Article
Clinical Neurology
Dionysis Nikolopoulos, Dimitrios Kitsos, Matilda Papathanasiou, Noemin Kapsala, Panagiotis Garantziotis, Antigone Pieta, Ourania Gioti, Alexandros Grivas, Konstantinos Voumvourakis, Dimitrios Boumpas, Antonis Fanouriakis
Summary: In a large SLE cohort, CNS demyelinating syndromes were characterized as neuropsychiatric SLE (NPSLE) or SLE-MS overlap. Patients with SLE-MS overlap had a higher likelihood of neurologic relapses, while those with SLE-demyelination were less likely to have neurological deficits at the last follow-up visit.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pediatrics
Wei Quan, Jingnan An, Gang Li, Guanghui Qian, Meifang Jin, Chenxi Feng, Si Li, Xiaozhong Li, Yunyun Xu, Xiaohan Hu
Summary: This study identified significantly elevated levels of IL-2, IL-10, and IL-21 in cSLE patients compared to healthy controls, with a positive correlation to disease activity. This suggests potential new approaches for regulating T lymphocyte subsets in cSLE diagnosis.
Review
Chemistry, Medicinal
Przemyslaw Kotyla, Olga Gumkowska-Sroka, Bartosz Wnuk, Kacper Kotyla
Summary: Systemic sclerosis and systemic lupus erythematosus are two distinct autoimmune diseases belonging to connective tissue disorders, with no groundbreaking therapeutic approaches developed yet. The discovery of JAK kinases may offer a new therapeutic potential for previously untreatable diseases.
Article
Biochemistry & Molecular Biology
Mark M. Melamud, Evgeny A. Ermakov, Anastasiia S. Boiko, Daria A. Kamaeva, Alexey E. Sizikov, Svetlana A. Ivanova, Natalia M. Baulina, Olga O. Favorova, Georgy A. Nevinsky, Valentina N. Buneva
Summary: The study revealed that 11 cytokines were increased in the cytokine profile of systemic lupus erythematosus patients, while 10 cytokines were significantly decreased in multiple sclerosis patients. These changes were associated with dysregulation of interleukins, TNF superfamily members, and chemokines in SLE, and abnormal levels of growth factors and chemokines in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Feng Chen, Ying Zheng, Xinying Chen, Zhanfa Wen, Youjia Xu, Jinghua Yang, Kaisi Xu
Summary: Belimumab is an important medication for the treatment of cSLE. However, there is a lack of sufficient research on its efficacy and safety, and further studies are needed to validate its clinical value.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lauren Goldschen, Jack Ellrodt, Hermioni L. Amonoo, Candace H. Feldman, Siobhan M. Case, Karestan C. Koenen, Laura D. Kubzansky, Karen H. Costenbader
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by unpredictable disease flares. A connection between posttraumatic stress disorder (PTSD) and the development of SLE has been identified, suggesting that stress-related disorders alter susceptibility to SLE. Perturbations in the autonomic nervous system, neuroendocrine system, and at the genomic level may cause and sustain immune dysregulation, contributing to the development and propagation of SLE in those predisposed genetically.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Review
Rheumatology
Luis Alonso Gonzalez, Manuel Francisco Ugarte-Gil, Graciela S. Alarcon
Summary: There has been an increasing interest in discovering and validating biomarkers for lupus, but few have been successfully utilized in clinical practice. Further validation in large-scale studies and identification of better biomarkers are needed for diagnosis, monitoring, and predicting disease activity. Novel omics techniques also offer new insights in understanding the molecular basis of lupus and identifying potential therapeutic targets.
Article
Immunology
Yimin Wang, Wenge Su, Yunlun Li, Jie Yuan, Minghao Yao, Xiaoyi Su, Yifei Wang
Summary: This study investigated the mechanisms of the co-occurrence of systemic lupus erythematosus (SLE) and atherosclerosis (AS). Gene expression profiles were analyzed to identify common differentially expressed genes (DEGs), and enrichment analysis revealed the involvement of the IL-17 signaling pathway. Five key genes (CCR1, CD163, IL1RN, MMP9, and SIGLEC1) were identified as potential drivers of monocyte differentiation into macrophages, and immune cell infiltration analysis showed the importance of monocytes in SLE and M0 macrophages in AS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Article
Rheumatology
George C. Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T. Boumpas, Nina Brodin, Ian N. Bruce, Miguel Angel Gonzalez-Gay, Soren Jacobsen, Gyorgy Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J. Macfarlane, Michael M. Ward, Michael T. Nurmohamed, Maria G. Tektonidou
Summary: This study developed recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, emphasizing the importance of regular screening and management of modifiable CVR factors as well as patient education. The recommendations covered CVR prediction tools, interventions on traditional CVR factors, and interventions on disease-related CVR factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Elisabet Svenungsson, Jonas Spaak, Karin Strandberg, Hakan N. Wallen, Stefan Agewall, Elin B. Brolin, Olov Collste, Maria Daniel, Christina Ekenback, Mats Frick, Loghman Henareh, Karin Malmqvist, Kerstin Elvin, Peder Sorensson, Shams Y-Hassan, Claes Hofman-Bang, Per Tornvall
Summary: Recent studies have shown an overrepresentation of prothrombotic antiphospholipid antibodies in patients with myocardial infarction due to coronary artery disease, but their association with MI with nonobstructive coronary arteries remains unclear. This study confirmed the higher levels of aPL IgG in patients with MI due to coronary artery disease, indicating a potential link with hypercoagulability.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Rheumatology
Sofie A. M. Gernaat, Julia F. Simard, Anna-Karin Wikstrom, Elisabet Svenungsson, Elizabeth V. Arkema
Summary: The study found a risk association between systemic lupus erythematosus (SLE) and gestational diabetes mellitus (GDM), with women with SLE being more likely to develop GDM during pregnancy compared to general population controls.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Charlotte de Vries, Guillermo Ruacho, Elin Kindstedt, Barbara Aleksandra Potempa, Jan Potempa, Bjorn Klinge, Pernilla Lundberg, Elisabet Svenungsson, Karin Lundberg
Summary: There is accumulating evidence suggesting that periodontitis is associated with an increased risk of systemic and autoimmune diseases. A recent study investigated the potential of antibodies to the Porphyromonas gingivalis virulence factor arginine gingipain as a biomarker for periodontitis patients at risk of autoimmunity and systemic disease. The study found that anti-Rgp IgG levels were elevated in severe periodontitis, individuals positive for certain autoantibodies, and myocardial infarction patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Sahwa Elbagir, Lina-Marcela Diaz-Gallo, Giorgia Grosso, Agneta Zickert, Iva Gunnarsson, Michael Mahler, Elisabet Svenungsson, Johan Ronnelid
Summary: HLA-DRB1 alleles are associated with thrombosis and production of aPL in SLE patients. HLA-DRB1*13 increases the risk of aPS-PT production and thrombosis, while HLA-DRB1*03 is associated with reduced thrombotic events and favorable lipid levels in aPL-positive SLE patients.
Article
Rheumatology
Guillermo Ruacho, Ronaldo Lira-Junior, Iva Gunnarsson, Elisabet Svenungsson, Elisabeth A. Bostrom
Summary: This study found that saliva could be a novel alternative body fluid for monitoring general disease activity (DA) in patients with SLE, while urine is more informative for SLE patients with predominantly renal DA.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Oscar Plunde, Elisabet Svenungsson, Giulia Ferrannini, Anders Franco-Cereceda, Magnus Back
Summary: The study revealed that antiphospholipid antibodies (aPL) are more common in calcific aortic valve stenosis (CAVS) patients in the general population. The positivity of aPL was associated with altered aortic valve transcriptomics related to interferon pathways. Further research is needed to establish aPL as a possible risk marker and/or causal factor for CAVS and to explore new precision therapeutic targets.
Article
Cardiac & Cardiovascular Systems
Giulia Ferrannini, Mariam Almosawi, Kare Buhlin, Ulf De Faire, Barbro Kjellstrom, Bjorn Klinge, Ake Nygren, Per Nasman, Elisabet Svenungsson, Lars Ryden, Anna Norhammar
Summary: In a long-term follow-up study of patients after their first myocardial infarction (MI) compared with matched controls, it was found that there was a higher risk of cardiovascular events in the MI group, while mortality did not differ significantly. The access to high-quality care and cardiac rehabilitation may contribute to the lower rates of adverse outcomes.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2022)
Article
Rheumatology
Christian Lundtoft, Christopher Sjowall, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Andreas Jonsen, Pascal Pucholt, Yee Ling Wu, Emeli Lundstrom, Maija-Leena Eloranta, Iva Gunnarsson, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Lennart Truedsson, Bo Nilsson, Sergey Kozyrev, Matteo Bianchi, Kerstin Lindblad-Toh, Chack-Yung Yu, Gunnel Nordmark, Johanna K. Sandling, Elisabet Svenungsson, Dag Leonard, Lars Ronnblom
Summary: This study reveals that a genetic pattern involving partial deficiencies of C2 and C4A in the classical complement pathway is a strong risk factor for SLE and primary SS, highlighting the central role of the complement system in the pathogenesis of both diseases.
ARTHRITIS & RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Helena Idborg, Sven-Christian Pawelzik
Summary: This article reviews the metabolism of primary prostanoids in humans, summarizes the levels of prostanoid metabolites in healthy individuals, and highlights the importance of existing biomarker studies.
Article
Rheumatology
Aliisa Hayry, Francesca Faustini, Agneta Zickert, Anders Larsson, Timothy B. Niewold, Elisabet Svenungsson, Vilija Oke, Iva Gunnarsson
Summary: This study investigated the potential of interleukin (IL) 16 as a biomarker for lupus nephritis (LN). The results showed that IL-16 levels were elevated in active systemic lupus erythematosus (SLE) patients and could differentiate between different subtypes of LN. The study also found that IL-16 was expressed in kidney infiltrating cells. These findings suggest that IL-16 could be used as a diagnostic and therapeutic target for LN.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Francesca Faustini, Helena Idborg, Enrico Fuzzi, Anders Larsson, Wen-Rong Lie, Sven Poetzsch, Shinji L. Okitsu, Elisabet Svenungsson, Iva Gunnarsson
Summary: This study investigated the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker for renal disease in Lupus nephritis (LN). The results showed that u-Gal-3BP levels were higher in LN patients and correlated with the activity index in renal biopsies. After treatment, u-Gal-3BP levels decreased. Therefore, u-Gal-3BP shows promise as a non-invasive urinary biomarker to help detect and monitor renal involvement in Lupus erythematosus patients.
Article
Rheumatology
Linnea Karlsson, Agneta Zickert, Elisabet Svenungsson, Jan Schmidt-Mende, Francesca Faustini, Iva Gunnarsson
Summary: This study retrospectively analyzed the histopathological findings of first-time kidney biopsies in 139 SLE patients. The results showed that 88.5% of the patients had histopathological findings consistent with lupus nephritis, while 11.5% had other renal diseases. These findings highlight the importance of kidney biopsy in diagnosing and managing inflammatory renal diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Lina-Marcela Diaz-Gallo, Vilija Oke, Emeli Lundstrom, Kerstin Elvin, Yee Ling Wu, Susanna Eketjall, Agneta Zickert, Johanna T. Gustafsson, Andreas Jonsen, Dag Leonard, Daniel J. Birmingham, Gunnel Nordmark, Anders A. Bengtsson, Lars Ronnblom, Iva Gunnarsson, Chack-Yung Yu, Leonid Padyukov, Elisabet Svenungsson
Summary: Our study identified four distinct subgroups among patients with SLE based on autoantibody profiles, which differ in associations with HLA-DRB1 alleles and immunological and clinical features, indicating diverse disease pathways.
ACR OPEN RHEUMATOLOGY
(2022)