Article
Microbiology
Subhankar Mukherjee, Punyasloke Bhadury, Shravani Mitra, Sharmi Naha, Bijan Saha, Shanta Dutta, Sulagna Basu
Summary: This study characterized hvKP/CR-hvKP strains causing neonatal sepsis in terms of resistance and virulence. About 26% of the strains belonged to hvKP, with hvKP-K2 being the prevalent pathotype. The majority of the strains exhibited strong biofilm-forming and high serum resistance ability. Additionally, this study reported for the first time the NDM-1-producing hvKP ST11-K2 and ST15-K54 strains causing fatal neonatal sepsis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Dongjie Chen, Yingrui Zhang, Jiafang Wu, Jun Li, Han Chen, Xiaoguang Zhang, Xinlan Hu, Falin Chen, Rongguo Yu
Summary: This study evaluates the clinical and genetic virulence characteristics of critically ill patients with hypervirulent Klebsiella pneumoniae (hvKP) and classic KP (cKP) infection. It found a high rate of hvKP infection in the Chinese population, with a higher probability of septic shock in hvKP-infected patients compared to cKP-infected patients. However, survival and length of hospital stay were similar between the two groups. Risk factors for hvKP infection included hospital-acquired infection and renal insufficiency.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Infectious Diseases
Junjun Chen, Huan Zhang, Xuelian Liao
Summary: Hypervirulent Klebsiella pneumoniae (hvKP), including multidrug-resistant hvKP (MDR-hvKP), is a global concern due to its ability to cause outbreaks with high pathogenicity and mortality. Key virulence agents associated with hvKP and MDR-hvKP include iron acquisition systems, increased capsule production, colibactin toxin, and hypermu-coviscosity. Recent advances have identified new hypervirulence factors and explored the evolution of MDR-hvKP. Further research is needed to identify reliable methods for detection and investigate innovative treatment targets.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Public, Environmental & Occupational Health
H. Namikawa, K. -I. Oinuma, K. Yamada, Y. Kaneko, H. Kakeya, T. Shuto
Summary: This study identified diabetes mellitus and liver abscess as predictors of hypervirulent Klebsiella pneumoniae infections through a systematic review and meta-analysis. Prudent management, including the search for multiple sites of infection and/or metastatic spread and the enforcement of an early and appropriate source control procedure, should be initiated for patients with these predictors.
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Microbiology
Jie Zhu, Tao Wang, Liang Chen, Hong Du
Summary: The review summarizes the virulence factors associated with hypervirulent Klebsiella pneumoniae to understand its molecular pathogenesis and provide new strategies for improving the prevention, diagnosis, and treatment of infections caused by hvKP.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Dakang Hu, Wenjie Chen, Qi Zhang, Meng Li, Zehua Yang, Yong Wang, Yunkun Huang, Gang Li, Dongxing Tian, Pan Fu, Weiwen Wang, Ping Ren, Qing Mu, Lianhua Yu, Xiaofei Jiang
Summary: This study investigated the epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) in mainland China. Molecular determination of CR-HvKP and Hv-CRKP showed biases compared to mouse lethality test, with the exact prevalence of CR-HvKP being less than 1.0% and that of Hv-CRKP even lower.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Yao-Chen Wang, Min-Chi Lu, Yia-Ting Li, Hui-Ling Tang, Pei-Yi Hsiao, Bo-Han Chen, Ru-Hsiou Teng, Chien-Shun Chiou, Yi-Chyi Lai
Summary: CG23-I is a significant lineage of hypervirulent Klebsiella pneumoniae. This study characterizes the within-patient microevolution of CG23-I K. pneumoniae. Selective pressures from continuous use of antibiotics favored point mutations contributing to bacterial resistance to antibiotics. The duplication of an initiator tRNA(fMet) gene helped CG23-I K. pneumoniae proliferate to reach a maximal population size during infections. For longer persistence inside a human host, the large virulence plasmid evolved with more flexible control of replication through duplication of the iteron-1 region. With the genomic alterations, the last isolate had a growth advantage over the initial isolate and exhibited enhanced virulence in BALB/c mice. This study gives us a deeper understanding of the genome evolution during the within-patient pathoadaptation of CG23-I K. pneumoniae.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Dakang Hu, Yuming Li, Ping Ren, Dongxing Tian, Wenjie Chen, Pan Fu, Weiwen Wang, Xiaobin Li, Xiaofei Jiang
Summary: The positive rates of virulence genes in Klebsiella pneumoniae vary significantly, with iucA, p-rmpA2, and p-rmpA being the primary genes leading to Hv-bla (KPC)(+)-KP. The formation of Hv-bla (KPC)(+)-KP is mostly due to bla (KPC)(+)-KP acquiring another plasmid carrying virulence genes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Bhuvan Yadav, Srujana Mohanty, Bijayini Behera
Summary: This study aimed to investigate the occurrence of hypervirulent Klebsiella pneumoniae (hvKP) isolates from different clinical specimens in a tertiary care hospital in eastern India, and to study the distribution of virulence factors, capsular serotypes, and antibiogram profile. The distribution of carbapenemase-encoding genes in convergent (hvKP and carbapenem-resistant) isolates was also examined.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Travis J. Kochan, Sophia H. Nozick, Rachel L. Medernach, Bettina H. Cheung, Samuel W. M. Gatesy, Marine Lebrun-Corbin, Sumitra D. Mitra, Natalia Khalatyan, Fiorella Krapp, Chao Qi, Egon A. Ozer, Alan R. Hauser
Summary: This study found that both multidrug-resistant high-risk clones and hypervirulent K. pneumoniae isolates are present in bloodstream isolates in the United States. It is particularly concerning that hypervirulent isolates are undergoing community spread in the United States, and these isolates are unrelated to travel history to Asia.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Ahalieyah Anantharajah, Matthieu Deltombe, Marie de Barsy, Stephanie Evrard, Olivier Denis, Pierre Bogaerts, Marie Hallin, Veronique Yvette Miendje Deyi, Denis Pierard, Peggy Bruynseels, Jerina Boelens, Youri Glupczynski, Te-Din Huang
Summary: This study investigated 22 clinical invasive isolates of Klebsiella pneumoniae and found that hypervirulent strains showed increased pathogenicity. The majority of the isolates expressed the K2 capsular serotype and belonged to various MLST lineages, while the remaining strains expressed K1 and were associated with liver abscesses. Among the patients, 36% had primary extra-hepatic infections, 95% had sepsis, and the mortality rate was 30%. Improved clinical and microbiological diagnostics are needed to better understand and manage community-acquired invasive infections caused by hypervirulent K. pneumoniae.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Microbiology
Arif Hussain, Razib Mazumder, Abdullah Ahmed, Umme Saima, Jody E. Phelan, Susana Campino, Dilruba Ahmed, Md Asadulghani, Taane G. Clark, Dinesh Mondal
Summary: This study investigates the genomic epidemiology of Klebsiella pneumoniae in Dhaka, Bangladesh, and identifies the presence of multidrug-resistant and hypervirulent clones. The findings highlight the need for immediate interventions to prevent untreatable life-threatening infections.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Jun Li, Mengli Tang, Zhaojun Liu, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou
Summary: This study investigated the molecular and clinical characteristics of hypervirulent Klebsiella pneumoniae (hvKP) in urinary tract infections (UTIs). The results showed that hvKP had a higher resistance rate and were more likely to cause complicated UTIs. The K64 hvKP isolates exhibited diversity in serotypes and genetic environments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Otavio Hallal Ferreira Raro, Patrice Nordmann, Manuel Dominguez Pino, Jacqueline Findlay, Laurent Poirel
Summary: There is an increasing occurrence of multidrug-resistant (MDR) and hypervirulent (hv) Klebsiella pneumoniae (MDR-hvKp) convergent clones. These strains can cause difficult-to-treat infections and have a higher mortality rate in healthy adults. This study in Switzerland identified a rate of 9.0% K. pneumoniae with a virulence genotype, producing carbapenemase and recovered from rectal swabs, urine, and blood. The presence of alarming MDR-hvKp and MDR nonhypervirulent K. pneumoniae (MDR-nhv-Kp) isolates highlights the need for surveillance networks to track and monitor their spread.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Wei Yu, Qixia Luo, Ping Shen, Yunbo Chen, Hao Xu, Yonghong Xiao, Yunqing Qiu
Summary: This study evaluated the antibacterial effects of several agents against carbapenem-resistant Klebsiella pneumoniae, finding that eravacycline, ceftazidime/avibactam, and meropenem/vaborbactam showed bactericidal effects against isolates carrying blaKPC-2, while aztreonam/avibactam and imipenemcilastatin/relebactam demonstrated therapeutic potential against the tested isolates.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)