Article
Chemistry, Analytical
C. Suarez, W. R. Premasiri, H. Ingraham, A. N. Brodeur, L. D. Ziegler
Summary: A simple water extraction and transfer procedure is found to produce reproducible and highly sensitive SERS spectra of dried bloodstains on Ag nanoparticle substrates. The water/Ag methodology allows the detection and identification of diluted bloodstains on Ag substrates, while avoiding potential DNA damage. However, this water-only procedure is not effective on Au SERS substrates, due to the difference in the lysis and denaturation effects of blood cells on Ag and Au nanoparticles, respectively. The use of acetic acid is required for obtaining SERS spectra of dried bloodstains on Au substrates.
Article
Spectroscopy
Shelby R. Khandasammy, Lenka Halamkova, Matthieu Baudelet, Igor K. Lednev
Summary: Firearm related evidence plays a significant role in forensic science. Researchers have been exploring the value of organic gunshot residue (OGSR) evidence, including factors like recoverability. Raman spectroscopy and LIBS are two nondestructive and rapid techniques used in this study to identify and characterize OGSR particles from closely related ammunition types. The goal is to differentiate between ammunition types of the same caliber and manufacturer, generated under identical firing conditions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Ruichan Lv, Zhan Wang, Yaqun Ma, Wenjing Li, Jie Tian
Summary: This article discusses the importance of combining machine learning methods with spectroscopic detection methods in disease detection, and highlights the effectiveness and potential of support vector machine and convolutional neural network in spectral analysis.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Spectroscopy
Lamyaa M. Almehmadi, Igor K. Lednev
Summary: Stand-off Raman spectroscopy combined with chemometrics has the potential to detect and identify biological stains from a distance for forensic purposes.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Spectroscopy
Anna Wojtowicz, Alexis Weber, Renata Wietecha-Posluszny, Igor K. Lednev
Summary: Menstrual blood (MB) is a significant forensic evidence, consisting of peripheral blood, vaginal fluid, and endometrial cells. Understanding the changes and biochemical analysis of menstrual blood using fluorescence spectroscopy can help differentiate the cause of blood presence in forensic investigations, whether it is due to assault or a natural cause. The mechanism of fluorescence changes in menstrual blood involves the kinetic transformation of three fluorophores: tryptophan, nicotinamide adenine dinucleotide, and flavins.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Medicine, Legal
T. Reese, C. Suarez, W. R. Premasiri, M. L. Shaine, H. Ingraham, A. N. Brodeur, L. D. Ziegler
Summary: SERS technology can provide highly specific identification of dried blood, distinguishing stains from different animals and types of blood. The unique SERS bloodstain spectrum differs from potential household substances and food stains that may resemble bloodstains. The optimized selection of extraction solvent controls the chemical composition of molecular components in complex biological mixtures in the SERS spectrum.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Mengke Su, Shixuan Yang, Min Xu, Shanshan Du, Liqin Zheng, Xian Wang, Cheng Qu, Honglin Liu
Summary: In this study, a novel SERS probe was developed using nucleic acid-peptide conjugates for high-specific profiling of abnormal protein levels in cancer patients. The probe showed rapid, simple, and multisignal detection capabilities. The effect of low-temperature storage time on blood samples was also analyzed, and it was found that plasma samples stored at 4°C for more than 2 days could generate false negative results due to TB hydrolysis, highlighting the importance of clinical sample analysis. This nucleic acid-peptide conjugate provides new ideas for future SERS sensing strategies.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tri Khoa Nguyen, Sangmin Jeong, Jong-Sang Youn, Seungbae Ahn, Ki-Hun Nam, Cheol-Min Park, Ki-Joon Jeon
Summary: This study investigates the performance of MoS2-based gas sensors at different temperatures, revealing that the sensor has better response and detection limit at higher temperatures. However, it is also found that there are line damages on the sensor at 200 degrees Celsius, affecting its recovery ability.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Tetiana Stepanenko, Grzegorz Zajac, Artur Czajkowski, Wiktoria Rutkowska, Andrzej Gorecki, Katarzyna Maria Marzec, Jakub Dybas
Summary: In this study, a sulfhemoglobinemia model was established on living functional human erythrocytes to investigate the interaction between sulfur donors and hemoglobin. By employing various spectroscopic techniques, two hemoglobin adducts with sulfur attachments were successfully distinguished and characterized. It was found that sulfur attachment altered hemoglobin structure and caused changes in protein packing inside red blood cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Chemistry, Analytical
Guillaume Falgayrac, Raffaele Vitale, Yann Delannoy, Helene Behal, Guillaume Penel, Ludovic Duponchel, Thomas Colard
Summary: Estimating the postmortem interval from skeletal remains is challenging, as it is influenced by various extrinsic and intrinsic factors. This study used Raman spectroscopy and advanced multivariate data analysis to evaluate the effect of these factors on the spectra and improve PMI estimation.
Article
Spectroscopy
Qiaoyun Wang, Guangfei Wu, Feifei Pian, Peng Shan, Zhigang Li, Zhenhe Ma
Summary: A reagent-free method for simultaneous and direct detection of glucose, TC, and TG in human blood based on FT-Raman spectroscopy was proposed. The method showed accurate prediction of analyte concentrations in blood.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Physics, Multidisciplinary
Dominik Wild, Cathrin Theiss, Gerhard Holl
Summary: The identification of energetic materials in containments is a crucial challenge for safety and security. The combined laser drilling method with subsequent Raman spectroscopic measurements through microscopic bore holes offers a solution to quickly and reliably identify target substances, even when shielded by covering materials.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Spectroscopy
Qingsheng Xue, Nan Wang, Hui Yang, Jingyao Yang, Haoxuan Bai
Summary: In this study, a method combining Spatial heterodyne technology and Raman spectroscopy was proposed for rapid, efficient, and accurate detection of microplastics. By building a spatial heterodyne spectrometer and an optical system, detection and identification of different types of microplastic samples were achieved. The results showed a higher signal-to-noise ratio with this method, indicating its good performance and potential in the field of microplastics detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Environmental Sciences
Ahmet H. Iri, Malek H. A. Shahrah, Ali M. Ali, Sayed A. Qadri, Talha Erdem, Ibrahim T. Ozdur, Kutay Icoz
Summary: Plastic pollution poses a significant threat to marine ecosystems, with the need for low-cost, portable microplastic detection systems becoming increasingly important. A prototype device based on an optical system has been developed, costing less than $370, capable of detecting microplastics in water at concentrations below 0.015% w/v. The designed portable device is expected to be widely used globally to monitor microplastic content in a more convenient and cost-effective manner.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemical Research Methods
Charles Farber, Rohini Morey, Mark Krimmer, Dmitry Kurouski, Artem S. Rogovskyy
Summary: This study explored the potential of Raman spectroscopy (RS) to detect Bb infection in mice. While RS did not directly detect Bb spirochetes in blood, it was able to sense biochemical changes associated with Bb infection. Despite the limited detectable changes in blood associated with Bb infection, the average true positive rates were 86% for 297, 89% for B31, and increment vlsE.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Spectroscopy
Gregory McLaughlin, Marisia A. Fikiet, Masahiro Ando, Hiro-o Hamaguchi, Igor K. Lednev
JOURNAL OF RAMAN SPECTROSCOPY
(2019)
Article
Chemistry, Analytical
Shelby R. Khandasammy, Alexander Rzhevskii, Igor K. Lednev
ANALYTICAL CHEMISTRY
(2019)
Review
Spectroscopy
Nicole M. Ralbovsky, Igor K. Lednev
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2019)
Article
Chemistry, Multidisciplinary
Elena Ryzhikova, Nicole M. Ralbovsky, Lenka Halamkova, Dzintra Celmins, Paula Malone, Eric Molho, Joseph Quinn, Earl A. Zimmerman, Igor K. Lednev
APPLIED SCIENCES-BASEL
(2019)
Article
Instruments & Instrumentation
Marisia A. Fikiet, David Tuschel, Vladimir V. Ermolenkov, Igor K. Lednev
APPLIED SPECTROSCOPY
(2020)
Article
Biochemical Research Methods
Entesar Al-Hetlani, Lenka Halamkova, Mohamed O. Amin, Igor K. Lednev
JOURNAL OF BIOPHOTONICS
(2020)
Article
Biochemistry & Molecular Biology
Alexis Weber, Anna Wojtowicz, Igor K. Lednev
Summary: Blood is a common body fluid found at crime scenes, allowing for identification and determination of the time since deposition (TSD); understanding the biochemical mechanisms of blood aging is crucial for forensic investigations; this study investigated the fluorescence properties of peripheral and menstrual blood over 24 hours post deposition using steady-state fluorescence spectroscopy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Analytical
Shelby R. Khandasammy, Nathan R. Bartlett, Lenka Halamkova, Igor K. Lednev
Summary: Gunshot residue (GSR) is an important forensic trace evidence and inorganic GSR particles are currently used to establish the fact of shooting. However, recent research has shown that organic GSR (OGSR) has great potential in providing additional information for crime scene investigation. This study used Raman spectroscopy and chemometric modeling to analyze smokeless powder, which is the precursor to OGSR. The proposed hierarchical model demonstrated the potential to determine the manufacture and bullet type based on smokeless powder analysis. Further research is needed to expand this approach to the analysis of OGSR and make it a useful tool for law enforcement agencies.
Article
Chemistry, Analytical
Alexis R. Weber, Igor K. Lednev
FORENSIC CHEMISTRY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Alani Aldarondo Torres, Manuel F. Rosario Alomar, Juan Lopez Garriga, Igor K. Lednev
Meeting Abstract
Biochemistry & Molecular Biology
Indra Gonzalez Ojeda, Tatiana Quinones Ruiz, Manuel Rosario Alomar, Igor K. Lednev, Juan Lopez Garriga
Article
Chemistry, Analytical
Ewelina Mistek, Lenka Halamkova, Igor K. Lednev
FORENSIC CHEMISTRY
(2019)
Article
Chemistry, Analytical
Robert Rosenblatt, Lenka Halamkova, Kyle C. Doty, Emanuel A. C. de Oliveira, Igor K. Lednev
FORENSIC CHEMISTRY
(2019)
Letter
Chemistry, Analytical
Jeff Salyards, William MacCrehan, Bonner Denton, Karen Kafadar, Igor Lednev, Hal Stern, William Thompson
FORENSIC CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Marisia A. Fikiet, Shelby R. Khandasammy, Ewelina Mistek, Yasmine Ahmed, Lenka Halamkova, Justin Bueno, Igor K. Lednev
PHYSICAL SCIENCES REVIEWS
(2019)