Article
Biotechnology & Applied Microbiology
R. Reshmy, Eapen Philip, Aravind Madhavan, K. B. Arun, Parameswaran Binod, Arivalagan Pugazhendhi, Mukesh Kumar Awasthi, Edgard Gnansounou, Ashok Pandey, Raveendran Sindhu
Summary: Cellulose nanomaterials are emerging as a promising environmentally friendly biomaterial extracted from native plant sources, with excellent physico-chemical and biological properties driving interest in biomedical applications. The review focused on greener production, demands, bio-properties, and innovative applications in tissue implants, drug delivery systems, wound healing, and biosensor applications, as well as discussing global commercial nanocellulose based products and their future potentials in biomedical applications.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Chemistry, Applied
Pariya Zare, Mohamad Pezeshki-Modaress, Seyed Mohammad Davachi, Pouria Zare, Fatemeh Yazdian, Sara Simorgh, Hadi Ghanbari, Hamid Rashedi, Zohreh Bagher
Summary: In this study, two different arrangements of laminated composite scaffolds were fabricated based on Alginate, showcasing improved mechanical features and sustained drug release. The optimized scaffold displayed advantages such as interconnected pores, controlled biodegradability, and no cytotoxic effect, making it a promising candidate for tissue regeneration.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Reza Eivazzadeh-Keihan, Ehsan Bahojb Noruzi, Hooman Aghamirza Moghim Aliabadi, Sahra Sheikhaleslami, Ali Reza Akbarzadeh, Seyed Masoud Hashemi, Mostafa Ghafori Gorab, Ali Maleki, Reza Ahangari Cohan, Mohammad Mahdavi, Roksana Poodat, Faeze Keyvanlou, Mir Saeed Esmaeili
Summary: This article introduces a novel biomaterial - hydrogels with 3D crosslinked polymeric structures obtained from natural polymers, which has been extensively studied in the field of biomedical applications. Pectin, a unique biopolymer found in the cell walls of fruits and vegetables, is widely used in the pharmaceutical, food, and textile industries. Pectin-based biomaterials have been thoroughly investigated for various potential biomedical applications including drug delivery, wound healing, tissue engineering, creation of implantable devices, and skin-care products, due to their biocompatibility, biodegradability, easy gelling capability, and facile manipulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Gayathri Chakrapani, Seeram Ramakrishna, Mina Zare
Summary: For centuries, nanofibers have been fabricated by converting polymeric materials into nanofibers with tunable properties and have shown great potential in various biomedical applications. In recent years, advances in nanotechnology have enabled the formation of electrospun nanofibers with customizable geometries and release properties. These nanofibers exhibit unique structural characteristics, such as a large surface-to-volume ratio and interconnected pores, which make them suitable for a wide range of healthcare, energy, and environmental applications. This review focuses on the recent advances in electrospun nanofibers for biomedical applications, including therapeutic delivery, tissue engineering, wound healing, and cancer research.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Tejal Patil, Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly, Tuhin Subhra Santra, Ki-Taek Lim
Summary: Nanocellulose, a biopolymer with superior physicochemical properties, has attracted wide attention from researchers. It can be extracted from various sources and can be chemically modified for biomedical applications.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Anabela Moreira, Dan Lawson, Lesley Onyekuru, Karolina Dziemidowicz, Ukrit Angkawinitwong, Pedro F. Costa, Norbert Radacsi, Gareth R. Williams
Summary: This review explores the potential of electrohydrodynamic (EHD) techniques in developing peptide and protein delivery systems, discussing the principles of various EHD methods and encapsulation of biological molecules using these approaches, as well as exploring the possibilities of localized delivery with stimuli-responsive systems and summarizing the advantages and challenges of electrospun and electrosprayed protein delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Weizhen Sun, Caroline S. Taylor, Yi Zhang, David A. Gregory, Mhd Anas Tomeh, John W. Haycock, Patrick J. Smith, Feng Wang, Qingyou Xia, Xiubo Zhao
Summary: The self-assembling I3K peptide nanofibers showed great potential in guiding neuronal cell attachment and proliferation on silk fibroin scaffold surfaces. Micro-patterning of the I3K peptide nanofibers using inkjet printing was effective in directing PC12 cell growth, offering a promising approach for nerve regeneration applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Saeed Farzamfar, Elissa Elia, Stephane Chabaud, Mohammad Naji, Stephane Bolduc
Summary: Electrospun scaffolds show great potential in urethral defect repair by mimicking native cells' niches and delivering drugs and cells, but there are still challenges and issues to be addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Qinqin Cheng, Zhefu Dai, Xiaojing Shi, Xinping Duan, Yiling Wang, Tianling Hou, Yong Zhang
Summary: Exosomes, as cell-derived extracellular vesicles, are crucial for intercellular communication and have emerged as promising nanocarriers for therapeutic applications. By genetically engineering exosomes, a new type of exosomes called GIFTed-Exos with specific functions can be created to efficiently deliver different types of protein cargos to target cells.
Article
Pharmacology & Pharmacy
Eduardo Anitua, Mar Zalduendo, Maria Troya, Itsasne Erezuma, Izeia Lukin, Raquel Hernaez-Moya, Gorka Orive
Summary: The study investigated the potential of three different bioinks based on gelatin and alginate for regenerative medicine. The bioinks containing hydroxyapatite and PRGF showed the highest cell compatibility and promoted osteogenic differentiation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Applied
Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie, Amin Shavandi
Summary: Fungal exopolysaccharides have diverse potential applications in various industries. However, there are only a few commercialized products based on fungal EPSs in the biomedical field. This review critically discusses the potential biomedical applications of fungal EPSs in tissue engineering, drug and gene delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Alakananda Parassini Madappura, Srinivas Madduri
Summary: This review focuses on the design, fabrication, and properties of silk fibroin (SF) hydrogel scaffolds for tissue regeneration applications, particularly for skin, bone, and neural tissues. It also discusses the potential of SF hydrogels as delivery systems for drugs, stem cells, genes, peptides, and growth factors, as well as future directions in the field.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Ayaz Mahmood, Dev Patel, Brandon Hickson, John DesRochers, Xiao Hu
Summary: Hydrogels from biopolymers have various characteristics and find wide applications in biomedicine, contributing to patient treatments and outcomes. Different types of biopolymer hydrogels can be synthesized for specific purposes, such as cell delivery and drug delivery, in the field of biomedicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Tao Yang, Haobo Han, Ying Chen, Liu Yang, Rachael Parker, Yamin Li, David L. Kaplan, Qiaobing Xu
Summary: The study demonstrates that synthetic lipid nanoparticles and protein cargo nanocomplexes can successfully cross the intestinal epithelial layer and deliver the protein cargo to targeted cells. These nanocomplexes can penetrate intestinal monolayer cells by temporarily interrupting tight junctions between cells, inducing gene recombination inside the cells below.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Yingji Mao, Yu Chen, Weifeng Li, Ying Wang, Jingjing Qiu, Yingxiao Fu, Jianzhong Guan, Pinghui Zhou
Summary: This study developed a multilayer nanofibrous membrane that mimics the endogenous cascades of bone regeneration. The membrane promotes migration and osteo-differentiation of bone marrow mesenchymal stem cells and exhibits good biocompatibility and a dual-delivery system, contributing to bone regeneration and vascularization.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yejin Woo, Madhumita Patel, Hyelin Kim, Jin Kyung Park, Yeon-Ju Jung, Sun-Shin Cha, Byeongmoon Jeong
Summary: Folic acid and clinically approved antifolates were found to significantly improve chondrogenic differentiation of mesenchymal stem cells. A poly(ethylene glycol)-poly(L-alanine) thermogelling system was used to incorporate stem cells and antifolates for sustained release. Pralatrexate was discovered as an effective compound for promoting chondrogenic differentiation, with nuclear binding factor and transcription factor involvement. This study highlights the potential of using antifolates in tissue engineering for cartilage repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Kanghee Cho, Donyoung Kang, Hyungsuk Lee, Won-Gun Koh
Summary: The study proposes an engineered multi-responsive actuator fabrication platform by combining electrospinning and hydrogel lithography techniques, successfully demonstrating a soft actuator with reversible bending and unbending capabilities. Computational modeling is used to elucidate the bending mechanism of the actuator and regulate the bending direction, showing that the fabrication process is versatile and adaptable.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Applied
Madhumita Patel, Maninder Meenu, Jitender Kumar Pandey, Pawan Kumar, Rajkumar Patel
Summary: Ion channels in nerve cells are responsible for transmitting electric signals, and their malfunction can lead to neurological diseases. Optogenetic technology, which utilizes light to control neuronal functions, has gained attention. Lanthanide-doped upconversion nanoparticles (UCNPs) are a promising candidate for optogenetics due to their ability to absorb low energy photons and emit high energy photons. UCNPs have potential for deep tissue manipulation of ion channels. This article summarizes the photoluminescence and tuning mechanisms of UCNPs, explores their application in neural circuit modulation through optogenetics, and discusses future perspectives in this field.
JOURNAL OF RARE EARTHS
(2022)
Review
Chemistry, Applied
Zirui Zheng, Madhumita Patel, Rajkumar Patel
Summary: The complex healing process of bone and cartilage injuries has led to efforts to develop various bone tissue engineering techniques. Composite hydrogel systems, such as those using hyaluronic acid, have shown potential in promoting osteogenesis and supporting stem cell activities. This review discusses recent advancements in the development of hyaluronic acid hydrogel systems for in vitro and in vivo applications in bone tissue engineering.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Engineering, Biomedical
Kihak Gwon, Hye Jin Hong, Alan M. Gonzalez-Suarez, Michael Q. Slama, Daheui Choi, Jinkee Hong, Harihara Baskaran, Gulnaz Stybayeva, Quinn P. Peterson, Alexander Revzin
Summary: In this study, bioactive microcapsules were developed to address the challenges of high cost and difficulty in scaling-up of human pluripotent stem cells (hPSC) differentiation protocols. The results showed that these microcapsules were able to induce and maintain pluripotency of hPSCs, as well as improve the differentiation outcomes.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Won Jun Choi, Ki Seob Hwang, Yongsoo Kim, Chanmin Lee, Sung Hwan Ju, Hyuk Jun Kwon, Won-Gun Koh, Jun-Young Lee
Summary: A poly(lactic acid)-based porous polymer with an interconnected pore structure and superior pore morphology was successfully fabricated using one-step digital light processing (DLP) 3D printing. To provide biodegradation property and UV-reactivity, a photocurable resin was synthesized by ring-opening polymerization of lactide and glycidyl methacrylate (GMA). The resin was fabricated using a high internal phase emulsion (HIPE) method to introduce the pore structure in 3D printing. The final product exhibited biodegradable characteristics and contained lactic acid components, and the enzymatic degradation tests confirmed the influence of the biodegradable moiety on erosion tendency, which is impacted by the pore structure.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Zhengyu Piao, Madhumita Patel, Jin Kyung Park, Byeongmoon Jeong
Summary: Poly(L-alanine-co-L-lysine)-graft-trehalose (PAK(T)) was synthesized as a cryoprotectant for mesenchymal stem cells (MSCs). The delivery of intracellular PEG-PAK(T) significantly improved cell recovery and maintained multilineage potential. The interaction between intracellular PEG-PAK(T) and water stabilized the cells during cryopreservation.
Article
Materials Science, Multidisciplinary
Jose M. de Hoyos-Vega, Hye Jin Hong, Kevin Loutherback, Gulnaz Stybayeva, Alexander Revzin
Summary: Liver cultures have evolved from hepatocyte monocultures to more complex co-cultures and precision-cut liver slices. This study presents a microfluidic device that allows for longer-term maintenance of functional organotypic liver cultures, displaying promising potential for disease modeling and individualized therapies.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
HanSol Kim, Eun Jo Jang, Narendra V. Sankpal, Madhumita Patel, Rajkumar Patel
Summary: Scientists have been studying the behavior and anatomy of various animals to gain insights into the human brain. However, due to the differences between animal and human brains, understanding how the brain works has remained challenging. Recently, brain-like organoids that mimic the characteristics of the human brain have been developed, which allows researchers to delve deeper into understanding the neurological structures and causes of brain diseases. This paper reviews the latest advancements in generating brain-like organoids using Matrigel and other alternatives, discusses gel-free methods to enhance organoid regeneration, and details the growth and development of vascularized brain organoids in both in vitro and in vivo conditions.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Jeongwoo Ham, Kyung Min Lee, Jaehan Ko, Kangwon Lee, Won -Gun Koh
Summary: Electrospun nanofibers with three-dimensional porous structures have attracted attention for sensing applications. In this study, shape-coded nanofiber microparticles were fabricated using a water-soluble and photocrosslinkable polymer. The microparticles were decorated with silver nanoparticles and used as capture substrates for a SERS-based immunoassay. The immunosensor showed low detection limits and high selectivity.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Applied
Maninder Meenu, Bandana Padhan, Madhumita Patel, Rajkumar Patel, Baojun Xu
Summary: Essential oils have gained popularity as natural food preservatives due to their potent antibacterial activity against food pathogens. This review discusses the antibacterial activity of essential oils from various plant parts and sources against important food pathogens such as Salmonella and Listeria, as well as the mechanisms behind their antibacterial activity.
Article
Engineering, Biomedical
Semin Kim, Geehong Kim, Yong Woo Ji, Chae-Eun Moon, Yuna Jung, Hyung Keun Lee, JaeJong Lee, Won-Gun Koh
Summary: This study proposes a sensing platform based on bioresponsive hydrogels, using moire patterns for real-time and label-free protein detection. The system demonstrates sensitive monitoring of pH-induced swelling and protein-induced shrinkage of the hydrogel, successfully detecting model proteins.
BIOACTIVE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Naomi Akiyama, Kapil D. Patel, Eun Jo Jang, Mark R. Shannon, Rajkumar Patel, Madhumita Patel, Adam Willis Perriman
Summary: The composition, morphology, and mechanical performance of nanomaterials are crucial for tissue engineering. Tubular nanomaterials (TNs), including carbon nanotubes, titanium oxide nanotubes, halloysite nanotubes, silica nanotubes, and hydroxyapatite nanotubes, have shown great potential in various applications due to their high surface area, versatile surface chemistry, well-defined mechanical properties, excellent biocompatibility, and monodispersity. This review focuses on the recent developments in TN-based biomaterials for structural tissue engineering, with a strong emphasis on bone tissue regeneration. It includes a detailed literature review on TN-based orthopedic coatings for metallic implants and composite scaffolds to enhance in vivo bone regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Jaeheung Im, Ja Won Kim, Yi Young Kang, Yunsu Nam, Won-Gun Koh, Jae-Won Ka, Ji-Hoon Lee
Summary: This study designed and synthesized five different H-shaped reactive monomers with various central core groups to achieve a negative dispersion of retardation. Mixing the H-shaped molecules with cylindrical reactive mesogen molecules resulted in a wide liquid crystalline phase and a uniform orientation when a benzene or a naphthalene ring was present in the core. Polymerizing the mixtures using UV light produced retarder films with either positive or negative dispersion of retardation depending on the chemical structure of the H-shaped molecules. The molecular orientation of the H-shaped molecules was investigated using UV-vis absorption anisotropy and out-of-plane retardation measurements, revealing that the retarder sample exhibited negative dispersion when the imine groups of the H-shaped molecules were aligned orthogonal to the slow axis of the sample.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Cell & Tissue Engineering
Hye Jin Hong, Jae-Min Cho, Yeo-Jun Yoon, DoJin Choi, Soohyun Lee, Hwajung Lee, Sujeong Ahn, Won-Gun Koh, Jae-Yol Lim
Summary: The thermoresponsive fiber-based scaffold facilitates the formation and retrieval of stem cell spheroids, promoting the expression of stem cell properties. Implantation of SGSC(spheroid) cells into damaged salivary glands improves salivary gland regeneration and function restoration.
JOURNAL OF TISSUE ENGINEERING
(2022)
