Review
Immunology
Dillon Mintoff, Isabella Borg, Nikolai Paul Pace
Summary: Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit with complex pathophysiology. The human microbiome plays an extensive and relevant role in HS, with potential impact on treatment and diagnosis.
Review
Immunology
Elia Rosi, Prisca Guerra, Gianmarco Silvi, Giulia Nunziati, Ilaria Scandagli, Antonella Di Cesare, Francesca Prignano
Summary: Hidradenitis suppurativa (HS) is an inflammatory skin disease and the role of bacteria in HS patients has been the focus of research. The bacterial composition in HS patients is different from that in healthy controls. The question of whether changes in microbial populations are the cause or reflection of HS development remains unanswered. The aim of this article is to provide an overview of different hypotheses explaining the bacterial role in HS pathogenesis.
Article
Allergy
Kristina Navrazhina, John W. Frew, Patricia Gilleaudeau, Mary Sullivan-Whalen, Sandra Garcet, James G. Krueger
Summary: The study found that tunnels in hidradenitis suppurativa (HS) play an immunologically active role in disease activity, showing inflammation characteristics and associated with increased infiltration of T cells, dendritic cells, and neutrophils. Treatment with medication reduced the size and draining of tunnels, indicating their involvement in disease inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Microbiology
Beata Jastrzab, Barbara Pasnik-Chwalik, Katarzyna Debska-Lasut, Tomasz Konopka, Piotr K. Krajewski, Jacek C. Szepietowski, Lukasz Matusiak
Summary: This study aimed to compare the composition of subgingival microbiome between patients with hidradenitis suppurativa (HS) and periodontitis. The results showed that the subgingival microbiome count was significantly higher in HS and periodontitis patients compared to controls. Additionally, there were similarities in the subgingival microbiome composition between HS and periodontitis patients.
Review
Biochemistry & Molecular Biology
Edyta Lelonek, Dorra Bouazzi, Gregor Jemec, Jacek Szepietowski
Summary: Hidradenitis suppurativa (HS) is a chronic skin disease that severely affects the quality of life. The disease is characterized by persistent purulent lesions and involves inflammation, genetics, the microbiome, and environmental factors. Research suggests a potential role for pathogenic bacteria in HS, but the exact mechanisms of gut-skin microbial interactions remain unclear.
Review
Pediatrics
Colleen H. H. Cotton, Stella X. X. Chen, Sadaf H. H. Hussain, Irene Lara-Corrales, Andrea L. L. Zaenglein
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disorder mainly affecting areas with apocrine glands. It is common in Western populations, occurring in up to 2% of people, and its incidence is increasing in children and adults. Pediatric cases represent about one-third of all cases, with initial symptoms often appearing in childhood. Limited clinical studies and guidelines exist for pediatric hidradenitis suppurativa. This review covers the epidemiology, clinical presentation, comorbidities, and management of the disease in children. It also discusses the barriers to timely diagnosis and the significant physical and emotional impact on children and adolescents.
Review
Dermatology
Ellie Choi, Xue Ting Ooi, Nisha Suyien Chandran
Summary: Interest and research in hidradenitis suppurativa (HS) have grown in the past decade, expanding knowledge about associated comorbidities and treatment efficacy. Limited understanding exists about pediatric-onset HS, but with increasing prevalence of childhood obesity and awareness of HS, physicians may encounter younger HS patients more frequently.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Dermatology
Kirsty J. L. Wark, Geoffrey D. Cains
Summary: A chronic autoinflammatory skin disease called Hidradenitis suppurativa (HS) is characterized by the development of abscesses and nodules in intertriginous anatomical sites. Bacteria play a role in disease pathogenesis. Research found studies examining the cutaneous microbiome and gut microbiome in HS, with potential for further research into the oral microbiome and relationship with co-morbidities. Metagenomics-focused studies may identify new pathways of disease pathogenesis and potential therapeutic targets.
DERMATOLOGY AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Zuzanna Swierczewska, Milosz Lewandowski, Agnieszka Surowiecka, Wioletta Baranska-Rybak
Summary: Interest in the microbiome of cutaneous diseases, especially the gut-brain-skin axis, has increased recently. The link between the commensals and the host in the pathogenesis of hidradenitis suppurativa is yet to be established. Studies consistently show increased abundance of specific bacterial species and a loss of commensal species in HS lesions. The role of gut and blood microbiome in HS is not fully understood, but there is a link to an increased risk of developing Crohn's disease and ulcerative colitis. Lifestyle, dietary approaches, and probiotics show promise as adjuvant therapy for HS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Amelia Glowaczewska, Radomir Reszke, Jacek C. Szepietowski, Lukasz Matusiak
Summary: HS is a chronic and debilitating skin condition that affects patients' quality of life. Indirect self-destructiveness, such as addictions and risky behaviors, can impede positive clinical effects in HS patients. This study assessed indirect self-destructive behaviors in 100 adult HS patients, revealing higher scores in smokers, particularly in the class of Helplessness and Passivity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Paola Maura Tricarico, Chiara Moltrasio, Anton Gradisek, Angelo Marzano, Vincent Flacher, Wacym Boufenghour, Esther von Stebut, Matthias Schmuth, Wolfram Jaschke, Matjaz Gams, Michele Boniotto, Sergio Crovella
Summary: The European consortium BATMAN has developed an integrated pipeline to investigate the molecular pathways involved in Hidradenitis suppurativa (HS) and develop personalized treatments. Their objectives include identifying genetic variants associated with HS susceptibility, designing in vitro cell models to study HS mechanisms, and creating holistic health records through remote patient monitoring.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Laura Macca, Vittoria Moscatt, Manuela Ceccarelli, Ylenia Ingrasciotta, Giuseppe Nunnari, Claudio Guarneri
Summary: Hidradenitis suppurativa (HS) is associated with human immunodeficiency virus (HIV), and HIV-infected individuals are more susceptible to developing HS, particularly in atypical sites due to HIV-related immunosuppression.
Review
Immunology
Divya Chopra, Rachel A. Arens, Watcharee Amornpairoj, Michelle A. Lowes, Marjana Tomic-Canic, Natasa Strbo, Hadar Lev-Tov, Irena Pastar
Summary: Hidradenitis Suppurativa is a chronic inflammatory skin disease with complex mechanisms. It is characterized by abnormal activation of the innate immune system, leading to unresolved inflammation. Imbalance in host immunity and dysbiosis of the microbiome play important roles, as well as the ability of pathogens associated with the disease to overcome host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson
Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Dermatology
Marina Senent-Valero, Alicia Matijasevich, Noelia Jara-Rico, Francisca Sivera, Jose C. Pascual
Summary: Despite limited scientific evidence, this retrospective cohort study conducted in Spain found that metformin has a relatively long drug survival in people with hidradenitis suppurativa. Half of the patients were still using metformin after one year of treatment, and one in five patients continued the treatment after two years.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Sofia H. C. Botvid, Lone Storgaard Hove, Dorra Bouazzi, Rune Kjaersgaard Andersen, Simon Francis Thomsen, Ditte Marie Saunte, Gregor B. E. Jemec
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Immunology
Tanja Roehmer Wriedt, Kristoffer Nagy Skaastrup, Pernille Lindsoe Andersen, Line Simmelsgaard, Gregor B. E. Jemec, Ditte M. L. Saunte
Article
Allergy
Farnam Barati Sedeh, Thorunn Elisabet Michaelsdottir, Gregor Borut Ernst Jemec, Ole Steen Mortensen, Kristina Sophie Ibler
Summary: This study examined the level of knowledge regarding skin protective behavior and risk factors for hand eczema among hospital cleaners in Denmark. The results showed that the cleaners had a low level of knowledge, with only about 5 out of 9 questions answered correctly on average. The study also found that cleaners born or raised outside of Denmark had a lower level of knowledge.
CONTACT DERMATITIS
(2023)
Article
Dermatology
K. R. van Straalen, T. Tzellos, A. Alavi, F. Benhadou, C. Cuenca-Barrales, M. Daxhelet, M. Daoud, O. Efthymiou, E. J. Giamarellos-Bourboulis, P. Guillem, W. Gulliver, G. B. E. Jemec, A. C. Katoulis, A. Koenig, E. Lazaridou, M. A. Lowes, A. Marzano, L. Matusiak, A. Molina-Leyva, C. Moltrasio, A. Pinter, C. Potenza, E. P. Prens, J. Romani, D. M. Saunte, C. J. Sayed, N. Skroza, D. Stergianou, J. C. Szepietowski, A. Trigoni, E. Vilarrasa, A. Kyrgidis, C. C. Zouboulis, H. H. van der Zee
Summary: This study validates the novel IHS4-55 outcome measure by showing its significant association with reduction in inflammatory lesion counts and achievement of MCIDs for DLQI, NRS Pain, and NRS Pruritus in an antibiotic-treated cohort. These findings support the use of IHS4-55 as a novel primary outcome measure in clinical trials.
Article
Critical Care Medicine
Mahmoud I. Abdel-Aziz, Jonathan Thorsen, Simone Hashimoto, Susanne J. H. Vijverberg, Anne H. Neerincx, Paul Brinkman, Wim van Aalderen, Jakob Stokholm, Morten Arendt Rasmussen, Michael Roggenbuck-Wedemeyer, Nadja H. Vissing, Martin Steen Mortensen, Asker Daniel Brejnrod, Louise J. Fleming, Clare S. Murray, Stephen J. Fowler, Urs Frey, Andrew Bush, Florian Singer, Gunilla Hedlin, Bjorn Nordlund, Dominick E. Shaw, Kian Fan Chung, Ian M. Adcock, Ratko Djukanovic, Charles Auffray, Aruna T. Bansal, Ana R. Sousa, Scott S. Wagers, Bo Lund Chawes, Klaus Bonnelykke, Soren Johannes Sorensen, Aletta D. Kraneveld, Peter J. Sterk, Graham Roberts, Hans Bisgaard, Anke H. Maitland-van der Zee
Summary: By analyzing the oropharyngeal microbiota of children with asthma or wheezing, four distinct clusters with unique clinical characteristics were identified, and the enrichment scores of transcriptomic pathways associated with exacerbation risk and airway remodeling varied among these clusters.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Christoffer Kursawe Larsen, Rune Kjaersgaard Andersen, Ditte Marie Lindhardt Saunte, Gregor Borut Ernst Jemec
Summary: An abscess is a pus-filled cavity in the tissue, commonly perceived as an infection. However, this diagnosis does not always require an infection. This study aims to review the microbiome of bacteria-positive primary skin abscesses to explore the reported microbiota.
Letter
Immunology
Dorra Bouazzi, Pernille Lindso Andersen, Ester Weihe Jacobsen, Maiken Cavling Arendrup, Gregor B. E. Jemec, Ditte M. L. Saunte
Letter
Dermatology
Hans Christian Ring, Jonathan Thorsen, Berit Lilje, Lene Bay, Thomas Bjarnsholt, Kurt Fuursted, Ditte Marie Saunte, Gregor Borut Jemec, Simon Francis Thomsen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Allergy
Rikke Bjersand Sunde, Jonathan Thorsen, Frederikke Skov, Laura Hesselberg, Julie Kyvsgaard, Nilofar V. Folsgaard, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bonnelykke, Bo Chawes
Summary: Fraction of exhaled nitric oxide is elevated in children with asthma and is correlated with asthma-associated traits depending on the presence of aeroallergen sensitization.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Dermatology
Pernille Lindso Andersen, Bente Villumsen, Ditte Marie Lindhardt Saunte, Kristoffer Solvsten Burgdorf, Maria Didriksen, Sisse Rye Ostrowski, Lise Wegner Thorner, Christian Erikstrup, Khoa Manh Dinh, Kaspar Rene Nielsen, Thorsten Brodersen, Mie Topholm Bruun, Karina Banasik, Thomas Folkmann Hansen, Ole Birger Pedersen, Gregor Borut Jemec
Summary: This study explores the possible association between HS and ADHD, and finds a positive correlation between ADHD and HS. This result has significant implications for the research on psychiatric comorbidity of HS.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Pernille Lindso Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjorup Saekmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
Summary: This study found two protective HLA alleles, DQB1*06:04 and DRB1*13:02, that can reduce the risk of onychomycosis.
SKIN APPENDAGE DISORDERS
(2023)
Review
Dermatology
Terri Shih, Sarah Park, Linnea R. Thorlacius, Steven Daveluy, Amit Garg, Susanne D. Goegji, Joslyn S. Kirby, Barry M. McGrath, Peter T. Riis, Bente Villumsen, Kari Zalik, Gregor B. E. Jemec, Jennifer L. L. Hsiao
Summary: Drainage from chronic wounds can greatly affect a patient's quality of life, and measuring the change in wound drainage is important for assessing treatment effectiveness. This study reviews existing tools for evaluating wound drainage, highlighting the limitations and gaps in the current measurement landscape. Development of a concise drainage measurement tool for inflammatory skin diseases with prominent drainage symptoms will enhance treatment monitoring.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
P. Lindso Andersen, G. B. Jemec, C. Erikstrup, M. Didriksen, K. M. Dinh, S. Mikkelsen, E. Sorensen, K. R. Nielsen, M. T. Bruun, H. Hjalgrim, T. F. Hansen, S. G. Saekmose, S. R. Ostrowski, D. M. L. Saunte, O. B. Pedersen
Summary: This study investigated the association between HLA alleles and MRSD, identifying five novel associations and confirming one previous association.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
