Review
Biology
Viana Jacquline Copeland, Alexander Fardman, Ariel Furer
Summary: Cardiogenic shock (CS) is a highly lethal condition that requires prompt and appropriate multimodality treatment. While research has mainly focused on left heart pathology, there is limited assessment of right heart pathology and its management in CS patients. This review aims to provide an in-depth assessment of the pathophysiology, presentation, and management of CS patients with right heart failure.
Article
Medicine, Legal
E. Doberentz, A. Wegner, L. Rochlitzer, B. Madea, J. Ulbricht
Summary: In cases of fatal hemorrhage, there is no induction of extensive Hsp27 or 70 expression, indicating that fatal blood loss does not cause cellular stress.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Review
Cardiac & Cardiovascular Systems
Jose A. Inia, Edward R. O'Brien
Summary: Atherosclerosis is the primary cause of heart attacks, and inflammation plays an important role in its development. Heat shock protein 27 (HSP27) has been identified as a potential anti-inflammatory agent that may be a novel therapeutic target for atherosclerosis and other inflammatory disorders.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Won Seob Kim, Jayasimha R. Daddam, Boon Hong Keng, Jaehwan Kim, Jongkyoo Kim
Summary: This study investigated the response of bovine satellite cells to different levels of heat stress and exposure times. The results showed that extreme heat exposure promotes the accumulation of heat shock proteins and modulates the expression of myogenic regulatory factors in satellite cells. HSP27 acts as a molecular chaperone by binding to Myf5, thereby regulating the division or differentiation of satellite cells in response to heat stress.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chuan-Lei Dong, Zhu Feng, Ming-Xing Lu, Yu-Zhou Du
Summary: Heat shock factor 1 (HSF1) plays a crucial role in maintaining cellular and organismal homeostasis under thermal stress. In this study, the gene encoding HSF1 was cloned from a rice pest and its expression was found to be highly correlated with survival at high temperatures. Additionally, the regulatory interactions between HSF1 and heat shock proteins (HSPs) were investigated, revealing specific HSEs in the promoter regions of HSP genes that are positively regulated by HSF1.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Emergency Medicine
Shino Katsuki, Kazuyuki Miyamoto, Hiroki Yamaga, Atsuo Maeda, Hiromi Takayasu, Masaharu Yagi, Jun Sasaki, Kenji Dohi, Munetaka Hayashi
Summary: This article reports a case of obstructive shock caused by compression of the right ventricle due to gastric tube dilation. By adjusting the patient's position to promptly release the right ventricular compression, the patient recovered.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medical Laboratory Technology
Michael R. Miller, Stephen R. Koch, Hyehun Choi, Fred S. Lamb, Ryan J. Stark
Summary: This study found that ASK1 expression increased in sepsis and after LPS challenge, with ASK1 inhibitors reducing cytokine production but not affecting permeability. Physical interaction between eNOS and ASK1 was observed, and ASK1 inhibition mainly impaired JNK activation, affecting cytokine production.
TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Jan Hrudka, Karolina Jelinkova, Hana Fiserova, Radoslav Matej, Vaclav Mandys, Petr Waldauf
Summary: Heat shock proteins (HSPs) are cytoprotective chaperones that play a critical role in maintaining cellular homeostasis. Overexpression of HSPs in cancer cells is associated with shorter overall survival and poorer prognosis. However, only HSP70 expression was found to have a significant impact on colorectal cancer prognosis in this study, with stage dependency.
Review
Cardiac & Cardiovascular Systems
Yifei Zou, Henghe Shi, Ning Liu, He Wang, Xianjing Song, Bin Liu
Summary: Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in various cellular stress states and plays a crucial role in regulating proteostasis and cellular response to stress. It has been extensively studied in cardiovascular diseases, where it is involved in oxidative stress, inflammatory responses, apoptosis, and potentially serves as a diagnostic and therapeutic target. Targeting HSP27 shows promise for the treatment of cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Aayushi Singh, Vandana Anang, Aarti Singh, Krishnamurthy Natarajan
Summary: Mycobacterium tuberculosis suppresses defence responses in alveolar macrophages to establish a favorable environment in the human lung during infection. Heat Shock Proteins (HSPs) show significantly higher expression in active TB patients compared to those with latent infection. Inhibiting HSP-27 and HSP-70 prior to mycobacterial infection leads to a significant decrease in mycobacterial growth within macrophages. Inhibiting HSPs also increases intracellular oxidative burst levels and enhances T cell activation while inhibiting T cell inhibitory molecules. Additionally, inhibiting HSPs promotes autophagy pathway and pro-inflammatory transcription factors. HSP-27 and HSP-70 are associated with anti-apoptotic proteins Bcl-2 and Beclin-1. These findings suggest a suppressive role of host HSP-27 and HSP-70 during mycobacterial infection.
MICROBES AND INFECTION
(2023)
Review
Cardiac & Cardiovascular Systems
Shruti Ghai, Alex Young, Kuo-Hui Su
Summary: Atherosclerosis is a major risk factor for cardiovascular diseases, and hypercholesterolemia is involved in its initiation. Heat shock factor 1 (HSF1) plays a critical role in controlling atherosclerosis by regulating heat shock proteins (HSPs) and lipid metabolism. Recent research shows that HSF1 directly interacts with and inhibits AMP-activated protein kinase (AMPK), promoting lipogenesis and cholesterol synthesis. This review highlights the roles of HSF1 and HSPs in critical metabolic pathways of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Scott H. Wirth, Haleh C. Heydarian, Elisa Marcuccio, Brooke E. Tepe, Laurel H. Stein, Garick D. Hill
Summary: This study evaluated the trends and factors influencing the first-stage palliation for hypoplastic left heart syndrome. It found that the use of right ventricle-to-pulmonary artery shunt increased over time, while the use of modified Blalock-Taussig shunt decreased. Higher-volume centers, male patients, and less complex patients were more likely to receive modified Blalock-Taussig shunt. However, compared to the right ventricle-to-pulmonary artery shunt, the modified Blalock-Taussig shunt was associated with higher mortality/transplant rates before the second-stage palliation.
ANNALS OF THORACIC SURGERY
(2023)
Review
Neurosciences
Bianka A. Holguin, Zacariah L. Hildenbrand, Ricardo A. Bernal
Summary: Small heat shock protein 27 plays a pivotal role in various physiological processes and its structural dynamics allow it to adapt to different functional requirements. Mutations in this protein could lead to neurodegenerative diseases, making structural investigations crucial for understanding the underlying mechanisms.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Oncology
Denise Traxler, Matthias Zimmermann, Elisabeth Simader, Elisa Einwallner, Dragan Copic, Alexandra Graf, Thomas Mueller, Cecilia Veraar, Mitja Lainscak, Robert Marcun, Mitja Kosnik, Matjaz Flezar, Ales Rozman, Peter Korosec, Walter Klepetko, Bernhard Moser, Hendrik J. Ankersmit
Summary: The study investigated the trajectory of fractional HSP27 urine excretion after acute exacerbation in COPD patients. It found that HSP27 urine excretion increased after exacerbation, especially in severe cases, and was associated with disease severity. Patients with lower HSP27 urine excretion levels showed significantly worse short-term survival outcomes.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Applied
Zhenjiang Ding, Qichao Wei, Chunjiang Zhang, Hong Zhang, Feng Huang
Summary: This study found that oxidation influences the activities of endogenous enzymes in muscle cells by regulating HSP27 and cytochrome c, thereby modulating the degradation process of myofibrillar proteins after slaughter.
Article
Biochemistry & Molecular Biology
Daniel Garcia-Perez, Maria Victoria Milanes
Article
Biochemistry & Molecular Biology
Elena Martinez-Laorden, Javier Navarro-Zaragoza, Maria-Victoria Milanes, Maria-Luisa Laorden, Pilar Almela
Review
Biochemistry & Molecular Biology
Elena Martinez-Laorden, Javier Navarro-Zaragoza, Maria Victoria Milanes, Maria Luisa Laorden, Pilar Almela
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Rocio Guerrero-Bautista, Aurelio Franco-Garcia, Juana M. Hidalgo, Francisco Fernandez-Gomez, M. Victoria Milanes, Cristina Nunez
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Article
Clinical Neurology
Sandra Montagud-Romero, Lidia Cantacorps, Francisco Jose Fernandez-Gomez, Cristina Nunez, Jose Minarro, Marta Rodriguez-Arias, Maria Victoria Milanes, Olga Valverde
Summary: In mice exposed to alcohol during early development, increased alcohol intake during adolescence was observed, with associated decrease in pCREB/CREB ratio in certain brain areas. Additionally, behavioral alterations such as increased anxiety-like responses during acute alcohol withdrawal and higher blood alcohol concentrations were noted in these early alcohol exposed mice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Javier Navarro-Zaragoza, E. Martinez-Laorden, F. Javier Teruel-Fernandez, Victoria Gomez-Murcia, Alberto Canovas, Maria-Victoria Milanes, Maria-Luisa Laorden, Pilar Almela
Summary: Our study aimed to investigate the role of the HPA axis in aversive memory expression and extinction in Swiss and B6 mice. We found that B6 mice showed stronger aversive memory and longer extinction times than Swiss mice. Differences in corticosterone levels and responses to a CRF1 receptor antagonist were observed between the two strains, suggesting a strain-specific mechanism in opioid withdrawal memory.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Rocio Guerrero-Bautista, Aurelio Franco-Garcia, Juana M. Hidalgo, Francisco Jose Fernandez-Gomez, Bruno Ribeiro Do Couto, M. Victoria Milanes, Cristina Nunez
Summary: Preventing relapse in cocaine addiction is a major challenge in treatment. Cocaine relapse activates memory-related nuclei, affecting emotional and episodic memories. D3 receptor antagonists are emerging as potential treatments for preventing drug relapse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, Maria-Luisa Laorden, Maria-Trinidad Herrero
Summary: HSP27 is an essential molecular chaperone involved in maintaining cellular homeostasis and protecting cells from toxic stress. Dysregulation of HSP27 is associated with various human diseases, including Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lorena Cuenca-Bermejo, Pilar Almela, Javier Navarro-Zaragoza, Emiliano Fernandez Villalba, Ana-Maria Gonzalez-Cuello, Maria-Luisa Laorden, Maria-Trinidad Herrero
Summary: Dysautonomia is a common non-motor symptom in Parkinson's disease, mainly characterized by alterations in the sympathetic and parasympathetic nervous systems. The imbalance of these nervous system components may lead to cardiovascular abnormalities, particularly tachycardia and vasoconstriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aurelio Franco-Garcia, Francisco Jose Fernandez-Gomez, Victoria Gomez-Murcia, Juana M. Hidalgo, M. Victoria Milanes, Cristina Nunez
Summary: This study investigates the molecular mechanisms involved in the retrieval and extinction of morphine withdrawal memories in the basolateral amygdala (BLA) and the hippocampal dentate gyrus (DG) of rats. The results show differential expression and activity of synaptic molecules in these regions during the extinction of aversive memories of opiate withdrawal, providing evidence for the development of therapeutic strategies to minimize relapses induced by morphine withdrawal-associated aversive memories.
Article
Environmental Sciences
Lucia Fernandez-Lopez, Rosanna Mancini, Maria-Concetta Rotolo, Javier Navarro-Zaragoza, Juan-Pedro Hernandez del Rincon, Maria Falcon
Summary: The study validated a tool to detect and quantify carbamazepine concentration in bone tissue. The results demonstrated that carbamazepine can be detected in bone and the proposed method is valid, reliable, and trustworthy.
Article
Genetics & Heredity
Juan Antonio Garcia-Carmona, Joaquin Amores-Iniesta, Jose Soler-Usero, Maria Cerdan-Sanchez, Javier Navarro-Zaragoza, Maria Lopez-Lopez, Juan Jose Soria-Torrecillas, Ainhoa Ballesteros-Arenas, Jose Antonio Perez-Vicente, Pilar Almela
Summary: We report a case of a 49-year-old patient with spastic paraplegia and analyzed the levels of heat shock proteins (hsp)-27, dopamine (DA), and its metabolites in their cerebrospinal fluid (CSF). The patient had a novel heterozygous mutation in the SPG-11 gene and a previously unreported mutation in the SYNJ1 gene. The levels of DA and its metabolites in the patient's CSF were significantly decreased, while the levels of hsp27 were significantly higher.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
