Article
Plant Sciences
Min Hao, Zhouhui Yao, Mengting Zhao, Ziyan Chen, Pingping Wang, Xianan Sang, Qiao Yang, Kuilong Wang, Xin Han, Gang Cao
Summary: This study elucidated the molecular mechanism of the multi-component and multi-target anti-liver fibrosis effect of Curcumae Rhizoma-Sparganii Rhizoma through mass spectrometry, network pharmacology, and western blotting technology. The research provides a theoretical evidence for the development and utilization of Curcumae Rhizoma-Sparganii Rhizoma herbal pair.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Wei, Xiaoping Wang, Ying Dong, Xiangjian Zhong, Xueyang Ren, Ruolan Song, Jiamu Ma, Axiang Yu, Qiqi Fan, Jianling Yao, Dongjie Shan, Fang Lv, Yuan Zheng, Qingyue Deng, Xianxian Li, Yingyu He, Shusheng Fan, Chongjun Zhao, Xiuhuan Wang, Ruijuan Yuan, Gaimei She
Summary: This study investigated the material basis and potential mechanisms of Curcumae Rhizoma-Sparganii Rhizoma (CR-SR) for the treatment of liver cancer. The results showed that CR-SR, as well as its individual components CR and SR, exhibited anti-liver cancer activities in both in vivo and in vitro models. Furthermore, they downregulated the expression of several oncogenes, suggesting the potential molecular mechanisms involved in their therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Li Zhang, Qiuxia Xu, Yao Li, Hui Zhao, Xingming Shi, Fu Peng, Chenghao Yu
Summary: The study found that the CRSR component compatibility had preventive and therapeutic effects on UL in rats, improving related parameters and reducing abnormal blood conditions.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Yewen Feng, Yumin Zhao, Yao Li, Teng Peng, Yu Kuang, Xingming Shi, Gang Wang, Fu Peng, Chenghao Yu
Summary: The study demonstrated that RCRS effectively reduces the expression of collagen, FAP, and transforming growth factor beta in rats with uterine leiomyoma. Additionally, RCRS inhibits the cell proliferation pathway, suggesting its potential mechanisms of action in preventing and treating uterine leiomyoma.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Guiren Xue, Shanshan Su, Pengfei Yan, Jiawei Shang, Jianxin Wang, Chengye Yan, Jiaxi Li, Qiao Wang, Yingfeng Du, Liang Cao, Huijun Xu
Summary: This study investigated the chemical composition differences of Zingiberis Rhizoma (ZR), Zingiberis Rhizoma Praeparatum (ZRP), and Carbonised Ginger (CG) through non-targeted metabolomics analysis. A total of 59 gingerols were identified, and 33 of them were nominated as novel markers for materials authentication. The findings showed that the content of gingerols decreased after processing, while shogaols and gingerone compounds increased, resulting in differences in application and pharmacodynamic efficacy.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
Yiyang Chen, Dan Yu, Jinhai Huo, Nannan Huang, Meng Zhang, Xiaowei Du
Summary: In this study, it was found that the fermented extract of Paridis Rhizoma with Fusarium sp. C39 had stronger inhibitory effects on liver, cervical, and lung cancer cells compared to the unfermented extract. Through the analysis of metabonomics and transcriptome, it was discovered that strain C39 synthesized diosgenin and altered the configurations, sugar chains, and substituents of steroidal saponins in Paridis Rhizoma, enhancing the inhibitory effect on cancer cell proliferation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Lixin Yang, Yinping Liu, Ze Cui, Yongmao Zhang, Jianbo Zhang, Kaoqi Lian
Summary: This study used a metabolomics approach to investigate the toxicity of SCCPs in rats, finding that high-dose SCCP exposure resulted in liver and kidney injury, affecting pathways related to energy metabolism, amino acid metabolism, glycerophospholipid metabolism, nucleotide metabolism, and vitamin B metabolism. Fluctuating levels of phospholipids and nucleotides may contribute to the neurotoxicity of SCCPs, while down regulation of folic acid induced by SCCPs may lead to malformations during early development in laboratory animals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Analytical
Xiao-fang Yang, Yu Miao, Da-wei Yang, Ren Kong, Bo Yuan, Jian-ye Quan, Wei Bu
Summary: This study compared the chemical profiles of Dioscoreae Nipponicae Rhizoma (DNR) from different geographical origins and found that DNR samples from Heilongjiang province exhibited higher antimyocardial ischemia activity. Metabolomics analysis using UPLC-Q TOF-MS identified 40 compounds and revealed 5 key markers correlated with the antimyocardial ischemia activity. Molecular docking experiments further confirmed the interactions between these markers and the target protein. This research provides insights for the rational utilization of DNR.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Xiuyun Li, Chenglun Zhang, Enhui Wu, Liang Han, Xiangliang Deng, Zhongfeng Shi
Summary: This study aimed to investigate the effects and mechanisms of action of Osthole (OST) in breast cancer 4T1 cells. The results showed that OST inhibited cell proliferation, blocked cells from remaining in S-phase, and induced apoptosis. OST mainly affected phospholipid biosynthesis, methyl histidine metabolism, pyrimidine metabolism, and beta-oxidation of very long-chain fatty acid pathways in 4T1 cells, possibly via inhibition of mTOR/SREBP1/FASN signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kai-Wei Chang, Chia-Yu Wu, Ting-Yi Renn, Tsung-Ming Chang, Augusta I-Chin Wei, Yen-Ying Kung, Ju-Fang Liu
Summary: Sparganii Rhizoma and Curcumae Rhizoma (SRCR) are natural herbs used in traditional Chinese medicine to treat tumors and activate blood circulation. Recent research has found that SRCR induces death in human oral squamous cell carcinoma (OSCC) cells but not in normal cells. SRCR also promotes the production of reactive oxygen species, calcium release, and endoplasmic reticulum stress in OSCC cells, leading to mitochondrial dysfunction and apoptosis. Additionally, SRCR inhibits the migration of OSCC cells by reducing matrix metalloproteinase-12 and -13 expression.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biochemical Research Methods
Su Guan, Kun Liu, Zimeng Liu, Liping Zhou, Bingjie Jia, Zichen Wang, Yao Nie, Xuyu Zhang
Summary: This study identified potential metabolic biomarkers to improve the diagnostic accuracy of sepsis, through metabolomic profiling and regression analysis. A model incorporating ten metabolic biomarkers and traditional physiological indicators showed better differentiation for sepsis diagnosis. The study suggests metabolomic profiling could be an effective tool for sepsis diagnosis.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Food Science & Technology
Luyao Zhao, Xiaoliang Duan, Hongbin Liu, Dong Zhang, Qian Wang, Jianlei Liu, Hui Sun
Summary: Through lipidomics analysis, the distinction between Wuchang Daohuaxiang (DHX) rice and other nine rice varieties was identified and verified using 26 potential biomarkers. The developed discrimination method achieved an accuracy of 97.14%. The results provide supplementary tools for supervision departments and industries.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Plant Sciences
Xiao-Yun Liu, Yan-Li Chang, Xiu-Huan Wang, Yu Wang, Xue-Yang Ren, Jia-Mu Ma, A-Xiang Yu, Jing Wei, Qi-Qi Fan, Ying Dong, Ruo-Lan Song, Jian-Ling Yao, Dong-jie Shan, Gai-Mei She
Summary: The study aimed to uncover the anti-tumor active materials of Curcumae Rhizoma-Sparganii Rhizoma water decoction via spectrum-effect relationship, molecular docking, and ADME evaluation. The results showed that the combination of Curcumae Rhizoma and Sparganii Rhizoma in 80% ethanol elution fraction had strong anti-tumor effects. Twenty-four compounds were identified to have potential anti-tumor effects, with five compounds validated experimentally to have good tumor inhibition effects. This study provided a rapid and useful strategy to explore the active material basis of traditional Chinese herbal couples using a multi-technology integrated approach.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Zheng Zhong, Yukai Huang, Qidang Huang, Shaoling Zheng, Zhixiang Huang, Weiming Deng, Tianwang Li
Summary: This study investigated the serum metabolic profiling of gout patients compared to healthy controls using UPLC-Q-TOF/MS, revealing significant differences in metabolites between the two groups. Bilirubin was identified as a potential biomarker for gout, and primary bile acid biosynthesis was suggested as a novel metabolic pathway.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Hong Huang, Chuanming Fang, Hongxia Niu, Xiangjun Yin, Jiazhao Ruan, Mengying Wei, Yuan Zhou
Summary: Metabolic profiling was used to investigate changes in plasma and urine metabolites following Aβ injection and donepezil treatment in rats. Donepezil improved cognitive impairment induced by Aβ through restoring metabolic disorders. This study provides basic data for understanding the effects of Aβ and donepezil on plasma and urine metabolites in rat models of AD.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Huarong Xu, Jiameng Qu, Jian Wang, Kefei Han, Qing Li, Wenchuan Bi, Ran Liu
Summary: This study developed a new method using high resolution mass spectrometry and in silico strategy to search for potential chemical ingredients in Polygonum cuspidatum (PC) that target the TGF-I3 RI. Resveratrol, a compound found in PC, was identified to have excellent biological activity on TGF-I3 RI and potential as a treatment for PF.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Jinshi Zheng, Xinran Jiang, Qian Zhang, Yiwen Zhang, Kaishun Bi, Donghao Li, Qing Li
Summary: The study introduces a novel biological sample preparation method for rapid and efficient analysis of amines, successfully applied to screening diagnostic biomarkers for various cancers and constructing clinical cancer diagnosis models.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Chunyu Yu, Qian Zhang, Yiwen Zhang, Liyuan Wang, Huarong Xu, Kaishun Bi, Donghao Li, Qing Li
Summary: In this study, an isotope labelled in suit derivatization-extraction integrated system was proposed for targeted analysis of all the metabolites in the amine/phenol submetabolome using LC-MS. The system demonstrated high efficiency, good repeatability, simple pretreatment steps, and high detection sensitivity and accuracy. It has the potential to be a useful tool for clinical biomarker discovery in disease.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Medicine, Research & Experimental
Xiaomeng Sun, Lun Ai, Yinfei Ran, Yiwen Zhang, Qian Zhang, Qing Li, Yan Cui, Lixin Sun
Summary: In this study, the representative components of Sang Xing decoction (SXD) were characterized using liquid chromatography-tandem mass spectrometry (LC-MS). The key targets, signaling pathways, and metabolic pathways associated with SXD in the treatment of acute bronchitis were identified via network prediction and metabolomics. In vivo experiments showed that SXD may maintain the production of inflammatory factors by regulating the PI3K/Akt/NF-kappa B signaling pathway, improving the metabolism of glutamine and glutamate to reduce oxidative stress, and inhibiting apoptosis. Simultaneously, the possibility of using SXD as an adjuvant drug for COVID-19 treatment was also revealed.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Analytical
Song Cang, Ran Liu, Kunqian Mu, Qi Tang, Haiyue Cui, Kaishun Bi, Yiwen Zhang, Qing Li
Summary: This study investigated the pathological changes of non-small cell lung cancer (NSCLC) from the perspective of endogenous polar and nonpolar molecules. Targeted metabolomics and lipidomics studies were conducted, revealing potential small molecule and lipid biomarkers for NSCLC. A new strategy for formulating an equation for NSCLC identification was proposed and successfully evaluated through clinical utility.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Plant Sciences
Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li
Summary: This study established a novel and multidimensional quality assessment approach for Traditional Chinese Medicines (TCMs) using Schisandra chinensis as an example, identifying comprehensive quality markers based on pharmacodynamics and chemical properties.
Article
Chemistry, Analytical
Chunyu Yu, Qian Zhang, Liyuan Wang, Yiwen Zhang, Meiyu Cui, Kaishun Bi, Donghao Li, Qing Li
Summary: A nanoconfined liquid phase nanoextraction (NLPNE) combined with in-fiber derivatization (IFD) strategy was proposed for simultaneous quantification of seventy amino-containing analytes in plasma. This method offers advantages of broad coverage, high sensitivity, time-and solvent-saving, and is applicable for cancer diagnosis.
Article
Food Science & Technology
Bo-sai He, Xiao Wang, Ying Zhang, Cheng Gao, Cheng-kai Wu, Si-rui Guo, Yan-ting Gu, Qing Li, Jia-hong Wang
Summary: The seeds of Moringa oleifera Lam have renal protective effects in diabetic nephropathy by modulating multiple signaling pathways, exerting anti-inflammatory, anti-fibrosis, and anti-oxidative effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Meilin Qu, Tao Han, Xiaoquan Chen, Qingqing Sun, Qing Li, Mingfang Zhao
Summary: This study discovered that Actinidia chinensis Planch root can regulate the immune response of hepatocellular carcinoma (HCC) by targeting EGF, BIRC5, and SPP1. A novel immune-based gene signature model was developed to predict the survival of HCC patients.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biochemical Research Methods
Minghui Tong, Qian Zhang, Yiwen Zhang, Luwen Xing, Kaishun Bi, Qing Li
Summary: Recent studies have shown that dysregulation of carboxyl submetabolome homeostasis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). This study established a convenient and efficient workflow for absolute quantification of carboxyl submetabolome, which was applied to monitor carboxyl metabolic profile in human plasma of the whole progressive course of HCC. Biomarkers of health-hepatitis-cirrhosis-HCC were screened out and a diagnostic model was established. The relevancy between carboxyl submetabolome disorders and the pathogenesis of HCC was also investigated.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Plant Sciences
Jiameng Qu, Fan Ke, Xiao Yang, Yue Wang, Huarong Xu, Qing Li, Kaishun Bi
Summary: The study found that dandelion can alleviate DOX-induced cardiotoxicity but attenuate the cytotoxicity of DOX towards TNBC by activating the drug efflux transporter P-glycoprotein.
Article
Biochemistry & Molecular Biology
Yue Wang, Yangyu Li, Wei Guo, Xiao Yang, Jiameng Qu, Mang Gao, Shuting Chen, Jiangru Dong, Qing Li, Tiejie Wang
Summary: This study examines the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs with similar origin. The study employs a combination of network pharmacology, molecular pharmacology, and metabolomics to investigate the similarities and differences in chemical components, efficacy, and mechanisms of action of the two herbs. The results show that while CMF and CIF have similar effects in lowering blood pressure, resistance to tissue damage, and improving dyslipidemia, they exhibit distinct effects in regulating inflammatory response, signaling pathways, lipid anabolism, and metabolic abnormalities. The study suggests that the comparable efficacies of CMF and CIF, despite their distinct mechanisms of action, may be attributed to the integration and counteraction of their different regulating capabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Qian Zhang, Minghui Tong, Huarong Xu, Yidi Yin, Peng Gao, Kaishun Bi, Yiwen Zhang, Qing Li
Summary: The lack of adequate lipid reference standards is a major challenge for accurate quantitative analysis in lipidomics. Through the discovery of regularity and predictability in chromatography-mass spectrometry behaviors of lipids, a protocol and strategy were developed to calculate correlations between compound structures and analytical parameters within each lipid subclass. This allowed for the prediction of relevant LC-tandem-MS parameters for unknown lipids, and the establishment and validation of a quantification parameter database for 4081 lipids. This methodology was applied to monitor lipid metabolism changes in the plasma of health-hepatitis-cirrhosis-hepatocellular carcinoma (HCC) progression, and resulted in the identification of lipid biomarkers for distinguishing between health and different diseases, as well as different stages of disease.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Luwen Xing, Yiwen Zhang, Saiyu Li, Minghui Tong, Kaishun Bi, Qian Zhang, Qing Li
Summary: Hepatocellular carcinoma (HCC) is the terminal stage of chronic liver diseases, and chronic inflammation may contribute to its formation. Dysregulation of bile acid homeostasis in the enterohepatic circulation is a key factor in the development of HCC. This study used a rat model to reproduce HCC and monitored the bile acid profile in plasma, liver, and intestine. Differences in bile acid levels, including potential biomarkers for early diagnosis of HCC, were identified. The study also identified a key enzyme, bile acid-CoA:amino acid N-acyltransferase (BAAT), involved in bile acid synthesis and the inflammatory-cancer transformation process. This research provides insights into the role of bile acid metabolism in the liver-gut axis during the inflammation-cancer transformation process and has implications for HCC diagnosis, prevention, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qi Tang, Ran Liu, Ge Chu, Yue Wang, Haiyue Cui, Tongrui Zhang, Kaishun Bi, Peng Gao, Zonghua Song, Qing Li
Summary: The lungs and large intestine can regulate inflammation and immunity through the lung-gut axis. The transportation of gut microbiota and metabolites is an important communication channel. During the transition from ulcerative colitis (UC) to colorectal cancer (CRC), the composition of gut microbiota and metabolites related to inflammation changes significantly, and corresponding inflammatory changes also occur in lung tissues. By detecting the changes in pulmonary metabolites and microbiota, key markers related to lung and gut diseases can be identified.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
