Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits

Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells

(2018) Hyemin Lee et al.   JOURNAL OF PINEAL RESEARCH

iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

(2018) Ronghua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma

(2017) Xian Chan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma

(2017) Brittani Seynnaeve et al.   Scientific Reports

Metastatic melanoma: Pathologic characterization, current treatment, and complications of therapy

(2016) Mark R. Wick et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Immunotherapy of melanoma: Present options and future promises

(2015) Anand Rotte et al.   CANCER AND METASTASIS REVIEWS

High nitric oxide production, secondary to inducible nitric oxide synthase expression, is essential for regulation of the tumour-initiating properties of colon cancer stem cells

(2015) Maria Ausiliatrice Puglisi et al.   JOURNAL OF PATHOLOGY

The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration

(2015) M. Meyer et al.   NEUROSCIENCE

Potential Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers

(2015) Ryan B. Corcoran et al.   Oncotarget

Melatonin Sensitizes H1975 Non-Small-Cell Lung Cancer Cells Harboring a T790M-Targeted Epidermal Growth Factor Receptor Mutation to the Tyrosine Kinase Inhibitor Gefitinib

(2014) Miyong Yun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin: functions and ligands

(2014) Mahaveer Singh et al.   DRUG DISCOVERY TODAY

Melatonin Combined with Endoplasmic Reticulum Stress Induces Cell Death via the PI3K/Akt/mTOR Pathway in B16F10 Melanoma Cells

(2014) Han Sung Kim et al.   PLoS One

High Expression of hTERT and Stemness Genes in BORIS/CTCFL Positive Cells Isolated from Embryonic Cancer Cells

(2014) Loredana Alberti et al.   PLoS One

Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma

(2013) Ao-Xue Wang et al.   IUBMB LIFE

Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

(2012) Virginia Alvarez-García et al.   JOURNAL OF PINEAL RESEARCH

Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations

(2012) J. G. Greger et al.   MOLECULAR CANCER THERAPEUTICS

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

(2012) J. E. Till et al.   RADIATION RESEARCH

Antitumor Activity of BRAF Inhibitor Vemurafenib in Preclinical Models of BRAF-Mutant Colorectal Cancer

(2011) H. Yang et al.   CANCER RESEARCH

Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

(2011) G. Civenni et al.   CANCER RESEARCH

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

(2011) Nikhil Wagle et al.   JOURNAL OF CLINICAL ONCOLOGY

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

(2010) Alexander D. Boiko et al.   NATURE

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

(2010) E. W. Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDR1 expression identifies human melanoma stem cells

(2008) Gilmor I. Keshet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB Mediates Mitogen-Activated Protein Kinase Pathway-Dependent iNOS Expression in Human Melanoma

(2008) Deon G. Uffort et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY