Review
Anatomy & Morphology
Rene Westerhausen, Marietta Papadatou-Pastou
Summary: Recent research casts doubt on the long-held belief that left or mixed hand preference is associated with a larger corpus callosum, suggesting that this relationship may not be as strong as previously thought.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Zulfar Ghulam-Jelani, Jessica Barrios-Martinez, Aldo Eguiluz-Melendez, Ricardo Gomez, Yury Anania, Fang-Cheng Yeh
Summary: This study identified three redundancy circuits in the primate brains, showing differences in redundancy pathways between human and rhesus macaque brains. The results support the hypothesis of less redundancy in human brain commissural pathways and call for further research to explore neuropathological implications.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Molly B. D. Prigge, Nicholas Lange, Erin D. Bigler, Jace B. King, Douglas C. Dean, Nagesh Adluru, Andrew L. Alexander, Janet E. Lainhart, Brandon A. Zielinski
Summary: This longitudinal study found different changes in brain volume at different ages in individuals with autism, including increased gray matter volume, enlarged ventricles, and smaller corpus callosum volume. These findings expand our understanding of volumetric brain-based abnormalities in males with autism.
Review
Psychology, Clinical
Rene Westerhausen
Summary: The study assessed the validity of two paradigms for evaluating callosal functioning and found that they could assess interhemispheric integration of the corpus callosum, but likely test distinct callosal functions.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Psychology, Developmental
Yun Zhang, Bin Qin, Longlun Wang, Ke Zhang, Cui Song, Jie Chen, Jinhua Cai, Tingyu Li
Summary: This study found that in children with ASD aged 2-4 years, females had larger CC volumes compared to males, which was particularly significant in female participants with ASD. This could be related to overgrowth of axons or/and axonal pruning disorders.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Tiffany Renteria-Vazquez, Warren S. Brown, Christine Kang, Mark Graves, Fulvia Castelli, Lynn K. Paul
Summary: The study found that individuals with AgCC and ASD lack social imagination in inferring interactions of animated triangles, displaying significantly less typicality in social attributions compared to the control group.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Neurosciences
Tatsuhide Tanaka, Nobuhiko Ohno, Yasuyuki Osanai, Sei Saitoh, Truc Quynh Thai, Kazuya Nishimura, Takeaki Shinjo, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: Single oligodendrocytes in the central nervous system produce myelin sheaths around multiple axons, and interfascicular oligodendrocytes (IOs) in the corpus callosum of adult mice have morphologically polarized cell bodies with processes of different thicknesses for myelinating axons. The myelin sheaths originating from specific IOs have biased thicknesses and are associated with axonal diameter. Despite potential axonal regulation of myelin sheath thickness, a single axon may also independently influence myelin thickness.
Review
Obstetrics & Gynecology
Filomena Giulia Sileo, Daniele Di Mascio, Giuseppe Rizzo, Massimo Caulo, Lucia Manganaro, Emma Bertucci, Sophie Masmejan, Marco Liberati, Alice D'Amico, Luigi Nappi, Danilo Buca, Tim Van Mieghem, Asma Khalil, Francesco D'Antonio
Summary: This study found that the rate of associated anomalies detected exclusively at fetal MRI in isolated ACC undergoing neurosonography is lower than previously reported. Cortical and posterior fossa anomalies are among the most common anomalies missed at ultrasound.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Psychiatry
Otto Simonsson, Jose Carlos Bouso, Florian Kurth, Draulio B. Araujo, Christian Gaser, Jordi Riba, Eileen Luders
Summary: Research suggests potential benefits of ayahuasca in treating movement and neurodegenerative disorders, with preliminary evidence showing a thicker corpus callosum in ayahuasca users compared to controls. Further studies with larger samples and longitudinal designs are needed to confirm these findings and provide implications for future clinical research.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Nonthue Alejandra Uccelli, Martin Gabriel Codagnone, Marianela Evelyn Traetta, Nadia Levanovich, Maria Victoria Rosato Siri, Leandro Urrutia, German Falasco, Silvia Vazquez, Juana Maria Pasquini, Analia Gabriela Reines
Summary: The study utilized the VPA rat model to investigate ultrastructural and cellular changes in the corpus callosum (CC) associated with autism spectrum disorder. Results showed reduced myelin content, altered oligodendroglial lineage, and global brain hypometabolism in VPA animals, suggesting compromised axon-oligodendroglia communication. These findings indicate that CC hypomyelination may contribute to atypical patterns of connectivity and metabolism in ASD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Kathrin Nickel, Evgeniy Perlov, Marco Reisert, Kimon Runge, Evelyn Friedel, Dominik Denzel, Dieter Ebert, Dominique Endres, Katharina Domschke, Ludger Tebertz van Elst, Simon Maier
Summary: This study analyzed magnetic resonance images of individuals with high-functioning ASD and typically developed individuals, and found a reduced fiber count and fiber volume in the anterior subsection of the corpus callosum, supporting the hypothesis of reduced long-distance connectivity in ASD.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2022)
Article
Psychology, Clinical
Fredric Schiffer, Alaptagin Khan, Kyoko Ohashi, Laura C. Hernandez Garcia, Carl M. Anderson, Lisa D. Nickerson, Martin H. Teicher
Summary: This study aimed to evaluate the effectiveness of a computer test in assessing individual differences in hemispheric emotional valence (HEV) and to determine if these differences were associated with differences in brain structure and connectivity. The results showed that the computer test scores correlated with laterality indices of the nucleus accumbens, amygdala, and hippocampus. Specifically, a positive left hemispheric valence was associated with a larger left-sided nucleus accumbens and hippocampus and a smaller left amygdala. The study also found correlations between the computer test results and total and segment-specific corpus callosal volumes.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Multidisciplinary Sciences
Isabel Pijuan, Elisa Balducci, Cristina Soto-Sanchez, Eduardo Fernandez, Maria Jose Barallobre, Maria L. Arbones
Summary: Mutation in the DYRK1A gene can affect the development of glial cells and the morphological features of the brain's white matter tract, potentially leading to abnormal neuronal circuit development and impaired brain function.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P. Lerch, Shigeharu Wakana, Thomas J. McHugh, Toru Takumi
Summary: The BTBR T(+)Itpr3(tf)/J (BTBR/J) strain is a valuable model for studying idiopathic autism and understanding its complexity. Another strain, BTBR TF/ArtRbrc (BTBR/R), exhibits more prominent autism core symptoms but relatively normal hippocampus-dependent memory, resembling autism in the high functioning spectrum. The disrupted epigenetic silencing mechanism leads to increased activity of endogenous retrovirus (ERV), which in turn increases copy number variations (CNV) formation in the BTBR strains, making it an evolving multiple-loci model for higher susceptibility to ASD. Moreover, the active ERV evades the host defense response and manipulates transcriptional machinery during embryonic development in the BTBR strains. These findings suggest that ERV plays dual roles in the pathogenesis of ASD, influencing host genome evolution and cellular pathways in response to viral infection, with immediate effects on embryonic development. Additionally, the wild-type Draxin expression in BTBR/R makes it a more precise model for investigating the core etiology of autism without the interference of impaired forebrain bundles observed in BTBR/J.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Developmental
Melissa Kirkovski, Mervyn Singh, Thijs Dhollander, Ian Fuelscher, Christian Hyde, Natalia Albein-Urios, Peter H. Donaldson, Peter G. Enticott
Summary: Fixel-based analysis was used to examine changes in white matter structure of the corpus callosum of individuals with and without ASD. The study found that young adolescents with ASD showed reduced fiber cross-section and density, while a marginally older ASD cohort showed reduced fiber density. Among the oldest ASD cohort, there was a non-significant trend of reduced fiber density. These findings suggest that white matter aberrations in ASD may diminish with age.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Behavioral Sciences
Ophelie Foubet, Miguel Trejo, Roberto Toro
Article
Neurosciences
Elodie Cauvet, Annelies van't Westeinde, Roberto Toro, Ralf Kuja-Halkola, Janina Neufeld, Katell Mevel, Sven Bolte
Review
Biology
Katja Heuer, Roberto Toro
PHYSICS OF LIFE REVIEWS
(2019)
Article
Neurosciences
Anne Biton, Nicolas Traut, Jean-Baptiste Poline, Benjamin S. Aribisala, Mark E. Bastin, Robin Buelow, Simon R. Cox, Ian J. Deary, Masaki Fukunaga, Hans J. Grabe, Saskia Hagenaars, Ryota Hashimoto, Masataka Kikuchi, Susana Munoz Maniega, Matthias Nauck, Natalie A. Royle, Alexander Teumer, Maria Valdes Hernandez, Uwe Voelker, Joanna M. Wardlaw, Katharina Wittfeld, Hidenaga Yamamori, Thomas Bourgeron, Roberto Toro
Article
Neurosciences
Hugo Peyre, Neha Mohanpuria, Katarzyna Jednorog, Stefan Heim, Marion Grande, Muna van Ermingen-Marbach, Irene Altarelli, Karla Monzalvo, Camille Michele Williams, David Germanaud, Roberto Toro, Franck Ramus
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
Article
Multidisciplinary Sciences
Claire Cury, Marzia Antonella Scelsi, Roberto Toro, Vincent Frouin, Eric Artiges, Antoine Grigis, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Jean-Baptiste Poline, Michael N. Smolka, Henrik Walter, Gunter Schumann, Andre Altmann, Olivier Colliot
Article
Biochemistry & Molecular Biology
Guillaume Dumas, Simon Malesys, Thomas Bourgeron
Summary: The study found that genes encoding brain-related proteins are among the most conserved in the human genome compared to early hominins and non-human primates. Some genes showing signatures of positive selection may lead to brain diseases like micro/macrocephaly, Joubert syndrome, dyslexia, and autism. These genes may have played a role in the expansion of human brain size during primate evolution.
Article
Endocrinology & Metabolism
Guillaume Dumas, Hany Goubran-Botros, Mariette Matondo, Cecile Pagan, Cyril Boulegue, Thibault Chaze, Julia Chamot-Rooke, Erik Maronde, Thomas Bourgeron
Summary: The human pineal gland regulates day-night dynamics of multiple physiological processes through the secretion of melatonin. Analysis of proteins in the pineal gland reveals diverse regulated clusters, with differences observed between day and night and between control specimens and donors diagnosed with autism.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Neurosciences
Adam Messinger, Nikoloz Sirmpilatze, Katja Heuer, Kep Kee Loh, Rogier B. Mars, Julien Sein, Ting Xu, Daniel Glen, Benjamin Jung, Jakob Seidlitz, Paul Taylor, Roberto Toro, Eduardo A. Garza-Villarreal, Caleb Sponheim, Xindi Wang, R. Austin Benn, Bastien Cagna, Rakshit Dadarwal, Henry C. Evrard, Pamela Garcia-Saldivar, Steven Giavasis, Renee Hartig, Claude Lepage, Cirong Liu, Piotr Majka, Hugo Merchant, Michael P. Milham, Marcello G. P. Rosa, Jordy Tasserie, Lynn Uhrig, Daniel S. Margulies, P. Christiaan Klink
Summary: Neuroimaging in non-human primates is specialized and requires custom solutions. Efforts have been made to transform the field towards more open and collaborative practices. PRIME-RE is an online platform for the exchange of knowledge and tools related to NHP neuroimaging.
Article
Neurosciences
Javier Rasero, Antonio Jimenez-Marin, Ibai Diez, Roberto Toro, Mazahir T. Hasan, Jesus M. Cortes
Summary: This study used a subtyping approach to analyze functional brain connectivity patterns in individuals with autism spectrum disorder (ASD). Two stable subtypes, one with hypoconnectivity and one with hyperconnectivity, were identified. Only the subtype with hyperconnectivity showed enrichment in genes associated with excitation/inhibition imbalance, a known mechanism in the pathophysiology of ASD. These findings contribute to our understanding of the heterogeneity in ASD and provide insights into the underlying molecular mechanisms.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biology
Neville Magielse, Roberto Toro, Vanessa Steigauf, Mahta Abbaspour, Simon B. Eickhoff, Katja Heuer, Sofie L. Valk
Summary: This study examines the evolution of the volumes of cerebellum and ansiforms in primates. The results suggest proportional scaling between cerebellum and cerebrum, while ansiforms have expanded faster. This indicates a general structural reorganization of ansiforms in primates, which is relevant for specialized brain functions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Varun Warrier, Roberto Toro, Hyejung Won, Claire S. Leblond, Freddy Cliquet, Richard Delorme, Ward De Witte, Janita Bralten, Bhismadev Chakrabarti, Anders D. Borglum, Jakob Grove, Geert Poelmans, David A. Hinds, Thomas Bourgeron, Simon Baron-Cohen, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, Joanna L. Mountain, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson
COMMUNICATIONS BIOLOGY
(2019)
Article
Neurosciences
Marianne Oldehinkel, Maarten Mennes, Andre Marquand, Tony Charman, Julian Tillmann, Christine Ecker, Flavio Dell'Acqua, Daniel Brandeis, Tobias Banaschewski, Sarah Baumeister, Carolin Moessnang, Simon Baron-Cohen, Rosemary Holt, Sven Bolte, Sarah Durston, Prantik Kundu, Michael Lombardo, Will Spooren, Eva Loth, Declan G. M. Murphy, Christian F. Beckmann, Jan K. Buitelaar, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Thomas Bourgeron, Carsten Bours, Michael Brammer, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Daisy Crawley, Flavio DellAcqua, Guillaume Dumas, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Mark H. Johnson, Emily J. H. Jones, Meng-Chuan Lai, Xavier Liogier D'ardhuy, David J. Lythgoe, Rene Mandl, Luke Mason, Andreas Meyer-Lindenberg, Nico Mueller, Bethany Oakley, Laurence O'Dwyer, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jose Caceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge, Marcel P. Zwiers
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2019)
Article
Neurosciences
Celine Delettre, Arnaud Messe, Leigh-Anne Dell, Ophelie Foubet, Katja Heuer, Benoit Larrat, Sebastien Meriaux, Jean-Francois Mangin, Isabel Reillo, Camino de Juan Romero, Victor Borrell, Roberto Toro, Claus C. Hilgetag
NETWORK NEUROSCIENCE
(2019)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)