Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia – a preliminary report

(2018) C. S. Paththinige et al.   Lipids in Health and Disease

Hyperlipidemic Inhibitory Effects of Phellinus pini in Rats Fed with a High Fat and Cholesterol Diet

(2018) Kyung Hoan Im et al.   MYCOBIOLOGY

Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments

(2018) Michelle L. Kimberland et al.   JOURNAL OF BIOTECHNOLOGY

Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7

(2018) Rui Lu et al.   EBioMedicine

CRISPR/Cas9-Mediated Deletion of Large Genomic Fragments in Soybean

(2018) Yupeng Cai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-atherosclerotic effect of hesperidin in LDLr −/− mice and its possible mechanism

(2017) Ye-Zi Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Refining strategies to translate genome editing to the clinic

(2017) Tatjana I Cornu et al.   NATURE MEDICINE

Deletion of a target gene in Indica rice via CRISPR/Cas9

(2017) Ying Wang et al.   PLANT CELL REPORTS

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE

(2017) Marie-Christine Birling et al.   Scientific Reports

Large fragment deletion using a CRISPR/Cas9 system in Saccharomyces cerevisiae

(2016) Huanhuan Hao et al.   ANALYTICAL BIOCHEMISTRY

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia

(2016) Manabu Niimi et al.   ATHEROSCLEROSIS

Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system

(2016) Yuning Song et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells

(2016) Qiupeng Zheng et al.   BIOTECHNIQUES

An inducible recA expression Bacillus subtilis genome vector for stable manipulation of large DNA fragments

(2015) Takafumi Ogawa et al.   BMC GENOMICS

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

(2015) C. Liu et al.   Disease Models & Mechanisms

Targeted Large-Scale Deletion of Bacterial Genomes Using CRISPR-Nickases

(2015) Kylie Standage-Beier et al.   ACS Synthetic Biology

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice

(2015) Katerina Kraft et al.   Cell Reports

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

(2013) B. G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII

(2011) Jingyuan Wei et al.   FEBS Journal