Design of novel dopamine D2 and serotonin 5-HT2A receptors dual antagonists toward schizophrenia: An integrated study with QSAR, molecular docking, virtual screening and molecular dynamics simulations

Classics in Chemical Neuroscience: Risperidone

(2018) Trevor C. Chopko et al.   ACS Chemical Neuroscience

5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

(2018) Yao Peng et al.   CELL

Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis

(2018) Marc Krause et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Cloning, Expression, Purification and Characterization of Oligomeric States of the Native 5HT2A G-Protein-Coupled Receptor

(2018) Gopa Mahesh et al.   PROTEIN AND PEPTIDE LETTERS

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex

(2018) Marta Szlachta et al.   Frontiers in Molecular Neuroscience

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

(2018) Sheng Wang et al.   NATURE

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction

(2018) Daniel E. Felsing et al.   PLoS One

Schizophrenia: A review of potential biomarkers

(2017) Daniela Rodrigues-Amorim et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Schizophrenia, primary negative symptoms, and soft outcomes in psychiatry

(2017) Stefan Leucht et al.   LANCET

Comprehensive review: Computational modelling of schizophrenia

(2017) Vincent Valton et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Real-world Effectiveness of Antipsychotics for the Treatment of Negative Symptoms in Patients with Schizophrenia with Predominantly Negative Symptoms

(2017) Diego Novick et al.   PHARMACOPSYCHIATRY

Clinical role of brexpiprazole in depression and schizophrenia

(2017) Nishant Parikh et al.   Therapeutics and Clinical Risk Management

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Neuroinflammation in Schizophrenia: A Critical Review and The Future

(2016) Feyza Aricioglu et al.   KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY

The Societal Cost of Schizophrenia: A Systematic Review

(2016) Huajie Jin et al.   PHARMACOECONOMICS

Structure based 3D-QSAR studies of Interleukin-2 inhibitors: Comparing the quality and predictivity of 3D-QSAR models obtained from different alignment methods and charge calculations

(2015) Sobia Ahsan Halim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Three-dimensional quantitative structure–activity relationship study on anti-cancer activity of 3,4-dihydroquinazoline derivatives against human lung cancer A549 cells

(2015) Sehyeon Cho et al.   JOURNAL OF MOLECULAR STRUCTURE

Schizophrenia in 2020: Trends in diagnosis and therapy

(2015) Wolfgang Gaebel et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Disability in Schizophrenia

(2014) Philip D. Harvey   JOURNAL OF CLINICAL PSYCHIATRY

The 4th Schizophrenia International Research Society Conference, 5–9 April 2014, Florence, Italy: A summary of topics and trends

(2014) Olukayode Abayomi et al.   SCHIZOPHRENIA RESEARCH

Phylogenetic Analysis and Selection Pressures of 5-HT Receptors in Human and Non-human Primates: Receptor of an Ancient Neurotransmitter

(2012) Padmanabhan Anbazhagan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

SwissBioisostere: a database of molecular replacements for ligand design

(2012) Matthias Wirth et al.   NUCLEIC ACIDS RESEARCH

Comparative QSARs for antimalarial endochins: Importance of descriptor-thinning and noise reduction prior to feature selection

(2011) Probir Kumar Ojha et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

(2011) J. Jean Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors

(2011) Laura Albizu et al.   NEUROPHARMACOLOGY

Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties

(2011) Adrian Newman-Tancredi et al.   PSYCHOPHARMACOLOGY

Structure-Based Discovery of Novel Chemotypes for Adenosine A2AReceptor Antagonists

(2010) Vsevolod Katritch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of A2AAdenosine Receptor Ligands

(2010) Jens Carlsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Best Practices for QSAR Model Development, Validation, and Exploitation

(2010) Alexander Tropsha   Molecular Informatics

On Two Novel Parameters for Validation of Predictive QSAR Models

(2009) Partha Pratim Roy et al.   MOLECULES

Structure-based discovery of  2-adrenergic receptor ligands

(2009) P. Kolb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schizophrenia, “just the facts” 4. Clinical features and conceptualization

(2009) Rajiv Tandon et al.   SCHIZOPHRENIA RESEARCH

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the impact of size of training sets for the development of predictive QSAR models

(2007) Partha Pratim Roy et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS