Article
Chemistry, Physical
Antonio Raiol, Mayra Pinheiro, Ezequiel Belo, Antonio R. da Cunha, Andrey M. R. Marinho, Simone Y. S. Silva, Sebastiao C. Silva, Tarciso Andrade-Filho, Rodrigo Gester
Summary: The study found that Spilanthol is the most abundant pharmacologic agent in Acmella oleracea and investigated its molecular structure and optical properties, suggesting its potential as a pharmacological agent. Additionally, the analysis showed that the UV-vis spectra are strongly affected by the number of C = C bonds, and undergo an uncommon blue shift from S1 to the S3 structure.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Sathya Bangaru, Govindammal Madhu, M. Srinivasan, Prasath Manivannan
Summary: Isorhapontigenin (IRPG) is a potential efficient inhibitor for H1N1 and H3N2 subtypes of influenza A virus. The molecule exhibits strong biological activity and has a high binding affinity for the viruses.
Article
Materials Science, Multidisciplinary
A. A. Al-Shamari, A. M. Abdelghany, Hany Alnattar, A. H. Oraby
Summary: In this study, an eco-friendly and cost-effective route using water was employed for the synthesis of gold nanoparticles via laser ablation technique, and various characterization techniques were used to study the composite thin film structure formed by the gold nanoparticles and polymer matrix. The results showed that the addition of gold nanoparticles significantly affected the optical properties of the composite thin film.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Physical
E. Dhanalakshmi, P. Rajesh, S. Suresh, M. Priyadharshini, M. Prabhaharan
Summary: The present study synthesized MIP compound from carbinol extract of Hybanthus Enneaspermus using a green synthesis method. Various analysis techniques were used to characterize the molecular structure and properties of MIP, and the results were validated through calculations and experiments. Molecular docking studies were also conducted to evaluate the compound's interaction with lung and kidney cancer-related receptors.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Oleksii M. Dykun, Viktor M. Anishchenko, Andrii M. Redko, Volodymyr Rybachenko
Summary: The sulfonylation of gossypol was conducted with stepwise increase of tosyl chloride content in the presence of 4-methoxypyridine N-oxide and triethylamine. It was found that 4-methoxypyridine N-oxide is a more effective catalyst compared to triethylamine, allowing selective tosylation of gossypol to 7,7'-ditosyloxygossypol. The study also investigated the structure and tautomeric equilibria of the obtained product in dichloromethane, showing that a dilactol tautomeric form is more preferable for 7,7'-ditosyloxygossypol.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Materials Science, Multidisciplinary
Kh S. Shaaban, Ateyyah M. Al-Baradi, Atif Mossad Ali
Summary: The 65Na(2)B(4)O(7)-25SiO(2)-(10 - x) CaO-x Cr2O3 glass system was synthesized and investigated for its optical, structural, and radiation shielding characteristics. The addition of Cr2O3 increased the density and decreased the molar volume of the glass. The study also found that the optical properties and radiation shielding ability of the glass were influenced by the presence of Cr2O3. These findings provide valuable insights for the development of glass materials with neutron attenuation applications.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Engineering, Electrical & Electronic
Roberto C. Longo, Nils Schewe, Peter G. Weidler, Stefan Heissler, Peter Thissen
Summary: The demand for different materials in the semiconductor field has driven strong research in the past decades, with atomic scale precision achieved for desired material properties through crystal doping. However, potential channel replacement materials for silicon like GaAs face safety and environmental concerns, prompting the search for non-toxic and environmentally friendly alternatives.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz, Hanna Trebacz, Angelika Barzycka, Edyta Leyk, Marek Wesolowski
Summary: Interactions between pharmaceutical excipients and active substances can affect the efficacy, stability, and safety of drugs. This study investigates the interactions between the oral antidiabetic drug linagliptin and different excipients, and emphasizes the importance of choosing appropriate excipients to minimize degradation.
Article
Polymer Science
Antonio D'Angelo, Luigi Vertuccio, Cristina Leonelli, Mohammad I. M. Alzeer, Michelina Catauro
Summary: The feasibility of encapsulating the potentially toxic acridine orange (AO) dye in a metakaolin based geopolymer while maintaining its structural integrity was investigated. Various analytical techniques were used to determine the structural, chemical, and mechanical stabilities of the final products, as well as the integrity and stability of the dye inside the geopolymer. The results showed that the addition of AO did not affect the thermal and mechanical properties of the geopolymer, and the dye remained stable within the matrix.
Review
Chemistry, Organic
K. Parimala
Summary: In this study, the TF5CP compound was extensively investigated both theoretically and experimentally, including vibrational assignments, structural benchmarks, and spectroscopic investigations. Molecular docking research was also conducted to predict the binding interactions between the compound and a receptor.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
C. Vidya, I. Ragavan, A. Arunkumar, P. M. Anbarasan, Mohd Shkir
Summary: In this study, the 4-dimethylaminopyridinium-2,4-dinitrophenolate (4DMAP + 2,4DNP) was prepared using the slow evaporation solution growth method. The experimental and computational results showed that the 4DMAP + 2,4DNP molecule exhibits excellent nonlinear optical properties, making it a potential candidate for optical limiting, frequency doubling, and optical switching applications.
JOURNAL OF MOLECULAR MODELING
(2023)
Article
Environmental Sciences
S. Tamilselvan, R. M. Soniya, R. Vasantharaja, M. Kannan, S. Supriya, B. Prabhu Dass Batvari, T. Ramesh, K. Govindaraju
Summary: This study investigated a simple silver nanoparticle that can be used for the qualitative and quantitative sensing of heavy metal ions in aqueous solutions. The particles exhibited changes in their UV-vis absorption spectrum, indicating the presence of different metal ions.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Physical
Debora H. Almeida de Brito, Francisco W. Q. Almeida-Neto, Lyanna R. Ribeiro, Emanuel P. Magalhaes, Ramon R. P. P. Bezerra de Menezes, TiagoL. Sampaio, Alice M. C. Martins, Paulo N. Bandeira, Marcia M. Marinho, Emmanuel S. Marinho, Antonio C. H. Barreto, Pedro de Lima-Neto, Gilberto D. Saraiva, Kirley M. Canuto, Helcio S. dos Santos, Alexandre M. R. Teixeira, Nagila M. P. Silva Ricardo
Summary: The study investigated the inhibitory effects of the chalcone BNZTHP against T. cruzi, demonstrating higher activity on trypomastigote forms and a more powerful inhibitory effect compared to benznidazole. Molecular docking studies indicated good affinity of the compound towards key enzymes in T. cruzi, making it a promising candidate for Chagas disease treatment development.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Engineering, Environmental
Alberto Mannu, Matteo Poddighe, Sebastiano Garroni, Luca Malfatti
Summary: In this study, FT-IR and UV-VIS spectroscopy were used to develop an analytical tool for distinguishing between edible and waste vegetable oils. Qualitative analysis indicated that FT-IR and UV-VIS were more suitable techniques for distinguishing between waste and edible samples. Statistical multivariate analysis revealed that the FT-IR-based method was more appropriate, despite the undesired distinction between edible oils of the same type. Furthermore, attempts on UV-VIS data obtained in reflection mode successfully differentiated between edible and waste oil samples.
RESOURCES CONSERVATION AND RECYCLING
(2022)
Article
Chemistry, Organic
Towseef Ahmad Hajam, H. Saleem, M. Syed Ali Padhusha, K. K. Mohammed Ameen
Summary: Experimental and theoretical investigations were conducted on the molecular structure, electronic and vibrational characteristics of 2-ethoxy-4-(pyridine-2yliminomethyl)-phenol (2E4P2P), including calculations of vibrational frequencies, simulation of vibrational spectra, electronic structure, nonlinear optical behavior, and molecular docking with topoisomerase DNA gyrase enzymes. The findings provide valuable insights into the properties and interactions of the novel compound.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Irem Kiris, Merve Karayel Basar, Betul Sahin, Busra Gurel, Julide Coskun, Tomasz Mroczek, Ahmet Tarik Baykal
Summary: The study aims to evaluate the therapeutic effects of lycoramine in Alzheimer's disease and understand its mechanism of action at the molecular level through differential protein expression analyses.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Chemical
Anna Gumieniczek, Izabela Kozak, Pawel Zmudzki, Urszula Hubicka
Summary: The evaluation of pH-dependent reactivity of three antihistaminic drugs, ketotifen, epinastine and emedastine, showed variation in stability levels under different pH conditions. The study demonstrated the degradation rates and kinetics of the drugs, suggesting important implications for drug manufacturing and administration to patients.
Article
Biochemistry & Molecular Biology
Piotr Okinczyc, Jaroslaw Widelski, Jakub Szperlik, Magdalena Zuk, Tomasz Mroczek, Krystyna Skalicka-Wozniak, Zuriyadda Sakipova, Gabriela Widelska, Piotr Marek Kus
Summary: The study focused on profiling 19 different Eurasian propolis samples, mostly from countries like Russia, Kazakhstan, Kyrgyzstan, Poland, Ukraine, and Slovakia. These propolis samples exhibited significant contents of polyphenols and flavonoids, along with potent antiradical and reducing activities. Marker compounds were used to classify propolis samples into different types, with poplar, aspen-birch, and aspen-birch-poplar types identified. The antioxidant properties of propolis samples were correlated with flavonoids, total polyphenols, or other polyphenols besides flavonoids content, showing variable activity among different propolis types.
Article
Plant Sciences
Elisavet-Foteini Varvouni, Gokhan Zengin, Konstantia Graikou, Christos Ganos, Tomasz Mroczek, Ioanna Chinou
Summary: The aim of this study was to analyze the phytochemical composition of the aerial parts of the endemic plant Phyllocara aucheri in Turkey. Sixteen secondary metabolites were identified, including thirteen phenolic constituents and three pyrrolizidine alkaloids. The methanol extract showed antioxidant properties and interesting biological activities in enzyme inhibition assays.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Dymek, Jaroslaw Widelski, Krzysztof Kamil Wojtanowski, Paulina Ploszaj, Rostyslav Zhuravchak, Tomasz Mroczek
Summary: Alkaloids from the Lycopodiaceae family have potential antioxidant, antidepressant, and AChE inhibitory effects, which are crucial for treating neurodegenerative diseases. By optimizing extraction conditions using modern PLE, efficient extraction of alkaloids was achieved with high recovery rates, analyzed by HPLC/ESI-QTOF-MS for potential AChE inhibitors.
Article
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz, Emilia Fornal, Barbara ZyZynska-Granica, Sebastian Granica
Summary: Forced degradation studies can assist in evaluating the stability of active pharmaceutical ingredients under specific conditions and estimating potential impurities. Research has revealed that vildagliptin is prone to degradation under different conditions, resulting in various degradation products, with pharmaceutical excipients impacting its stability.
Article
Biochemistry & Molecular Biology
Bagda Sagynaikyzy Zhumakanova, Izabela Korona-Glowniak, Krystyna Skalicka-Wozniak, Agnieszka Ludwiczuk, Tomasz Baj, Krzysztof Kamil Wojtanowski, Aleksandra Jozefczyk, Karlygash Altynbekovna Zhaparkulova, Zuriyadda Bektemirova Sakipova, Anna Malm
Summary: The chemical compositions and activities of hydroethanolic extracts from Thymus marschallianus Willd and Thymus seravschanicus Klokov were analyzed, revealing differences in composition and similar antioxidant activity. Thymus seravschanicus showed higher antibacterial activity, particularly against Helicobacter pylori.
Article
Biochemistry & Molecular Biology
Aleksandra Dymek, Jaroslaw Widelski, Krzysztof Kamil Wojtanowski, Vladyslav Vivcharenko, Agata Przekora, Tomasz Mroczek
Summary: This study aimed to search for new Lycopodiaceae alkaloids as potent AChE inhibitors. Methanolic extracts of three plant species were isolated, identified, and evaluated for their anticholinesterase and cytotoxic activities. Analysis via HPLC/ESI-QTOF-MS identified over 50 compounds, including new ones. The tested plant extracts showed rich sources of AChE inhibitors, with H. selago exhibiting the highest anti-AChE activity, and were found to be safe for skin fibroblasts.
Article
Chemistry, Medicinal
Lukasz Swiatek, Elwira Sieniawska, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Krzysztof Kamil Wojtanowski, Barbara Rajtar, Malgorzata Polz-Dacewicz, Mehmet Yavuz Paksoy, Gokhan Zengin
Summary: This study evaluates the chemical properties and biological activities of O. aquatica and O. silaifolia, including antioxidant, enzyme inhibitory, cytotoxic, and antiviral activities. The results show that O. aquatica has high phenolic content and antioxidant capacity, while the methanolic extract of O. silaifolia exhibits strong inhibitory effects on certain enzymes. Both plant extracts show selective toxicity towards cancer cells, and the aqueous extract of O. aquatica shows significant antiviral activity against HSV-1.
Article
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz, Hanna Trebacz, Angelika Barzycka, Edyta Leyk, Marek Wesolowski
Summary: Interactions between pharmaceutical excipients and active substances can affect the efficacy, stability, and safety of drugs. This study investigates the interactions between the oral antidiabetic drug linagliptin and different excipients, and emphasizes the importance of choosing appropriate excipients to minimize degradation.
Review
Biochemistry & Molecular Biology
Natalia Smyrska-Wieleba, Tomasz Mroczek
Summary: This article provides an updated description and comparison of natural inhibitors of cholinesterases (IChEs), namely, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), based on data from the last 15 years. It also highlights the potential impact of compound structures on the therapeutic effects of cholinesterase inhibitors. The findings suggest that natural sources are still promising for the discovery of new compounds with significant pharmacological activity, and further research is needed to understand the mechanisms of action and structure-activity correlation of cholinesterase inhibitors for medical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Gumieniczek, Karolina Lejwoda, Natalia Data
Summary: The chemical stability of diphenhydramine, azelastine, and bepotastine was examined in solutions and solids. The drugs exhibited degradation under high temperature and UV/VIS light, and also interacted with excipients in solid mixtures.
Review
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz
Summary: This paper is the second part of a review on the metabolism and chemical degradation of new antidiabetic drugs from glutides, gliflozins and gliptins. The paper discusses the importance of metabolism data for determining safe levels of degradation impurities and their toxicological aspects. It also summarizes analytical tools, including liquid chromatography (LC) and liquid chromatography coupled with mass spectrometry (LC-MS or LC-MS/MS), for conducting modern drug metabolism and degradation experiments. The paper focuses on the analytical approaches used to examine the metabolism and degradation pathways of gliptins, specifically DPP-4 inhibitors.
Review
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz
Summary: The article discusses the possible links between metabolic and degradation pathways for new antidiabetic drugs, focusing on glutides, gliflozins, and gliptins. It highlights the importance of metabolism data in determining safe levels of degradation impurities and improving product quality. Various analytical approaches, including chromatographic methods and radioactive labeling, are mentioned for examining the metabolism and degradation pathways.
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)