Article
Oncology
Yan-Ping Wang, Ting Wei, Xiao Ma, Xiao-Liang Zhu, Long-Fei Ren, Lei Zhang, Fang-Hui Ding, Xun Li, Hai-Ping Wang, Zhong-Tian Bai, Ke-Xiang Zhu, Long Miao, Jun Yan, Wen-Ce Zhou, Wen-Bo Meng, Yu-Qin Liu
Summary: This study used UPLC-HDMS metabolomics to analyze plasma samples from patients with superficial gastritis, early gastric cancer, and advanced gastric cancer, revealing metabolic phenotype changes and potential biomarkers. The results showed differences in biomarkers related to amino acid, lipid, and fatty acid metabolism pathways, with glycerophosphocholine and neopterin identified as key biomarkers associated with gastric cancer progression. This method could be useful for biomarker identification and potential diagnosis of gastric cancer.
Review
Biochemistry & Molecular Biology
Alessia Paganelli, Valeria Righi, Elisabetta Tarentini, Cristina Magnoni
Summary: Metabolomic profiling is a promising field for studying metabolites in biological systems. Skin metabolomics has potential applications in the diagnosis, prognosis, and therapy of skin disorders. This review provides a comprehensive overview of published studies in skin metabolomics, with a focus on inflammatory dermatoses and immune-mediated cutaneous disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Tianyang Wang, Ping Li, Xiangyu Meng, Jinling Zhang, Qi Liu, Cuicui Jia, Nana Meng, Kunjie Zhu, Dan Lv, Lei Sun, Tinghuizi Shang, Yan Lin, Weipan Niu, Song Lin
Summary: This study used an integrated multi-omic approach to differentiate healthy subjects from schizophrenia patients. By combining metabolomic and transcriptomic platforms, 86 differential metabolites and 189 differential expression genes were identified as potential biomarkers for schizophrenia. The functional relationships between metabolites and genes were further studied, providing more precise information on the mechanism and diagnostic evidence of schizophrenia. The establishment of characteristic diagnostic formulas enhances the predictive ability of the diagnostic spectrums.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Wenqian Zhang, Hongjun Zhao, Pei Du, Haobo Cui, Shuang Lu, Zhongyuan Xiang, Qianjin Lu, Sujie Jia, Ming Zhao
Summary: This study identified biomarkers associated with different clinical phenotypes in SLE patients, which could facilitate a more precise diagnosis and assessment of disease progression in SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhangjian Chen, Shuo Han, Jiahe Zhang, Pai Zheng, Xiaodong Liu, Yuanyuan Zhang, Guang Jia
Summary: This study identified potential biomarkers of occupational exposure to low concentrations of TiO2 NPs in urine samples of workers through metabolomics analysis. A total of 1760 differentially expressed metabolites were found, with 60 confirmed as potential biomarkers. Among these biomarkers, 10 showed good sensitivity and specificity, including compounds like dibenzyl ether and quassimarin. Pathway enrichment analysis revealed significant alterations in the metabolic pathway related to long chain acyl-coa dehydrogenase deficiency. These findings provide insights into early health effects of TiO2 NPs exposure.
Article
Environmental Sciences
Quanwei Li, Jianzhao Liao, Chaiqin Lei, Jian Shi, Hui Zhang, Qingyue Han, Jianying Guo, Lianmei Hu, Ying Li, Jiaqiang Pan, Zhaoxin Tang
Summary: The study found that exposure to copper can lead to significantly increased serum biochemical parameters in pigs, severe structural abnormalities in cardiomyocytes with high copper concentrations exposure, and specific changes in mRNA and protein expression levels in cardiomyocytes at day 80 of the trial.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Besevic, Sarah Lewington, Jonathan Emberson
Summary: This study found that metabolic biomarkers were independently associated with the risk of T2D, and further addition of metabolic biomarker principal components improved the prediction of T2D risk.
Article
Biochemistry & Molecular Biology
Tong Yue, Huiling Tan, Yu Shi, Mengyun Xu, Sihui Luo, Jianping Weng, Suowen Xu
Summary: This study investigated the changes in metabolism during aging using machine learning and identified biomarkers associated with aging. The findings provide insights into potential therapeutic targets for delaying the effects of aging.
Article
Chemistry, Applied
Tao Liu, Ning Qiao, Fangjian Ning, Xueyong Huang, Liping Luo
Summary: In this study, the maturation patterns of Triadica cochinchinensis honey were investigated using targeted and untargeted metabolomics analyses. A characteristic compound, N1, N5, N10-(E)-tricoumaryl spermidine, derived from plants, was identified in the honey. Two patterns of honey maturation were observed, one involving a reduction in plant-derived compounds with strong reducing activity, and the other involving the formation of lactone glycoside analogs and organic acids facilitated by bee-secreted enzymes.
Article
Food Science & Technology
Min Jeong Kang, Joon Hyuk Suh
Summary: This review summarizes recent progress in using metabolomics approaches to evaluate the quality and safety of nuts (ground and tree nuts). The factors influencing the chemical profiles and qualities of nuts before and after harvesting are presented, along with relevant metabolomics studies. The review also discusses recent research on multi-omics approaches in this field.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Marine & Freshwater Biology
Yan Chen, Bo Cheng, Yang Liu, Yucen Bai, Xiaofei Yang, Shaogang Xu
Summary: This study aimed to evaluate the physiological responses of golden trout to acute copper exposure. The results showed that at a concentration of 60 µg/L, the fish exhibited gluconeogenesis, pentose-phosphate pathway activation, and alteration of fatty acid composition in response to copper exposure. At a concentration of 120 µg/L, the fish showed signs of metabolic stress.
AQUATIC TOXICOLOGY
(2022)
Article
Food Science & Technology
Eirini Trichia, Albert Koulman, Isobel D. Stewart, Soren Brage, Simon J. Griffin, Julian L. Griffin, Kay-Tee Khaw, Claudia Langenberg, Nicholas J. Wareham, Fumiaki Imamura, Nita G. Forouhi
Summary: The study identified metabolites associated with habitual dairy consumption and found that consuming milk, butter, and total dairy products is associated with lower risk of type 2 diabetes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.
Article
Biochemistry & Molecular Biology
Mark Jansen, Maike Schuldt, Beau O. van Driel, Amand F. Schmidt, Imke Christiaans, Saskia N. van der Crabben, Yvonne M. Hoedemaekers, Dennis Dooijes, Jan D. H. Jongbloed, Ludolf G. Boven, Ronald H. Lekanne Deprez, Arthur A. M. Wilde, Judith J. M. Jans, Jolanda van der Velden, Rudolf A. de Boer, J. Peter van Tintelen, Folkert W. Asselbergs, Annette F. Baas
Summary: This exploratory case-control study identified metabolites associated with severe phenotypes in carriers of MYBPC3 founder variants. The identified metabolites are involved in multiple metabolic pathways, including acylcarnitine, histidine, lysine, purine and steroid hormone metabolism, and proteolysis. Further studies are needed to explore the role of these biomarkers in the pathogenesis of HCM and their potential contribution to risk stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yingxu Zeng, Baichuan Deng, Zixin Kang, Pedro Araujo, Svein Are Mjos, Ruina Liu, Jianhui Lin, Tao Yang, Yuangao Qu
Summary: Microplastics (MPs) are a major environmental threat to marine organisms and ecosystems on a global scale. This study focused on the impacts of MPs accumulation in Litopenaeus vannamei, showing that MPs accumulate in various organs and have negative effects on growth, swimming behavior, and swimming performance of the shrimp. MPs exposure also led to oxidative stress, lipid peroxidation, and hepatopancreatic damage, which worsened with increasing MPs concentrations. Metabolomics analysis revealed alterations in metabolic profiles and disrupted glycolysis, lipolysis, and amino acid metabolism pathways in the hepatopancreas of L. vannamei. This research enhances our understanding of the sublethal impacts and toxic modes of action of MPs in L. vannamei.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Clinical Neurology
Jan P. Bembenek, Katarzyna Kurczych, Bozena Klysz, Lukasz Smolinski, Tomasz Litwin, Anna Czlonkowska
Summary: This study investigated whether patients with Wilson disease have abnormal motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation. The results showed that abnormal MEP parameters were found in both newly diagnosed and treated patients. After one year of treatment introduction, there was no significant improvement in MEP parameters. Further studies on large cohorts are needed to determine the usefulness of MEPs in detecting pyramidal tract damage and improvement after anticopper treatment introduction in Wilson disease.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Grazyna Gromadzka, Adam Przybylkowski, Tomasz Litwin, Agata Karpinska
Summary: The decreased antioxidant capacity in patients with Wilson's disease is correlated with liver injury.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Clinical Neurology
Tjalf Ziemssen, Lukasz Smolinski, Anna Czlonkowska, Katja Akgun, Agnieszka Antos, Jan Bembenek, Iwona Kurkowska-Jastrzebska, Adam Przybylkowski, Marta Skowronska, Barbara Redzia-Ogrodnik, Tomasz Litwin
Summary: This study analyzed the frequency and risk factors of early neurological deterioration in Wilson's disease (WD). The results showed that early deterioration is common in WD patients, particularly in the neurological phenotype. The severity of initial neurological disease and pre-treatment serum neuro-filament light chain (sNfL) concentrations were identified as significant risk factors.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Barbara Redzia-Ogrodnik, Anna Czlonkowska, Agnieszka Antos, Jan Bembenek, Iwona Kurkowska-Jastrzebska, Adam Przybylkowski, Marta Skowronska, Lukasz Smolinski, Tomasz Litwin
Summary: Wilson's disease (WD) is a treatable genetic disorder caused by impaired copper metabolism. Brain magnetic resonance imaging (MRI) is used for diagnosis and treatment monitoring. The frequency and significance of potential brain MRI pathognomonic signs for WD were analyzed in a large cohort of patients. These signs occurred relatively rarely and were most often found in patients with early onset and severe neurological symptoms, improving the diagnosis of WD. However, these signs are not truly pathognomonic of WD as they can also be found in other disorders.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Nutrition & Dietetics
Marcela D. D. Radtke, Gwen M. M. Chodur, Michael C. S. Bissell, Leslie C. C. Kemp, Valentina Medici, Francene M. M. Steinberg, Rachel E. E. Scherr
Summary: This study aimed to explore the criterion validity between Diet ID(TM) and other measures of dietary intake. The results showed significant correlations between Diet ID(TM) and other methods in terms of diet quality, calories, carbohydrates, protein, fiber, and cholesterol. Additionally, Diet ID(TM) can also measure the intake of vitamins and carotenoids, and is correlated with carotenoid levels in the skin and plasma.
Article
Biochemistry & Molecular Biology
Louis C. Penning, Marina Berenguer, Anna Czlonkowska, Kay L. Double, Petr Dusek, Carmen Espinos, Svetlana Lutsenko, Valentina Medici, Wiebke Papenthin, Wolfgang Stremmel, Jose Willemse, Ralf Weiskirchen
Summary: Wilson disease is a rare inherited metabolic disorder with diverse clinical presentations affecting the liver, neurological system, psychiatric status, and vision, often in combination. Mutations in the ATP7B gene lead to copper accumulation in hepatocytes and/or neurons, making clinical diagnosis challenging. Diagnosis is complicated by mild and non-specific manifestations, mutations with unclear effects on protein function, and ambiguous laboratory tests, particularly concerning serum ceruloplasmin levels. Establishing a global collaboration of researchers, clinicians, and patient advocacy groups is crucial for identifying and addressing the outstanding challenges of Wilson disease.
Article
Clinical Neurology
Agnieszka Piechal, Jan Bembenek, Anna Baranowska, Tomasz Litwin, Dagmara Mirowska-Guzel, Anna Czlonkowska
Summary: This study evaluated olfactory dysfunction in patients with Wilson's Disease (WD) and found that patients with WD had a weaker sense of smell compared to healthy controls. Older individuals and those with predominantly neurological symptoms were more likely to experience olfactory disorders.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Review
Clinical Neurology
Agnieszka Antos, Anna Czlonkowska, Lukasz Smolinski, Jan Bembenek, Adam Przybylkowski, Marta Skowronska, Iwona Kurkowska-Jastrzebska, Tomasz Litwin
Summary: The aim of this study was to evaluate the occurrence and outcome of early neurological deterioration in patients with Wilson's disease (WD). The results showed that early neurological deterioration was more common in patients with neurological WD and occurred most frequently in patients treated with d-penicillamine, trientine, or zinc salts. Further investigations are needed to differentiate the natural course of WD from treatment-related early deterioration and to develop a standard definition for treatment-induced effects.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Agnieszka Antos, Anna Czlonkowska, Jan Bembenek, Marta Skowronska, Iwona Kurkowska-Jastrzebska, Tomasz Litwin
Summary: Wilson's disease is an inherited disorder of copper metabolism that can cause hepatic and/or neuropsychiatric symptoms. Early diagnosis and anti-copper treatment are key for a favorable outcome. New treatment modalities are being sought to prevent neurological deterioration. Serum biomarkers are important for disease management, and there is a need for blood-based biomarkers for central nervous system (CNS) injury.
Review
Clinical Neurology
Tomasz Litwin, Petr Dusek, Agnieszka Antos, Anna Czlonkowska, Jan Bembenek
Summary: Wilson's disease is an inherited disorder that impairs copper metabolism, leading to various symptoms, including hepatic and neurological symptoms. Anti-copper drugs are the main treatment option, but some patients may experience neurological deterioration or persistent symptoms. Treatment should be individualized based on the patient's condition.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Monika Misztal, Anna Czlonkowska, Agnieszka Cudna, Anna Palejko, Tomasz Litwin, Agnieszka Piechal, Iwona Kurkowska-Jastrzebska
Summary: This study assessed changes in serum markers for brain damage and blood-brain barrier dysfunction in patients with Wilson's disease (WD) and examined correlations with neurological impairment. The results showed that ICAM1 concentrations were elevated in WD patients and positively correlated with neurological advancement. Treatment led to a substantial decrease in ICAM1, indicating BBB impairment improvement. P-selectin concentrations remained elevated, suggesting a systemic inflammatory process.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2023)
Letter
Gastroenterology & Hepatology
Tomasz Litwin, Agnieszka Antos, Lukasz Smolinski
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Medicine, General & Internal
Tomasz Litwin, Agnieszka Antos, Jan Bembenek, Adam Przybylkowski, Iwona Kurkowska-Jastrzebska, Marta Skowronska, Anna Czlonkowska
Summary: This systematic review examines the occurrence of copper deficiency (CD) in Wilson's disease (WD) patients during treatment. CD diagnosis is based on symptoms and blood tests, and regular monitoring of copper metabolism is necessary during treatment. Temporary cessation of anti-copper treatment can usually reverse serum copper reductions seen in CD.
Review
Biology
Agnieszka Antos, Anna Czlonkowska, Jan Bembenek, Iwona Kurkowska-Jastrzebska, Tomasz Litwin
Summary: Wilson's disease is a genetic disorder that causes copper accumulation in various tissues, leading to clinical symptoms. D-penicillamine (DPA) is a commonly used drug in its treatment, but it can also induce myasthenia gravis (MG). This case report discusses a patient with WD who developed symptoms of MG after 15 months of DPA treatment.
Letter
Clinical Neurology
Tomasz Litwin, Lukasz Smolinski, Agnieszka Antos, Jan Bembenek, Anna Czlonkowska
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
