Article
Cardiac & Cardiovascular Systems
Nathan Haywood, J. Hunter Mehaffey, Sarah Kilbourne, Hannah Mannem, Max Weder, Christine Lau, Alexander S. Krupnick, Avinash Agarwal
Summary: This study evaluated the experience of a small to medium size center following implementation of a new lung allocation policy, finding several changes in accordance with policy intention, but also concerning shifts including increased waitlist mortality and resource utilization.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Ha Eun Kim, Young Ho Yang, Hyo Chae Paik, Su Jin Jeong, Song Yee Kim, Moo Suk Park, Jin Gu Lee
Summary: This study evaluated the use and effects of HLA crossmatching in lung transplantation in Korean patients. The results showed that positive crossmatching results may have an impact on the outcomes and survival rates of lung transplantation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Max Shin, Amit Iyengar, Mark R. Helmers, John J. Kelly, Cindy Song, David Rekhtman, Marisa Cevasco
Summary: The study found that changing the allocation policy can improve waitlist outcomes for patients undergoing heart-lung transplantation, with no impact on post-transplant survival.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Marcelo Cypel, Jonathan Yeung, Laura Donahoe, Kazuhiro Yasufuku, Aizhou Wang, Richard Pietroski, Paul Lange, Andrew Pierre, Marc De Perrot, Thomas K. Waddell, Shaf Keshavjee
Summary: This study evaluated the outcomes of lung transplant patients in Canada using declined lungs from the United States and compared them with patients receiving lungs from Canadian donors. The results showed that there were similar short-term and long-term outcomes between the two groups.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuriko Terada, Tsuyoshi Takahashi, Ramsey R. Hachem, Jingxia Liu, Chad A. Witt, Derek E. Byers, Rodrigo Vazquez Guillamet, Hrishikesh S. Kulkarni, Ruben G. Nava, Benjamin D. Kozower, Bryan F. Meyers, Michael K. Pasque, G. Alexander Patterson, Daniel Kreisel, Varun Puri
Summary: This study analyzed a lung transplant database and found that some single lung transplants were performed after aborted double lung transplants, with acceptable long-term outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Schiavon, Stefania Camagni, Federico Venuta, Lorenzo Rosso, Massimo Boffini, Francesco Parisi, Alessandro Bertani, Federica Meloni, Piero Paladini, Eleonora Faccioli, Michele Colledan, Daniele Diso, Margherita Cattaneo, Fabrizio Scalini, Sara Alfieri, Domenica Giunta, Monica Morosini, Luca Luzzi, Giulia Lorenzoni, Andrea Dell'Amore, Federico Rea
Summary: This study analyzed the experience of pediatric lung transplantation in Italy and found that the outcomes were comparable to current literature. Attention should be paid to the Oto score and recipient body mass index, and adult donors and graft reductions can be safely used to expand the donor pool.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Samantha Greissman, Michaela Anderson, Angela Dimango, Harpreet Grewal, Gabriela Magda, Hilary Robbins, Lori Shah, Joseph Costa, Bryan Stanifer, Frank D'-Ovidio, Miguel Leiva Juarez, Philippe Lemaitre, Joshua Sonett, Selim Arcasoy, Luke Benvenuto
Summary: Candidates with blood group O have lower lung transplantation rates despite being the most common blood type. The study reveals that waitlist outcomes for these candidates and those with other blood types vary based on disease severity and lung allocation score (LAS).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jay M. Brahmbhatt, Travis Hee Wai, Christopher H. Goss, Erika D. Lease, Christian A. Merlo, Siddhartha G. Kapnadak, Kathleen J. Ramos
Summary: Improved predictive models are needed for lung transplantation in the United States to accurately predict long-term post-transplant survival and fairly allocate organs. The existing models show poor accuracy in predicting 1-year and 3-year post-transplant mortality, and tend to overestimate the risk of death in patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Surgery
Hidenao Kayawake, Toyofumi F. Chen-Yoshikawa, Satona Tanaka, Yuka Tanaka, Hideki Ohdan, Yojiro Yutaka, Yoshito Yamada, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Hiroto Egawa, Hiroshi Date
Summary: This study found that the R-type single nucleotide polymorphisms in the FCGR2A gene are associated with infectious complications after lung transplantation, suggesting that recipients with the H/R or R/R genotype may require closer attention to infectious complications.
TRANSPLANT INTERNATIONAL
(2021)
Article
Immunology
Robert M. Cannon, David S. Goldberg, Devin E. Eckhoff, Douglas J. Anderson, Babak J. Orandi, Jayme E. Locke
Summary: This study evaluated the early outcomes of liver transplant recipients under the safety net policy regarding subsequent kidney transplantation. The results showed that patients under the safety net had higher survival rates within one year, quicker access to kidney transplantation, and better survival outcomes.
Article
Immunology
Robert M. Cannon, David S. Goldberg, Devin E. Eckhoff, Douglas J. Anderson, Babak J. Orandi, Jayme E. Locke
Summary: This study evaluated the early outcomes of liver transplant recipients who opted for kidney transplantation under the safety net policy. It was found that the policy provided rapid access to kidney transplantation with good early survival for eligible patients. Further understanding of the survival of patients unable to qualify for kidney transplant after liver transplant is needed before any further restrictions on simultaneous liver-kidney transplant.
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Critical Care Medicine
Jarrod E. Dalton, Paul R. Gunsalus, Carli J. Lehr, Johnie Rose, Belinda L. Udeh, Maryam Valapour
Summary: The current U.S. lung transplant mortality risk models do not consider the disease progression of patients over time. This study investigated the impact of accrued waitlist time on mortality in lung transplant candidates and recipients beyond clinical deterioration and proposed a new framework for conceptualizing mortality risk in end-stage lung disease.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Travis D. Hull, Gregory A. Leya, Andrea L. Axtell, Philicia Moonsamy, Asishana Osho, David C. Chang, Thoralf M. Sundt, Mauricio A. Villavicencio
Summary: Restricted listing preference is associated with increased waitlist mortality, but DLT recipients have superior posttransplant survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Javier De Miguel-Diez, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, David Carabantes-Alarcon, Jose J. J. Zamorano-Leon, Natividad Cuadrado-Corrales, Ricardo Omana-Palanco, Francisco Javier Gonzalez-Barcala, Ana Lopez-de-Andres
Summary: This study examined the clinical characteristics and hospital outcomes of COPD patients undergoing lung transplantation in Spain from 2016 to 2020, and assessed the impact of the COVID-19 pandemic on the number and outcomes of lung transplantations. The results showed a continuous increase in the number of lung transplantations from 2016 to 2019, but a significant decrease in 2020. Nearly half of the patients experienced complications, with lung transplant rejection and infection being the most common. The study received a rating of 8 out of 10.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jeanne E. Conner, Joshua A. Steinberg
Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Alejandra Escobar Vasco, Julie -Ann Talano, Larisa Broglie
Summary: HLH is a rare but fatal disease, and maintaining a high level of suspicion is crucial for patients with evidence of hyperinflammation. Adolescents with HLH should undergo genetic evaluation for familial HLH, and primary immune deficiencies and dysregulation disorders should also be considered. Early diagnosis and treatment are necessary to prevent morbidity and mortality related to HLH's hyperinflammation.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kathleen Ryan
Summary: Fevers of unknown origin (FUO) present a diagnostic challenge, with a wide range of potential causes including infectious, autoimmune, and malignant. Some adolescents with FUO may never have an identifiable etiology, but the prognosis is generally favorable in the absence of red flag symptoms.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Brett J. Bordini, Ryan D. Walsh, Donald Basel, Tejaswini Deshmukh
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Hsi Yen, Leah Lalor
Summary: The article emphasizes the importance of increased awareness among healthcare providers when faced with severe adolescent acne that may not be typical teenage acne. It provides a summary of uncommon causes of severe adolescent acne and a simplified diagnostic approach. Additionally, it discusses rare autoinflammatory syndromic causes of acne and acne associated with excess androgen states.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bethany Auble, Justin Dey
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kaitlin V. Kirkpatrick, James J. Nocton
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Louella Amos
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Tracey Thompson, Ashley Phimister, Alexander Raskin
Summary: Heart failure occurs as a result of pressure or volume overload in congenital and acquired heart diseases, and its treatment varies depending on the underlying cause.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Allison Remiker, Kristina Bolling, James Verbsky
Summary: CVID is a heterogeneous group of disorders characterized by abnormal B-cell differentiation and impaired production of specific immunoglobulin. Clinical manifestations vary and include recurrent bacterial infections, lymphoproliferation, autoimmunity, pulmonary disease, gastrointestinal disease, granulomas, and increased cancer risk. The diagnosis of CVID is complex, requiring exclusion of other causes of immunoglobulin deficiency and assessment based on clinical criteria models. Treatment involves regular immunoglobulin replacement therapy, infection prevention, and surveillance for complications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Vaishali Singh, Scott K. Van Why
Summary: Hypertension in adolescents is rare, and evaluation for identifiable causes beyond primary hypertension is necessary. Common causes of hypertension in this age group are usually acquired or congenital renal or vascular diseases. If these etiologies are not found, exploration for rare causes, including monogenic hypertension, should be pursued.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Dominic O. Co
Summary: Acquired demyelinating syndromes (ADS) are a group of inflammatory demyelinating conditions that include optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Differentiating between subtypes of ADS is important for optimal patient management, and this can be achieved by considering clinical features, laboratory tests (especially autoantibodies), and MRI findings.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Meghan K. Konda, Matthew Harmelink
Summary: Pediatric adolescent muscle weakness can have various causes. A methodical diagnostic evaluation is necessary to determine the specific disease category, which may require specialized care or extensive testing. The ultimate diagnosis is crucial for prognostication.
MEDICAL CLINICS OF NORTH AMERICA
(2024)