Article
Environmental Sciences
Ruth L. Airs, Rachael Beale, Luca Polimene, Yin Chen, Michaela A. Mausz, David J. Scanlan, Claire E. Widdicombe, Glen A. Tarran, E. Malcolm S. Woodward, Carolyn Harris, Andrea McEvoy
Summary: Glycine betaine (GBT) is a nitrogenous osmolyte found throughout the marine environment. This study presents a seasonal dataset of GBT concentrations in marine suspended particulate material, showing peaks in summer and autumn. The GBT concentrations are associated with specific phytoplankton groups or species, suggesting different environmental drivers for different periods of the GBT seasonality.
Article
Environmental Sciences
Erin L. McParland, Harriet Alexander, Winifred M. Johnson
Summary: Marine organisms play a crucial role in the carbon cycle by producing and consuming organic matter. Osmolytes are small metabolites that regulate osmolarity and can be released as abundant dissolved substrates. The genetic potential of marine microbes suggests active recycling of osmolytes, which can serve as a significant source of nutrients for diverse microbial groups in the marine ecosystem.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Shan Huang, Si Ying Lim, Sock Hwee Tan, Mark Y. Chan, Wuzhong Ni, Sam Fong Yau Li
Summary: The relationship between TMAO, betaine, and choline with acute myocardial infarction (AMI) is unclear. This study found that high betaine + low TMAO levels are associated with a significant protective effect against AMI. Furthermore, age is positively correlated with TMAO concentration, indicating a potential interplay between age and the risk of AMI associated with metabolite combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Chemistry, Analytical
Mark F. Fitzsimons, Mia Tilley, Charlotte H. L. Cree
Summary: This review critically assesses the knowledge and challenges in determining volatile, low molecular weight amines, particularly methylamines, in marine aquatic systems. Despite the development of sensitive analytical methods in recent decades, they have not been widely adopted by the oceanographic community for studying the biogeochemistry of methylamines. Different analytical techniques, including gas chromatography, high performance liquid chromatography, ion chromatography, and infusion-mass spectrometry, are discussed and evaluated. The increasing interest in the marine occurrence and cycling of methylamines, due to their potential role in climate regulation, highlights the need for robust and reproducible methods to investigate nitrogen biogeochemical cycles and populate marine models. Recommendations for future research in this area are provided.
ANALYTICA CHIMICA ACTA
(2023)
Article
Plant Sciences
Sergio G. Hernandez-Leon, Elisa M. Valenzuela-Soto
Summary: This review summarizes the role of glycine betaine (GB) in plant response to abiotic stress and its potential as a phytohormone-like compound. GB participates in various plant responses to cope with stressful conditions and influences plant growth, development, and productivity.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Endocrinology & Metabolism
Retu Haikonen, Olli Karkkainen, Ville Koistinen, Kati Hanhineva
Summary: 5-Aminovaleric acid betaine (5-AVAB) is a gut microbiota-associated compound that accumulates in metabolically active tissues. It has been found in higher concentrations in the heart, muscle, and brown adipose tissue. It has positive health effects on fetal brain development, insulin secretion, and reduced cancer risk, but it is also associated with negative health outcomes such as cardiovascular disease and fatty liver disease.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Ashal Ilyas, Yasanandana Supunsiri Wijayasinghe, Ilyas Khan, Nourhan M. El Samaloty, Mohd Adnan, Tanveer Ali Dar, Nitesh Kumar Poddar, Laishram R. Singh, Hemlata Sharma, Shahanavaj Khan
Summary: Osmolytes are small organic molecules that play a critical role in maintaining cellular protein stability in all life forms. Trimethylamine N-oxide (TMAO) and betaine, two methylamine osmolytes, have diverse effects on human health, with TMAO correlated to the pathogenesis of diseases like cardiovascular disease, while betaine demonstrates antioxidant and anti-inflammatory activities in various human diseases. Further research into their molecular mechanisms could provide insights for the prevention, diagnosis, and treatment of human diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Environmental Sciences
Richard W. Hill
Summary: Quaternary ammonium compounds (QACs) and tertiary sulfonium compounds (TSCs) play important roles in the photobiology of corals. TSCs, particularly DMSP, affect the photon and thermal fluxes to which corals are exposed, while QACs protect the coral photosystems. Further research is needed to understand the physiological effects of QACs in corals.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Plant Sciences
Muhammad Anwar-ul-Haq, Irfan Iftikhar, Javaid Akhtar, Muhammad Maqsood
Summary: Salt stress is a major problem affecting agricultural productivity worldwide, with 20% of arable lands and 33% of irrigated areas already affected by soil salinity. This study aimed to investigate the effect of osmolytes on soybean growth under salt stress. The results showed that supplementation of osmoprotectants, particularly 20 mM proline, improved soybean tolerance to salinity stress by enhancing growth, physiological response, antioxidant activity, and reducing lipid peroxidation. Among the genotypes tested, the Ajmeri genotype showed the most promising outcomes.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Article
Veterinary Sciences
Sarah M. Cavanaugh, Ryan P. Cavanaugh, Renee Streeter, Aline B. Vieira, Gregory E. Gilbert, Jennifer K. Ketzis
Summary: Feeding a plant-based diet to dogs can reduce circulating levels of TMAO precursors choline and betaine, but does not affect TMAO itself. This study suggests that commercial extruded plant-based diets can lower choline and betaine levels in healthy adult dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Na Yang, Runting Ding, Jianguo Liu
Summary: In this study, a halophilic archaea strain was identified to synthesize and accumulate glycine betaine via the choline oxidation pathway. The presence of the choline oxidation pathway was found to have no significant effects on the adaptation of halophilic archaea to high salinity habitats.
Article
Ecology
Chun-Yang Li, Michaela A. Mausz, Andrew Murphy, Nan Zhang, Xiu-Lan Chen, Shu-Yan Wang, Chao Gao, Maria M. Aguilo-Ferretjans, Eleonora Silvano, Ian D. E. A. Lidbury, Hui-Hui Fu, Jonathan D. Todd, Yin Chen, Yu-Zhong Zhang
Summary: Through genomics analyses and biochemical analyses, a DMSP-specific transporter, DmpXWV, was identified in the marine bacteria Ruegeria pomeroyi DSS-3. The substrate binding protein of DmpXWV, DmpX, showed high specificity and affinity towards DMSP. DmpX proteins are prevalent in cosmopolitan marine bacteria, and dmpX transcription is consistently high in the global ocean. This study provides new insights into DMSP transport and the environmental adaptation of marine bacteria.
Article
Chemistry, Multidisciplinary
Marina Cvjetko Bubalo, Thanos Andreou, Manuela Panic, Mia Radovic, Kristina Radosevic, Ivana Radojcic Redovnikovic
Summary: This study established a connection between osmolytes and deep eutectic solvents, two major research fields that were previously advancing in parallel. We proposed a new model to explain the function of osmolytes based on the formation of deep eutectic systems with emergent and synergistic properties. This bio-inspired approach can be a remarkable tool for studying complex natural systems and engineering sustainable processes.
Article
Plant Sciences
Galina N. Raldugina, Sergey V. Evsukov, Liliya R. Bogoutdinova, Alexander A. Gulevich, Ekaterina N. Baranova
Summary: In this study, transgenic tobacco lines overexpressing the bacterial enzyme choline oxidase gene were evaluated for their response to NaCl stress. The results showed that these transgenic plants had better regeneration and survival ability under high salt stress.
Article
Biochemistry & Molecular Biology
Galina N. Raldugina, Lilia R. Bogoutdinova, Olga V. Shelepova, Vera V. Kondrateva, Ekaterina V. Platonova, Tatiana L. Nechaeva, Varvara V. Kazantseva, Pyotr V. Lapshin, Helen I. Rostovtseva, Tatiana S. Aniskina, Pyotr N. Kharchenko, Natalia V. Zagoskina, Alexander A. Gulevich, Ekaterina N. Baranova
Summary: Transgenic tobacco plants overexpressing the choline oxidase gene showed increased resistance to salinity. However, under normal conditions, these transgenic plants exhibited characteristics of juvenilization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Deborah J. Steele, Susan A. Kimmance, Daniel J. Franklin, Ruth L. Airs
ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Engineering, Environmental
Sina C. Hackenberg, Stephen J. Andrews, Ruth L. Airs, Steve R. Arnold, Heather A. Bouman, Denise Cummings, Alastair C. Lewis, Jamie K. Minaeian, Kristen M. Reifel, Alison Small, Glen A. Tarran, Gavin H. Tilstone, Lucy J. Carpenter
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2017)
Article
Environmental Sciences
S. C. Hackenberg, S. J. Andrews, R. Airs, S. R. Arnold, H. A. Bouman, R. J. W. Brewin, R. J. Chance, D. Cummings, G. Dall'Olmo, A. C. Lewis, J. K. Minaeian, K. M. Reifel, A. Small, G. A. Tarran, G. H. Tilstone, L. J. Carpenter
GLOBAL BIOGEOCHEMICAL CYCLES
(2017)
Article
Limnology
Stephen D. Archer, Jacqueline Stefels, Ruth L. Airs, Tracy Lawson, Timothy J. Smyth, Andrew P. Rees, Richard J. Geider
LIMNOLOGY AND OCEANOGRAPHY
(2018)
Review
Chemistry, Organic
Ruth L. Airs
CURRENT ORGANIC CHEMISTRY
(2018)
Article
Limnology
Charlotte H. L. Cree, Ruth Airs, Stephen D. Archer, Mark F. Fitzsimons
LIMNOLOGY AND OCEANOGRAPHY-METHODS
(2018)
Article
Ecology
Eleanor Jameson, Jason Stephenson, Helen Jones, Andrew Millard, Anne-Kristin Kaster, Kevin J. Purdy, Ruth Airs, J. Colin Murrell, Yin Chen
Article
Marine & Freshwater Biology
R. Barlow, T. Lamont, D. Louw, M-J Gibberd, R. Airs, A. van der Plas
AFRICAN JOURNAL OF MARINE SCIENCE
(2018)
Article
Ecology
Ana Moura Queiros, Nicholas Stephens, Stephen Widdicombe, Karen Tait, Sophie J. McCoy, Jeroen Ingels, Saskia Ruehl, Ruth Airs, Amanda Beesley, Giorgia Carnovale, Pierre Cazenave, Sarah Dashfield, Er Hua, Mark Jones, Penelope Lindeque, Caroline L. McNeill, Joana Nunes, Helen Parry, Christine Pascoe, Claire Widdicombe, Tim Smyth, Angus Atkinson, Dorte Krause-Jensen, Paul J. Somerfield
ECOLOGICAL MONOGRAPHS
(2019)
Article
Limnology
Michaela A. Mausz, Ruth L. Airs, Joanna L. Dixon, Claire E. Widdicombe, Glen A. Tarran, Luca Polimene, Sarah Dashfield, Rachael Beale, David J. Scanlan, Yin Chen
Summary: Choline and glycine betaine are important nutrient sources and osmolytes for marine microbes, and their degradation can produce climate active trace gases. Sea surface temperature, salinity, and the presence of phytoplankton species significantly influence the uptake of these substrates by prokaryotes.
LIMNOLOGY AND OCEANOGRAPHY
(2022)
Article
Environmental Sciences
Ruth L. Airs, Rachael Beale, Luca Polimene, Yin Chen, Michaela A. Mausz, David J. Scanlan, Claire E. Widdicombe, Glen A. Tarran, E. Malcolm S. Woodward, Carolyn Harris, Andrea McEvoy
Summary: Glycine betaine (GBT) is a nitrogenous osmolyte found throughout the marine environment. This study presents a seasonal dataset of GBT concentrations in marine suspended particulate material, showing peaks in summer and autumn. The GBT concentrations are associated with specific phytoplankton groups or species, suggesting different environmental drivers for different periods of the GBT seasonality.
Correction
Environmental Sciences
Ruth L. Airs, Rachael Beale, Luca Polimene, Yin Chen, Michaela A. Mausz, David J. Scanlan, Claire E. Widdicombe, Glen A. Tarran, E. Malcolm S. Woodward, Carolyn Harris, Andrea McEvoy
Article
Environmental Sciences
Xuerong Sun, Robert J. W. Brewin, Shubha Sathyendranath, Giorgio Dall'Olmo, Ruth Airs, Ray Barlow, Astrid Bracher, Vanda Brotas, Malika Kheireddine, Tarron Lamont, Emilio Maranon, Xose Anxelu G. Moran, Dionysios E. Raitsos, Fang Shen, Gavin H. Tilstone
Summary: Understanding the response of phytoplankton to climate change is crucial, and satellite remote sensing of ocean colour is the only means of monitoring phytoplankton at large scales. However, addressing ambiguity in ocean colour signal is necessary for developing algorithms for climate change studies. Enriching ocean colour data with sea surface temperature information can help tackle this issue.
REMOTE SENSING OF ENVIRONMENT
(2023)
Article
Oceanography
R. Barlow, T. Lamont, M. -J. Gibberd, R. Airs, L. Jacobs, K. Britz
DEEP-SEA RESEARCH PART I-OCEANOGRAPHIC RESEARCH PAPERS
(2017)
Article
Environmental Sciences
Robert J. W. Brewin, Stefano Ciavatta, Shubha Sathyendranath, Thomas Jackson, Gavin Tilstone, Kieran Curran, Ruth L. Airs, Denise Cummings, Vanda Brotas, Emanuele Organelli, Giorgio Dall'Olmo, Dionysios E. Raitsos
FRONTIERS IN MARINE SCIENCE
(2017)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
