Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Lijun Wang, Fang Wang, Qiang Zhou, Yanfei Wang, Haixiang Song, Haiyang Yang
Summary: In this study, novel nitrobenzoxadiazole fluorophore-functionalized polyester-based amphiphilic polymers were synthesized, and their self-assembled fluorescent polymeric nanoparticles showed excellent fluorescence performance and biocompatibility, providing a new strategy for the design and preparation of biocompatible fluorescent amphiphilic polymers for biological imaging agents.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Xiao Fu, Yulin Zhang, Gaorui Zhang, Xingang Li, Shilei Ni, Jiwei Cui
Summary: This study reports the synthesis of targeted nanoparticles encapsulated with multiple therapeutics for catalyzing cascade reactions in tumor microenvironments, providing a promising approach for combinational therapy.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Physical
Vittorio Bianco, Massimo D'Agostino, Daniele Pirone, Giusy Giugliano, Nicola Mosca, Maria Di Summa, Gianluca Scerra, Pasquale Memmolo, Lisa Miccio, Tommaso Russo, Ettore Stella, Pietro Ferraro
Summary: A generalized computational strategy based on self-consistent statistical inference is shown to achieve intracellular multi-specificity in single cells. Additionally, virtual reality is introduced for the first time to handle the information content of multi-specificity in single cells. This opens the way to a metaverse for 3D microscopy.
Article
Biochemistry & Molecular Biology
Mara Goncalves, Visvaldas Kairys, Joao Rodrigues, Helena Tomas
Summary: The study evaluated the potential of bis-MPA-based dendrimers as delivery vehicles for doxorubicin and found that surface functionalization could affect drug delivery properties.
Review
Chemistry, Multidisciplinary
Yang Qin, Xiaorui Geng, Yue Sun, Yitong Zhao, Wenyu Chai, Xiaobing Wang, Pan Wang
Summary: Ultrasound (US) is a mechanical wave that can penetrate biological tissues and has diverse applications in diagnosis and treatment. With the advancements in nanotechnology, US has found wider applications in precision medicine, particularly in tumor theranostics. This review focuses on the combination of US with micro and nanoparticles for tumor theranostics, discussing topics such as US-assisted drug delivery and sonodynamic antitumor strategy. The collaborative efficiency and physicochemical processes of US and nano-sensitizers are also analyzed. Furthermore, the review highlights the new applications of US and diagnostic nanoparticles in tumor monitoring and image-guided combined therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Marjolein I. Priester, Timo L. M. ten Hagen
Summary: Significant advancements have been made in the development of solid tumor treatment, particularly through the implementation of nanosystems for drug delivery, which have reduced side effects and improved drug delivery to tumor regions. However, challenges still exist in clinical translation, and the development of smart drug delivery systems that can be actively manipulated to control drug release shows promise as a powerful strategy to improve drug activity at the target site.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Natalia Lopuszynska, Wladyslaw P. Weglarz
Summary: Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, improve its solubility and stability, enhance distribution and targeting, ensure sustained release, and reduce drug resistance. Nanotechnology enables the combination of therapeutics with biomedical imaging agents to overcome the challenges of disease diagnosis and therapy. This paper presents scientific reports on polymeric nanocarriers for MRI-guided drug delivery, focusing on their contrasting properties and categorizing them into three main groups based on the type of contrast agents.
Article
Chemistry, Multidisciplinary
Ambika Somasundar, Ayusman Sen
Summary: The development of nano and micromotors for actively delivering drugs to disease sites in vivo faces challenges such as safety, biocompatibility, ability to traverse body fluids, and reach cellular targets. Furthermore, scalability and uniformity in production are critical factors.
Article
Polymer Science
Guofei Feng, Ximin Feng, Xiong Liu, Wenqi Guo, Chengjian Zhang, Xinghong Zhang
Summary: This article introduces a method to convert the pollutant CS2 into valuable sulfur-containing polymers using a cooperative organocatalyst system. The copolymerization reaction is highly efficient, avoids small-molecule byproducts, and produces polythiocarbonates with highly regular sequences. The polythiocarbonates demonstrate desirable thermal and mechanical properties.
Review
Chemistry, Multidisciplinary
Jinping Wang, Beilu Zhang, Jingyu Sun, Wei Hu, Hongjun Wang
Summary: Porous nanomaterials with high surface area, tunable porosity, and large mesopores have attracted attention in cancer therapy and imaging. Researchers have been working on fabricating various porous nanomaterials and exploring their potentials in oncology applications.
Review
Medicine, Research & Experimental
Jiang Zhao, Chi Zhang, Weihao Wang, Chen Li, Xupeng Mu, Kebang Hu
Summary: Nanotechnology, with its potential to combine treatment with diagnostic imaging tools, is emerging as a promising therapy for prostate cancer. Nanoparticles can accumulate at the site of pathology through passive and active targeting techniques, reducing side effects on healthy tissues. Additionally, nanotechnology can synergize with other treatment methods to enhance efficacy and reduce resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Mohini Sikarwar, Vaishali Sunil Mishra, Preeti Tiwari, Madhu Gupta, Sunny Dholpuria, Piyush Kumar Gupta
Summary: Unveiling the potential of polyester nanomedicines in revolutionizing the treatment of visceral leishmaniasis through enhanced drug loading and precise targeting.
Review
Biochemistry & Molecular Biology
Jhanvi Jhaveri, Zarna Raichura, Tabassum Khan, Munira Momin, Abdelwahab Omri
Summary: The development of nanotechnology-based drug delivery systems has significant implications for drug formulation research, allowing for improved administration of new and complex drugs. Chitosan, a polysaccharide widely used in nano drug delivery systems, plays a crucial role in enhancing drug delivery and reducing side effects across various disease categories. Recent advancements in functionalized chitosan have shown promise in areas such as anticancer therapeutics, cancer immunotherapy, and multistage delivery systems.
Review
Food Science & Technology
Yinghan Chan, Venkata Sita Rama Raju Allam, Keshav Raj Paudel, Sachin K. Singh, Monica Gulati, Muralikrishnan Dhanasekaran, Piyush Kumar Gupta, Niraj Kumar Jha, Hari Prasad Devkota, Gaurav Gupta, Philip M. Hansbro, Brian Gregory George Oliver, Dinesh Kumar Chellappan, Kamal Dua
Summary: Nutraceuticals, such as probiotics, vitamins, and phytochemicals, have been found to modulate the pathological mechanisms of inflammatory respiratory diseases, leading to improved therapeutic outcomes and overall health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Instruments & Instrumentation
Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A. A. Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi, Murtaza M. Tambuwala
Summary: This study demonstrates the use of a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability and hepatoprotective activity of Thymoquinone (TQ). TQ-SNEDDS showed smaller droplet size, high stability, and increased bioavailability compared to pure TQ, leading to significant hepatoprotective effects.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Sreenath Pappuru, Dina Shpasser, Oz M. Gazit
Summary: This study presents a new supported ionic liquid (IL) functionalized organic ligand that can accept metal sites. After incorporating di-nuclear magnesium, it was used as a single-component solid catalyst for the copolymerization of CO2 and cyclohexene oxide. The obtained solid catalyst showed high activity under mild CO2 pressures, with high selectivity towards polycarbonates and high molecular weights of the obtained polymers.
Review
Pharmacology & Pharmacy
G. Sabarees, G. P. Tamilarasi, V. Velmurugan, V. Alagarsamy, Belay Zeleke Sibuh, Mohini Sikarwar, Pankaj Taneja, Akhilesh Kumar, Piyush Kumar Gupta
Summary: Drug delivery systems based on silk fibroin protein have been widely studied for their advantages in immunogenicity, sterilization, biocompatibility, and biodegradability. Silk fibroin has been used in wound healing and influences various cell types during the healing process. Electrospun nanofibers, with the ability to incorporate bioactive chemicals and enhance biological activity, have shown promise in treating challenging wounds. Silk nanofiber biomaterials have potential in drug delivery and tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sabya Sachi Das, Srushti Tambe, Priya Ranjan Prasad Verma, Purnima Amin, Neeru Singh, Sandeep Kumar Singh, Piyush Kumar Gupta
Summary: Flavonoids, a major group of polyphenolic compounds, have shown significant potential in inhibiting tumor proliferation, cell cycle, angiogenesis, migration, and invasion in lung cancer. However, their clinical application is limited due to poor solubility, low permeability, and quick blood clearance. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers, and nanotubes can greatly enhance the targeted action of flavonoids with improved efficacy and pharmacokinetic properties, making them suitable for treating lung cancer. This review highlights the therapeutic potential of flavonoids and the cutting-edge progress in nanoengineered systems incorporating flavonoids for lung cancer treatment.
Article
Biochemistry & Molecular Biology
Siva Chander Chabattula, Piyush Kumar Gupta, Kavitha Govarthanan, Sudha Varadaraj, Suresh Kumar Rayala, Debashis Chakraborty, Rama Shanker Verma
Summary: Inorganic nanoparticles, particularly Zinc Oxide (ZnO) nanoparticles, have shown promise as nano-drug delivery systems for cancer therapy. In this study, Nat-ZnO nanoparticles were synthesized using a cost-effective method and characterized. These nanoparticles exhibited a crystalline nature and triangular shape. They were found to be biocompatible and hemocompatible, and demonstrated potent anti-cancer activity in lung and cervical cancer cells.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Priyanka Thakur, Vishnu Kirthi Arivarasan, Gaurav Kumar, Gaurav Pant, Rohit Kumar, Soumya Pandit, Manu Pant, Anjuvan Singh, Piyush Kumar Gupta
Summary: The study presents a green synthesis approach for sustainable nano-hydroxyapatite (nHAp) using materials obtained from environmental biowastes, such as HAp from eggshells and pectin from banana peels. The physicochemical characterization of the synthesized nHAp was conducted using various techniques including XRD, FTIR, FESEM, EDX, and HRTEM. The results demonstrated the potential of pectin-bound nHAp as an antibacterial agent for various biomedical and healthcare applications.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Editorial Material
Chemistry, Medicinal
Srushti Tambe, Rohit Kumar, Purnima Amin, Monalisa Mishra, Madhu Gupta, Kavitha Govarthanan, Ashwin Kumar Narasimhan, Piyush Kumar Gupta
Summary: Organoids offer an opportunity to study the effects of diseases on cellular physiology, human tissues, and organs. They are crucial tools for analyzing biomaterial toxicity, discovering new drugs, and advancing regenerative medicine.
FUTURE MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Aishaanya Mishra, Rohit Kumar, Janhavi Mishra, Khushboo Dutta, Priyanca Ahlawat, Akhilesh Kumar, Sugapriya Dhanasekaran, Ashish Kumar Gupta, Somya Sinha, Dillip Kumar Bishi, Piyush Kumar Gupta, Sunita Nayak
Summary: The blood-brain barrier is a crucial protective architecture in the central nervous system, which hinders the efficacy of many brain-targeted drug delivery systems. Nanoparticle-mediated drug delivery systems have emerged as effective tools for treating brain diseases. This review explores the structural and functional aspects of the blood-brain barrier and the utilization of nanoparticle systems for drug delivery to the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Bableen Flora, Rohit Kumar, Preeti Tiwari, Akhilesh Kumar, Janne Ruokolainen, Ashwin Kumar Narasimhan, Kavindra Kumar Kesari, Piyush Kumar Gupta, Anjuvan Singh
Summary: A successful attempt was made to improve the mechanical properties of Hydroxyapatite (HAp) and reduced graphene oxide (rGO) composite nanoparticles (NPs). Different proportions of HAp and rGO were synthesized to enhance the mechanical properties. The HAp NPs were prepared using the wet precipitation method and calcination, while the rGO-HA composites were prepared through ball milling. The strength of the variants significantly increased with the concentration of rGO, while the porosity also increased.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Medicine, Research & Experimental
Shivam Chowdhary, Rahul Deka, Kingshuk Panda, Rohit Kumar, Abhishikt David Solomon, Jimli Das, Supriya Kanoujiya, Ashish Kumar Gupta, Somya Sinha, Janne Ruokolainen, Kavindra Kumar Kesari, Piyush Kumar Gupta
Summary: Human viral oncogenesis is a complex phenomenon that contributes significantly to the global cancer burden. Recent findings have uncovered cellular and molecular pathways involved in the development and initiation of malignancy during viral infections. Antiviral treatment has emerged as a strategy to eliminate viral infections and prevent oncogenesis. Exploring the molecular pathogenesis of various oncogenic viruses and developing potent antiviral therapies could enhance the eradication of infected malignant cells while sparing normal ones. This review discusses the advancements in natural and synthetic antivirals and highlights the challenges and future prospects of using antivirals in viral oncogenesis.
MOLECULAR PHARMACEUTICS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Vaishali Sunil Mishra, Preeti Tiwari, Madhu Gupta, Piyush Kumar Gupta
Summary: Lipid-based nanodrug delivery systems have great potential in the therapeutic intervention for leishmaniasis by improving drug solubility and targeted delivery.
Editorial Material
Biotechnology & Applied Microbiology
Neha Raina, Parvaiz Ahmad Shiekh, Akhilesh Kumar, Manu Smriti Singh, Piyush Kumar Gupta, Madhu Gupta
Review
Cell & Tissue Engineering
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Ruchi Sharma, Georgina Faura, Lars Eide, Rama Shanker Verma, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Goran Petrovski, Kapil Bharti
Summary: Retinal pigment epithelium (RPE) is a critical cell monolayer forming the blood-retina-barrier (BRB) and a permeable bridge between the choriocapillaris and the retina. Loss of the RPE is associated with degenerative diseases like age-related macular degeneration (AMD). Pluripotent stem cell-derived RPE (pRPE) has been extensively explored as a regenerative module for treating AMD, and strategies for RPE derivation and transplantation have been discussed in this review.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tahseena Naaz, Dibyajit Lahiri, Soumya Pandit, Moupriya Nag, Piyush Kumar Gupta, Noura Al-Dayan, Nishant Rai, Kundan Kumar Chaubey, Ashish Kumar Gupta
Summary: Surface colonization and the formation of biofilms by microbes are well acknowledged. These biofilms, composed of microorganisms surrounded by extracellular polymeric substances, pose a significant threat to modern medicine. Antimicrobial peptides (AMPs) have shown potential in preventing and eradicating microbial biofilms, as well as altering their structure. This review discusses the severity of diseases caused by microbial biofilm formation and explores the use of AMPs and their mechanisms against microbial biofilms, along with strategies to enhance their activity.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
