Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression

The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test

(2015) Mauricio P. Cunha et al.   AMINO ACIDS

Comparative quantification of dietary supplemented neural creatine concentrations with 1 H-MRS peak fitting and basis spectrum methods

(2015) Clare E. Turner et al.   MAGNETIC RESONANCE IMAGING

Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine

(2015) Mauricio P. Cunha et al.   MOLECULAR NEUROBIOLOGY

Creatine as a booster for human brain function. How might it work?

(2015) Caroline D. Rae et al.   NEUROCHEMISTRY INTERNATIONAL

Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats

(2015) Patricia J. Allen et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

(2015) Mauricio P. Cunha et al.   Purinergic Signalling

The NIMH experimental medicine initiative

(2015) Thomas R. Insel   World Psychiatry

Systematic review of management for treatment-resistant depression in adolescents

(2014) Xinyu Zhou et al.   BMC Psychiatry

A mitochondrial bioenergetic basis of depression

(2014) N. Jennifer Klinedinst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Sex differences in mitochondrial (dys)function: Implications for neuroprotection

(2014) Tyler G. Demarest et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity

(2014) Matthew T.J. Lowe et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice

(2014) Mauricio P. Cunha et al.   Pharmacological Reports

A Review of the Clinical, Economic, and Societal Burden of Treatment-Resistant Depression: 1996–2013

(2014) David A. Mrazek et al.   PSYCHIATRIC SERVICES

National Institute of Mental Health Clinical Trials

(2014) Thomas R. Insel et al.   JAMA Psychiatry

Optimizing early Go/No Go decisions in CNS drug development

(2014) William Z Potter   Expert Review of Clinical Pharmacology

Brain creatine depletion in vegetarians? A cross-sectional 1H-magnetic resonance spectroscopy (1H-MRS) study

(2013) Marina Yazigi Solis et al.   BRITISH JOURNAL OF NUTRITION

A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depression

(2013) Boris Nemets et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Evidence for the Management of Adolescent Depression

(2013) R. E. Lewandowski et al.   PEDIATRICS

Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: Effects on energy metabolism

(2013) Miroslav Adzic et al.   PSYCHONEUROENDOCRINOLOGY

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder

(2012) In Kyoon Lyoo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?

(2012) Patricia J. Allen   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats

(2012) Patricia J. Allen et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The creatine kinase system and pleiotropic effects of creatine

(2011) Theo Wallimann et al.   AMINO ACIDS

Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study

(2011) Douglas G. Kondo et al.   JOURNAL OF AFFECTIVE DISORDERS

Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A)

(2011) Kathleen Ries Merikangas et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study

(2011) Su-Jin Yang et al.   PSYCHIATRY RESEARCH

A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis

(2010) Nazem Atassi et al.   Amyotrophic Lateral Sclerosis

Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: An updated review

(2010) Kristin L. Bigos et al.   Gender Medicine

Psychometric Properties of the Children's Depression Rating Scale–Revised in Adolescents

(2010) Taryn L. Mayes et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Measurement of creatine kinase reaction rate in human brain using magnetization transfer image-selected in vivo spectroscopy (MT-ISIS) and a volume 31P/1H radiofrequency coil in a clinical 3-T MRI system

(2010) Eun-Kee Jeong et al.   NMR IN BIOMEDICINE

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

(2010) Ann Gardner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Update on the Use of MR for Assessment and Diagnosis of Psychiatric Diseases

(2010) Nivedita Agarwal et al.   RADIOLOGY

Cross-National Associations Between Gender and Mental Disorders in the World Health Organization World Mental Health Surveys

(2009) Soraya Seedat et al.   ARCHIVES OF GENERAL PSYCHIATRY

Sex, trauma, stress hormones and depression

(2009) E Young et al.   MOLECULAR PSYCHIATRY

Chronic Creatine Supplementation Alters Depression-like Behavior in Rodents in a Sex-Dependent Manner

(2009) Patricia J Allen et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression

(2009) Semra Ulusoy Kaymak et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder

(2008) Dan V. Iosifescu et al.   BIOLOGICAL PSYCHIATRY

Functions and effects of creatine in the central nervous system

(2008) Robert H. Andres et al.   BRAIN RESEARCH BULLETIN

Efficacy of antidepressants in juvenile depression: meta-analysis

(2008) Evangelia M. Tsapakis et al.   BRITISH JOURNAL OF PSYCHIATRY

Switching to Another SSRI or to Venlafaxine With or Without Cognitive Behavioral Therapy for Adolescents With SSRI-Resistant Depression

(2008) David Brent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The ABCs of depression: Integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression.

(2008) Janet Shibley Hyde et al.   PSYCHOLOGICAL REVIEW

Stress, sensitive periods and maturational events in adolescent depression

(2008) Susan L. Andersen et al.   TRENDS IN NEUROSCIENCES