期刊
JOURNAL OF DIGESTIVE DISEASES
卷 20, 期 4, 页码 181-188出版社
WILEY
DOI: 10.1111/1751-2980.12709
关键词
diet; gastrointestinal microbiome; gut-liver axis; metabolite; non-alcoholic fatty liver disease
资金
- Ministry of Science and Technology of the People's Republic of China [2017YFC0908903]
- National Natural Science Foundation of China [81470840, 81600464, 81873565]
Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial liver disease that has emerged as a global challenge due to its increasing prevalence and lack of sustainable treatment options. Gut microbiota possess vital functions in fermenting dietary nutrients and synthesizing bioactive molecules. This function is of great importance in maintaining health because these microbial metabolites are essential in regulating energy metabolism, immune response, and other vital physiological processes. Altered gut flora can result in a change in gut microbial metabolites, affecting the onset and progression of multiple diseases. In this review we summarize the metabolites that may have beneficial or harmful effects on the development and progression of NAFLD. This will help us better understand the possible mechanisms underlying the pathogenesis of NAFLD and facilitate the identification of potential therapeutic approaches for NAFLD.
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