Article
Multidisciplinary Sciences
Morgan A. Brown, Kara M. Zappitelli, Loveprit Singh, Rachel C. Yuan, Melissa Bemrose, Valerie Brogden, David J. Miller, Matthew C. Smear, Stuart F. Cogan, Timothy J. Gardner
Summary: This report describes the integration of a 3D microelectrode array on a thin-film flexible cable for neural recording. The fabrication process combines traditional thin-film processing techniques and direct laser writing of 3D structures at micron resolution via two-photon lithography. The report provides a method for producing high-aspect-ratio structures.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Miheng Dong, Patcharin Chen, Kun Zhou, Minsu Liu, Sebastian Thomas, Harold A. Coleman, Dan Li, James B. Fallon, Mainak Majumder, Helena C. Parkington, John S. Forsythe
Summary: In this study, flexible three-dimensional and two-dimensional recording electrodes made of reduced graphene oxide were introduced for long-term and acute recordings. The results showed that these electrodes had good recording capabilities and excellent biocompatibility in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Gerardo Montoya, Klaudia Wagner, Gregory Ryder, Aida Shoushtari Zadeh Naseri, Shaikh Nayeem Faisal, Vitor Sencadas, Marc In Het Panhuis, Geoffrey M. Spinks, Gordon G. Wallace, Gursel Alici, David L. Officer
Summary: This paper reports on the mechanical and electrochemical properties of a polydimethyl-siloxane (PDMS) composite with edge-functionalized graphene (EFG) and demonstrates its potential for use in neural implants by fabricating a novel neural cuff electrode. The composite showed desirable stretchability, mechanical stability, and increased electrochemical properties after reduction, making it a promising material for interfacing with soft tissue.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
Kaikai Wang, Baoliang Feng, Dazheng Zhao, Tao Meng, Jun Wang, Gang Wu, Binjun Shi, Guokun Zuo, Changcheng Shi
Summary: This study proposed a method to enhance the quality of sleeping electrocardiogram (ECG) signals. By adding parallel capacitors at both ends of the coupling capacitance, the signal-to-noise ratio of the ECG signals can be improved, resulting in more accurate monitoring. The experimental results showed that the proposed system obtained ECG signals consistent with the reference system and had a low average heart rate error.
IEEE SENSORS JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Qiang Li, Yifan Zhang, Xiajin Li, Tianshuo Song, Chaoqun Xia
Summary: Brain implantable neural electrode is a crucial part of nerve therapy and nerve prosthetic instruments. The focus of current research is on developing miniature and thin brain implantable flexible neuro electrodes with good biocompatibility and adaptability to brain tissues.
Review
Computer Science, Information Systems
Chi Gu, Jianjuan Jiang, Tiger H. Tao, Xiaoling Wei, Liuyang Sun
Summary: Penetrating neural interfaces, essential for brain-computer interfaces, have become a focus of attention due to their ability to collect neural electrophysiological signals. The main challenge for traditional neural interfaces is the instability of chronic recording, but novel neural probes have been developed to improve long-term performance. These advancements in materials, structures, and implantation methods are enabling further progress in neuroscience research related to neural decoding, analysis of neural circuit mechanisms, and treatment of neurological diseases.
SCIENCE CHINA-INFORMATION SCIENCES
(2021)
Article
Engineering, Biomedical
Kevin Joseph, Matthias Kirsch, Midori Johnston, Christian Munkel, Thomas Stieglitz, Carola A. Haas, Ulrich G. Hofmann
Summary: Long-term implantation of (micro-)probes into neural tissue leads to unique responses in glial cells. While animals implanted for 18 weeks show signs of recovery, upregulation of certain genes suggests that structural and functional remodeling is not complete at this time point.
Article
Mechanics
Shun Zhang, Chengjun Wang, Changhong Linghu, Suhao Wang, Jizhou Song
Summary: This paper reviews recent advances in mechanics strategies to facilitate the insertion of flexible neural probes, summarizing the basic concepts of each strategy and discussing their advantages and disadvantages briefly. The results provide guidance for reliable implantation of flexible neural probes for chronic brain electrophysiological recording and the clinical treatment of neurological disorders.
JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
(2021)
Article
Computer Science, Information Systems
Qingyun Zhang, Xinhua Zhao, Liang Liu, Tengda Dai
Summary: An adaptive sliding mode control algorithm based on a neural network was proposed to improve the tracking performance of a flexible parallel robot system and reduce vibration amplitudes. By establishing an accurate dynamic model and pre-calculating driving torques, the control accuracy requirements were met and vibrations were effectively suppressed.
Editorial Material
Engineering, Electrical & Electronic
Seung Hwan Ko
Summary: The electrical and mechanical robustness of thin metal film electrodes can be improved by adding an atomically thin interlayer, such as graphene, between the metal and the flexible substrate.
NATURE ELECTRONICS
(2021)
Review
Chemistry, Multidisciplinary
Viet Huong Nguyen, Dorina T. Papanastasiou, Joao Resende, Laetitia Bardet, Thomas Sannicolo, Carmen Jimenez, David Munoz-Rojas, Ngoc Duy Nguyen, Daniel Bellet
Summary: Transparent electrodes are crucial in various modern devices, and the search for alternative materials to replace conventional indium tin oxide (ITO) has led to the interest in metallic nanomaterials. This review provides a comparison between metallic nanomaterials and other transparent conductive materials, discusses the development and fabrication technologies of metal-based TCMs, examines the challenges they face in integration, and summarizes their successful and potential applications.
Article
Chemistry, Analytical
Tianfang Yan, Seiji Kameda, Katsuyoshi Suzuki, Taro Kaiju, Masato Inoue, Takafumi Suzuki, Masayuki Hirata
Summary: This study investigated the tissue response related to electrode implantation and a fully implantable wireless BMI device in a 6-month experiment on beagles, showing no adverse events during the implantation period, indicating good biocompatibility. The findings suggest that fully implantable wireless devices and subdural electrodes can be stably maintained with sufficient biocompatibility in vivo.
Article
Audiology & Speech-Language Pathology
Simon Konrad, Andreas Buechner, Thomas Lenarz, Gerrit Paasche
Summary: This study aimed to evaluate impedance development after implantation of Hybrid-L electrodes. The results showed that despite smaller contacts, impedance values after electrical stimulation were comparable to published values of Contour electrodes, indicating less tissue growth with the Hybrid-L electrode array.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2022)
Article
Engineering, Biomedical
Chia-Han Chiang, Charles Wang, Katrina Barth, Shervin Rahimpour, Michael Trumpis, Suseendrakumar Duraivel, Iakov Rachinskiy, Agrita Dubey, Katie E. Wingel, Megan Wong, Nicholas S. Witham, Thomas Odell, Virginia Woods, Brinnae Bent, Werner Doyle, Daniel Friedman, Eckardt Bihler, Christopher F. Reiche, Derek G. Southwell, Michael M. Haglund, Allan H. Friedman, Shivanand P. Lad, Sasha Devore, Orrin Devinsky, Florian Solzbacher, Bijan Pesaran, Gregory Cogan, Jonathan Viventi
Summary: The study introduces a flexible, high-resolution thin-film electrode for recording neural activity in animals and humans. The electrodes offer higher electrode density, reduced stiffness, and lower impedance, allowing observation of high-frequency neural activity and improving efficiency in the operating room setup.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Junjie Wang, Tengjiao Wang, Haoyan Liu, Kun Wang, Kumi Moses, Zhuoya Feng, Peng Li, Wei Huang
Summary: This article introduces the current research and application prospects of brain-computer interface (BCI), highlighting the limitations of traditional rigid electrodes and the advantages and development directions of flexible electrodes as alternatives. The article provides a systematic review of electrode classification, materials, fabrication methods, and requirements for flexible electrodes.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Lan Luan, Colin T. Sullender, Xue Li, Zhengtuo Zhao, Hanlin Zhu, Xiaoling Wei, Chong Xie, Andrew K. Dunn
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Chemistry, Multidisciplinary
Xiaoling Wei, Lan Luan, Zhengtuo Zhao, Xue Li, Hanlin Zhu, Ojas Potnis, Chong Xie
Article
Multidisciplinary Sciences
Fei He, Colin T. Sullender, Hanlin Zhu, Michael R. Williamson, Xue Li, Zhengtuo Zhao, Theresa A. Jones, Chong Xie, Andrew K. Dunn, Lan Luan
Editorial Material
Chemistry, Multidisciplinary
Yi Hou, Xiaoling Wei, Yunfeng Yan, Jing Hao
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Biomedical
Austin Veith, Xue Li, Hailey Modi, Ali Abbaspour, Chong Xie, Lan Luan, Aaron B. Baker
Summary: This study developed a hyperflexible regenerative sieve electrode as a peripheral neural interface, and demonstrated its potential in enhancing neurovascular invasion, reducing tissue reaction, and creating a stable tissue-device interface in long-term implantation.
Review
Computer Science, Information Systems
Chi Gu, Jianjuan Jiang, Tiger H. Tao, Xiaoling Wei, Liuyang Sun
Summary: Penetrating neural interfaces, essential for brain-computer interfaces, have become a focus of attention due to their ability to collect neural electrophysiological signals. The main challenge for traditional neural interfaces is the instability of chronic recording, but novel neural probes have been developed to improve long-term performance. These advancements in materials, structures, and implantation methods are enabling further progress in neuroscience research related to neural decoding, analysis of neural circuit mechanisms, and treatment of neurological diseases.
SCIENCE CHINA-INFORMATION SCIENCES
(2021)
Article
Engineering, Biomedical
Zhengtuo Zhao, Hanlin Zhu, Xue Li, Liuyang Sun, Fei He, Jason E. Chung, Daniel F. Liu, Loren Frank, Lan Luan, Chong Xie
Summary: Penetrating flexible electrode arrays enable long-term stable electrophysiological recordings and inference of patterns of neural information flow.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Yu Zhou, Chi Gu, Jizhi Liang, Bohan Zhang, Huiran Yang, Zhitao Zhou, Meng Li, Liuyang Sun, Tiger H. Tao, Xiaoling Wei
Summary: The combination of optogenetics and electrophysiological recording allows for high-precision bidirectional interactions between neural interfaces and neural circuits, offering a promising approach for studying progressive neurophysiological phenomena. In this study, a hybrid probe (Silk-Optrode) composed of a silk protein optical fiber and flexible microelectrode arrays is reported. The Silk-Optrode exhibits accurate implantation into the brain and enables synchronized optogenetic stimulation and multichannel recording in freely behaving animals. By utilizing the hydration of the silk optical fiber, the Silk-Optrode adapts to the environment after implantation and reduces its own mechanical stiffness to ensure high fidelity implantation while maintaining mechanical compliance with the surrounding tissue. The probe with 128 recording channels can detect well-isolated single units and perform intracranial light stimulation with low optical losses, surpassing previous similar work. Results from a two-month post-surgery evaluation suggest that the Silk-Optrode probe exhibits improved implant-neural interfaces with less immune response and tissue damage.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Yu Zhou, Huiran Yang, Xueying Wang, Heng Yang, Ke Sun, Zhitao Zhou, Liuyang Sun, Jianlong Zhao, Tiger H. H. Tao, Xiaoling Wei
Summary: Advancements in microscale electrode technology have revolutionized neuroscience and clinical applications, offering high temporal and spatial resolution. Flexible neural probes outperform rigid devices due to their mechanical compliance and longevity. Inspired by mosquito mouthparts, a biomimetic neuroprobe system with nonvisual monitoring capability has been developed, reducing the risk of brain vessel damage during implantation. This system demonstrates exceptional sensitivity, adaptability, and performance, showing promising potential for future applications in neuroscience and brain-machine interfaces.
MICROSYSTEMS & NANOENGINEERING
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Feihong Xu, Zhitao Zhou, Haoyuan Li, Xiaoling Wei, Tiger H. Tao
Summary: A set of flexible microelectrode arrays capable of high-quality ECoG signal acquisition was reported, with in-plane shielding designs that improved resistance to external disturbances. Simulation and in vitro experiments showed that the bell-type shielding design had better performance, and successful recording of high SNR neural signals was achieved in a mouse model with implanted devices.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Chi Gu, Huiran Yang, Bohan Zhang, Haoyuan Li, Xueying Wang, Zhitao Zhou, Zhifeng Shi, Ying Mao, Xiaoling Wei, Tiger H. Tao
Summary: We have developed a silk-based neural probe that integrates optogenetic stimulation and in-situ electrophysiological recording, allowing for simultaneous control of animal motion in a mice model.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
Review
Neurosciences
Lan Luan, Jacob T. Robinson, Behnaam Aazhang, Taiyun Chi, Kaiyuan Yang, Xue Li, Haad Rathore, Amanda Singer, Sudha Yellapantula, Yingying Fan, Zhanghao Yu, Chong Xie
Article
Physics, Condensed Matter
Hongyu Zhen, Kan Li, Yaokang Zhang, Lina Chen, Liyong Niu, Xiaoling Wei, Xu Fang, Peng You, Zhike Liu, Dongrui Wang, Feng Yan, Zijian Zheng
JOURNAL OF SEMICONDUCTORS
(2018)