Article
Chemistry, Multidisciplinary
Martina Canton, Jessica Groppi, Lorenzo Casimiro, Stefano Corra, Massimo Baroncini, Serena Silvi, Alberto Credi
Summary: The research describes the modular design of a pseudorotaxane-based supramolecular pump and its photochemically driven autonomous nonequilibrium operation in a dissipative regime. These properties are a result of careful engineering of the energy maxima and minima along the threading coordinate and their light-triggered modulation, making this second-generation system amenable to functionalization for integration into more complex devices.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Tong Wu, Michael J. Wilhelm, Jianqiang Ma, Yujie Li, Yuhao Wu, Hai-Lung Dai
Summary: Phase transitions of lipid bilayer membranes affect the passive transport of molecules. This study measured the transport rate of a molecular cation across E. coli liposomes using second harmonic light scattering and found dramatic jumps in transport rate at the known phase transition points.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Baomei Xu, Jianhui Li, Shuai Zhang, Johar Zeb, Shunli Chen, Qunhui Yuan, Wei Gan
Summary: Subtle variations in lipid membrane structure and composition can greatly affect the transport of functional molecules and cell functions. This study compares the permeability of bilayers made of three lipids and reveals that the structural mismatch between saturated and unsaturated alkane chains leads to looser packing in lipid bilayers and better permeability. It also shows that surface curvature in certain vesicles disturbs the bilayer structure. This information provides clues for drug development and other medical and biological studies.
Article
Multidisciplinary Sciences
Guillaume Revillod, Julien Duboisset, Isabelle Russier-Antoine, Emmanuel Benichou, Christian Jonin, Pierre-Francois Brevet
Summary: A general model has been developed to describe the polarization-resolved second harmonic scattering (SHS) response from a liquid solution of molecular aggregates, considering both coherent and incoherent contributions based on the spatial order of the molecules. The model shows that the SHS response can differentiate between centrosymmetric and non-centrosymmetric spatial arrangements of the nonlinear dipoles, providing insights into the spatial arrangements of dyes in aggregates despite their small nanoscale dimensions.
Article
Chemistry, Multidisciplinary
Danjun Liu, Yunxia Wang, Qiang Zhang, Ye Ming Qing, Yaorong Wang, Haitao Huang, Chi Wah Leung, Dangyuan Lei
Summary: This research presents a photoswitchable molecule-sandwiched metallic particle-on-film nanocavity that can achieve light-controlled linear and nonlinear optical tuning. It has the potential for developing miniaturized integrated optical circuits for ultrafast all-optical information processing and communication.
Article
Chemistry, Multidisciplinary
Lun Qu, Lu Bai, Chunyan Jin, Qiang Liu, Wei Wu, Bofeng Gao, Juntao Li, Wei Cai, Mengxin Ren, Jingjun Xu
Summary: Metasurfaces is an intriguing framework for nonlinear optics, offering compact design and flexibility in manipulating light. However, the nonlinearity is often limited due to the short interaction lengths with light. In this study, we demonstrate a record high efficiency of second harmonic generation using LN membrane metasurfaces, significantly improving the efficiency of nonlinear metasurfaces.
Article
Optics
Guan Gui, Nathan J. Brooks, Henry C. Kapteyn, Margaret M. Murnane, Chen-Ting Liao
Summary: The study observes the second-harmonic spatiotemporal orbital angular momentum of an optical pulse and reveals the conservation of topological charge during frequency doubling. The experiment suggests a general nonlinear scaling rule for ST-OAM, analogous to conventional OAM of light, and demonstrates that the topology of a second-harmonic ST-OAM pulse can be modified by complex spatiotemporal astigmatism.
Article
Multidisciplinary Sciences
Yuki M. Itahashi, Toshiya Ideue, Shintaro Hoshino, Chihiro Goto, Hiromasa Namiki, Takao Sasagawa, Yoshihiro Iwasa
Summary: The authors observe second-order nonlinear transport in time-reversal-symmetric PbTaSe2, where the nonlinearity is enhanced in the superconducting state.
NATURE COMMUNICATIONS
(2022)
Article
Orthopedics
A. N. Jambor, E. M. Shelton, R. Kijowski, C. R. Henak, P. J. Campagnola
Summary: The study effectively demonstrated the disorganized collagen structure resulting from trypsin and collagenase degradation in cartilage, with collagenase showing the most significant effect. Application of a LD model successfully classified control and degraded tissues, indicating distinct activity of these enzymes on collagen assembly. Results from human cartilage suggested that collagenase effects were more representative of in vivo degeneration, emphasizing the potential of using high-resolution SHG and optical scattering as an earlier diagnostic tool for OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biophysics
Michael J. Wilhelm, Mohammad Sharifian Gh, Tong Wu, Yujie Li, Chia-Mei Chang, Jianqiang Ma, Hai-Lung Dai
Summary: The bacterial surface charge is a critical characteristic that influences the cell's interaction with the environment. The second-harmonic light scattering method is capable of quantifying the surface charge by detecting molecular ions adsorbed on the exterior bacterial surface. This study reveals differences in molecular transport rates and adsorption saturation densities of different cellular ultrastructures.
BIOPHYSICAL JOURNAL
(2021)
Review
Medicine, Research & Experimental
Mohammad Gh Sharifian
Summary: This review discusses recent developments in experimental approaches and theoretical models for quantitative and real-time analysis of membrane transport of drug-like molecules through mimetic and living cell membranes. The focus is on time-resolved fluorescence-based, surface plasmon resonance, and second-harmonic light scattering approaches, as well as the current understanding of how properties of the membrane and permeant affect the permeation process.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Asela S. Dikkumbura, Alexandra Aucoin, Rasidah O. Ali, Aliyah Dalier, Dylan W. Gilbert, Gerald J. Schneider, Louis H. Haber
Summary: Time-resolved second harmonic generation spectroscopy was used to investigate the changes in adsorption and transport properties of MGITC dye to DOPC liposomes induced by acetaminophen. The study found that acetaminophen increased the adsorption of MGITC to the liposome interface and decreased the transport rate. This research provides a detailed foundation for developing potential liposome-based drug-delivery systems.
Article
Chemistry, Physical
Krzysztof Nadolski, Christian Jonin, Estelle Salmon, Zacharie Behel, Katarzyna Matczyszyn, Pierre-Francois Brevet
Summary: In this study, the sensitivity of the Second Harmonic response from gold nanoparticles is explored. The response primarily comes from the nanoparticle surface at small sizes as opposed to the whole volume of the nanoparticle at larger sizes. Upon addition of Glycerol to an aqueous solution of nanoparticles, Surface Plasmon Resonance peak shifts are observed, but cannot fully explain the Second Harmonic intensity changes recorded. Polarization-resolved Second Harmonic measurements are performed to gain further insights into the origin of the observed changes in the experimental data. A mechanism involving modification of the first hyperpolarizability of the nanoparticles followed by nanoparticle aggregation is proposed. The potential alternative use of this nonlinear optical method of Second Harmonic scattering for sensing purposes is discussed based on a proposed figure of merit to describe the observed sensing sensitivity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Optics
Vishal Choudhury, Santosh Aparanji, Roopa Prakash, V Balaswamy, V. R. Supradeepa
Summary: In Near Infrared fiber laser systems, visible light flashes were observed, likely due to high-peak-power parasitic pulses enabling Cherenkov-type phase-matched harmonic generation in optical fibers. This phenomenon could potentially occur in any laser system with high optical power.
Article
Optics
Chenglin Wang, Ran Shi, Lei Gao, Alexander S. Shalin, Jie Luo
Summary: In this study, it was found that the second-harmonic generation (SHG) from a tiny nonlinear particle can be greatly suppressed when placed near a subwavelength epsilon-near-zero (ENZ) particle. This quenching effect is due to the prohibition of electric fields near the ENZ particle caused by evanescent scattering waves, which is universal in both isotropic and anisotropic ENZ particles regardless of their shapes. Based on this principle, a dynamically controllable optical metasurface with switchable SHG quenching effect is proposed. This work enriches the understanding of optical nonlinearity with ENZ media and could have applications in optical switches and modulators.
PHOTONICS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Georgi A. Georgiev, Mohammad Sharifian Gh, Jeff Romano, Karina L. Dias Teixeira, Craig Struble, Denise S. Ryan, Rose K. Sia, Jay P. Kitt, Joel M. Harris, Ku-Lung Hsu, Adam Libby, Marc G. Odrich, Tatiana Suarez, Robert L. McKown, Gordon W. Laurie
Summary: Complex lipids enriched with proteins at air/liquid interfaces reduce surface tension, maintaining the stability of the tear film on the eyes. Dry eye disease, affecting 7 to 10% of individuals globally, may be caused by alterations in specific proteome and lipidome, leading to incomplete processing of the protein lacritin's C-terminus and subsequent loss of tear stability. The turnover of lacritin proteoforms in tears can restore stability and prevent collapse of the tear film, demonstrating a natural slow release mechanism for maintaining epithelial homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biophysics
Michael J. Wilhelm, Mohammad Sharifian Gh, Tong Wu, Yujie Li, Chia-Mei Chang, Jianqiang Ma, Hai-Lung Dai
Summary: The bacterial surface charge is a critical characteristic that influences the cell's interaction with the environment. The second-harmonic light scattering method is capable of quantifying the surface charge by detecting molecular ions adsorbed on the exterior bacterial surface. This study reveals differences in molecular transport rates and adsorption saturation densities of different cellular ultrastructures.
BIOPHYSICAL JOURNAL
(2021)
Review
Medicine, Research & Experimental
Mohammad Gh Sharifian
Summary: This review discusses recent developments in experimental approaches and theoretical models for quantitative and real-time analysis of membrane transport of drug-like molecules through mimetic and living cell membranes. The focus is on time-resolved fluorescence-based, surface plasmon resonance, and second-harmonic light scattering approaches, as well as the current understanding of how properties of the membrane and permeant affect the permeation process.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Hui Fang, Michael J. Wilhelm, Jianqiang Ma, Yi Rao, Danielle L. Kuhn, Zachary Zander, Brendan G. DeLacy, Hai-Lung Dai
Summary: The lifetime of hot electrons injected from Ag nanoplatelets to TiO2 nanorods was found to be 13.1 ± 1.5 fs, comparable to smaller spherical Ag nanoparticles. The larger surface to bulk ratio and larger surface area for direct contact with the semiconductor on Ag nanoplatelets explain the decrease in injection rate with increasing particle size. Ag nanoplatelets exhibit stronger coupling with TiO2 and higher efficiency as photosensitizers for photocatalysis due to their fast injection rate and stronger optical absorption compared to Au and dye molecules.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Engineering, Chemical
Mostafa Dadashi Firouzjaei, Mehdi Pejman, Mohammad Sharifian Gh, Sadegh Aghapour Aktij, Ehsan Zolghadr, Ahmad Rahimpour, Mohtada Sadrzadeh, Ahmad Arabi Shamsabadi, Alberto Tiraferri, Mark Elliott
Summary: A novel method of decorating polyamide forward osmosis membranes with silver-based metal azolate frameworks has been proposed to improve fouling and transport performance. By adding minimal additives, biofouling can be effectively suppressed while maintaining high selectivity and transport properties, with minimal generation of waste products.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Hui Fang, Michael J. Wilhelm, Jianqiang Ma, Danielle L. Kuhn, Zachary Zander, Hai-Lung Dai
Summary: Photosensitized semiconducting nanomaterials have attracted attention for their applications in photocatalytic and photoelectronic devices. The size of the semiconductor nanoparticles can influence the diffusion and lifetime of photoexcited electrons. A physical model that includes all known electron dynamic processes provides quantitative explanations for the observed multiexponential decays. This universally applicable model can be used to analyze data from different laboratories.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Tong Wu, Michael J. Wilhelm, Yujie Li, Jianqiang Ma, Hai-Lung Dai
Summary: Indole signaling in bacteria plays an important role in antibiotic resistance, persistence, and tolerance. Exogenous indole can increase bacterial uptake of antimicrobials through interaction with the Mtr permease.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Tong Wu, Michael J. Wilhelm, Jianqiang Ma, Yujie Li, Yuhao Wu, Hai-Lung Dai
Summary: Phase transitions of lipid bilayer membranes affect the passive transport of molecules. This study measured the transport rate of a molecular cation across E. coli liposomes using second harmonic light scattering and found dramatic jumps in transport rate at the known phase transition points.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Ophthalmology
Karina Luiza Dias-Teixeira, Gh. Mohammad Sharifian, Jeff Romano, Fatemeh Norouzi, Gordon W. Laurie
Summary: The cornea and tear film play a crucial role in maintaining transparency and refraction of light in the eye. The avascular cornea serves as a model for studying the role of autophagy in homeostasis regulation. Mutations and inflammation can disrupt autophagic flux and lead to dystrophies or worsen inflammation. Novel topical therapies can be developed based on this model to restore homeostasis.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Optics
Tracy J. Baker, Russell G. Tonkyn, Christopher J. Thompson, Megan K. Dunlap, Paul G. Koster van Groos, Nikita A. Thakur, Michael J. Wilhelm, Tanya L. Myers, Timothy J. Johnson
Summary: This article presents the construction of a database of quantitative infrared spectra for volatile fluorocarbon gases, aiming to assist in understanding treatment processes and improving quantification. The spectra in the database are obtained through weighted averaging of multiple measurements, covering a wide range of infrared signatures. An application of the database is demonstrated for identifying and quantifying thermal decomposition products.
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2023)
Article
Nanoscience & Nanotechnology
Michael J. J. Wilhelm, Timothy J. J. Johnson, Tanya L. L. Myers
Summary: In this study, a method was developed to simulate the convoluted rotational contours in the gas-phase spectra of C-1 molecules by combining existing ab initio calculations with Colin Western's PGOPHER program. The simulated contours showed good agreement with the measured spectra from the Pacific Northwest National Laboratory infrared gas-phase database.
Article
Chemistry, Physical
Hui Fang, Michael J. Wilhelm, Danielle L. Kuhn, Zachary Zander, Hai-Lung Dai, George A. Petersson
Summary: The electronic and vibrational spectra of TSPP were computationally studied, showing good agreement with experimental measurements. In addition, an infrared absorption feature in the excited states was discovered and used to investigate the vibrational dynamics of the excited state.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Jonathan M. Smith, Matthew Nikow, Michael J. Wilhelm, Hai-Lung Dai
Summary: In this study, the energy transfer mechanism of highly vibrationally excited acetylene during collisional relaxation is investigated using time-resolved Fourier transform infrared emission spectroscopy. The results show different energy transfer efficiencies of acetylene in different vibrational energy ranges.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Correction
Chemistry, Medicinal
Tong Wu, Michael J. Wilhelm, Yujie Li, Jianqiang Ma, Hai-Lung Dai
ACS INFECTIOUS DISEASES
(2023)
Article
Chemistry, Physical
Tanya L. Myers, Bruce E. Bernacki, Michael J. Wilhelm, Karissa L. Jensen, Timothy J. Johnson, Oliva M. Primera-Pedrozo, Russell G. Tonkyn, Steven C. Smith, Sarah D. Burton, Ashley M. Bradley
Summary: This paper investigates the accuracy of deriving the composite optical constants of binary mixtures and validates the results experimentally. The findings suggest that in miscible liquids where the average geometry of the cross-interactions can be considered isotropic, the refractive indices of the mixtures can be modeled using composite refractive indices derived from volume fractions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)