Article
Clinical Neurology
Aleksandra Maruszak, Edina Silajdzic, Hyunah Lee, Tytus Murphy, Benjamine Liu, Liu Shi, Chiara de Lucia, Abdel Douiri, Evgenia Salta, Alejo J. Nevado, Charlotte E. Teunissen, Pieter J. Visser, Jack Price, Henrik Zetterberg, Simon Lovestone, Sandrine Thuret
Summary: Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. An assay using a human hippocampal progenitor cell line and longitudinal serum samples revealed that the systemic environment affects hippocampal neurogenesis in individuals with mild cognitive impairment, predicting Alzheimer's disease progression. This assay shows potential for early prognosis, monitoring disease progression, and further research.
Article
Neurosciences
Carlo Abbate
Summary: Alzheimer's disease starts in neural stem cells and their migration processes, with amyloid pathology exacerbating tau pathology. The chronic inflammation triggered by extracellular amyloid-beta deposits further amplifies tau pathogenesis, leading to degeneration of neuronal networks. This cascade of events contributes to the development and spread of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Santiago Ramirez, Abhisek Mukherjee, Sofia Sepulveda, Andrea Becerra-Calixto, Nicolas Bravo-Vasquez, Camila Gherardelli, Melissa Chavez, Claudio Soto
Summary: The study successfully adapted the controlled cortical impact (CCI) model for inducing traumatic brain injury (TBI) in human cerebral organoids (COs) derived from induced pluripotent stem cells (iPSCs), showing that COs recapitulate primary pathological changes of TBI. This novel approach using human COs in vitro holds great potential for understanding and treating TBI.
Article
Biotechnology & Applied Microbiology
Chen Li, Maria C. Virgilio, Kathleen L. Collins, Joshua D. Welch
Summary: This paper introduces a model called MultiVelo, which extends the RNA velocity framework using differential equations to incorporate epigenomic data. The model improves the accuracy of cell fate prediction by estimating the temporal relationship between chromatin accessibility and gene expression. The study reveals different classes of genes and cell states, and identifies time lags between transcription factor expression and binding site accessibility, as well as disease-associated SNP accessibility and linked gene expression.
NATURE BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Nutrition & Dietetics
Danbi Lee, Namkwon Kim, Seung Ho Jeon, Min Sung Gee, Yeon-Joo Ju, Min-Ji Jung, Jae Seok Cho, Yeongae Lee, Sangmin Lee, Jong Kil Lee
Summary: By activating the AMPK/CREB signaling pathway, HSP can increase the proliferation of NSCs and restore neurogenesis in 5xFAD mice, reducing amyloid-beta accumulation and improving memory dysfunction.
Article
Multidisciplinary Sciences
Mercedes F. Paredes, Cristina Mora, Quetzal Flores-Ramirez, Arantxa Cebrian-Silla, Ashley Del Dosso, Phil Larimer, Jiapei Chen, Gugene Kang, Susana Gonzalez Granero, Eric Garcia, Julia Chu, Ryan Delgado, Jennifer A. Cotter, Vivian Tang, Julien Spatazza, Kirsten Obernier, Jaime Ferrer Lozano, Maximo Vento, Julia Scott, Colin Studholme, Tomasz J. Nowakowski, Arnold R. Kriegstein, Michael C. Oldham, Andrea Hasenstaub, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Eric J. Huang
Summary: Research has revealed that the human embryonic ventral forebrain contains nests of proliferative neuroblasts which play a crucial role in generating a sufficient number of functional interneurons for the human brain.
Article
Oncology
Zoe Schmal, Ben Hammer, Andreas Mueller, Claudia E. Ruebe
Summary: Despite advances in hippocampus-sparing radiation therapy, radiation-induced injury to the neural stem cell compartment may impact neurocognitive functions. Low doses of ionizing radiation induced inflammatory responses in the hippocampus, with activated microglia and reactive astrocytes, suggesting a shift from neurogenesis to gliogenesis. These findings emphasize the importance of limiting radiation dose to preserve neurocognitive functions, particularly in the juvenile hippocampus.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Felipe Mora-Bermudez, Elena Taverna, Wieland B. Huttner
Summary: Comparing the neural cells of hominids reveals significant differences in the regulation of processes such as proliferation and differentiation of neural stem and progenitor cells (NSPCs) and maturation of neurons, with the timing of these processes emerging as a foundational difference in neocortex development among hominids.
Article
Biochemistry & Molecular Biology
Rongzi Li, Wei Xiong, Boying Li, Yixuan Li, Bing Fang, Xifan Wang, Fazheng Ren
Summary: Adult hippocampal neurogenesis (AHN) is crucial for cognitive function and is dysregulated in Alzheimer's disease (AD). Plasmalogen (PLA), a group of phospholipids, has neuroprotective properties, but its effect on altered AHN in AD has not been studied. In this study, PLA was found to attenuate the decrease in neural stem cell viability and neuronal differentiation induced by β-amyloid (Aβ), partly through regulating the Wnt/β-catenin pathway. In AD mice, PLA supplementation improved impaired AHN and memory function. Therefore, PLA could regulate NSC differentiation and ameliorate AD-related memory impairment by up-regulating AHN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silvia Benito-Kwiecinski, Stefano L. Giandomenico, Magdalena Sutcliffe, Erlend S. Riis, Paula Freire-Pritchett, Iva Kelava, Stephanie Wunderlich, Ulrich Martin, Gregory A. Wray, Kate McDole, Madeline A. Lancaster
Summary: Research shows that neuroepithelial cell shape in apes is a protracted process, while human brain organoids are larger due to a delay in this transition. RNA sequencing reveals differences in expression dynamics of cell morphogenesis factors, including ZEB2.
Article
Biochemistry & Molecular Biology
Konstantin Yenkoyan, Tigran Margaryan, Senik Matinyan, Vergine Chavushyan, Margarita Danielyan, Tigran Davtyan, Michail Aghajanov
Summary: This study investigated the development of Alzheimer's disease and the brain's defense mechanisms against chronic injuries. The results showed that injection of beta-amyloid can induce stem cell proliferation and neurogenesis, but this process is incomplete and leads to neural stem cell immaturity. The study suggests that enhancing adult neurogenesis may be a promising strategy for preventing and treating Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Claudia Colussi, Claudio Grassi
Summary: Nucleoporins play a crucial role in chromatin interaction and gene expression modulation, particularly in maintaining the balance of stemness and differentiation in stem cells. They are increasingly implicated in central nervous system functions, impacting neurogenesis, neurophysiology, and neurological disorders. However, the role of Nup-mediated epigenetic regulation in neural stem cells remains largely unexplored, with mechanisms of action still being unveiled.
Article
Biochemistry & Molecular Biology
Ekaterina A. Rudnitskaya, Tatiana A. Kozlova, Alena O. Burnyasheva, Natalia A. Stefanova, Nataliya G. Kolosova
Summary: Studies suggest that immaturity during early brain development, especially inadequate glial support, may be a primary factor leading to neurodegenerative processes and the manifestation of AD pathology later in life.
Article
Neurosciences
Shawn F. Sorrells, Mercedes F. Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E. Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J. Huang, Jose Manuel Garcia-Verdugo, Michael C. Oldham, Zhengang Yang, Arturo Alvarez-Buylla
Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Serena Sabatini, Obioha C. Ukoumunne, Clive Ballard, Rachel Collins, Sarang Kim, Anne Corbett, Dag Aarsland, Adam Hampshire, Helen Brooker, Linda Clare
Summary: This study explored the factors associated with subjective age, finding that it may result from the interaction between factors that increase or decrease age-related thoughts and mental processes. The results show that individuals reporting an older subjective age are more likely to experience significant negative changes and engage in negative age-related thoughts. Women experience a more negative subjective age and more age-related events than men.
PSYCHOLOGY & HEALTH
(2023)
Article
Geriatrics & Gerontology
Rotem Perach, Sanna Read, Ben Hicks, Peter R. Harris, Jennifer Rusted, Carol Brayne, Margaret Dangoor, Eleanor Miles, Josie Dixon, Louise Robinson, Alan Thomas, Sube Banerjee
Summary: This study aims to identify factors that predict loneliness for individuals with dementia and their caregivers during the COVID-19 pandemic. The study found that caregiver's loneliness was directly associated with caregiver type, anxiety levels, formal day activities, and cognitive impairment. For individuals with dementia, caregiver type, initial levels of social resources, wellbeing, and cognitive impairment predicted changes in loneliness through indirect effects on social contacts.
AGING & MENTAL HEALTH
(2023)
Article
Chemistry, Applied
M. Corrado, P. Zafeiriou, J. H. Ahn-Jarvis, G. M. Savva, C. H. Edwards, B. A. Hazard
Summary: The staling behavior of high-amylose bread and conventional bread during storage under different conditions was compared. It was found that the high-amylose bread had less starch digestion and maintained a more stable texture compared to the conventional bread.
FOOD HYDROCOLLOIDS
(2023)
Article
Geriatrics & Gerontology
Connor D. Richardson, Hannah Roscoe, Emma Green, Racheal Brooks, Linda Barnes, Fiona E. Matthews, Carol Brayne
Summary: The prevalence of loneliness among older people has increased during the COVID-19 pandemic compared to before. Factors associated with prevalent loneliness include prior loneliness, living alone, being female, living in a deprived area, separation from family during the pandemic, and frequent pre-pandemic social contact at community groups. Weekly technology-mediated contact using telephone or video calls is associated with lower odds of loneliness.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Multidisciplinary Sciences
Deborah L. O. King, Richard Henson, Rogier Kievit, Noham Wolpe, Carol Brayne, Lorraine K. Tyler, James B. A. Rowe, Kamen A. Tsvetanov, Cam-CAN
Summary: Cardiovascular ageing is associated with cognitive impairment, but the specific contributions of different cardiovascular factors to cognitive function are not clear.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Sebastian Walsh, Ishtar Govia, Ruth Peters, Edo Richard, Blossom C. M. Stephan, Nikki-Anne Wilson, Lindsay Wallace, Kaarin J. Anstey, Carol Brayne
Summary: Dementia is a global public health challenge, and individual-level prevention strategies have limited potential. A population-level approach is needed to reduce the incidence of dementia and address global inequalities in risk. This approach can be highly cost-effective.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Carol Brayne
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alex Tsui, Natalie Yeo, Samuel D. Searle, Helen Bowden, Katrin Hoffmann, Joanne Hornby, Arley Goslett, Maryse Weston-Clarke, David Lanham, Patrick Hogan, Anna Seeley, Mark Rawle, Nish Chaturvedi, Elizabeth L. Sampson, Kenneth Rockwood, Colm Cunningham, E. Wesley Ely, Sarah J. Richardson, Carol Brayne, Graciela Muniz Terrera, Zoe Tieges, Alasdair M. J. MacLullich, Daniel Davis
Summary: This study examines the relationship between cognitive function and the severity of delirium in older adults. The authors find a U-shaped relationship, indicating that both lower and higher cognitive function are associated with more severe delirium symptoms. This highlights the importance of cognitive function in the prevention and treatment of delirium.
Article
Public, Environmental & Occupational Health
Michelle C. Odden, Adina Zhang, Neal Jawadekar, Annabel Tan, Andrew E. Moran, M. Maria Glymour, Carol Brayne, Adina Zeki Al Hazzouri, Sebastian Calonico
Summary: Regression discontinuity design (RDD) is a quasi-experimental method used for causal inference. This study aims to estimate the effect of statins on myocardial infarction (MI) using RDD and compare it with other methods. The findings suggest that RDD is superior in replicating the protective effect of statins with MI, although precision is poor.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Zhirong Yang, Chang Wei, Xiaojuan Li, Jinqiu Yuan, Xuefeng Gao, Bingyu Li, Ziyi Zhao, Sengwee Toh, Xin Yu, Carol Brayne, Zuyao Yang, Feng Sha, Jinling Tang
Summary: This study found that the regular use of laxatives is associated with a higher risk of all-cause dementia, especially in individuals who use multiple types of laxatives or osmotic laxatives.
Article
Clinical Neurology
Mohammed D. Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E. Matthews, Li Su, Paul G. Ince, Stephen B. Wharton, Dennis Wang
Summary: This study applies machine learning approaches to identify critical features of Alzheimer-related pathologies associated with dementia. Results show that Braak neurofibrillary tangle stage, beta-amyloid, and cerebral amyloid angiopathy are the most important features for dementia classification. The best-performing dementia classifier achieved 79% sensitivity, 69% specificity, and 75% precision using the top eight neuropathological features.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Communication
Ahmet Begde, Manisha Jain, Maria Goodwin, Carol Brayne, Linda Barnes, Rachael Brooks, Emma Green, Connor Richardson, Tom Dening, Thomas Wilcockson, Eef Hogervorst
Summary: Technology is seen as a solution for the aging population in the UK to improve independence and health. However, factors such as age, gender, access to technology, and physical health affect older adults' willingness to use memory assistive and ADL supportive technologies. Healthcare providers, policymakers, and technology producers should target older people, females, and those with less access to technology to promote healthy and independent aging.
INFORMATION COMMUNICATION & SOCIETY
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Richard Merrick, Carol Brayne
Article
Geriatrics & Gerontology
Emma Nichols, Richard Merrick, Simon Hay, Dibya Himali, Jayandra J. Himali, Sally Hunter, Hannah A. D. Keage, Caitlin S. Latimer, Matthew R. Scott, Jaimie Steinmetz, Jamie M. Walker, Stephen B. Wharton, Crystal Wiedner, Paul K. Crane, Dirk Keene, Lenore J. Launer, Fiona E. Matthews, Julie Schneider, Sudha Seshadri, Lon White, Carol Brayne, Theo Vos
Summary: This study aimed to harmonise neuropathology measures across multiple community-based autopsy cohorts and assess the prevalence, correlation, and co-occurrence of neuropathologies in the ageing population. The results showed that the co-occurrence of neuropathologies in older adults was strongly associated with dementia status, highlighting the complexity of underlying brain pathologies. Rating: 9 out of 10.
LANCET HEALTHY LONGEVITY
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)