Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage

(2018) Songyun Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway

(2018) Yu Inata et al.   FASEB JOURNAL

Impact of lipid modulation on the intestinal microcirculation in experimental sepsis

(2018) Annette Wegner et al.   MICROVASCULAR RESEARCH

Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model

(2018) Satoshi Sunahara et al.   Scientific Reports

Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis

(2017) Xianghong Zhang et al.   FASEB JOURNAL

Understanding Immunosuppression after Sepsis

(2017) Fatemeh Fattahi et al.   IMMUNITY

Mitochondrial networking in human blood cells with application in acute care illnesses

(2017) David H. Jang et al.   MITOCHONDRION

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

The Role of Autophagy in Critical Illness-induced Liver Damage

(2017) Steven E. Thiessen et al.   Scientific Reports

Autophagy confers resistance to lipopolysaccharide-induced mouse hepatocyte injury

(2016) Gadi Lalazar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Heme Oxygenase-1/Carbon Monoxide-regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-induced Acute Lung Injury in Rats and in Lipopolysaccharide-activated Macrophages

(2016) Jianbo Yu et al.   ANESTHESIOLOGY

Blame it on Southern, but it's a western blot

(2016) Daniel J. Klionsky   Autophagy

Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis

(2016) G. McCreath et al.   BRITISH JOURNAL OF ANAESTHESIA

Mitochondrial quality control by the Pink1/Parkin system

(2016) Cornelia Rüb et al.   CELL AND TISSUE RESEARCH

Rapamycin Protects Sepsis-Induced Cognitive Impairment in Mouse Hippocampus by Enhancing Autophagy

(2016) Wenyu Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart

(2016) Haleh Vaez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

Epidemiology of severe sepsis: 2008-2012

(2016) Jeremy Stoller et al.   JOURNAL OF CRITICAL CARE

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis

(2015) Alan L. Chang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults

(2015) Yaseen M. Arabi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement

(2015) Pedro Bullón et al.   PHARMACOLOGICAL RESEARCH

Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism

(2015) Melissa E. Hansen et al.   SHOCK

Role of Mitofusin-2 in High Mobility Group Box-1 Protein-Mediated Apoptosis of T Cellsin Vitro

(2014) Zong-sheng Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery

(2014) Virginia Vanasco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

(2014) A. S. Gonzalez et al.   FREE RADICAL RESEARCH

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*

(2013) David F. Gaieski et al.   CRITICAL CARE MEDICINE

Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver

(2013) Evie H. Carchman et al.   FASEB JOURNAL

Long-term mortality and quality of life after septic shock: a follow-up observational study

(2013) Nicolas Nesseler et al.   INTENSIVE CARE MEDICINE

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury

(2013) Yu-Ting Yen et al.   SURGERY

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

(2012) Steven Lo et al.   ANNALS OF SURGERY

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes

(2012) Claude A. Piantadosi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Up-regulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca2+-NFAT signaling pathway

(2012) Guang-ju Zhao et al.   CYTOKINE

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Complete Induction of Autophagy Is Essential for Cardioprotection in Sepsis

(2011) Chi-Hsun Hsieh et al.   ANNALS OF SURGERY

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

Suppression of Autophagy in Rat Liver at Late Stage of Polymicrobial Sepsis

(2011) Wei-Shan Chien et al.   SHOCK

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

(2011) Hsiu-Wen Hsiao et al.   SHOCK

Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis

(2010) Jane E. Carré et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

The Surviving Sepsis Campaign: robust evaluation and high-quality primary research is still needed

(2010) Simon Finfer   INTENSIVE CARE MEDICINE

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome

(2009) Anna J. Dare et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mortality in ICU patients with bacterial community-acquired pneumonia: when antibiotics are not enough

(2008) Alejandro Rodriguez et al.   INTENSIVE CARE MEDICINE

Statins for infection and sepsis: a systematic review of the clinical evidence

(2008) M. E. Falagas et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE