期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 106, 期 1, 页码 209-218出版社
WILEY
DOI: 10.1002/JLB.4MR1118-419R
关键词
meningitis; microglia; Streptococcus agalactiae; Streptococcus pneumoniae
资金
- German Ministry of Education and Research [01EO0803, 01GL1746A, 535 01EK1602A]
- German Research Council [SFB/TRR167, HE3127/9-1, HE3127/12-1]
In the healthy brain, microglia and other CNS macrophages are the most abundant immune cell type. Thus, they form the natural immune cell interface with streptococci, which are the leading cause of bacterial meningitis and encephalitis in infants and young children. In homeostasis, the blood-brain barrier allows for very limited access of immune cells circulating in the periphery. During bacterial meningoencephalitis, however, origin and fate of CNS macrophages are massively altered. This review summarizes the emerging knowledge on the sequence of reciprocal events between streptococci and CNS macrophages leading to host resistance, acute inflammation, changes in resident innate immune cells of the brain, and long-term neuronal damage.
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