期刊
JOURNAL OF GENE MEDICINE
卷 21, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/jgm.3084
关键词
gene carriers; imaging; multifunctional; nanohybrids; therapy
资金
- National Key Research and Development Program of China [2016YFA0201501, 2017YFA0106100]
- National Natural Science Foundation of China [51773013, 51733001]
- Fundamental Research Funds for the Central Universities [BHYC1705A, XK1802-2]
- Fundamental Research Funds for the Central Universities and Research projects on biomedical transformation of China-Japan Friendship Hospital [PYBZ1826]
In this review, we summarize the rational design and versatile application of organic/inorganic hybrid gene carriers as multifunctional delivery systems. Organic/inorganic nanohybrids with both organic and inorganic components in one nanoparticle have attracted intense attention because of their favorable properties. Particularly, nanohybrids comprising cationic polymers and inorganic nanoparticles are considered to be promising candidates as multifunctional gene delivery systems. In this review, we begin with an introduction of gene delivery and gene carriers to demonstrate the incentive for fabricating nanohybrids as multifunctional carriers. Next, the construction strategies and morphology effects of organic/inorganic hybrid gene carriers are summarized and discussed. Both sections provide valuable information for the design and synthesis of hybrid gene carriers with superior properties. Finally, an overview is provided of the application of nanohybrids as multifunctional gene carriers. Diverse therapies and versatile imaging-guided therapies have been achieved via the rational design of nanohybrids. In addition to a simple combination of the functions of organic and inorganic components, the performances arising from the synergistic effects of both components are considered to be more intriguing. In summary, this review might offer guidance for the understanding of organic/inorganic nanohybrids as multifunctional gene delivery systems.
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