Review
Oncology
Shirin Azizidoost, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Bartosz Kempisty, Paul Mozdziak, Klaudia Radoszkiewicz, Maryam Farzaneh
Summary: Colorectal cancer is a gastrointestinal tumor with unsatisfactory prognosis. Research has shown that the long non-coding RNA TUG1 plays a role in the pathogenesis of CRC and may serve as a predictive/prognostic biomarker for diagnosis of CRC.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ying Zhang, Haizhen Zhang, Langtao Hu, Jiali Wei, Chunyang Ma
Summary: Renal fibrosis is a common complication of chronic kidney diseases. This study investigates the roles of lncRNA TUG1 and miR-140-3p in hyperuricemia-induced renal fibrosis. The results show that inhibiting TUG1 or CtsD or upregulating miR-140-3p can alleviate renal fibrosis in hyperuricemic rats. The study highlights the potential therapeutic effects of targeting TUG1, miR-140-3p, and CtsD in the treatment of renal fibrosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Le Lu, Jingjing Huang, Jiantao Mo, Xuanbo Da, Qiaoxin Li, Meng Fan, Hongwei Lu
Summary: Exosomes derived from cancer-associated fibroblasts (CAFs) promote migration, invasion, and glycolysis in hepatocellular carcinoma (HCC) cells through the miR-524-5p/SIX1 axis. TUG1 and SIX1 are upregulated in HCC patients with metastasis, while miR-524-5p is downregulated.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Peripheral Vascular Disease
Shiliang Liu, Jing Gao, Jianbin Chen
Summary: The study revealed that TUG1 promotes angiogenesis in HUVECs by modulating the miR-505-3p/VEGFA axis, affecting cell proliferation, migration, and tube formation capabilities.
MICROVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zhongjie Guo, Xuan Lin, Xiaoxia Guo
Summary: The study showed that long non-coding RNA (lncRNA) TUG1 is upregulated in endometrial cancer (EC) and interacts with FXR1 protein to promote proliferative and migratory potentials of cancer cells.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Oncology
Yiqiang Cao, Wenying Chai, Yonggang Wang, Dang Tang, Dongchuan Shao, Hai Song, Jiang Long
Summary: The study revealed that TUG1 had low expression in glioma cells, while EZH2 expression was opposite. Abnormal expression of TUG1 and EZH2 promoted proliferation and cancer stem cell-like properties of glioma cells, while inhibiting apoptosis, thus enhancing resistance to TMZ. TUG1 alleviated TMZ resistance of glioma cells by inhibiting EZH2 expression, and overexpression of TUG1 suppressed tumorigenicity of glioma cells by downregulating EZH2 expression in vivo.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Prakash P. P. Pillai, Muthukumar Kannan, Susmita Sil, Seema Singh, Annadurai Thangaraj, Ernest T. T. Chivero, Raghubendra Singh Dagur, Ashutosh Tripathi, Guoku Hu, Palsamy Periyasamy, Shilpa Buch
Summary: HIV-1 infection is associated with premature aging, and astrocyte senescence mediated by lncRNA TUG1 contributes to HIV-1-induced brain aging and neurocognitive impairments. Silencing TUG1 expression can reverse HIV-1 Tat-induced astrocyte senescence. This study suggests that targeting lncRNA TUG1 may be a potential therapeutic strategy for combating accelerated aging in HIV-1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Miao-Xian Yuan, Chun-Yi Ji, Hong-Qiang Gao, Xin-Yi Sheng, Wei-Xin Xie, Qiang Yin
Summary: The study revealed that TUG1 was upregulated and miR-204-5p was downregulated in hepatoblastoma tissues and cells. TUG1 inhibited the suppressive effect of miR-204-5p on the JAK2/STAT3 pathway, thereby promoting angiogenesis in hepatoblastoma cells. These findings suggest novel targets for hepatoblastoma treatment.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Weiwei Wei, Xingquan Wang, Yaqing Wei, Shilin Liu, Shengyu Gao, Hao Tian, Dewang Su
Summary: The incidence of obesity and type 2 diabetes mellitus is increasing, threatening global health. Sleeve gastrectomy has become a common surgical approach for treating type 2 diabetes. Research has shown that the long non-coding RNA TUG1 can alleviate damage to intestinal epithelial cells under high glucose and high fat conditions by regulating protein expression levels.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Miao Da, Jing Zhuang, Yani Zhou, Quan Qi, Shuwen Han
Summary: The abnormally expressed long non-coding RNA (lncRNA) TUG1 plays a critical role in regulating gene expression in malignant tumors, making it a potential clinical biomarker or therapeutic target for cancer. This review provides a basis for new research directions in cancer prevention, diagnosis, and treatment involving lncRNA TUG1.
MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gabrijela Dumbovic, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Summary: The study reveals the impact of intron retention on the spatial distribution of TERT and TUG1 transcripts within cells, with TERT introns being spliced during mitosis. This demonstrates the significance of intron retention in RNA localization within cells.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Qi Huang, Jingjing Wu, Hui Wang, Na Li, Zhen Yang, Mingjun Zhang
Summary: High expression of TUG1 is significantly correlated with poor prognosis and advanced clinicopathological features in various cancers, especially in gastrointestinal cancer, urinary tumors, gynecological tumors, hematological tumors, and osteosarcoma.
Review
Medicine, Research & Experimental
Maryam Farzaneh, Majid Ghasemian, Farhoodeh Ghaedrahmati, Jafar Poodineh, Sajad Najafi, Tariq Masoodi, Dedy Kurniawan, Shahab Uddin, Shirin Azizidoost
Summary: This review summarizes the potential roles of long non-coding RNA TUG1 in hepatocellular carcinoma (HCC), including mediating HCC cell growth, EMT, and metastasis.
Article
Cell Biology
Wei Liu, Jin Meng, Rongjun Su, Changjun Shen, Shuai Zhang, Yantao Zhao, Wenqi Liu, Jiang Du, Shuai Zhu, Pan Li, Zhigang Wang, Xiaoxia Li
Summary: This study elucidates the mechanism by which long non-coding RNA TUG1 promotes tumor formation in colorectal cancer. SP1 regulates TUG1 and the miR-421/KDM2A/ERK axis, providing novel insights into the development of colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Yuexia Wang, Yue Wang, Xue Wang, Yuan Ma, Zhaojin Li, Yu Di
Summary: The study suggests that TUG1 may play a regulatory role in retinopathy of prematurity (ROP) by interacting with miR-145-5p and CCN1 to affect retinal neovascularization. This regulatory mechanism could provide a new theoretical basis for the prevention and treatment of ROP.
FRONTIERS IN MEDICINE
(2022)
Review
Endocrinology & Metabolism
Sahar Alijanpour, Mohammad Miryounesi, Soudeh Ghafouri-Fard
Summary: This review focuses on the role of EAAT2 in epilepsy and other neurological disorders, and provides an overview of the therapeutic modulation of this protein.
METABOLIC BRAIN DISEASE
(2023)
Review
Endocrinology & Metabolism
Maryam Khayamzadeh, Vahid Niazi, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard, Mohammad Samadian
Summary: Brain tumors, particularly glioblastoma, are aggressive and often fatal due to inadequate treatment and late detection. Recent studies have found that glioblastoma cells produce extracellular vesicles containing miRNAs and other components that enhance their malignant behavior and impact neighboring cells. Understanding the molecular composition of these extracellular vesicles is crucial in developing effective therapies against this type of tumor.
METABOLIC BRAIN DISEASE
(2023)
Article
Pathology
Lina Moallemi-Rad, Amin Ghorbani, Maryam Dadyar, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Solat Eslami, Mohammad Taheri, Elena Jamali, Soudeh Ghafouri-Fard
Summary: This study evaluated the expression of five Treg-related long non-coding RNAs in breast cancer tissues. The results showed significantly higher expression levels of RMRP, TH2-LCR, MAFTRR, and GATA3-AS1 in breast cancer samples compared to non-tumoral tissues. Positive associations were found between the expression levels of RMRP and MAFTRR genes in tumor tissues and certain tumor characteristics. Additionally, differences in FLICR expression were observed among tumors with different levels of the HER2/neu receptor. These findings suggest that Treg-associated lncRNAs may contribute to the pathogenesis of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Summary: LINC00152 is an important lncRNA in human disorders and is mainly considered as a tumor-promoting lncRNA. It acts as a molecular sponge for multiple miRNAs and regulates the activity of various signaling pathways. This review summarizes the role of LINC00152 in tumor development and progression, as well as its potential as a diagnostic or prognostic tumor marker and therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Sheyda Khalilian, Atefeh Bijanvand, Hamid Abedinlou, Soudeh Ghafouri-Fard
Summary: MicroRNA-210 (miR-210) is a crucial miRNA in the pathophysiology of human disorders, up-regulated in various cancer types and associated with poor clinical outcomes.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Fariborz Rashnoo
Summary: MAGI2-AS3 is a long non-coding RNA that is abnormally expressed in various malignancies and is associated with multiple clinical characteristics. It may play a role in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease, and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 acts as a molecular sponge for multiple miRNAs to regulate the expression of their mRNA targets. This review highlights the importance of MAGI2-AS3 in different disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Ashkan Pourtavakoli, Bashdar Mahmud Hussen, Mohammad Taheri, Arda Kiani
Summary: LINC-ROR is a long non-coding RNA that plays diverse roles in human disorders, including cancer and autoimmune and neurodegenerative disorders. It contributes to disease development by altering gene expression, affecting cancer-related signaling pathways, and sequestering tumor suppressor miRNAs. Understanding the functions of LINC-ROR holds potential for developing therapeutic strategies against cancer and related diseases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Majid Mokhtari
Summary: Recent decades have witnessed significant progress in understanding the role of different long non-coding RNAs (lncRNAs) in human diseases. ADAMTS9-AS2 is a notable lncRNA with diverse roles in various disorders. While it is generally recognized as a tumor suppressor lncRNA in different cancers, it has been found to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma, and glioblastoma. Additionally, ADAMTS9-AS2 may play a role in the pathoetiology of pulpitis, acute ischemic stroke, type 2 diabetes, and its complications. This review aims to summarize the role of ADAMTS9-AS2 in different diseases, particularly focusing on its diagnostic and prognostic values.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Solmaz Hassani Fard Katiraei, Bashdar Mahmud Hussen, Mohammadreza Hajiesmaeili
Summary: This review article explores the functions of miR-328 in the development of human carcinogenesis and highlights the discrepancies in different studies, which may be attributed to different stages/grades of tumor tissues or other clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Fatemeh Movahedi Motlagh, Sepideh Kadkhoda, Maryam Motamedrad, Parisa Javidzade, Sheyda Khalilian, Mohammad Hossein Modarressi, Soudeh Ghafouri-Fard
Summary: In order to control or stop the burden of cancer, various methods have been applied. However, these treatments often fail due to drug resistance or cancer recurrence. Combining the modulation of non-coding RNA (ncRNA) expression with other treatments can increase treatment sensitivity, but there are still challenges to overcome. Gathering information in this field is essential for finding more efficient cancer cures.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Mohammad Taheri, Ashkan Pourtavakoli, Solat Eslami, Soudeh Ghafouri-Fard, Arezou Sayad
Summary: This study assessed the expression of calcium signaling-related genes and non-coding RNAs in patients with epilepsy. The results showed dysregulation of these genes in epileptic patients, suggesting their potential as biomarkers for epilepsy.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Mohammad Taheri, Amir Nicknam, Atena Bagan, Solat Eslami, Azadeh Rakhshan, Soudeh Ghafouri-Fard
Summary: In this study, a bioinformatics analysis was used to identify significant differences in genes and pathways between tumor tissues of NFPA patients and normal pituitary tissues. The study focused on investigating the expression of specific lncRNAs in NFPA samples compared to healthy tissues adjacent to the tumors. Results showed dysregulation of three lncRNAs in NFPA tissues, suggesting their potential role as important regulators of pathogenic events in these tumors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Bashdar Mahmud Hussen, Khozga Hazhar Abdullah, Snur Rasool Abdullah, Nasik Mahmood Majeed, Sayran Mohamadtahr, Mohammed Fatih Rasul, Peixin Dong, Mohammad Taheri, Majid Samsami
Summary: miRNAs play critical roles in the development and metastasis of breast cancer brain metastases. Certain miRNAs are overexpressed and promote tumor growth and metastasis, while others are downregulated and act as tumor suppressors. Strategies to modulate miRNA expression hold promise for treating breast cancer brain metastases.
NON-CODING RNA RESEARCH
(2023)
Article
Biochemical Research Methods
Soudeh Ghafouri-Fard, Arian Askari, Alireza Zangooie, Hamed Shoorei, Hasan Pourmoshtagh, Mohammad Taheri
Summary: This review provides a comprehensive examination of the role of different non-coding RNAs in the activity and development of NK cells, highlighting the detrimental effects of dysregulated non-coding RNAs on NK cell function and the potential contribution to diverse disorders.
MOLECULAR AND CELLULAR PROBES
(2023)
