Article
Neurosciences
Nina E. Baumgartner, Shannon M. McQuillen, Samantha F. Perry, Sangtawan Miller, Matthieu J. Maroteaux, Robert B. Gibbs, Jill M. Daniel
Summary: Elevated levels of brain estrogen receptor a (ERa) enhances cognitive aging and short-term estrogen use near menopause can have lasting effects on hippocampal function and memory. Insulin-like growth factor-1 (IGF-1) can activate ERa through ligand-independent mechanisms and requires synthesis of brain-derived neuroestrogens. Decreased neuroestrogen activity and impaired memory in a rat model of menopause can be reversed by short-term estradiol treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Aurore Billebeau, Olivier Fain, David Launay, Isabelle Boccon-Gibod, Laurence Bouillet, Delphine Gobert, Genevieve Plu-Bureau, Anne Gompel
Summary: Most postmenopausal women with HAE remain stable, with improvement seen in those with previous estrogen sensitivity. However, some patients do experience worsening of symptoms, highlighting the need for further research on how to manage climacteric symptoms in menopausal women with HAE.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Pakagamon Tumsutti, Mart Maiprasert, Pansak Sugkraroek, Rungsima Wanitphakdeedecha, Akkarach Bumrungpert
Summary: The study demonstrates that supplementation with a blend of Glycine max, Cimicifuga racemosa, Vitex agnus-castus, and Oenothera biennis extracts is beneficial for skin health and antioxidant status in women after menopause.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengjie Zhang, Sarah Flury, Chun K. Kim, Wilson C. J. Chung, Jonathan A. Kirk, Toni R. Pak
Summary: The study revealed a consistent pattern of ER beta phosphorylation in the hippocampus of women of different ages and in rats that have undergone menopause. Changes in phosphorylation levels at certain sites with age and loss of E-2 may affect ER beta's transcription factor activity. This suggests that ER beta's primary function may not necessarily require E-2 binding, and phosphorylation at specific sites could alter its DNA-binding efficiency.
Article
Endocrinology & Metabolism
Jacob Zeitlin, Michael K. K. Parides, Joseph M. M. Lane, Linda A. A. Russell, Kyle N. N. Kunze
Summary: A machine learning model incorporating clinical, laboratory, and imaging data was developed to predict the 10-year risk of menopause-related osteoporosis. The predictions are sensitive and specific, identifying distinct clinical risk profiles that can help identify patients at high risk of osteoporosis.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Clinical Neurology
Kimberly M. Albert, Brian D. Boyd, Warren D. Taylor, Paul A. Newhouse
Summary: This study investigated the modulation effect of estrogen on neural and emotional cognitive responses to stress in postmenopausal women. The results suggest a differential effect of estrogen on emotional and neural responses in postmenopausal women with and without a history of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Kotoko Arisawa, Miyuki Kaneko, Ayumi Matsuoka, Natsuki Ozawa, Rie Kawawa, Tomoko Ishikawa, Ikuyo Ichi, Yoko Fujiwara
Summary: Postmenopausal women are more susceptible to obesity and chronic disease. Piceatannol (PIC), a natural analog of resveratrol, can inhibit adipogenesis and have an antiobesity effect. This study investigated the effect of PIC on postmenopausal obesity and its mechanism, showing that PIC can decrease visceral fat volume in ovary-removed mice and promote lipolysis in white adipose tissue (WAT) while inducing the expression of uncoupled protein 1 in brown adipose tissue (BAT).
Article
Biochemistry & Molecular Biology
Takemi Akahane, Daisuke Kaya, Ryuichi Noguchi, Kosuke Kaji, Haruna Miyakawa, Yukihisa Fujinaga, Yuki Tsuji, Hiroaki Takaya, Yasuhiko Sawada, Masanori Furukawa, Koh Kitagawa, Takahiro Ozutsumi, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Hitoshi Yoshiji
Summary: Equol production is related to NASH histological features, showing potential predictive value, especially prominent in women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Carrie A. Karvonen-Gutierrez, Aleda Leis
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic and systemic inflammation, affecting multiple organ systems, showing a strong female predominance and potentially leading to earlier menopause, increasing cardiovascular and osteoporotic risks. There is currently limited knowledge on strategies for mitigating the increased risk faced by women with SLE during the menopausal transition.
Article
Health Care Sciences & Services
Vladimir Sobolev, Anna Soboleva, Elena Denisova, Malika Denieva, Eugenia Dvoryankova, Elkhan Suleymanov, Olga V. Zhukova, Nikolay Potekaev, Irina Korsunskaya, Alexandre Mezentsev
Summary: This study identified six estrogen-responsive genes with differential expression in the skin of menopausal female psoriasis patients, shedding light on the biological effects of estrogen in lesional skin. The levels of estradiol and progesterone were found to be significantly lower, while testosterone levels were significantly higher in the blood of psoriasis patients compared to healthy controls. Protein ontology analysis of LC-MS/MS data revealed altered expression of proteins like HMOX1, KRT19, LDHA, HSPD1, MAPK1, and CA2 in the lesional skin of female patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Qinghai Meng, Yu Li, Tingting Ji, Ying Chao, Jun Li, Yu Fu, Suyun Wang, Qi Chen, Wen Chen, Fuhua Huang, Youran Wang, Qichun Zhang, Xiaoliang Wang, Huimin Bian
Summary: The study found that post-menopausal women have decreased autophagy and ER alpha expression in the aortic endothelium, with increased inflammation and pyroptosis. Estrogen treatment can accelerate autophagy and improve cell pyroptosis in OVX ApoE-/- mice and Hcy-treated HUVECs. Estrogen prevents atherosclerosis by upregulating ERα expression and subsequently inducing autophagy to reduce inflammation and pyroptosis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Hematology
Irene Lambrinoudaki, Dimitrios Delialis, Georgios Georgiopoulos, Simon Tual-Chalot, Nikolaos I. Vlachogiannis, Raphael Patras, Evmorfia Aivalioti, Eleni Armeni, Areti Augoulea, Nikolaos Tsoltos, Anastasia Soureti, Konstantinos Stellos, Kimon Stamatelopoulos
Summary: Elevated levels of Alpha beta 1-40 may be associated with the progression of atherosclerosis in postmenopausal women. Patterns of persistently high or increasing Alpha beta 1-40 levels could be linked to accelerated subclinical atherosclerosis progression.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, Research & Experimental
Graziele F. Deriggi-Pisani, Uliana S. Stotzer, Rita C. Marqueti, Maria F. C. Rodrigues, Bruna G. Biffe, Karina A. Silva, Victor Fabricio, Clifford J. Rosen, Heloisa Sobreiro Selistre-de-Araujo
Summary: This study evaluated the effects of resistance training on bone properties, morphology, and bone extracellular matrix remodeling markers in an ovariectomy rat model. The results showed that resistance training could reverse the negative effects of ovariectomy on bone mineral density, stiffness, maximal load, and calcium content. Additionally, resistance training was effective in increasing trabecular thickness and cortical bone volume, improving bone resistance.
Article
Biochemistry & Molecular Biology
Renata R. Bruno, Fernanda C. Rosa, Paula C. Nahas, Flavia M. S. de Branco, Erick P. de Oliveira
Summary: Aging is associated with decreased muscle strength and increased reactive oxygen species. This cross-sectional study found that serum levels of alpha-carotene were positively associated with muscle strength in older adults, while other antioxidants were not. This suggests that alpha-carotene may have a beneficial effect on muscle strength in aging individuals.
Article
Biochemistry & Molecular Biology
Filomena Marafon, Beatriz da Silva Rosa Bonadiman, Sabine de Rocco Donassolo, Katiuska Marins, Mariane Magalhaes Zanchi, Greicy Cristine Kosvosky, Helena Fornari Basso, Ariane Zamoner, Margarete Dulce Bagatini
Summary: This study aimed to measure the activity of purinergic ectoenzymes and interleukins in patients with head and neck cancer (HNC), oral cavity cancer, and larynx cancer. The findings revealed dysregulation in the purinergic signaling pathway, associated with immune alterations and immunosuppression in these cancer patients. These findings are important for understanding the biological mechanisms of HNC and may serve as potential diagnostic markers and therapeutic targets in the future.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Daniela C. dos Santos, Jamal Rafique, Sumbal Saba, Valdelucia M. A. S. Grinevicius, Danilo W. Filho, Ariane Zamoner, Antonio L. Braga, Rozangela C. Pedrosa, Fabiana Ourique
Summary: This study investigates the antitumor mechanism of a selenylated imidazo[1,2-a]pyridine derivative in glioblastoma cells. The results demonstrate that the compound can inhibit glioblastoma growth by modulating intracellular redox state, inducing apoptosis, and inhibiting multiple signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Multidisciplinary
Simone Schneider Weber, Alessandra Carla Sampaio de Souza, Denise Caroline Luiz Soares, Caroline Carvalho Lima, Ana Carolina Rabello de Moraes, Stephanie Viegas Gkionis, Tanara Arenhart, Luiz Gustavo Goncalves Rodrigues, Sandra Regina Salvador Ferreira, Rozangela Curi Pedrosa, Denise Brentan Silva, Edgar Julian Paredes-Gamero, Renata Trentin Perdomo, Eduardo Benedetti Parisotto
Summary: The study found that A. bisporus extracts obtained by supercritical fluid extraction showed excellent performance in terms of antimicrobial, antiaggregant, and anticoagulant activities.
Article
Respiratory System
Gabriela Datsch Bennemann, Emilia Addison Machado Moreira, Leticia Cristina Radin Pereira, Maiara Brusco de Freitas, Diane de Oliveira, Julia Carvalho Ventura, Eduardo Benedetti Parisotto, Yara Maria Franco Moreno, Erasmo Benicio Santos Moraes Trindade, Eliana Barbosa, Norberto Ludwig Neto, Danilo Wilhelm Filho
Summary: This study aims to evaluate the influence of bacterial infection on oxidative stress in children with cystic fibrosis. The results indicate a systemic oxidative stress in children with cystic fibrosis, and bacterial infection, particularly Pseudomonas aeruginosa, may exacerbate oxidative damage to proteins.
CLINICAL RESPIRATORY JOURNAL
(2022)
Article
Immunology
Leticia Souza Lima, Suellen Rodrigues Ramalho, Graziele Custodia Sandim, Eduardo Benedetti Parisotto, Janaina de Orlandi Sardi, Maria Ligia Rodrigues Macedo
Summary: This study investigates the antimicrobial and antibiofilm activity of a new synthetic peptide, KWI18, against Pseudomonas aeruginosa and Candida parapsilosis biofilms. The results show that KWI18 has antimicrobial activity and can inhibit biofilm formation and cell viability. Its mechanism of action involves ergosterol and induction of oxidative damage. Furthermore, KWI18 exhibits low toxicity to erythrocytes and Galleria mellonella, suggesting its potential as an effective antibiofilm agent.
MICROBIAL PATHOGENESIS
(2022)
Article
Pharmacology & Pharmacy
Carla Elise Heinz Rieg, Daiane Cattani, Nathalia Ferrazzo Naspolini, Vitoria Hayduck Cenci, Vera Lucia de Liz Oliveira Cavalli, Amanda Virtuoso Jacques, Marcus Vinicius Pereira Dos Santos Nascimento, Eduardo Monguilhott Dalmarco, Ana Carolina Rabello De Moraes, Maria Claudia Santos-Silva, Fatima Regina Mena Barreto Silva, Eduardo Benedetti Parisotto, Ariane Zamoner
Summary: The present study investigated the effects of perinatal exposure to glyphosate-based herbicide (GBH) in offspring's liver. The results showed that perinatal exposure to GBH increased Ca2+ influx, oxidative damage and inflammation in the liver of offspring. Additionally, the study found that GBH exposure led to increased levels of iron in the liver, blood and bone marrow, which might contribute to iron-driven hepatotoxicity. These findings indicate the potential harmful effects of GBH on liver function in offspring.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biology
Marcelo Falchetti, Marina Delgobo, Helena Zancanaro, Karoline Almeida, Raquel Nascimento das Neves, Barbara dos Santos, Natalia Marceli Stefanes, Alexander Bishop, Maria Claudia Santos-Silva, Alfeu Zanotto-Filho
Summary: This study characterizes the transcriptional and genetic alterations associated with auranofin response in cancer cells. It identifies a signature of 29 genes that are associated with auranofin resistance, with mutations in NRF2 pathway genes strongly linked to overexpression of these genes. The study also predicts the sensitivity of different cancer types to auranofin based on their gene expression patterns.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Vanessa Staldoni de Oliveira, Katiuska Marins, Ana Karla Bittecourt Mendes, Ariane Zamoner, Gabriel Adan Araujo Leite, Fatima Regina Mena Barreto Silva
Summary: We studied the effects of pyriproxyfen on zebrafish ovarian morphology and oxidative stress. Exposure to pyriproxyfen resulted in increased generation of reactive oxygen species and decreased glutathione content in the ovaries. Additionally, enzyme activities related to antioxidative defense mechanisms were altered. The histological analysis showed disrupted follicular maturation and various abnormalities in the ovary. These findings suggest that pyriproxyfen acts as an endocrine disruptor and can impair fish reproduction.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Plant Sciences
Djaceli Sampaio de Oliveira Dembogurski, Iluska Senna Bonfa, Luciane Candeloro, Eduardo Benedetti Parisotto, Monica Cristina Toffoli Kadri, Denise Brentan Silva
Summary: This study aimed to determine the chemical profile of Miconia albicans aqueous extract (MAAE), investigate its anti-inflammatory and hyperalgesic effects, and evaluate its toxicity. The results showed that MAAE had significant anti-inflammatory and anti-hyperalgesic properties, and did not exhibit acute and repeated-dose toxicities.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Giovana Bicudo Gomes, Claudia Stutz Zubieta, Jhefferson dos Santos Guilhermi, Monica Cristina Toffoli-Kadri, Adilson Beatriz, Jamal Rafique, Eduardo Benedetti Parisotto, Sumbal Saba, Renata Trentin Perdomo
Summary: Incidence rates of colon cancer are increasing annually due to genetic and epigenetic alterations that lead to drug resistance. Recent studies have found that novel synthetic selenium compounds, such as MRK-107, are more effective and less toxic than conventional drugs, exhibiting biocompatibility and pro-oxidant effects on tumor cells. MRK-107 inhibits cell proliferation, prevents cell regeneration and metastatic transition, and induces apoptosis in colon cancer cells through oxidative stress and activation of apoptotic pathways.
Review
Environmental Sciences
Mariane Magalhaes Zanchi, Katiuska Marins, Ariane Zamoner
Summary: Pesticide exposure and poisoning can increase the risk of mental health problems and suicidal tendencies. A systematic review found that farmers exposed to pesticides had a higher prevalence of depressive disorders, and previous pesticide poisoning increased the risk of depression. Financial difficulties and poor health were also linked to depression in this population. Additionally, suicide rates were higher in areas with intensive pesticide consumption, highlighting the need for greater attention to the mental health of farmers and further research on occupational exposure to pesticides.
ENVIRONMENTAL POLLUTION
(2023)
Editorial Material
Pharmacology & Pharmacy
Ariane Zamonera, Maria L. Pereira, Marco G. Alves
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daiane Cattani, Paula Pierozan, Ariane Zamoner, Eva Brittebo, Oskar Karlsson
Summary: Concerns have been raised about the potential adverse health effects of glyphosate, a widely used herbicide. This study found that developmental exposure to a glyphosate-based herbicide (GBH) led to reduced serum melatonin levels, oxidative stress-related changes in the striatum, and increased neuron numbers in adult rats. Mechanistic studies also suggested that glyphosate could affect melatonin secretion and cell viability.
Article
Environmental Sciences
Claudia Daniele Bianco, Fabiana Ourique, Daniela Coelho dos Santos, Rozangela Curi Pedrosa, Maicon Roberto Kviecisnki, Ariane Zamoner
Summary: This study investigated the effects of glyphosate herbicide on the survival and proliferation of glioblastoma cells and found that it may lead to oxidative damage and inflammation, giving the cells an advantage in terms of growth. The study also explored the molecular mechanisms underlying these effects, including the activation of signaling pathways, oxidative imbalance, and inflammation.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)