期刊
MICROBIOLOGY-SGM
卷 165, 期 4, 页码 386-395出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000783
关键词
Bacterial transcription; promoters; activators; DNA-dependent RNA polymerase
类别
资金
- UK BBSRC
- Wellcome Trust
- Leverhulme Trust
Activation of the transcription of genes is central to many processes of adaptation and differentiation in bacteria. Here, I review the molecular mechanisms by which transcription factors can activate the initiation of specific transcripts at bacterial promoters. The story is presented in the context of Marjory Stephenson's pioneering work on enzymatic adaptation in bacteria, and sets the different mechanisms in the greater context of how transcription regulatory mechanisms evolved.
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