Review
Medicine, Research & Experimental
Paromita Sarbadhikary, Blassan P. George, Heidi Abrahamse
Summary: Photodynamic Therapy (PDT) has emerged as a promising alternative in cancer diagnosis and treatment, utilizing light-induced activation of photosensitizers to kill cancer cells. PDT offers advantages such as minimal invasiveness and spatio-temporal control, with proper planning of parameters being crucial for efficacy. The design of PS formulations for imaging-guided PDT has shown promising potential, with recent advances in activatable phototheranostic agents enhancing the specificity of treatment.
Review
Pharmacology & Pharmacy
Yunong Ma, Fengfeng Xiao, Cuixia Lu, Liewei Wen
Summary: Photodynamic Therapy (PDT) is a non-invasive treatment method with many advantages, but it is only effective for local tumor control and has limited therapeutic effects. Recently, smart nanomedicine-based strategies have been developed to overcome the drawbacks of traditional PDT, particularly by enhancing the therapeutic efficiency through eliciting host immune system. This review summarizes the pathways of PDT-induced tumor destruction, focusing on the recent progress of nanosystems-enhanced PDT through eliciting innate immunity and adaptive immunity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yilin Liu, Yuan Liang, Pengpeng Lei, Zhen Zhang, Yongming Chen
Summary: A user-friendly microemulsion method was developed to assemble multifunctional superparticles, enabling real-time imaging, magnetic targeting, and photodynamic therapy. The superparticles showed high tumor accumulation under magnetic targeting and demonstrated great potential in targeted cancer treatment.
Article
Oncology
Anie Priscilla Masilamani, Alexandra Fischer, Susanne Schultze-Seemann, Irina Kuckuck, Isis Wolf, Franz Friedrich Dressler, Christian Gratzke, Philipp Wolf
Summary: The study developed a targeted toxin EGF-PE40, which showed significant cytotoxicity against EGFR-expressing bladder cancer cells with high specificity. The results indicated that EGF-PE40 could induce apoptosis to kill the bladder cancer cells effectively, suggesting its potential as a promising candidate for future bladder cancer treatment.
ANTICANCER RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Alex Yang-Hao Yu, Ru-Huei Fu, Shan-hui Hsu, Chen-Feng Chiu, Wei-Hsiang Fang, Chun-An Yeh, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Utilizing collagen gold nanoparticles as a carrier for EGFR siRNA shows promising results in treating lung cancer, leading to significant tumor suppression effects and improved survival rates.
MATERIALS TODAY ADVANCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Xuwen Da, Fei-Hu Yu, Chao Zhang, Zhanhua Wang, Yao Jian, Yuanjun Hou, Yong Chen, Xuesong Wang, Qianxiong Zhou
Summary: This work proposes a bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions for precise cancer cell imaging and photodynamic therapy (PDT). The assembly exhibits luminescence turn-on and singlet oxygen generation upon irradiation, demonstrating the potential of using supramolecular interaction for bioorthogonal chemistry.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Nanoscience & Nanotechnology
Jin Liu, Ge Ding, Shiya Chen, Caoye Xue, Mian Chen, Xu Wu, Quan Yuan, Jing Zheng, Ronghua Yang
Summary: This study introduces a novel azoreductase-responsive, mitochondrion-targeted programmable DNA nanotrain for activatable hypoxia imaging and enhanced photodynamic therapy (PDT).
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Jincong Yan, Tian Gao, Zhongzhong Lu, Jingbo Yin, Ye Zhang, Renjun Pei
Summary: Aptamers, short oligonucleotide sequences with selective binding abilities, have shown promise in improving controlled and accurate delivery of photosensitizers into tumor sites for enhanced photodynamic therapy. Modification of aptamers onto PSs or nanocarriers enables specific recognition and binding to tumor cells, resulting in superior therapeutic efficiency. The development of aptamer-targeted platforms for tumor therapy holds potential for synergistic treatment modalities like PDT, photothermal therapy, and chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jasper Vonk, Jaron G. de Wit, Floris J. Voskuil, Yang Hang Tang, Wouter T. R. Hooghiemstra, Matthijs D. Linssen, Evert van den Broek, Jan J. Doff, Sebastiaan A. H. J. de Visscher, Kees-Pieter Schepman, Bert van der Vegt, Gooitzen M. van Dam, Max J. H. Witjes
Summary: This study investigated the use of fluorescence imaging to detect lymph node metastases in oral cancer patients. The results showed that fluorescence molecular imaging could accurately detect tumor-positive lymph nodes, reducing the need for microscopic assessment and identifying additional metastases missed by standard histopathologic analysis.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Katarzyna Szklener, Paulina Chmiel, Adam Michalski, Slawomir Mandziuk
Summary: This study presents and analyzes the current literature on the epidemiology, genetics, and histopathology of bladder cancer, as well as the latest treatment methods. It highlights the high prevalence of FGFR3 mutations and overexpression in bladder cancer and discusses the importance of targeted therapy for specific patient groups.
Article
Biochemistry & Molecular Biology
Fabiola Sciscione, Simon Guillaume, Abil E. Aliev, Declan T. Cook, Hugo Bronstein, Helen C. Hailes, Paul C. Beard, Tammy L. Kalber, Olumide Ogunlade, Alethea B. Tabor
Summary: Semiconducting polymer nanoparticles (SPN) have potential as exogenous contrast agents for photoacoustic imaging (PAI), but require active targeting strategies and effective characterization techniques. This study developed EGFR-targeted SPN using peptide conjugation and a new NMR method. Preliminary experiments indicated ineffective delivery or destabilization of the formulation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Fenge Li, Huancheng Wu, Xueming Du, Yimo Sun, Barbara Nassif Rausseo, Amjad Talukder, Arjun Katailiha, Lama Elzohary, Yupeng Wang, Zhiyu Wang, Gregory Lizee
Summary: The EGFR gene is frequently overexpressed and mutated in various solid tumors, and peptide vaccines targeting mutated EGFR have shown promising clinical efficacy and safety profiles.
Article
Nanoscience & Nanotechnology
Shuo Qi, Gongyuan Liu, Jiangbo Chen, Peng Cao, Xiaohua Lei, Chengming Ding, Guodong Chen, Yachao Zhang, Lidai Wang
Summary: The study presents a multifunctional CXCR4-targeted nanoparticle for effective and minimally invasive phototherapeutics of orthotopic small hepatocellular carcinoma (SHCCs) guided by real-time quantitative optical imaging. The nanoparticle provides accurate diagnosis and targeted photothermal therapy (PTT) and photodynamic therapy (PDT), showing high specificity and biocompatibility.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Medicinal
Elif Yildiz Gul, Elanur Aydin Karatas, Hatice Aydin Dogan, Omer Faruk Karatas, Buenyemin Cosut, Esra Tanriverdi Ecik
Summary: In this study, smart photosensitizers containing BODIPY, erlotinib, and hydrophilic units were prepared and their physicochemical properties and PDT effects were investigated. The halogenated derivatives showed lower fluorescence and good ROS generation ability under red light. In vitro experiments demonstrated the potent activity of the halogenated conjugates on cancer cell viability and their low dark toxicity.
Article
Materials Science, Biomaterials
Ancheng Ouyang, Dongmu Zhao, Xianglei Wang, Wei Zhang, Tianyu Jiang, Aiying Li, Wei Liu
Summary: The study focused on a type of nanoparticles based on RGD peptide, silicon phthalocyanine, and graphene oxide for fluorescence imaging-guided cancer-targeted combination phototherapy. The nanoparticles demonstrated excellent biological stability, high-contrast fluorescence imaging, enhanced NIR absorption, and high photothermal conversion efficiency.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Oncology
Yibing Ji, Rahul Kumar, Abhiram Gokhale, Hseu-Ping Chao, Kiera Rycaj, Xin Chen, Qiuhui Li, Dean G. Tang
Summary: LRIG1 functions as a tumor suppressor in various cancers and regulates the quiescence of adult stem cells. It is regulated by androgen receptor in prostate cancer, and its expression levels are associated with treatment status. LRIG1 not only exhibits tumor-suppressive functions in androgen-dependent prostate cancer but also in castration-resistant prostate cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Sukanya Basu, Yang Dong, Rahul Kumar, Collene Jeter, Dean G. Tang
Summary: Cancer cell heterogeneity and plasticity pose significant challenges to effective clinical treatments. Research has shown that cancer cells can exhibit stem-like characteristics and undergo dynamic changes during tumor progression. In addition, tumors also contain a population of non-proliferative cells that are resistant to anti-mitotic drugs. Understanding these unique cell populations in tumors can lead to the development of new therapeutic strategies to prevent relapse and metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mohamed E. El-Khouly, Ahmed M. Kobaisy, Gehan Sallam, Matsushita Yoshihisa
Summary: This report focuses on the construction and characterization of a supramolecular light harvesting system composed of zinc(II) phthalocyanine tetrasulfonic acid (ZnPcS4) and meso-tetra(N-methyl-4-pyridyl) porphyrin toluene sulfonate (TMPP). The results demonstrate the formation of aggregated forms in water and significant changes in absorption and fluorescence spectra in cationic and anionic micelles. Interaction with ZnPcS4 leads to the formation of a light harvesting porphyrin-phthalocyanine supramolecular complex and an efficient intra-supramolecular electron transfer process. This finding is of great importance for the construction of artificial photosynthetic reaction centers.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2022)
Article
Chemistry, Applied
Hadeer A. Shereef, Shaban Y. Shaban, Yasmine S. Moemen, Mohamed E. El-Khouly, Ahmed M. El-Nahas
Summary: The purpose of this study was to explore the protein binding and antibacterial/cytotoxic effects of [Ru(NO)(Et(2)NpyS(4))]Br (RuNOTSP) and its ligand (TSP). The results demonstrated that the ruthenium center not only improved reaction rate through coordination affinity but also changed the binding process. RuNOTSP and TSP showed high antibacterial and cytotoxic activities against bacteria and HepG2 human liver cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Polymer Science
Kexin Wang, Xinzhu Wang, Mohamed E. El-Khouly, Qiang Che, Zhizheng Zhao, Bin Zhang, Yu Chen
Summary: Novel soluble cyanospirobifluorene-based conjugated polymers were synthesized via Suzuki coupling copolymerization, showing improved thermal stability with the incorporation of rigid cyanospirobifluorene moieties. These polymers exhibit good nonvolatile rewritable information storage performance, making them promising materials for information storage applications.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Oncology
Junhui Li, Rati Lama, Samuel L. Galster, Joseph R. Inigo, Jin Wu, Dhyan Chandra, Sherry R. Chemler, Xinjiang Wang
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Zhizheng Zhao, Weiwei Huan, Chen Sun, Mohamed E. El-Khouly, Bin Zhang, Yu Chen
Summary: The azulene-based conjugated polymer, PAV, exhibits proton-gated and electrical-gated changes in its conductivity. The unique behavior of PAV is attributed to the direct formation of azulenium cation radicals.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Qiang Che, Xinzhu Wang, Mohamed E. El-Khouly, Guangwei Li, Jiaxuan Liu, Bin Zhang, Yu Chen
Summary: The study presents a new encapsulation approach for improving the long-term stability of BPQD-based electronic devices by in situ polymerizations, demonstrating excellent nonvolatile memory performance.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Multidisciplinary Sciences
Zhizheng Zhao, Qiang Che, Kexin Wang, Mohamed E. El-Khouly, Jiaxuan Liu, Yubin Fu, Bin Zhang, Yu Chen
Summary: Polymer memristors, such as PCVTPA, show excellent multilevel storage and history-dependent memristive switching performance, providing new insights for constructing high-performance synaptic biomimicking and neuromorphic computing systems in the future.
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The key to protecting sensitive information stored in electronic memory devices is to develop transient electronic devices that can be quickly destroyed in an emergency. Researchers have successfully fabricated a flexible electronic device capable of protecting sensitive information by using a highly water-soluble active material. This device can emulate the learning and memorizing functions of biological systems and can be rapidly destroyed when water is added.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Oncology
Joseph R. Inigo, Dhyan Chandra
Summary: Mitochondria play a crucial role in tumor growth and progression. However, the increased demand for mitochondrial activity in cancer leads to the production of more reactive oxygen species, accumulation of mutations in mitochondrial DNA, and the development of mitochondrial dysfunction. The mitochondrial unfolded protein response (UPRmt) is an evolutionary quality control mechanism that helps combat mitochondrial stress and maintain mitochondrial integrity to support tumor growth.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Steven G. Turowski, Farukh A. Durrani, Walter A. Tabaczynski, Joseph Cacaccio, Joseph R. Missert, Leslie Curtin, Sandra Sexton, Ronald Alberico, Craig M. Hendler, Joseph A. Spernyak, Zachary Grossman, Ravindra K. Pandey
Summary: In this study, a tumor-avid chlorophyll a derivative, HPPH, currently undergoing clinical trials, was conjugated with Gd(III)tetraxetan (DOTA) moieties to create a conjugate with potential for both tumor imaging and photodynamic therapy (PDT). The conjugate showed tumor specificity and low organ toxicity in mice, indicating its potential as a cancer imaging and treatment agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Kexin Wang, Jiaxuan Liu, Mohamed E. El-Khouly, Xiaosheng Cui, Qiang Che, Bin Zhang, Yu Chen
Summary: The development of transient electronic devices is crucial for protecting sensitive information stored in electronic memory devices. A flexible electronic device with a highly water-soluble active material has been successfully fabricated, showing rewritable resistive random access memory effect and history-dependent memristive switching performance. This device emulates the learning and memorizing functions of biological systems and can be rapidly destroyed by adding water.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra
Summary: The study identified the essential roles of mitochondrial proteins HSP60 and ClpP in the development of prostate cancer, highlighting their importance in maintaining mitochondrial function and promoting cancer cell survival. Inhibition of the interaction between HSP60 and ClpP can suppress PCa growth and progression.
JOURNAL OF CLINICAL INVESTIGATION
(2022)