Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway

Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways

(2018) Zihan Liu et al.   ATHEROSCLEROSIS

ADAR1 prevents small intestinal injury from inflammation in a murine model of sepsis

(2018) Shanshou Liu et al.   CYTOKINE

Diethyl Blechnic, a Novel Natural Product Isolated from Salvia miltiorrhiza Bunge, Inhibits Doxorubicin-Induced Apoptosis by Inhibiting ROS and Activating JNK1/2

(2018) Jie Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

(2018) Yu Gu et al.   Journal of Translational Medicine

Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model

(2018) Rongzong Qiu et al.   LIFE SCIENCES

Overexpression of Sirt1 in Mesenchymal Stem Cells Protects against Bone Loss in Mice by FOXO3a Deacetylation and Oxidative Stress Inhibition

(2018) Wen Sun et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Effect of Lactoferrin and Pepsin-Treated Lactoferrin on IEC-6 Cell Damage Induced by Clostridium Difficile Toxin B

(2018) Kosuke Otake et al.   SHOCK

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury

(2017) Mian Ge et al.   Cell Death & Disease

Zeolite-Containing Mixture Supplementation Ameliorated Dextran Sodium Sulfate-Induced Colitis in Mice by Suppressing the Inflammatory Bowel Disease Pathway and Improving Apoptosis in Colon Mucosa

(2017) Weida Lyu et al.   Nutrients

Role of Myoendothelial Gap Junctions in the Regulation of Human Coronary Artery Smooth Muscle Cell Differentiation by Laminar Shear Stress

(2016) Zongqi Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis

(2016) Zili Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Are Synchronized Changes in Connexin-43 and Caveolin-3 a Bystander Effect in a Phoneutria nigriventer Venom Model of Blood-Brain Barrier Breakdown?

(2016) Edilene Siqueira Soares et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Propofol attenuated liver transplantation-induced acute lung injury via connexin43 gap junction inhibition

(2016) Dongdong Yuan et al.   Journal of Translational Medicine

Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK

(2016) Jung Seok Hwang et al.   PHARMACOLOGICAL RESEARCH

The Shift of an Intestinal “Microbiome” to a “Pathobiome” Governs the Course and Outcome of Sepsis Following Surgical Injury

(2016) Monika A. Krezalek et al.   SHOCK

Propofol Attenuated Acute Kidney Injury after Orthotopic Liver Transplantation via Inhibiting Gap Junction Composed of Connexin 32

(2015) Chenfang Luo et al.   ANESTHESIOLOGY

SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens

(2015) D. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

(2015) Gabriele Pizzino et al.   MEDIATORS OF INFLAMMATION

Anti-inflammatory effects of benzenediamine derivate FC-98 on sepsis injury in mice via suppression of JNK, NF-κB and IRF3 signaling pathways

(2015) Yuxian Song et al.   MOLECULAR IMMUNOLOGY

Opposite Effects of Interferon Regulatory Factor 1 and Osteopontin on the Apoptosis of Epithelial Cells Induced by TNF-α in Inflammatory Bowel Disease

(2014) Ruihan Tang et al.   INFLAMMATORY BOWEL DISEASES

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

(2014) Jannie Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of IKKβ in Enterocytes Exacerbates Sepsis-Induced Intestinal Injury and Worsens Mortality

(2013) Jessica A. Dominguez et al.   CRITICAL CARE MEDICINE

The Mechanism of Sevoflurane Preconditioning-Induced Protections against Small Intestinal Ischemia Reperfusion Injury Is Independent of Mast Cell in Rats

(2013) Xiaoliang Gan et al.   MEDIATORS OF INFLAMMATION

Testing for a Gap Junction-Mediated Bystander Effect in Retinitis Pigmentosa: Secondary Cone Death Is Not Altered by Deletion of Connexin36 from Cones

(2013) Katharina Kranz et al.   PLoS One

CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER Stress

(2012) Arindam P. Ghosh et al.   PLoS One

Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

(2012) Nicolas Theodoric et al.   PLoS One

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

(2011) Manlio Vinciguerra et al.   AGING CELL

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

(2011) Ismail Syed et al.   DIABETES

Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

(2011) Zhanguo Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion

(2010) Joep Grootjans et al.   GASTROENTEROLOGY

TLR2 Mediates Gap Junctional Intercellular Communication through Connexin-43 in Intestinal Epithelial Barrier Injury

(2009) Birgit Ey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43

(2008) S Cottin et al.   CANCER GENE THERAPY

SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes

(2008) Cong Cao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE