Article
Multidisciplinary Sciences
Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barres, Nils J. Faergeman, Jonas T. Treebak, Zachary Gerhart-Hines
Summary: NAMPT controls the molecular clock and metabolic biorhythms in a tissue-specific manner. It plays a key role in the amplitude of the core clock in brown adipose tissue, has moderate dependence on NAD+ biosynthesis in white adipose tissue, and is completely refractory to loss in skeletal muscle. NAMPT also differentially orchestrates oscillation of clock-controlled gene networks and metabolite levels in different tissues.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Binglin Yue, Hui Wang, Xin Cai, Jiabo Wang, Zhixin Chai, Wei Peng, Shi Shu, Changqi Fu, Jincheng Zhong
Summary: Adipose tissue-secreted exosomes play a significant role in the intercellular communication between organs, especially with skeletal muscle. These exosomes transfer various molecules that can affect the physiological and pathological processes in recipient cells. Therefore, studying the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle is of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ziye Xu, Wentao Chen, Liyi Wang, Wenjing You, Yanfang Wang, Yizhen Wang, Jianguo Zhao, Tizhong Shan
Summary: This study investigated the lipid profiles and regulatory pathways in the skeletal muscles of UCP1 KI pigs using lipidomics and transcriptomics. The results showed altered contents of glycerophospholipids and acyl carnitines in UCP1 KI skeletal muscles, as well as enriched metabolic regulatory pathways. Comparison of transcriptomes suggested a possible crosstalk between adipose and skeletal muscle tissues through nervous system or chemokine signaling in UCP1 KI pigs. Additionally, associations between UCP1 KI-induced metabolic alterations and metabolic and muscle dysfunction were identified using lipid biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Takayuki Yamamoto, Kazushi Sugimoto, Syuhei Ichikawa, Kei Suzuki, Hideki Wakabayashi, Kaoru Dohi, Norihiko Yamamoto
Summary: This study investigated the relationship between body composition and the prognosis of COVID-19. The results showed that high intra-muscular adipose tissue content (IMAC) may predict the severe disease course of COVID-19 in non-obese Japanese patients, but it did not predict disease severity in obese patients or mortality.
Article
Agriculture, Multidisciplinary
Long Ke-ren, Li Xiao-kai, Zhang Ruo-wei, Gu Yi-ren, Du Min-jie, Xing Xiang-yang, Du Jia-xiang, Mai Miao-miao, Wang Jing, Jin Long, Tang Qian-zi, Hu Si-lu, Ma Ji-deng, Wang Xun, Pan Deng-ke, Li Ming-zhou
Summary: Follistatin (FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to members of the TGF-beta superfamily. This study generated transgenic pigs that express human FST specifically in skeletal muscle tissues and found that these pigs exhibited increased muscle growth, decreased adipose deposition, and improved metabolism. Transcriptome analysis revealed the involvement of various signaling pathways and metabolic processes in the phenotypic changes observed. These findings provide new insights into the molecular mechanisms underlying the effects of FST in pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Mu Zeng, Shanying Yan, Peng Yang, Qiaowei Li, Jiju Li, Xinhao Fan, Xiaoqin Liu, Yilong Yao, Wei Wang, Ruipu Chen, Guohao Han, Yalan Yang, Zhonglin Tang
Summary: By conducting a comprehensive analysis of circRNA expression profiles in Chinese local breed Luchuan pigs and Western commercial breed Duroc pigs, we identified a total of 56,254 circRNAs, of which 42.9% were not previously annotated. Furthermore, we found that 33.7% of these circRNAs were differentially expressed between the two breeds, and they might contribute to the phenotypic differentiation. Additionally, we discovered a tissue-specific circRNA, circPSME4, which regulates skeletal muscle development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: This study found a nonlinear relationship between muscle mass and BMI, and suggested that baseline muscle mass and eFFMI are more reliable predictors of diabetes remission than BMI.
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: The study found a non-linear relationship between muscle mass and BMI, with psoas muscle mass and eFFMI being better predictors of diabetes remission after Roux-en-Y gastric bypass surgery compared to BMI.
Article
Nutrition & Dietetics
Masayasu Horibe, Naoki Takahashi, Alexander D. Weston, Kenneth Philbrick, Satoshi Yamamoto, Hiroaki Takahashi, Santhi Swaroop Vege
Summary: In patients with acute pancreatitis, skeletal muscle and subcutaneous adipose tissue are associated with disease severity, while visceral adipose tissue is not.
CLINICAL NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Dawei Zhang, Liangcai Shen, Wenjing Wu, Keke Liu, Jin Zhang
Summary: This study identifies the porcine adipose tissue-specific gene LGALS12 and identifies a 4 kb fragment of the LGALS12 promoter that exhibits adipocyte-specific promoter activity. These findings provide new evidence for understanding porcine fat deposition and offer a promoter element for adipose tissue-specific genetic modification in pigs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kirti Magudia, Christopher P. Bridge, Camden P. Bay, Ana Babic, Florian J. Fintelmann, Fabian M. Troschel, Nityanand Miskin, William C. Wrobel, Lauren K. Brais, Katherine P. Andriole, Brian M. Wolpin, Michael H. Rosenthal
Summary: This study demonstrated the validity of fully automated, deep learning body composition (BC) analysis from abdominal CT examinations in predicting survival. Population reference curves for BC were generated, showing significant variations by age, race, and sex. The z scores derived from these curves better captured the demographic distribution of BC compared with standard methods and proved to be predictive of survival.
Article
Cell Biology
Miriam A. Holzman, Abigail Ryckman, Tova M. Finkelstein, Kim Landry-Truchon, Kyra A. Schindler, Jenna M. Bergmann, Lucie Jeannotte, Jennifer H. Mansfield
Summary: Hoxa5 plays a critical role in embryonic BAT development and negatively regulates formation of epaxial muscle. The protein is expressed in embryonic adipocytes as early as day 12.5.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Luiz Eduardo Mateus Brandao, Daniel Espes, Jakub Orzechowski Westholm, Teemu Martikainen, Nestori Westerlund, Lauri Lampola, Alexandru Popa, Heike Vogel, Annette Schurmann, Suzanne L. Dickson, Christian Benedict, Jonathan Cedernaes
Summary: This study demonstrated that acute sleep loss leads to increased circulating levels of FGF21 in healthy young men, independent of tissue-based stress response in metabolic peripheral tissues. DNA methylation in the FGF21 promoter region increased in adipose tissue, while muscle showed adverse transcriptional changes.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Junrong Cai, Shenglu Jiang, Yuping Quan, Jiayan Lin, Shaowei Zhu, Jing Wang, Wenqing Jiang, Yunjun Liao, Feng Lu
Summary: Transplantation of brown adipose tissue (BAT) can improve obesity, but the microenvironment of the recipient site affects graft function, with sub-muscular transplantation showing better results.
Article
Biochemistry & Molecular Biology
Ivan J. Vechetti, Bailey D. Peck, Yuan Wen, R. Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. McCarthy
Summary: Regular physical activity may improve health by releasing factors from skeletal muscle through extracellular vesicles (EVs) containing miR-1, promoting adipose tissue metabolic adaptations. EVs are preferentially taken up by eWAT, enhancing adrenergic signaling and lipolysis, ultimately benefiting overall health.
Article
Agriculture, Dairy & Animal Science
Anna Perkowska, Tatiana Flisikowska, Carolin Perleberg, Krzysztof Flisikowski, Monika Stachowiak, Joanna Nowacka-Woszuk, Dieter Saur, Alexander Kind, Angelika Schnieke, Marek Switonski
ANIMAL BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Joanna Nowacka-Woszuk, Izabela Szczerbal, Monika Stachowiak, Maciej Szydlowski, Wojciech Nizanski, Stanislaw Dzimira, Artur Maslak, Rita Payan-Carreira, Eline Wydooghe, Tomasz Nowak, Marek Switonski
Article
Agriculture, Dairy & Animal Science
P. Krzeminska, M. Stachowiak, M. Skrzypski, T. Nowak, A. Maslak, M. Switonski
Article
Agriculture, Dairy & Animal Science
Joanna Nowacka-Woszuk, Izabela Szczerbal, Monika Stachowiak, Stanislaw Dzimira, Wojciech Nizanski, Janusz Biezynski, Tomasz Nowak, Maciej Gogulski, Marek Switonski
ANIMAL REPRODUCTION SCIENCE
(2020)
Article
Genetics & Heredity
Agata Sikorska, Monika Stachowiak, Tatiana Flisikowska, Joanna Stachecka, Krzysztof Flisikowski, Marek Switonski
Article
Biotechnology & Applied Microbiology
Joanna Nowacka-Woszuk, Monika Stachowiak, Izabela Szczerbal, Maciej Szydlowski, Alicja Szabelska-Beresewicz, Joanna Zyprych-Walczak, Paulina Krzeminska, Tomasz Nowak, Anna Lukomska, Zuzanna Ligocka, Janusz Biezynski, Stanislaw Dzimira, Wojciech Nizanski, Marek Switonski
Summary: This study found that a missense SNP of the PADI6 gene is significantly associated with the XX DSD phenotype in certain breeds, while no associated variant was found in another breed of XY DSD.
Article
Multidisciplinary Sciences
Monika Stachowiak, Izabela Szczerbal, Joanna Nowacka-Woszuk, Tomasz Nowak, Natalia Sowinska, Anna Lukomska, Maciej Gogulski, Malgorzata Badura, Karolina Sklorz-Mencel, Dariusz Jagodka, Wojciech Nizanski, Stanislaw Dzimira, Marek Switonski
Summary: The genetic background of feline disorders of sex development (DSDs) was investigated, revealing that abnormalities of sex chromosomes are important causes of feline DSDs. Additionally, a specific variant of the LHCGR gene was identified as a potential marker associated with the XY DSD phenotype.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Izabela Szczerbal, Joanna Nowacka-Woszuk, Monika Stachowiak, Anna Lukomska, Kacper Konieczny, Natalia Tarnogrodzka, Jakub Wozniak, Marek Switonski
Summary: In this study, genetic analysis was conducted on five DSD heifers. Four of them were identified as freemartins, while the fifth one had a normal female sex chromosome complement but lacked Y-chromosome-derived genes. Anatomical examination revealed normal reproductive organs in the fifth heifer, but molecular detection indicated the presence of a cell line carrying the Y chromosome. Further analysis suggested the presence of XX/XY chimerism. The etiology of this phenomenon remains unknown.
Article
Biotechnology & Applied Microbiology
Izabela Szczerbal, Emilian Malek, Antonella Rigillo, Anna Lukomska, Kamil Kacprzak, Stefania Gasparini, Joanna Nowacka-Woszuk, Monika Stachowiak, Mehmet O. Aksoy, Marek Switonski
Summary: A 14-month-old female Miniature Poodle dog presented with an enlarged clitoris and asymmetry in the placement of the teats. Histological and genetic studies revealed diffuse hyperplasia of theca cells with atretic primary follicles in the ovaries and pure X monosomy. This is the first reported case of X monosomy associated with virilization in a dog.
JOURNAL OF APPLIED GENETICS
(2023)
Article
Genetics & Heredity
Adrianna Bilinska, Marcin Pszczola, Monika Stachowiak, Joanna Stachecka, Franciszek Garbacz, Mehmet Onur Aksoy, Izabela Szczerbal
Summary: Extracellular miRNAs play important roles in intercellular communication and can be potential biomarkers for diseases. This study aimed to analyze the expression of intracellular and extracellular miRNAs during in vitro adipogenesis by quantifying eight specific miRNAs. It was found that inflammatory-associated miRNAs were highly expressed in differentiated adipocytes and secreted by cells, while all miRNAs associated with adipocyte differentiation showed high abundance in both cells and cell culture medium with characteristic upregulation during differentiation.
Article
Veterinary Sciences
Sebastian Smulski, Marcin Pszczola, Monika Stachowiak, Adrianna Bilinska, Izabela Szczerbal
Summary: This study aimed to quantify selected miRNAs in the milk of mastitic cows. The results showed that miR-146a is a promising marker for bovine mastitis.
JOURNAL OF VETERINARY RESEARCH
(2023)
Article
Reproductive Biology
Joanna Nowacka-Woszuk, Paulina Krzeminska, Tomasz Nowak, Maciej Gogulski, Marek Switonski, Monika Stachowiak
Article
Veterinary Sciences
Marek Gehrke, Beata Blaszak, Monika Stachowiak, Izabela Szczerbal, Barbara Stefanska, Jedrzej M. Jaskowski, Wlodzimierz Nowak, Marek Switonski
JOURNAL OF VETERINARY RESEARCH
(2019)
Article
Agriculture, Dairy & Animal Science
Adrian Grzemski, Monika Stachowiak, Krzysztof Flisikowski, Monika Mankowska, Paulina Krzeminska, Maciej Gogulski, Roman Aleksiewicz, Maciej Szydlowski, Marek Switonski, Joanna Nowacka-Woszuk
ANNALS OF ANIMAL SCIENCE
(2019)