Review
Endocrinology & Metabolism
Zijia Huang, Huiling Su, Tiejun Zhang, Yuwen Li
Summary: Diabetes mellitus has a negative association with abdominal aortic aneurysm, but is also associated with poorer outcomes following AAA repair. Hypoglycemic medications may have a protective effect against AAA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kristoffer Nilsson, Emelie Andersson, Sofie Persson, Kristina Karlsdotter, Josefin Skogsberg, Staffan Gustavsson, Johan Jendle, Katarina Steen Carlsson
Summary: This study performed a model-based analysis to evaluate the health benefits and costs of increased implementation of empagliflozin for people with type 2 diabetes and established cardiovascular disease in Sweden. The results indicated that the broader implementation of empagliflozin would lead to further benefits, such as increased life years gained and reduced incidence of cardiovascular deaths and heart failures, even in the short term.
DIABETES OBESITY & METABOLISM
(2023)
Article
Neurosciences
Juraj Secnik, Hong Xu, Emilia Schwertner, Niklas Hammar, Michael Alvarsson, Bengt Winblad, Maria Eriksdotter, Sara Garcia-Ptacek, Dorota Religa
Summary: This study analyzed the all-cause mortality among users of six glucose-lowering drugs in patients with and without dementia. The results showed that insulin and sulfonylurea were associated with higher mortality risk among dementia patients, while GLP-1a and SGLT-2i were associated with lower risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Medicine, General & Internal
F. Frost, M. J. Walshaw, D. Nazareth
Summary: Cystic fibrosis (CF) is a common life-threatening inherited condition in the Caucasian population, with pulmonary disease being the main contributor to morbidity. While life expectancy has improved, new challenges have arisen, with an increasing prevalence of CF-related diabetes being a significant issue.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Environmental Sciences
Jinyoung Moon
Summary: This study found that the mortality and morbidity risks of diabetes patients increase slightly during heatwaves. The risk of mortality for diabetics may increase further when considering lag days of 10 days or more.
ENVIRONMENTAL RESEARCH
(2021)
Article
Microbiology
Alexander Franklin, Sebastian Wurster, Dierdre B. Axell-House, Ying Jiang, Dimitrios P. Kontoyiannis
Summary: Mucormycosis (MCR) is commonly seen in patients with diabetic ketoacidosis, hyperglycemia, hematologic malignancies (HMs), and hematopoietic stem cell transplantation (HSCT). This study investigated the impact of hyperglycemia on MCR outcomes in patients with HMs or HSCT. The results showed that severe and persistent hyperglycemia were not associated with increased mortality in MCR patients, while insulin use prior to MCR diagnosis may be linked to decreased mortality.
Review
Endocrinology & Metabolism
Meghna Julian Sebastian, Shahanas K. A. Khan, Joseph M. Pappachan, Mohammad Sadiq Jeeyavudeen
Summary: Diabetes mellitus (DM) has been identified as a major risk factor for cognitive dysfunction, and its prevalence is rising worldwide. DM affects neuronal function and mental capacity through various mechanisms, including cerebrovascular disease, altered glucose transporters, insulin resistance, and hypoglycemic episodes. Understanding the pathobiology of cognitive dysfunction in relation to DM and its management is crucial for optimal care.
WORLD JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Yi-Na Zhang, Ying-Jie Dai, Yu Cui, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: This study aimed to investigate whether diabetes and fasting blood glucose (FBG) levels affect the efficacy of remote ischaemic conditioning (RIC) in acute moderate ischaemic stroke. The results showed that diabetes and high FBG levels were associated with functional outcomes, but did not influence the neuroprotective effect of RIC.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Mohammed Bashir, Ibrahim Ibrahim, Fatin Eltaher, Stephen Beer, Khaled Baagar, Mahmoud Aboulfotouh, Justin C. Konje, Abdul-Badi Abou-Samra
Summary: The prevalence of gestational diabetes varies when diagnosed using different criteria like WHO-2013 and NICE. A study on high-risk population found that there were fewer patients who met both criteria.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Elias K. Spanakis, Agustina Urrutia, Rodolfo J. Galindo, Priyathama Vellanki, Alexandra L. Migdal, Georgia Davis, Maya Fayfman, Thaer Idrees, Francisco J. Pasquel, Walkiria Zamudio Coronado, Bonnie Albury, Emmenlin Moreno, Lakshmi G. Singh, Isabel Marcano, Sergio Lizama, Chikara Gothong, Kashif Munir, Catalina Chesney, Rebecca Maguire, William H. Scott, M. Citlalli Perez-Guzman, Saumeth Cardona, Limin Peng, Guillermo E. Umpierrez
Summary: The efficacy and safety of continuous glucose monitoring (CGM) in adjusting inpatient insulin therapy have been evaluated in this study. The results showed that compared with point-of-care (POC) group, the CGM group achieved similar improvement in glycemic control and significant reduction in recurrent hypoglycemic events.
Article
Environmental Sciences
Han Jiang, Changlei Xia, Junqing Lin, Hakim AL. Garalleh, Amr Alalawi, Arivalagan Pugazhendhi
Summary: Diabetes mellitus is a severe disease caused by deficiencies in insulin action and secretion, resulting in long-term hyperglycemia and damage to essential organs. Carbon nanomaterials (CNMs) have shown potential interest in the treatment of diabetes, acting as implantable nanosensors to track blood glucose levels and as drug carriers for selective and effective treatment. This review explores the types, synthesis, and anti-diabetic properties of CNMs, aiming to provide a detailed view of their mechanism in diabetes mellitus.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Chinyere Aloke, Chinedu Ogbonnia Egwu, Patrick Maduabuchi Aja, Nwogo Ajuka Obasi, Jennifer Chukwu, Blessing Oluebube Akumadu, Patience Nkemjika Ogbu, Ikechukwu Achilonu
Summary: Diabetes mellitus is a rising epidemic globally and poses a significant socio-economic burden. Different treatment options have been developed, but their optimization and addressing challenges such as minimizing complications, improving patient compliance, and ensuring safety and ethical considerations are important for effective clinical treatment.
Review
Pharmacology & Pharmacy
Remigio Usai, Stephen Majoni, Freeborn Rwere
Summary: The use of medicinal plants and herbs in treating and managing diabetes is an important part of African tradition, particularly in urban areas of Zimbabwe. This review examines indigenous plants found in Zimbabwe and their anti-diabetic properties, as well as the mechanisms of action in treating and managing diabetes. The findings of these studies can contribute to the discovery of new plant-based medicines and promote the regulation of herbal remedies for diabetes by the Zimbabwean government and other African countries.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Askiel Bruno
Summary: This review discusses the potential therapeutic benefits of lowering hyperglycemia in chronic hyperglycemia and acute ischemic stroke. However, there is currently a lack of evidence that lowering hyperglycemia during acute ischemic stroke improves functional outcomes.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Environmental Sciences
Sun-Wung Hsieh, Szu-Chia Chen, Chun-Hung Chen, Ming-Tsang Wu, Chih-Hsing Hung
Summary: This study aims to investigate the risks of cognition from incense smoke. Data from Taiwan Biobank in the community were obtained. The study found that incense exposure is one of the independent risk factors for cognitive decline.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Peter G. Osborne, Raghavendra Rao Pasupuleti, Ming-Tsang Wu, Chien-Hung Lee, Vinoth Kumar Ponnusamy
Summary: Betel quid (BQ), an addictive carcinogenic stimulant chewed by millions in Asia, contains slaked lime which affects the levels of alkaloids in the betel quid. Chewing BQ leads to stimulant effects, while unripe green betel nut could potentially be used as a replacement therapy for BQ substance use disorder.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Chung Chen, Chun-Chieh Wu, Yi-Hsun Chen, Jui-Ying Lee, Yao-Kuang Wang, Nian-Siou Wu, Ming-Tsang Wu, I-Chen Wu
Summary: This study aimed to investigate the expression of PD-L1 in esophageal squamous cell carcinoma (ESCC) tissues before and after concurrent chemoradiation therapy (CCRT). The results showed a decrease in PD-L1 expression after CCRT, and high pre-CCRT PD-L1 expression was associated with poor prognosis.
Article
Environmental Sciences
Tsung-Lin Tsai, Chia-Jung Hsieh, Ming-Tsang Wu, Mei-Lien Chen, Po-Hsiu Kuo, Shu-Li Wang
Summary: Our study found that prenatal exposure to toxic metals and PAEs may contribute to certain DSM-5-oriented problems in children at 4 years of age. Reducing exposure to toxic metals and PAEs during pregnancy is recommended to prevent increased mental health problems in children.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Hsing-Kang Chen, Shu-Li Wang, Yu-Hsun Chang, Chien-Wen Sun, Ming-Tsang Wu, Mei-Lien Chen, Yu-Jie Lin, Chia -Jung Hsieh
Summary: This study examines the associations between prenatal phthalate exposure and neonatal neurobehavioral development. It found that phthalate exposure was negatively associated with neurobehaviors in female infants and positively associated with neurobehaviors in male infants. These findings highlight the gender-specific effects of maternal phthalate exposure on the neurodevelopment of newborns.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Karthikeyan Prakasham, Swapnil Gurrani, Jen-Taie Shiea, Ming-Tsang Wu, Chia-Fang Wu, Yi-Jia Ku, Tseng-Yu Tsai, Hung-Ta Hua, Yu-Jia Lin, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: A fast mycotoxin extraction (FaMEx) technique was developed for the rapid identification and quantification of carcinogenic ochratoxin-A (OTA) in food and agricultural soil samples. The method showed excellent linearity, sensitive detection, and low limits of quantification, making it suitable for mycotoxin detection in various samples.
Article
Medical Laboratory Technology
Hui-Ming Chen, Chou-Cheng Chen, Jia-Jen Chen, Chia-Fang Wu, Sih-Syuan Lee, Fu-Chen Kuo, Chien-Wen Sun, Mei-Lien Chen, Chia-Jung Hsieh, Shu-Li Wang, Ming-Tsang Wu
Summary: This study aims to establish reference intervals for important biochemical parameters in cord blood of newborns in Taiwan and investigate their sex differences. It also examines the correlation between maternal blood levels and neonatal cord blood levels.
CLINICA CHIMICA ACTA
(2023)
Article
Food Science & Technology
Karthikeyan Prakasham, Swapnil Gurrani, Jentaie Shiea, Ming-Tsang Wu, Reeta Rani Singhania, Anil Kumar Patel, Cheng-Di Dong, Yu-Chia Lin, Bongee Tsai, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: This study presents a novel semi-automated in-syringe-based fast mycotoxin extraction (IS-FaMEx) technique coupled with direct-injection electrospray-ionization tandem mass spectrometer (ESI-MS/MS) detection for the quantification of ochratoxin A in coffee and tea samples. The developed method showed remarkable linearity, with a correlation coefficient of > 0.999 and > 92% extraction recovery with a precision of 6%. The detection and quantification limits for ochratoxin A were lower than the European Union regulatory limit, making it a potential methodology for mycotoxin detection in food products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Multidisciplinary Sciences
Cheng-Yin Chung, Shang-Yu Wu, Huei-Hsuan Chiu, Tzu-Ning Wu, Your-Tong Wang, Ming-Yen Lin
Summary: This longitudinal cohort study found no significant linear and non-linear associations between air pollutant exposures and long-term kidney function changes in patients with chronic kidney disease (CKD).
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Ming-Yen Lin, Yi-Wen Chiu, Yu-Hsuan Lin, Yihuang Kang, Ping-Hsun Wu, Jeng-Huei Chen, Hsing Luh, Shang-Jyh Hwang
Summary: The concept of chronic kidney disease (CKD) originated in the 2000s, with an estimated 850 million patients worldwide. This review examines the burden, existing care models, effectiveness, challenges, and developments of CKD care. Multidisciplinary teams show potential profits in achieving comprehensive and preferable outcomes. In addition, a novel CKD care structure using modern technologies, biosensors, data visualization, machine learning algorithms, and mobile care is proposed to reduce human contact and protect the vulnerable population from infectious diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Yi-Chun Tsai, Chia-Fang Wu, Wei-Wen Hung, Ping-Shaou Yu, Chia-Chu Liu, Tusty-Jiuan Hsieh, Chu-Chih Chen, Sih-Syuan Li, Jia-Jen Chen, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Tsang Wu
Summary: This prospective cohort study investigated the impact of melamine exposure on kidney outcomes in type 2 diabetes mellitus (T2D) patients. The findings showed a significant association between melamine exposure and adverse kidney outcomes in T2D patients, especially in those with male, well sugar control or good baseline kidney function.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Applied
Karthikeyan Prakasham, Swapnil Gurrani, Jentaie Shiea, Ming-Tsang Wu, Chia-Fang Wu, Yu -Chia Lin, Bongee Tsai, Po-Chin Huang, Gangadhar Andaluri, Vinoth Kumar Ponnusamy
Summary: In this study, a novel semi-automated in-syringe-based coagulant-assisted liquid-liquid microextraction (IS-CGA-LLME) technique coupled with UHPLC-MS/MS was developed for the quantification of mycotoxin (OT-A) in coffee and tea samples. The method showed highly sensitive detection and quantification limits for OT-A, excellent extraction recovery and precision. This method provides a simple, highly sensitive, semi-automated, low-matrix effect, and efficient procedure for mycotoxin determination in food samples.
Article
Urology & Nephrology
Ming-Yen Lin, Chia-Te Liao, Ming-Huang Lin, Hsiao-Ting Wu, Mai-Szu Wu, Yung-Ho Hsu, Chih-Cheng Hsu
Summary: The Taiwan Renal Data System (TWRDS) is crucial in reducing the incidence and mortality of kidney disease and improving kidney health and care policymaking. It plays a significant role in kidney disease surveillance, providing research materials, and achieving precision prevention and care through complex algorithms. TWRDS can also contribute to building a resilient society against communicable disease threats and promoting equitable distribution of healthcare resources.
Meeting Abstract
Urology & Nephrology
C-C Liu, T-J Hsieh, C-F Wu, C-H Lee, Y-C Tsai, T-Y Huang, S-C Wen, C-H Lee, T-M Chien, Y-C Lee, Y-H Chou, S-P Huang, Y-S Juan, W-J Wu, M-T Wu
Meeting Abstract
Clinical Neurology
Wen-Ching Chen, Ping-Hsun Wu, Yi-Ting Lin, Ming-Yen Lin, Teng-hui Huang, Yi-Wen Chiu, Jer-Chia Tsai, Shang-Jyh Hwang
CEREBROVASCULAR DISEASES
(2022)
