What’s Bred in the Bone: Calcium Channels in Lymphocytes

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1

(2016) Samuel Bertin et al.   GUT

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense

(2015) Carola Ledderose et al.   JOURNAL OF INFECTIOUS DISEASES

Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells

(2014) C. M. Wang et al.   EMBO JOURNAL

CD4+ and CD8+ T cell–dependent antiviral immunity requires STIM1 and STIM2

(2014) Patrick J. Shaw et al.   JOURNAL OF CLINICAL INVESTIGATION

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

(2014) Samuel Bertin et al.   NATURE IMMUNOLOGY

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

STIM1 and STIM2-mediated Ca2+influx regulates antitumour immunity by CD8+T cells

(2013) Carl Weidinger et al.   EMBO Molecular Medicine

Interference with Ca2+release activated Ca2+(CRAC) channel function delays T-cell arrest in vivo

(2013) Janelle C. Waite et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Agonist-Selected T Cell Development Requires Strong T Cell Receptor Signaling and Store-Operated Calcium Entry

(2013) Masatsugu Oh-hora et al.   IMMUNITY

Orai1 Function Is Essential for T Cell Homing to Lymph Nodes

(2013) M. L. Greenberg et al.   JOURNAL OF IMMUNOLOGY

Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation

(2013) K.-D. Kim et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression byN-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells

(2013) Sascha Kahlfuß et al.   MOLECULAR AND CELLULAR BIOLOGY

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

(2013) Sonal Srikanth et al.   MOLECULES AND CELLS

Modulation of T Cell Metabolism and Function through Calcium Signaling

(2013) Kelley M. Fracchia et al.   Frontiers in Immunology

CaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression

(2012) Damian G. Wheeler et al.   CELL

Extracellular ATP Exerts Opposite Effects on Activated and Regulatory CD4+ T Cells via Purinergic P2 Receptor Activation

(2012) S. Trabanelli et al.   JOURNAL OF IMMUNOLOGY

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation

(2012) Nico Melzer et al.   PLoS One

NMDA receptors as a possible component of store-operated Ca2+ entry in human T-lymphocytes

(2011) L. F. Zainullina et al.   BIOCHEMISTRY-MOSCOW

TRP expression pattern and the functional importance of TRPC3 in primary human T-cells

(2011) Anna S. Wenning et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium signalling in T-lymphocytes

(2011) V. Robert et al.   BIOCHIMIE

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

(2011) Kyla Omilusik et al.   IMMUNITY

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Splicing at C Terminus of CaV1.4 Calcium Channel Modulates Calcium-dependent Inactivation, Activation Potential, and Current Density

(2011) Gregory Ming Yeong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

(2011) Andre Limnander et al.   NATURE IMMUNOLOGY

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Functional Properties of RYR1 Mutations Identified in Swedish Patients with Malignant Hyperthermia and Central Core Disease

(2010) Mirko Vukcevic et al.   ANESTHESIA AND ANALGESIA

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

(2010) P Affaticati et al.   CELL DEATH AND DIFFERENTIATION

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

(2010) Jian Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ca 2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells

(2010) Takuro Numaga et al.   JOURNAL OF CELL SCIENCE

Store-Operated Ca2+ Entry through ORAI1 Is Critical for T Cell-Mediated Autoimmunity and Allograft Rejection

(2010) C.-A. McCarl et al.   JOURNAL OF IMMUNOLOGY

Trpm4 Differentially Regulates Th1 and Th2 Function by Altering Calcium Signaling and NFAT Localization

(2010) K. S. Weber et al.   JOURNAL OF IMMUNOLOGY

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

(2010) C. Y. Park et al.   SCIENCE

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia

(2009) Christie-Ann McCarl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

STIM1-Independent T Cell Development and Effector Function In Vivo

(2009) N. Beyersdorf et al.   JOURNAL OF IMMUNOLOGY

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

(2009) Mithilesh K Jha et al.   NATURE IMMUNOLOGY

STIM1Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

(2009) Capucine Picard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis

(2009) D. Matza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Scaffold Protein, AHNAK1, Is Required for Calcium Signaling during T Cell Activation

(2008) Didi Matza et al.   IMMUNITY

Store-operated Ca2+Influx Causes Ca2+Release from the Intracellular Ca2+Channels That Is Required for T Cell Activation

(2008) Sepehr Dadsetan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling