Article
Biochemistry & Molecular Biology
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jerome, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis
Summary: Food odour coding is crucial for food intake, and dopamine plays a regulatory role in food odour information processing in the ventral striatum.
Article
Psychiatry
Ekin Soenmez Guengoer, Cengiz Celebi, Yildiz Akvardar
Summary: The study found that food addiction is significantly associated with more serious eating pathologies, more frequent weight-cycling, higher impulsivity, and higher BMI. The severity of food addiction was predictive of an increase in BMI. Impulsivity showed a correlation with the severity of food addiction, suggesting a relationship between impulsivity and weight gain in some individuals.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Morgane M. Moss, Peter Zatka-Haas, Kenneth D. Harris, Matteo Carandini, Armin Lak
Summary: Research suggests that dopamine in the striatum plays a critical role in visual decision-making, encoding visual stimuli and rewarded actions in a lateralized fashion. Contrary to previous beliefs, dopamine signals in the DMS respond to contralateral stimuli and rewarded actions, facilitating associations between specific visual stimuli and actions.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Allen P. F. Chen, Lu Chen, Thomas A. Kim, Qiaojie Xiong
Summary: Dopamine plays a crucial role in controlling CNS function and its dysregulation can lead to various cognitive symptoms associated with neuropsychiatric diseases. Different brain areas have varying functions and roles for dopamine, suggesting potential differential dysregulation in different disease states.
Article
Surgery
Marianna Maspero, Camillo Leonardo Bertoglio, Lorenzo Morini, Bruno Alampi, Michele Mazzola, Valerio Girardi, Andrea Zironda, Gisella Barone, Carmelo Magistro, Giovanni Ferrari
Summary: A study of 322 obese patients undergoing laparoscopic ventral hernia repair found that class III obesity was associated with a longer hospital stay, but showed no significant differences in postoperative complications and long-term outcomes compared to class I and II obesity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Neurosciences
Xinqi Zhou, Ting Xu, Yixu Zeng, Ran Zhang, Ziyu Qi, Weihua Zhao, Keith M. Kendrick, Benjamin Becker
Summary: Social deficits and dysregulations in dopaminergic midbrain-striato-frontal circuits are common symptoms across psychiatric disorders. The present study investigated the effects of the AT1R antagonist losartan on social reward and punishment processing in humans. The findings suggest that losartan modulates approach-avoidance motivation and emotional salience during social punishment versus social reward by influencing the core nodes of the midbrain-striato-frontal circuits.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Marybeth Alejandra Tellez-Rodriguez, Adriana Amaya-Hernandez, Mayaro Ortega-Luyando, Carlos Alberto Serrano-Juarez, Guillermina Yanez-Tellez, Veronica Elsa Lopez-Alonso, Juan Manuel Mancilla-Diaz, Rodrigo Erick Escartin-Perez
Summary: This study aimed to investigate the severity of food addiction (FA) in Mexican adults in relation to executive dysfunction, depressive symptoms, and binge eating problems. The results showed that FA symptoms were associated with executive dysfunction, reward sensitivity, and depressive and binge eating problems. In women, changes in BMI were linked to decreased crystallized intellectual capacity and inability to control food intake.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Letter
Clinical Neurology
Pedro Barbosa, Bimali Hapuarachchi, Atbin Djamshidian, Kate Strand, Andrew J. Lees, Rohan de Silva, Janice L. Holton, Thomas T. Warner
Summary: Pagano and collaborators found lower D3 receptor availability in the ventral striatum of Parkinson's disease patients, while our study reported lower alpha-synuclein pathology and D3R levels in the nucleus accumbens of PD patients with ICD. These findings together support the hypothesis that D3R levels are downregulated due to excessive synaptic dopamine.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Cell Biology
Rafael Sandoval-Rodriguez, Jenifer Alejandra Parra-Reyes, Wenfei Han, Pavel E. Rueda-Orozco, Isaac O. Perez, Ivan E. de Araujo, Luis A. Tellez
Summary: Although the consumption of carbohydrates is necessary for survival, it can lead to obesity due to their reinforcing properties. Sugar overconsumption is regulated by brain reward systems, but the specific cell types controlling the initiation and termination of sugary meals are still unknown.
Review
Nutrition & Dietetics
Gemma Mestre-Bach, Marc N. Potenza
Summary: This review article discusses the relevance of the reward system in behavioral addictions such as gambling disorder, internet gaming disorder, and food addiction/binge eating disorder. Specifically, it explores the role of the ventral striatum as a possible biomarker for these conditions and discusses studies analyzing brain changes following interventions for these disorders.
Article
Endocrinology & Metabolism
Yu-Jie Duan, Mou-Xiong Zheng, Jia-Jia Wu, Jie Ma, Xiang-Xin Xing, Zhen-Zhen Ma, Si-Si Li, Yu-Lin Li, Xin Xue, Xu-Yun Hua, Jian-Guang Xu
Summary: This study explored the relationship between BMI and regional cerebral glucose metabolism using PET/MRI and found that lower cerebral glucose metabolism in reward- and motivation-related regions was associated with more severe obesity. Additionally, the study found that regional cerebral glucose metabolism activities were negatively correlated with BMI and that more severe obesity was accompanied by a larger range of areas with significant differences, irrespective of current dietary status.
Article
Behavioral Sciences
Vinicia Garzella Metz, Jessica Leandra Oliveira da Rosa, Domenika Rubert Rossato, Marilise Escobar Burger, Camila Simonetti Pase
Summary: This study investigated the effects of CBD treatment on relapse behavior triggered by stress in rats after amphetamine-induced conditioned place preference (CPP). The results showed that CBD treatment prevented amphetamine reinstatement and exerted anxiolytic activity. At the molecular level, CBD restored neuroadaptations in the dopaminergic and endocannabinoid systems in brain areas closely involved in addiction.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Behavioral Sciences
John G. Howland, Rutsuko Ito, Christopher C. Lapish, Franz R. Villaruel
Summary: Emerging evidence suggests that the rodent medial prefrontal cortex (mPFC) plays a crucial role in adapting behavior to changing information. The mPFC subregions, such as the dorsal and ventral mPFC, have specific functions in regulating action control and translating affective signals. However, these subregions also interact and influence each other in the modulation of adaptive behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Johannes W. de Jong, Kurt M. Fraser, Stephan Lammel
Summary: Ventral tegmental area dopamine neurons encode reward prediction errors, but their release in the nucleus accumbens is involved in reinforcement learning, motivation, aversion, and incentive salience. The contrast between the homogeneous role of dopamine neuron activity and the heterogeneous functions of dopamine release raises questions about how VTA dopamine activity translates into NAc dopamine release.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Review
Psychiatry
Shinichiro Nakajima, Hiroyoshi Takeuchi, Eric Plitman, Gagan Fervaha, Philip Gerretsen, Fernando Caravaggio, Jun Ku Chung, Yusuke Iwata, Gary Remington, Ariel Graff-Guerrero
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Shinichiro Nakajima, Fernando Caravaggio, David C. Mamo, Benoit H. Mulsant, Jun Ku Chung, Eric Plitman, Yusuke Iwata, Philip Gerretsen, Hiroyuki Uchida, Takefumi Suzuki, Wanna Mar, Alan A. Wilson, Sylvain Houle, Ariel Graff-Guerrero
SCHIZOPHRENIA RESEARCH
(2015)
Article
Psychiatry
Shinichiro Nakajima, Hiroyoshi Takeuchi, Gagan Fervaha, Eric Plitman, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Yukiko Mihashi, Philip Gerretsen, Gary Remington, Benoit Mulsant, Ariel Graff-Guerrero
SCHIZOPHRENIA RESEARCH
(2015)
Review
Clinical Neurology
Shinichiro Nakajima, Philip Gerretsen, Hiroyoshi Takeuchi, Fernando Caravaggio, Tiffany Chow, Bernard Le Foll, Benoit Mulsant, Bruce Pollock, Ariel Graff-Guerreo
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2013)
Review
Clinical Neurology
Eric Plitman, Shinichiro Nakajima, Camilo de la Fuente-Sandoval, Philip Gerretsen, M. Mallar Chakravarty, Jane Kobylianskii, Jun Ku Chung, Fernando Caravaggio, Yusuke Iwata, Gary Remington, Ariel Graff-Guerrero
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Neurosciences
Philip Gerretsen, M. Mallar Chakravarty, David Mamo, Mahesh Menon, Bruce G. Pollock, Tarek K. Rajji, Ariel Graff-Guerrero
HUMAN BRAIN MAPPING
(2013)
Article
Neurosciences
Philip Gerretsen, Mahesh Menon, M. Mallar Chakravarty, Jason P. Lerch, David C. Mamo, Gary Remington, Bruce G. Pollock, Ariel Graff-Guerrero
HUMAN BRAIN MAPPING
(2015)
Review
Geriatrics & Gerontology
Philip Gerretsen, Eric Plitman, Tarek K. Rajji, Ariel Graff-Guerrero
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2014)
Editorial Material
Psychology, Clinical
Philip Gerretsen, Bruce G. Pollock
JOURNAL OF CLINICAL PSYCHIATRY
(2011)
Review
Behavioral Sciences
Philip Gerretsen, Pablo Diaz, David Mamo, Doug Kavanagh, Mahesh Menon, Bruce G. Pollock, Ariel Graff-Guerrero
Article
Psychiatry
Philip Gerretsen, Gary Remington, Carol Borlido, Lena Quilty, Sabrina Hassan, Gina Polsinelli, Celine Teo, Wanna Mar, Regina Simon, Mahesh Menon, David D. Pothier, Shinichiro Nakajima, Fernando Caravaggio, David C. Mamo, Tarek K. Rajji, Benoit H. Mulsant, Vincenzo Deluca, Rohan Ganguli, Bruce G. Pollock, Ariel Graff-Guerrero
PSYCHIATRY RESEARCH
(2014)
Article
Psychiatry
Philip Gerretsen, Benoit H. Mulsant, Angela Y. Liu, Eric Granholm, Mahesh Menon, Ariel Graff-Guerrero, Bruce G. Pollock, David C. Mamo, Tarek K. Rajji
SCHIZOPHRENIA RESEARCH
(2013)
Article
Neurosciences
Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Tiffany W. Chow, M. Mallar Chakravarty, Fernando Caravaggio, Philip Gerretsen, Eric E. Brown, Yusuke Iwata, Benoit H. Mulsant, Ariel Graff-Guerrero
JOURNAL OF ALZHEIMERS DISEASE
(2015)
Article
Clinical Neurology
N. Lipsman, P. Gerretsen, C. Torres, A. M. Lozano, P. Giacobbe
JOURNAL OF NEUROSURGICAL SCIENCES
(2012)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)