期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 191, 期 -, 页码 8-20出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2018.10.011
关键词
Antimicrobial agents; Biocompatibility; Copper coordination compounds; Methicillin-resistant Staphylococcus aureus; Magnetic properties
资金
- CEITEC 2020 [LQ1601]
- ERDF Multidisciplinary research to increase application potential of nano materials in agricultural practice [CZ.02.1.01/0.0/0.0/16025/0007314]
- Ministry of Science and Higher Education
- Polish Ministry of Science and Higher Education
- Wroclaw Centre of Biotechnology
In the present study, two binuclear copper(II) coordination compounds bridged by hydroxy- and thiodipropionic acid have been synthesized. The structure of compounds was determined by X-ray crystallography. The central copper atoms exist in square pyramidal surroundings. Basal plane is formed by nitrogen atoms of amines and oxygen atoms of bridges, whereas apical positions are occupied by oxygen atoms of coordinated water molecules. Temperature dependence study of magnetic susceptibility proved strong antiferromagnetic exchange between copper atoms in hydroxy-bridged complex. These coordination compounds were also tested for their biological activities in vitro. Both coordination compounds exhibit pronounced cytocompatibility in mammalian epithelial cells with no induction of oxidative stress and DNA fragmentation. Moreover, synthesized compounds are hemocompatible and do not alter expression of a marker of multiple cellular stress, p53. On the other hand, both compounds had stimulatory effect on expression of metallothioneins (MT-1/2 and MT-3). Antimicrobial testing on Escherichia colt, Staphylococcus aureus and methicillin-resistant Staphylococcus aureus revealed that both copper compounds exhibit antibacterial activity regardless the cell wall composition. Overall, current work presents a synthesis of Cu(II) coordination compounds with interesting biological behavior and with a promising potential to be further tested in pre-clinical models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据