Article
Nutrition & Dietetics
Anna Pietrzak, Marcin Banasiuk, Mariusz Szczepanik, Agnieszka Borys-Iwanicka, Tomasz Pytrus, Jaroslaw Walkowiak, Aleksandra Banaszkiewicz
Summary: This study evaluated the effectiveness of oral sodium butyrate as an add-on to standard therapy in children and adolescents with newly diagnosed IBD. The results showed that a 12-week supplementation with sodium butyrate did not show efficacy in these patients.
Article
Nutrition & Dietetics
Guangcong Ruan, Minjia Chen, Lu Chen, Fenghua Xu, Zhifeng Xiao, Ailin Yi, Yuting Tian, Yi Ping, Linling Lv, Yi Cheng, Yanling Wei
Summary: The pathogenesis of ulcerative colitis is unclear but is believed to be related to an imbalance in gut microbiota. This study found that Roseburia intestinalis may play a role in relieving colitis by upregulating Toll-like receptor 5 transcription.
Article
Gastroenterology & Hepatology
Andreas Blesl, Philipp Wurm, Silvio Waschina, Hans Peter Groechenig, Gottfried Novacek, Christian Primas, Walter Reinisch, Maximilian Kutschera, Constanze Illiasch, Barbara Hennlich, Pius Steiner, Robert Koch, Wolfgang Tillinger, Thomas Haas, Gerhard Reicht, Andreas Mayer, Othmar Ludwiczek, Wolfgang Miehsler, Karin Steidl, Lukas Binder, Simon Reider, Christina Watschinger, Stefan Fuerst, Patrizia Kump, Alexander Moschen, Konrad Aden, Gregor Gorkiewicz, Christoph Hoegenauer, Austrian IBD Study Grp ATISG
Summary: This study examined the association between fecal microbial composition and response to systemic corticosteroids in patients with active ulcerative colitis. It found that baseline microbial diversity and composition could not predict response to corticosteroids, but responders had significant changes in microbial diversity and composition after 4 weeks of treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Xinyu Shao, Shishuo Sun, Yuqing Zhou, Huiyu Wang, Yang Yu, Tong Hu, Yizhou Yao, Chunli Zhou
Summary: Disruption of gut microbiota plays a crucial role in the development of colitis-associated cancer (CAC) in patients with ulcerative colitis (UC). Targeted intervention with Bacteroides fragilis can reverse microbiota disruption, reduce intestinal inflammation, and restrict CAC development.
Article
Gastroenterology & Hepatology
Juan F. Burgueno, Julia Fritsch, Eddy E. Gonzalez, Kevin S. Landau, Ana M. Santander, Irina Fernandez, Hajar Hazime, Julie M. Davies, Rebeca Santaolalla, Matthew C. Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernandez, Gregory E. Conner, Maria T. Abreu
Summary: Chronic colonic inflammation can lead to dysplasia and cancer. Activation of TLR4 is associated with up-regulation of DUOX2 and NOX1, leading to increased epithelial production of H2O2, promoting colorectal tumor formation.
Article
Biotechnology & Applied Microbiology
Zheng Zhou, Jiasheng Cao, Xiaoming Liu, Mingsong Li
Summary: This study investigated shared genes and pathways in intestinal tissues of pediatric and adult UC, revealing that butyrate metabolism is a critical pathway associated with both pediatric and adult UC. Additionally, butyrate suppressed colitis in mice, providing a theoretical basis for potential treatment of UC with butyrate.
Article
Multidisciplinary Sciences
Luke Goudie, Nicole L. Mancini, Timothy E. Shutt, Graham P. Holloway, Chunlong Mu, Arthur Wang, Derek M. McKay, Jane Shearer
Summary: Intestinal homeostasis relies on optimal epithelial barrier function and permeability, which are regulated by intestinal epithelial cells (IEC) acting as gatekeepers. Mitochondrial-based processes provide the energy for these energy demanding processes. However, routine methods for examining IEC mitochondrial function are limited. This study presents standardized methods for quantifying mitochondrial energetics in an immortalized IEC line.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Cristina Bauset, Lluis Lis-Lopez, Sandra Coll, Laura Gisbert-Ferrandiz, Dulce C. Macias-Ceja, Marta Seco-Cervera, Francisco Navarro, Juan Esplugues, Sara Calatayud, Dolores Ortiz-Masia, Maria D. Barrachina, Jesus Cosin-Roger
Summary: This study found that the succinate receptor SUCNR1 plays a role in both basal and stimulated inflammatory pathways in intestinal epithelial cells. It is significantly involved in inflammasome activation in Ulcerative Colitis (UC).
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Gastroenterology & Hepatology
Caroline Voskens, Diane Stoica, Marita Rosenberg, Francesco Vitali, Sebastian Zundler, Marion Ganslmayer, Heike Knott, Manuel Wiesinger, Jutta Wunder, Mirko Kummer, Britta Siegmund, Elisabeth Schnoy, Timo Rath, Arndt Hartmann, Holger Hackstein, Beatrice Schuler-Thurner, Carola Berking, Gerold Schuler, Raja Atreya, Markus F. Neurath
Summary: This study reports a successful case of adoptive transfer of ex vivo expanded Tregs in a patient with refractory UC, showing positive responses. These findings suggest that adoptive Treg therapy might be effective in refractory UC.
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aurora Mazzei, Grazia Serino, Alessandro Romano, Emanuele Piccinno, Viviana Scalavino, Anna Maria Valentini, Raffaele Armentano, Roberta Schiavone, Gianluigi Giannelli, Tiziano Verri, Amilcare Barca
Summary: SLC15A4/PHT1 has been identified as a key path marker of immune/autoimmune/inflammatory pathways in immune cells, and this study found its overexpression in the colonic epithelium of ulcerative colitis (UC) patients. In vitro experiments successfully mirrored the inflammatory onset in spontaneously differentiated enterocyte-like monolayers of Caco-2 cells specifically exposed to DSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria K. Magnusson, Alexander Vidal, Lujain Maasfeh, Stefan Isaksson, Rajneesh Malhotra, Henric K. Olsson, Lena Ohman
Summary: The study found that while butyrate had inhibitory effects on T cell activation and proliferation in patients with active ulcerative colitis (UC), it was unable to reduce cytokine secretion and induce the expression of the inhibitory molecule CTLA-4. This dysfunction in butyrate-induced immune regulation could be linked to impaired CTLA-4 signaling in T cells from UC patients during a flare.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hauke Christian Tews, Tanja Elger, Stefan Gunawan, Tanja Fererberger, Stefanie Sommersberger, Johanna Loibl, Muriel Huss, Gerhard Liebisch, Martina Mueller, Arne Kandulski, Christa Buechler
Summary: The analysis of urinary 3-indoxyl sulfate and fecal SCFAs does not have diagnostic value for IBD and PSC-IBD or monitoring disease severity.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Gastroenterology & Hepatology
Jay Pravda
Summary: This study provides an evidence-based analysis of the causal role of colonic epithelial hydrogen peroxide (H2O2) in the pathogenesis and relapse of ulcerative colitis (UC). Novel therapy targeting the removal of H2O2 mediated chemotactic signal has shown promising results in achieving complete histologic resolution of colitis in refractory patients. It challenges the current treatment guidelines based on immune suppression in UC patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Kevin L. Winthrop, Severine Vermeire, Millie D. Long, Julian Panes, Siew C. Ng, Nicole Kulisek, Rajiv Mundayat, Nervin Lawendy, Ivana Vranic, Irene Modesto, Chinyu Su, Gil Y. Melmed
Summary: The incidence rates of herpes zoster in patients with ulcerative colitis remained stable during 7.8 years of tofacitinib exposure. Older age, lower weight, geographic region, and prior tumor necrosis factor inhibitor failure were identified as significant risk factors for herpes zoster.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Dahham Alsoud, Bram Verstockt, Severine Vermeire
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Walter Reinisch, Adrian Serone, Xavier Hebuterne, Tanja Kuehbacher, Maria Klopocka, Xavier Roblin, Jens Brodbeck, Kim Etchevers, Rene Galien, Ethan Grant, Chantal Tasset, Oh Kyu Yoon, Shiva Zaboli, Severine Vermeire
Summary: This study examines the relationship between endoscopic, histologic, and molecular activity in patients with Crohn's disease. The findings suggest that histologic activity should be considered when assessing inflammatory burden in CD patients.
Article
Gastroenterology & Hepatology
Silvio Danese, Marc Ferrante, Brian G. Feagan, Laurent Peyrin-Biroulet, Toshifumi Hibi, William J. Sandborn, Stefan Schreiber, Timothy Ritter, Edward V. Loftus, Gerhard Rogler, Alessandra Oortwijn, Chohee Yun, Franck-Olivier Le Brun, Jason Dinoso, Jeremy Hsieh, Severine Vermeire
Summary: This study evaluated the efficacy and sustainability of filgotinib in treating moderately to severely active ulcerative colitis (UC) patients using the Mayo Clinic Score (pMCS) and patient-reported subscores. The results showed that treatment with filgotinib improved UC symptoms within 7 days and a higher proportion of patients achieved clinical remission at weeks 10 and 58.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Pieter Sinonquel, Severine Vermeire, Frederik Maes, Raf Bisschops
Summary: This article reviews the latest developments in advanced GI endoscopy, focusing on screening, diagnosis, and surveillance of common upper and lower GI pathology. The importance of artificial intelligence in the field is emphasized, and the potential future impact of the literature is assessed.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Wannee Kantasiripitak, Sebastian G. Wicha, Debby Thomas, Ilse Hoffman, Marc Ferrante, Severine Vermeire, Karen van Hoeve, Erwin Dreesen
Summary: The study aimed to develop a multi-model model-based software tool for guiding personalized infliximab induction treatment in pediatric inflammatory bowel disease patients. The study found that using the tool for individualized dosing improved the chances for children to achieve deep remission at 6 months.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Article
Gastroenterology & Hepatology
Daan Jansen, Gwen Falony, Sara Vieira-Silva, Ceren Simsek, Tine Marcelis, Clara Caenepeel, Kathleen Machiels, Jeroen Raes, Severine Vermeire, Jelle Matthijnssens
Summary: This study found that the composition of gut viruses is associated with the pathophysiology and therapeutic success of inflammatory bowel disease (IBD), identifying two distinct gut viral configurations. These findings suggest a potential clinical relevance of gut viruses in the development and treatment of IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Julian Panes, Severine R. Vermeire, Geert D'Haens, Silvio Danese, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana R. Bravata, Daniel Gaya, Laurent Peyrin-Biroulet, Axel Dignass
Summary: This study compared two treatment strategies for Crohn's disease patients and found that regardless of whether the treatment was "treat-to-target" or "standard of care", ustekinumab was effective in improving the health-related quality of life and work productivity of patients over a 2-year follow-up period.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Immunology
Jeroen Geldof, Marie Truyens, Joao Sabino, Marc Ferrante, Jo Lambert, Hilde Lapeere, Tom Hillary, An Van Laethem, Kurt de Vlam, Patrick Verschueren, Elizaveta Padalko, Triana Lobaton, Severine Vermeire
Summary: The BELCOMID study confirms the benign course of COVID19 infection and vaccination in a large real-life population of patients with immune-mediated inflammatory diseases. However, the results emphasize the need for repeated vaccination and smoking cessation in IMID patients treated with immune-modulating therapies or systemic steroids during the pandemic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
S. Haenen, B. Verstockt, M. Ferrante, S. Vermeire, J. Sabino
Summary: Crohn's disease (CD) is a chronic inflammatory bowel disease that rarely affects the lungs. However, in this case report, CD presented with pulmonary manifestations as the first sign.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Eric B. Collins, Gil Y. Melmed, Severine Vermeire, Silvio Danese, Peter D. R. Higgins, Christina S. Kwon, Wen Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, Si-Tien Wang
Summary: Indirect evidence suggests that Upadacitinib may be more effective than other advanced therapies in achieving clinical response, clinical remission, and endoscopic response in patients with moderately to severely active ulcerative colitis over a one-year period, with similar safety profiles across different therapies.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Remo Panaccione, Maria T. Abreu, David T. Rubin, Subrata Ghosh, Axel Dignass, Anita Afzali, Douglas C. Wolf, Michael Chiorean, Severine Vermeire, Anjali Jain, Lorna Charles, Garrett Lawlor, Mark T. Osterman, Hsiuanlin Wu, James B. Canavan, Annkatrin Petersen, Jean-Frederic Colombel, Miguel Regueiro
Summary: This interim analysis examines the efficacy and safety of ozanimod treatment in patients with ulcerative colitis over a period of approximately 3 years. The results show that a high percentage of patients maintain clinical and mucosal efficacy during the treatment. No new safety concerns arise from long-term use of ozanimod.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Biochemical Research Methods
Bryan Linggi, Jonathan Cremer, Zhongya Wang, Tanja Van Viegen, Severine Vermeire, Pavine Lefevre, Lisa M. Shackelton, Vipul Jairath, Wendy Teft, Niels Vande Casteele, Bram Verstockt
Summary: Clinical trials of novel therapies for ulcerative colitis may benefit from immune cell profiling, but implementation is limited by the necessity of timely isolation and processing of peripheral blood mononuclear cells (PBMC). The use of Becton Dickinson Vacutainer CPTTM Cell Preparation Tubes (CPTTM) allows for delayed processing of PBMC, with ideal processing within 48 hours. Delayed processing may be considered for cell types that are robust to these conditions.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
S. Deleu, C. Caenepeel, S. Verstockt, J. F. Vazquez Castellanos, K. Arnauts, S. Braekeleire, K. Machiels, F. Baert, F. Mana, L. Pouillon, P. Hindryckx, T. Lobaton Ortega, E. Louis, D. Franchimont, B. Verstockt, M. Ferrante, J. Sabino, S. Vieira-Silva, G. Falony, J. Raes, S. Vermeire
JOURNAL OF CROHNS & COLITIS
(2023)