Review
Oncology
Harshal A. Shah, Sandra Leskinen, Hamza Khilji, Vinayak Narayan, Netanel Ben-Shalom, Randy S. D'Amico
Summary: The current studies on 5-ALA fluorescence in brain metastases are limited and do not confirm its efficacy in improving the extent of resection or post-operative survival. Fluorescence varies greatly across and within tumor types.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Makiko Sasaki, Mamoru Tanaka, Hiroshi Ichikawa, Taketo Suzuki, Hirotada Nishie, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka
Summary: The study demonstrated the clinical potential of photodynamic diagnosis (PDD) with 5-aminolevulinic acid (5-ALA) for GIST diagnosis by showing PpIX accumulation in GIST-T1 cells and xenograft tumors, with distinct identification of tumor and normal tissues based on relative PpIX fluorescence.
Article
Neurosciences
Pietro Zeppa, Raffaele De Marco, Matteo Monticelli, Armando Massara, Andrea Bianconi, Giuseppe Di Perna, Stefania Greco Crasto, Fabio Cofano, Antonio Melcarne, Michele Maria Lanotte, Diego Garbossa
Summary: This study compared the use of 5-ALA and SF in GBM patients and found no significant differences in terms of resection extent and postoperative functional status. However, the concomitant use of both fluorophores may improve overall survival.
Article
Clinical Neurology
Alexander Micko, Benjamin I. Rapoport, Brett E. Youngerman, Reginald P. Fong, Jennifer Kosty, Andrew Brunswick, Shane Shahrestani, Gabriel Zada, Theodore H. Schwartz
Summary: The study found limited utility of 5-aminolevulinic acid (5-ALA) fluorescence in the majority of endonasal skull base surgeries, although other pathology may be worth investigating, with the possible exception of meningiomas.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Alexander Micko, Benjamin Rapoport, Brett E. Youngerman, Reginald P. Fong, Jennifer Kosty, Andrew Brunswick, Shane Shahrestani, Gabriel Zada, Theodore H. Schwartz
Summary: This study found that the utility of 5-ALA fluorescence in most endonasal skull base surgeries is limited, though it may be helpful in certain cases such as meningiomas.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Giuseppe Maria Della Pepa, Grazia Menna, Alessandro Olivi
Summary: This paper summarizes the authors' institutional experience with 5-ALA-guided procedures over a decade and provides five surgical tricks to simplify the surgical workflow. The results include analysis of visualization, techniques to reduce residual risk, assessment of fluorescence levels, and analysis of false positive cases. The importance of 5-ALA employment is evaluated.
Article
Oncology
Simone Pacioni, Quintino Giorgio D'Alessandris, Stefano Giannetti, Giuseppe Maria Della Pepa, Martina Offi, Martina Giordano, Valerio Maria Caccavella, Maria Laura Falchetti, Liverana Lauretti, Roberto Pallini
Summary: In this study, fluorescence microscopy analysis was used to assess the number of fluorescence-positive tumor cells induced by 5-aminolevulinic acid (5-ALA) in both low-grade and high-grade gliomas. The ability of 5-ALA to cross the blood-brain barrier (BBB) was also investigated. It was found that 32.7-75.5 percent of cells in high-grade gliomas displayed 5-ALA induced fluorescence, while low-grade gliomas did not show fluorescence following 5-ALA. Immunofluorescence analysis suggested that 5-ALA does not cross the BBB. These findings have important implications for the neurosurgical resection of gliomas.
Review
Medicine, General & Internal
Georgios Solomou, Aref-Ali Gharooni, Waqqas Patel, Conor S. Gillespie, Melissa Gough, Ashwin Venkatesh, Michael T. C. Poon, Victoria Wykes, Stephen John Price, Michael D. Jenkinson, Colin Watts, Puneet Plaha
Summary: This study aims to conduct a systematic review of the surgical outcomes and diagnostic accuracy of 5-ALA in tumors of the central nervous system other than high-grade gliomas. The study will evaluate the available evidence and provide recommendations for future research.
Article
Clinical Neurology
Eric Suero Molina, Sonke J. Hellwig, Anna Walke, Astrid Jeibmann, Herbert Stepp, Walter Stummer
Summary: This study introduces a triple-LED headlight/loupe device for fluorescence-guided resections and compares it to the BLUE400 system. The new device provides slightly higher fluorescence intensities compared to BLUE400, while having similar spectra and illumination intensities.
JOURNAL OF NEUROSURGERY
(2022)
Article
Engineering, Biomedical
Robert Pola, Eliska Grosmanova, Michal Pechar, Dominik Horak, Tereza Krunclova, Jan Pankrac, Maxime Henry, Martin Kana, Jan Boucek, Ludek Sefc, Jean-Luc Coll, Tomas Etrych
Summary: In this study, long-circulating stimuli-responsive polymer nanoprobes were developed for fluorescently-guided surgery of solid tumors. The nanoprobes were designed to accumulate preferentially in solid tumors, showing stimuli-sensitive release behavior and activating fluorescent signals. These probes demonstrated excellent diagnostic potential for surgical removal of tumors with high efficacy and accuracy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Editorial Material
Clinical Neurology
Ben A. Strickland, Gabriel Zada
Summary: Glioblastoma multiforme is the most common primary brain tumor in adults, often treated with maximal safe resection, chemotherapy, and radiation. Intraoperative use of blue light endoscopy can enhance tumor fluorescence visualization, aiding in achieving a more accurate resection.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Laurent J. Livermore, Martin Isabelle, Ian M. Bell, Oliver Edgar, Natalie L. Voets, Richard Stacey, Olaf Ansorge, Claire Vallance, Puneet Plaha
Summary: Raman spectroscopy can accurately differentiate between tumor and normal brain tissue in fresh samples and performs better than 5-ALA-induced fluorescence, showing potential as an intraoperative tool for guiding glioma surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Laurent J. Livermore, Martin Isabelle, Ian M. Bell, Oliver Edgar, Natalie L. Voets, Richard Stacey, Olaf Ansorge, Claire Vallance, Puneet Plaha
Summary: The study demonstrates the superior performance of Raman spectroscopy in distinguishing between tumor and normal brain tissue, making it a crucial intraoperative tool for glioma surgery guidance. When used in conjunction with 5-ALA-induced fluorescence, Raman spectroscopy outperforms the latter and shows better predictive value.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Sergey A. Goryaynov, Svetlana B. Buklina, Ivan V. Khapov, Artyom I. Batalov, Alexander A. Potapov, Igor N. Pronin, Artem U. Belyaev, Andrey A. Aristov, Vadim U. Zhukov, Galina V. Pavlova, Evgenii Belykh
Summary: The simultaneous use of 5-ALA fluorescence and awake speech mapping in patients with left frontal gliomas can enhance the extent of resection for infiltrative high-grade gliomas and identify foci of anaplasia in non-enhancing gliomas, while maintaining safe limits of functional resection based on speech mapping. Positive 5-ALA fluorescence in diffuse Grade 2 gliomas may indicate a more aggressive disease course.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
Wiebke K. Guder, Wolfgang Hartmann, Clarissa Buhles, Maike Burdack, Maike Busch, Nicole Dunker, Jendrik Hardes, Uta Dirksen, Sebastian Bauer, Arne Streitbuerger
Summary: This study analyzed the fluorescence rate and photodynamic therapy (PDT) effects of musculoskeletal tumors using chick chorio-allantoic membrane (CAM) model exposed to 5-aminolevulinic acid (5-ALA). The results showed that the fluorescence rate of tumors was correlated with tumor type, and PDT could cause partial or complete regression of tumors. This study provides evidence for further investigation of PDT effects on musculoskeletal tumors and the incorporation of 5-ALA FGS in clinical Orthopedic Oncology care.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)