Article
Microbiology
Francesca Gaccioli, Susanne Lager, Marcus C. de Goffau, Ulla Sovio, Justyna Dopierala, Sungsam Gong, Emma Cook, Andrew Sharkey, Ashley Moffett, Wai Kwong Lee, Christian Delles, Cristina Venturini, Judith Breuer, Julian Parkhill, Sharon J. Peacock, D. Stephen Charnock-Jones, Gordon C. S. Smith
NATURE MICROBIOLOGY
(2020)
Article
Immunology
Dhon Romeo Makanga, Thierry Guillaume, Catherine Willem, Nolwenn Legrand, Katia Gagne, Anne Cesbron, Ketevan Gendzekhadze, Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Marie C. Bene, Patrice Chevallier, Christelle Retiere
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Dhon Romeo Makanga, Francesca Da Rin de Lorenzo, Gaelle David, Catherine Willem, Lea Dubreuil, Nolwenn Legrand, Thierry Guillaume, Pierre Peterlin, Amandine Lebourgeois, Marie Christine Bene, Alice Garnier, Patrice Chevallier, Ketevan Gendzekhadze, Anne Cesbron, Katia Gagne, Beatrice Clemenceau, Christelle Retiere
Article
Immunology
Mickael Vourc'h, Gaelle David, Benjamin Gaborit, Alexis Broquet, Cedric Jacqueline, Tanguy Chaumette, Jocelyne Caillon, Antoine Roquilly, Christelle Retiere, Karim Asehnoune
INFECTION AND IMMUNITY
(2020)
Article
Immunology
Jake R. Thomas, Anna Appios, Xiaohui Zhao, Roksana Dutkiewicz, Maria Donde, Colin Y. C. Lee, Praveena Naidu, Christopher Lee, Joana Cerveira, Bing Liu, Florent Ginhoux, Graham Burton, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Naomi McGovern
Summary: Hofbauer cells are an important immune cell population found in the placenta, involved in placental angiogenesis and remodeling. Additionally, there is another population of maternal macrophages in the placenta that aid in surface repair.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
N. Legrand, G. David, A. Rodallec, A. Gaultier, D. Salmon, A. Cesbron, L. Wittkop, F. Raffi, K. Gendzekhadze, C. Retiere, C. Allavena, K. Gagne
Summary: The genetic combinations of KIR/HLA affect the clearance and chronic infection conditions of NK and T cells in HIV-HCV co-infected individuals, with European subjects with spontaneous clearance characterized by specific KIR/HLA genetic features.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Oncology
Lea Dubreuil, Bercelin Maniangou, Patrice Chevallier, Agnes Quemener, Nolwenn Legrand, Marie C. Bene, Catherine Willem, Gaelle David, Mehdi Alizadeh, Dhon Romeo Makanga, Anne Cesbron, Ketevan Gendzekhadze, Katia Gagne, Christelle Retiere
Article
Immunology
Norman Shreeve, Delphine Depierreux, Delia Hawkes, James A. Traherne, Ulla Sovio, Oisin Huhn, Jyothi Jayaraman, Amir Horowitz, Hormas Ghadially, John R. B. Perry, Ashley Moffett, John G. Sled, Andrew M. Sharkey, Francesco Colucci
Summary: Genetic ablation of NKG2A in dams mated with wild-type males may result in suboptimal maternal vascular responses during pregnancy, leading to various abnormalities similar to human preeclampsia. The study also suggests that the maternal HLA-B allele plays a significant role in influencing NKG2A education, potentially affecting the risk of developing preeclampsia.
Article
Biology
Malwina Prater, Russell S. Hamilton, Hong Wa Yung, Andrew M. Sharkey, Paul Robson, N. Erlyani Abd Hamid, Eric Jauniaux, D. Stephen Charnock-Jones, Graham J. Burton, Tereza Cindrova-Davies
Summary: The human placenta undergoes significant changes in gene expression and DNA methylation patterns in response to shifts in nutrition and oxygen concentration during early pregnancy. Early placental cells primarily focus on hormone synthesis and oxygen transport, while later in pregnancy they are more involved in the transport of oxygen, lipids, and other substances.
Review
Immunology
Oisin Huhn, Xiaohui Zhao, Laura Esposito, Ashley Moffett, Francesco Colucci, Andrew M. Sharkey
Summary: Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa before and during pregnancy, with tissue-resident natural killer (NK) cells and ILCs being the main subsets. Recent advances in single-cell RNA sequencing and high dimensional flow and mass cytometry have significantly enhanced our understanding of the heterogeneity within the uILC compartment. These advancements may help answer key clinical questions regarding infertility, miscarriage, and pregnancy disorders related to uILC subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Lea Dubreuil, Patrice Chevallier, Christelle Retiere, Katia Gagne
Summary: Immunotherapies show promise in treating acute leukemias, with NK cells playing a crucial role in eliminating leukemic cells. Understanding the impact of genetic markers like KIR and HLA on NK cell subsets can improve patient outcomes. Investigating the immunogenetics of KIR/HLA and the immunobiology of NK cells may lead to improved treatments for leukemic patients undergoing HSCT.
Article
Multidisciplinary Sciences
Delphine M. Depierreux, Emily Seshadri, Evgeniya Shmeleva, Jens Kieckbusch, Delia A. Hawkes, Francesco Colucci
Summary: This study presents a simple method for isolating and phenotyping mouse group 1 uterine innate lymphoid cells (g1 uILCs) from individual pregnant uteruses using flow cytometry. Despite losing spatial information, this protocol has successfully been used to investigate uILC heterogeneity, their response to pregnancy-related factors, gene expression profiles, and functions.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Immunology
Delphine M. Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A. Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
Summary: Reproductive immunology focuses on understanding how the maternal immune system supports fetal growth. Maternal uterine natural killer (uNK) cells, in partnership with fetal trophoblast cells, regulate physiological vascular changes in the uterus to build the placenta and sustain fetal growth. The education of uNK cells by maternal MHC-I is crucial for optimal fetal growth.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern
Summary: The human placenta is an additional site of primitive haematopoiesis, where placental erythro-myeloid progenitors (PEMPs) generate HBC-like cells lacking expression of HLA-class II. This is mediated through epigenetic silencing of the CIITA gene, which regulates HLA-class II expression.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Immunology
N. Shreeve, Ja Traherne, U. Sovio, D. Hawkes, D. Depierreux, O. Huhn, J. Jayaraman, A. Horowitz, H. Ghadially, J. R. B. Perry, A. Moffett, J. G. Sled, A. M. Sharkey, F. Colucci
JOURNAL OF IMMUNOLOGY
(2021)
