure.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Surgery
Sooyeon Kim, Haekyung Jeon-Slaughter, Xiaofei Chen, Bala Ramanan, Melissa L. Kirkwood, Carlos H. Timaran, J. Gregory Modrall, Shirling Tsai
Summary: This study analyzed the effect of AAA size between 5.0 and 5.5 cm on mid-term mortality after EVAR using a large national cohort database. Results showed that patients with AAA size 5.0-5.5 cm had better 5-year survival outcomes compared to patients with larger AAA >5.5 cm, and similar survival to patients with smaller AAA between 4.0-5.0 cm. Larger AAA size was associated with male sex and coronary artery disease, but negatively associated with active smoking.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Psychology, Clinical
Jessica Wiblin, Nicholas Holder, Ryan Holliday, Haekyung Jeon-Slaughter, James LePage, Alina Suris
Summary: This study identified the optimal factor structure of the Suicide Cognitions Scale (SCS) for veterans with military sexual trauma-related posttraumatic stress disorder, revealing a novel factor of negative urgency. The SCS demonstrated good internal consistency and convergent validity among this population, providing initial support for its potential as a tool for detecting future suicidal self-directed violence risk.
JOURNAL OF TRAUMA & DISSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Stefanos Giannopoulos, Haekyung Jeon-Slaughter, Ravi S. Kahlon, Ishita Tejani, Amutha Baskar, Subhash Banerjee, Ehrin J. Armstrong
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Subhash Banerjee, Haekyung Jeon-Slaughter, Ehrin J. Armstrong, Christopher Bajzer, Mazen Abu-Fadel, Houman Khalili, Anand Prasad, Bassel Bou Dargham, Preeti Kamath, Tayo Addo, Michael Luna, Osvaldo Gigliotti, Mazin Foteh, Ian Cawich, Scott Kinlay, Mujtaba Ali, Bala Ramanan, Khusrow Niazi, Shirling Tsai, Nicolas W. Shammas, Emmanouil S. Brilakis
JOURNAL OF INVASIVE CARDIOLOGY
(2019)
Article
Education & Educational Research
Mary E. Camp, Haekyung Jeon-Slaughter, Anne E. Johnson, John Z. Sadler
GERONTOLOGY & GERIATRICS EDUCATION
(2018)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)