期刊
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
卷 53, 期 5, 页码 757-765出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2018.12.013
关键词
Carbapenem-resistant K. pneumoniae; Integron; Klebsiella pneumoniae; Old antibiotic; Trimethoprim-sulfamethoxazole
资金
- National Natural Science Foundation of China [81171614]
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health talents [[2012]241]
Background / purpose: Trimethoprim-sulfamethoxazole (TMP-SMZ) is broadly administered to treat multiple infections, and the paucity of effective treatment alternatives for infections caused by Klebsiella pneumoniae has led to a renewed interest in TMP-SMZ. The aim of this study is to evaluate the antibacterial efficacy of TMP-SMZ against K. pneumoniae. Methods: The resistance genes of K. pneumoniae clinical isolates were investigated by PCR, followed by conjugation experiments and multilocus sequence typing. Results: The resistance rate of K. pneumoniae to TMP-SMZ decreased over the collection period from 26.7% (88/330) to 16.9% (56/332). The high carrying rates (173/175, 98.9%) of resistance determinants (sul genes or dfr genes) were the main mechanisms of TMP-SMZ resistance isolates, with sul1 (142/175, 81.1%) and dfrA1 (119/175, 68.0%). Only class 1 integron was detected, the prevalence of which in TMP-SMZ resistant K. pneumoniae was 63.4% (111/175). Conclusion: These results provided insights into the antimicrobial efficacy of TMP-SMZ against K. pneumoniae, also illustrating the wide distribution of SMZ and TMP resistance genes among resistant K. pneumoniae. Simultaneously, the present study highlights the significance of reasonable administration and effective continued monitoring. Copyright (C) 2019, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
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