期刊
JOURNAL OF COORDINATION CHEMISTRY
卷 72, 期 5-7, 页码 908-919出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2019.1583332
关键词
Ruthenium(II); halido complex; arene ligand; benzimidazole derivatives; cytotoxicity
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172035, 41026]
- FP7 RegPot project FCUB ERA GA [256716]
Three new ruthenium(II)-arene halido complexes, [((6)-p-cymene) RuX(L)] (1-3), were synthesized in a reaction of [((6)-p-cymene)RuX2](2) with 5-chloro-1H-benzimidazole-2-carboxylic acid (HL) in ethanol (X- = Cl- (1), Br- (2), I- (3)). The complexes were characterized by elemental analysis, mass spectrometry, IR, H-1 and C-13 NMR spectroscopy. The cytotoxic activity of the ligand precursor and its ruthenium complexes was tested by MTT assay in human cancer cell lines: lung adenocarcinoma (A549), myelogenous leukemia (K562) as well as in one normal human fetal lung fibroblast cell line (MRC-5). The results show that ruthenium(II)-arene complexes possess enhanced cytotoxicity when compared to HL in the range of concentrations up to 300 mu M. In terms of halido ligand substitution, cytotoxic activity toward A549 and K562 cell lines in 1-3 serie significantly increased (e.g., IC50 values for K562: 1: 205.76 mu M; 2: 174.77 mu M; 3: 83.97 mu M). All studied compounds were found to be ineffective toward MRC-5. Hydrolysis of 1-3 was followed by UV-vis spectroscopy at 25 degrees C, revealing ligand-substitution reactions at the Ru(II) center. Compounds 2 and 3 underwent rapid hydrolysis ranging from a few minutes for the aquation to ca. 20min, confirming typical Ru-arene behavior in aqueous solutions. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据