Targeting the ROS/PI3K/AKT/HIF‐1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2‐Deoxy‐d‐glucose

CRLF1 promotes malignant phenotypes of papillary thyroid carcinoma by activating the MAPK/ERK and PI3K/AKT pathways

(2018) Shi-Tong Yu et al.   Cell Death & Disease

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro

(2017) Rui Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG

(2017) Bhushan S. Pattni et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NFκB signalling

(2017) Gan Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway

(2017) Baojun Yang et al.   OncoTargets and Therapy

Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation

(2017) Xiaobo B Han et al.   Cell Death & Disease

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

(2017) Sijia Chen et al.   PLoS One

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

(2016) Carly C. Barron et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neomorphic mutations create therapeutic challenges in cancer

(2016) V Takiar et al.   ONCOGENE

Inhibition of NADPH Oxidase-4 Potentiates 2-Deoxy-d-Glucose-Induced Suppression of Glycolysis, Migration, and Invasion in Glioblastoma Cells: Role of the Akt/HIF1α/HK-2 Signaling Axis

(2015) Priyanka Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

(2015) Rahul Checker et al.   CANCER LETTERS

Inhibition of tumor energy pathways for targeted esophagus cancer therapy

(2015) Abbas Shafaee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cardiotoxicity of anticancer treatments

(2015) Michael S. Ewer et al.   Nature Reviews Cardiology

Mitochondrial ROS and cancer drug resistance: Implications for therapy

(2015) Imoh S. Okon et al.   PHARMACOLOGICAL RESEARCH

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

(2014) Jose L. Orgaz et al.   Nature Communications

Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions

(2013) Colin R. Kennedy et al.   CANCER LETTERS

Prognostic Relevance of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow of Patients with Squamous Cell Carcinoma of the Oral Cavity

(2013) A. Grobe et al.   CLINICAL CANCER RESEARCH

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Polydatin, a natural precursor of resveratrol, induces cell cycle arrest and differentiation of human colorectal Caco-2 cell

(2013) Salvatore De Maria et al.   Journal of Translational Medicine

Polydatin: A review of pharmacology and pharmacokinetics

(2013) Qiao-Hui Du et al.   PHARMACEUTICAL BIOLOGY

2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways

(2012) María Cristina Estañ et al.   BIOCHEMICAL PHARMACOLOGY

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment

(2012) Xingmin Wang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice

(2012) Lvyi Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells

(2012) Xi Xie et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inhibition of Akt Potentiates 2-DG-Induced Apoptosis via Downregulation of UPR in Acute Lymphoblastic Leukemia

(2012) J. DeSalvo et al.   MOLECULAR CANCER RESEARCH

Defining principles of combination drug mechanisms of action

(2012) J. R. Pritchard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells

(2011) Huanhai Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sugar-free approaches to cancer cell killing

(2010) N El Mjiyad et al.   ONCOGENE

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

(2009) H. Wu et al.   CANCER RESEARCH

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

(2009) C. D. Simpson et al.   CANCER RESEARCH

MicroRNA-206 Targetsnotch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation

(2009) Guisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects

(2009) BS Dwarakanath et al.   Journal of Cancer Research and Therapeutics

Cytotoxicity,radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucoseIn vitro

(2009) BS Dwarakanath   Journal of Cancer Research and Therapeutics

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH