Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Ali Ahmadi, A. Wallace Hayes, Gholamreza Karimi
Summary: The endoplasmic reticulum (ER) performs essential functions in cellular biology, such as synthesizing lipids and controlling protein folding. Inflammation and oxidative stress can lead to protein misfolding in the ER. Resveratrol (RSV) has various bioactive properties and is known for its potential beneficial effects on health.
PHYTOTHERAPY RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Carlos Ardavin, Natalia Alvarez-Ladron, Margarita Ferriz, Alejandra Gutierrez-Gonzalez, Adrian Vega-Perez
Summary: Large peritoneal macrophages (LPMs) are tissue-resident macrophages with important roles in defense against peritoneal pathologies and maintenance of self-tolerance. Recent research in mice has revealed the mechanisms by which LPMs repair peritoneal injuries, control infections, and protect against tumor metastasis. However, peritoneal tumors can subvert LPM function and promote tumor growth. The plasticity of LPMs can be harnessed to develop immunotherapeutic approaches against peritoneal tumor metastasis based on macrophage reprogramming.
Article
Cell Biology
Fuquan Wang, Jiamin Ma, Jingxu Wang, Ming Chen, Haifa Xia, Shanglong Yao, Dingyu Zhang
Summary: This study found that increased expression of SIRT1 can significantly improve sepsis-related lung injury and inhibit ER stress response and macrophage apoptosis. The protective effect of SIRT1 is mediated through the PERK/eIF2-alpha/ATF4/CHOP pathway.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Mokarram Hossain, Raymond Shim, Woo-Yong Lee, Arlene H. Sharpe, Paul Kubes
Summary: Emerging evidence suggests that resident macrophages within tissues play a role in tumor growth. In this study, the authors discovered that GATA6(+) large peritoneal macrophages can invade growing metastases in the liver and promote tumor growth.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Wolfgang Vivas, Sebastian Weis
Summary: Pathogens and their toxic byproducts can cause tissue damage in infected hosts, triggering stress responses such as the unfolded protein response (UPR) to limit pathogenesis. However, prolonged or excessive activation of UPR may have detrimental effects including cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Li Ji, Huan Gu
Summary: The study showed that rhein has inhibitory effects on weight, inflammatory factors, and oxidative stress, and improves insulin resistance, blood lipid levels, and pathological injury. Moreover, rhein also affects ERs in peripheral blood and adipose tissue, significantly reducing cell apoptosis levels. Additionally, rhein treatment decreases adipogenic differentiation and increases p62 expression, while impacting PPAR gamma and INSR levels.
Article
Cell Biology
Subramani Yuvaraj, Arumugam Kalaiselvi Ajeeth, Shanavas Syed Mohamed Puhari, Albert Abhishek, Tharmarajan Ramprasath, Varadaraj Vasudevan, Narasimman Vignesh, Govindan Sadasivam Selvam
Summary: This study reveals that chrysin attenuates ER stress and shows a cardioprotective effect through the activation of the Nrf2 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Immunology
Wenmin Yang, Minqiang Liu, Xi Yu, Yu Huang, Jie Zeng, Yongdong Dai, Hongping Luo, Qinqin Huang, Lin Fan, Jianping Xie
Summary: The study identified the role of Rv1515c in the physiology and pathogenesis of mycobacterium, showing that it is a cell surface-associated protein that disrupts the cytokine profile and promotes endoplasmic reticulum stress-mediated apoptosis. Expression of Rv1515c in M. smegmatis enhanced resistance to various stressors and cellular survival within macrophages.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Yaxin Fu, Wenming Ji, Quan Liu, Lin Zhang, Caina Li, Yi Huan, Lei Lei, Xuefeng Gao, Leilei Chen, Cunyu Feng, Liran Lei, Jiayu Zhai, Pingping Li, Hui Cao, Shuainan Liu, Zhufang Shen
Summary: This study evaluated the effects and underlying mechanism of voglibose on glycemic control and intestinal inflammation in type 2 diabetic mice. The results showed that voglibose improved glucose metabolism by enhancing GLP-1 secretion and ameliorated intestinal inflammation by reducing pro-inflammatory macrophages and increasing tight junction proteins. These findings suggest that voglibose has potential anti-inflammatory effects on the intestine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Nurhan Akaras, Mustafa Ileriturk, Cihan Gur, Sefa Kucukler, Mehmet Oz, Fatih Mehmet Kandemir
Summary: This study aimed to investigate the protective effects of chrysin (CHR) against cadmium (Cd)-induced lung toxicity in rats. Rats were treated with CHR (25 mg/kg and 50 mg/kg) after Cd administration for 7 days. Results showed that CHR reduced oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histological changes in the lung tissues of Cd-administered rats. These findings suggest that CHR may have potential protective effects against Cd-induced lung toxicity in rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jae-Hyung Park, Jaechan Leem, Sun-Jae Lee
Summary: Renal fibrosis, a common feature of chronic kidney disease, is a promising therapeutic target. This study found that carnosol (CS), a compound found in rosemary plants, improved renal function and reduced renal tubular injury and interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). CS achieved this by suppressing oxidative stress, endoplasmic reticulum stress, apoptotic and necroptotic cell death, as well as cytokine production and immune cell infiltration in the kidneys.
Article
Urology & Nephrology
Yixiu Yan, Na Zhu, Dan Jin, Feihong Lin, Ya Lv
Summary: The study aimed to investigate the effect of remifentanil on endoplasmic reticulum stress (ERS) and inflammatory response in an in vitro lipopolysaccharide (LPS)-stimulated renal tubular epithelial cell (HK-2) model and its mechanism. The results showed that remifentanil has a protective effect on LPS-induced cell injury, inflammation, activation of TLR4/NF-kappa B signaling, and ERS.
Article
Biochemistry & Molecular Biology
Gang Lu, Qingqing Li, Jianjun Liu, Yanan Jia, Jianguo Tang, Xuemin Zhang
Summary: ER stress inhibitors play a protective role in sepsis by reducing CD4(+) T cell apoptosis and maintaining function, thus enhancing immune function and prognosis of patients with sepsis.
Article
Immunology
Garyfallia Gouna, Christian Klose, Mar Bosch-Queralt, Lu Liu, Ozgun Gokce, Martina Schifferer, Ludovico Cantuti-Castelvetri, Mikael Simons
Summary: Microglia play a key role in promoting myelin repair after demyelinating injury, with cholesterol esterification being essential for myelin debris clearance and lipid droplet generation. TREM2 is crucial for adapting to excess cholesterol exposure and regulating lipid droplet formation, ultimately impacting the innate immune response and remyelination.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.