Article
Medicine, Research & Experimental
Xin-Yu Yang, Hang Yu, Jie Fu, Hui-Hui Guo, Pei Han, Shu-Rong Ma, Li-Bin Pan, Zheng-Wei Zhang, Hui Xu, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Xian-Feng Zhang, Wei Yang, Jing-Yue Wang, Jing-Yu Jin, Hui-Cong Zhang, Dong-Rui Li, Jin-Yue Lu, Yuan Lin, Jian-Dong Jiang, Qian Tong, Yan Wang
Summary: In this study, the efficacy of hydroxyurea in treating atherosclerosis in high-fat diet-fed ApoE-/-mice was investigated. It was found that hydroxyurea effectively reduced serum cholesterol levels and modulated the composition of gut microbiota. Furthermore, the expression of NPC1L1 in small intestinal epithelial cells was significantly reduced after hydroxyurea treatment, affecting cholesterol absorption.
Article
Microbiology
Jing Yang, Songhao Liu, Qian Zhao, Xiaobing Li, Kangfeng Jiang
Summary: This study reveals the close association between the host gut microbiota and the severity of T. gondii infection. The findings provide evidence that ALA can alleviate T. gondii-induced colitis by improving the dysregulation of the host gut microbiota and suppressing the production of pro-inflammatory cytokines via the MyD88/NF-kappa B pathway.
Article
Nutrition & Dietetics
Judit Gil-Zamorano, Montserrat Cofan, Maria-Carmen Lopez Hazas, Tatiana Garcia-Blanco, Almudena Garcia-Ruiz, Monica Domenech, Merce Serra-Mir, Irene Roth, Cinta Valls-Pedret, Sujatha Rajaram, Joan Sabate, Emilio Ros, Alberto Davalos, Aleix Sala-Vila
Summary: This study investigates the mechanisms behind the lipid-lowering effect of nuts, particularly walnuts. The researchers found that long-term supplementation with walnuts can decrease LDL-cholesterol levels independently of changes in circulating microRNAs. Additionally, the study suggests that the upregulation of hsa-miR-551a, which is associated with reduced cell migration and invasion in cancers, may be a novel mechanism of walnuts in reducing cancer risk.
Article
Immunology
Junbin Yan, Yunmeng Nie, Yuan Liu, Jingya Li, Liyan Wu, Zhiyun Chen, Beihui He
Summary: The study aims to investigate the treatment effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine its association with gut microbiota, and clarify the regulating mechanism. The results showed that YBT could improve NASH mice by enhancing the diversity and richness of gut microbiota, particularly in the regulation of alpha-Linolenic acid metabolism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hong Zhang, Yunhui Zhang, Tong Mu, Jianxin Cao, Xiaoxia Liu, Xingbin Yang, Daoyuan Ren, Ke Zhao
Summary: This study aimed to investigate the relationship between inulin, a dietary fiber, and gut microbiota, as well as the impact on distal intestine function. The results showed that inulin supplementation significantly reduced body weight, fat deposition, and fasting blood glucose levels, and induced changes in cecal microbiota structure and ileum transcriptomic profiling. Inulin also reversed the expression levels of certain bacterial species and intestinal genes. In conclusion, inulin may alleviate high-fat diet-induced fat deposition and metabolic disorders through regulating lipid metabolism in the ileum, with the interaction between sPLA2s and gut microbes playing important roles in the process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Shijia Pan, Yuan Guo, Fan Hong, Pengfei Xu, Yonggong Zhai
Summary: Colorectal cancer (CRC) is a common gastrointestinal malignancy with complex development processes. Obesity and dysbacteriosis are main risk factors, while melatonin plays a potential role in lipid metabolism and beneficial effects on CRC, and gut microbiota plays a significant role in the relationship between obesity and increased CRC risk.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Chunlin Xie, Xiaoyan Zhu, Baoyang Xu, Yaorong Niu, Xuelei Zhang, Libao Ma, Xianghua Yan
Summary: This study compared the characteristics of fat deposition and gut microbial community between Laiwu pigs and DLY pigs and investigated the effects of fecal microbiota transplantation (FMT) on lipid metabolism in pigs. The results showed that the gut microbiota may regulate lipid metabolism and enhance the accumulation of lipid droplets in the liver of pigs.
Article
Engineering, Environmental
Biran Zhu, Lei Lei, Yumiao Sun, Xiongjie Shi, Kaiyu Fu, Jianghuan Hua, Christopher J. Martyniuk, Jian Han, Lihua Yang, Bingsheng Zhou
Summary: This study examined the accumulation and distribution of niclosamide in different tissues of adult male zebrafish fed a normal diet or high-fat diet. The results showed that the liver accumulated the highest concentration of niclosamide, followed by the brain and gonads. High-fat diet increased the burden of niclosamide in the liver and brain compared to the normal diet. Niclosamide effectively controlled weight gain and improved insulin and glucose levels in high-fat diet-fed fish. However, it also had potential effects on the liver-gut axis, disrupting mitochondrial energy production, inhibiting glycemic and triacylglycerol biosynthesis, impairing the physical barrier of the intestine, and causing inflammatory, oxidative stress, and microbiota dysbiosis. These findings emphasize the importance of evaluating the potential impacts of niclosamide on the health of wild animals and humans.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang
Summary: Elemicin exposure can lead to hepatomegaly and mild hepatosteatosis, and depletion of gut microbiota can alleviate this liver damage. Elemicin can also alter the structure of fecal microbiota and affect gut microbiota function. In addition, specific microbial genera are associated with Elemicin exposure and significantly correlated with liver-related indicators such as ALT, AST, and TG.
Article
Pharmacology & Pharmacy
Yuyan Gu, Yaxin Zhang, Mei Li, Zhiyong Huang, Jing Jiang, Yihao Chen, Junqi Chen, Yuhua Jia, Lihua Zhang, Fenghua Zhou
Summary: Ferulic acid (FA) can significantly alleviate atherosclerotic injury in mice by modulating lipid metabolism and gut microbiota. This improvement may be partly achieved through the AMPK alpha/SREBP1/ACC1 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Laura Bonfili, Massimiliano Cuccioloni, Chunmei Gong, Valentina Cecarini, Michele Spina, Yadong Zheng, Mauro Angeletti, Anna Maria Eleuteri
Summary: This study investigated the effects of probiotics on lipid metabolism in AD mice, demonstrating that probiotic treatment can inhibit cholesterol biosynthesis, influence bile acid synthesis pathways, regulate inflammation, and improve lipid composition, with arachidonic acid playing a key role in these interactions.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Choufei Wu, Wentao Lyu, Qihua Hong, Xiaojun Zhang, Hua Yang, Yingping Xiao
Summary: Transplantation of gut microbiota from obese Jinhua pigs promoted intramuscular fat accumulation and transferred the properties to mouse recipients, indicating a potential role of manipulating intestinal microbiota in improving meat quality and flavor in pigs and even ameliorating metabolic syndrome in humans.
FRONTIERS IN NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Arianna Peruzzo, Marta Vascellari, Andrea Massaro, Marzia Mancin, Annalisa Stefani, Massimiliano Orsini, Patrizia Danesi, Sara Petrin, Antonio Carminato, Michele Matteo Santoro, Roberto Speranza, Carmen Losasso, Gioia Capelli
Summary: This study compared two groups of clinically healthy German shepherd dogs differing for G. duodenalis colonization. The results showed that G. duodenalis exerts an effect upon the gut microbiota affecting the proportion of bacterial taxa known to be associated with improved lipids metabolism and protection from gut inflammation. Moreover, giardia infection does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease, suggesting caution in administering antiparasitic treatments to asymptomatic subjects.
Article
Agriculture, Multidisciplinary
Xiaoping Li, Yexuan Yao, Yu Wang, Lun Hua, Min Wu, Fang Chen, Ze-Yuan Deng, Ting Luo
Summary: This study investigated the mechanism underlying the impact of hesperidin on nonalcoholic fatty liver. The results showed that hesperidin improved liver dysfunction and serum lipid profiles induced by a high-fat diet, altered the expression of genes involved in lipid metabolism, and changed the composition of the intestinal microbiota. Liver metabolomics analysis indicated that hesperidin enhanced the abundance of metabolites in specific pathways, which were predicted to be positively correlated with the gut bacteria enriched by hesperidin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Fang Xie, Hang-Fei Xu, Jing Zhang, Xiao-Ni Liu, Bu-Xin Kou, Meng-Yin Cai, Jing Wu, Jin-Ling Dong, Qing-Hua Meng, Yi Wang, Dexi Chen, Yang Zhang
Summary: ASPP2 deficiency promotes NAFLD progression, alters fatty acid metabolism, and causes gut microbiota dysbiosis. EPA, a long-chain fatty acid, is significantly negatively correlated with the abundance of Bifidobacterium, a specific feature of NAFLD in ASPP2-deficient mice. The results provide evidence for the mechanism of ASPP2 in dysregulation of fatty acid metabolism and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Ana Camacho Benitez, Rossana Vasconcellos, Paula Lombide, Helen Viotti, William Perez, Nicolas Cazales, Daniel Cavestany, Graeme B. Martin, Graciela Pedrana
Summary: Heat shock protein 90 (HSP90) immunoexpression in mare endometrium varies during different estrous phases, with the strongest expression during estrus. HSP90 may be involved in regulating sex steroid receptor function in cyclic mares, playing a key role in endometrial function. Further studies are needed to explore its potential significance in pathological conditions such as endometritis.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2021)
Article
Agriculture, Dairy & Animal Science
G. E. Banchero, K. Stefanova, D. R. Lindsay, G. Quintans, F. Baldi, J. T. B. Milton, G. B. Martin
Summary: Analysis of experimental data in Uruguay over a 14-year period revealed that overall energy intake had the greatest impact on ovulation rate in ewes. During short-term nutritional supplementation, the intake of highly digested protein or protein protected from rumen degradation were key factors influencing ovulation rate.
Article
Multidisciplinary Sciences
Cesar A. Rosales-Nieto, Maribel Rodriguez-Aguilar, Francisco Santiago-Hernandez, Venancio Cuevas-Reyes, Manuel J. Flores-Najera, Juan M. Vazquez-Garcia, Jorge Urrutia-Morales, Morteza Hosseini Ghaffari, Cesar A. Meza-Herrera, Antonio Gonzalez-Bulnes, Graeme B. Martin
Summary: Supplementation with Opuntia cladodes, with or without protein enrichment, increased fertility rate and reproductive rate of female sheep without affecting body weight. The activation of specific metabolites/metabolomic pathways, such as glucose, methane, tyrosine, and glycerolipids, may play a role in the reproductive responses to Opuntia in sheep. Further research is needed to understand the mechanisms through which nutrition affects the reproductive system.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Umar Farooq, Irek A. Malecki, Graeme B. Martin, Misbah Mahmood
Summary: The study developed a method to measure sperm mobility (SM) and investigated its relationship with egg fertility. The results showed that adjustments in Accudenz concentration and incubation temperature had an impact on SM and sperm motility, but there was a weak correlation between SM and egg fertility.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Agriculture, Dairy & Animal Science
Jose Manuel Hernandez-Hernandez, Graeme B. Martin, Carlos Miguel Becerril-Perez, Arturo Pro-Martinez, Cesar Cortez-Romero, Jaime Gallegos-Sanchez
Summary: The study investigates the potential of intravenous application of kisspeptin to stimulate LH pulsatile secretion in suckling ewes during postpartum anestrus. The results show that kisspeptin administration increases LH pulse frequency, suggesting that suckling may inhibit ovulation by reducing kisspeptin neuronal activity. Additionally, the effects of kisspeptin and suckling on LH secretion appear to be independent, possibly operating through different neural pathways.
Article
Multidisciplinary Sciences
Shamshad Ul Hassan, Eng Guan Chua, Erwin A. Paz, Parwinder Kaur, Chin Yen Tay, Johan C. Greeff, Shimin Liu, Graeme B. Martin
Summary: By analyzing the transcriptomes of sheep with different susceptibility to diarrhea, we identified differentially expressed genes that are associated with immune suppression and tissue repair processes.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
P. Clemens Khaiseb, Penelope A. R. Hawken, Graeme B. Martin
Summary: The study suggests that short-term nutritional supplementation can enhance ovarian activity and prolificacy in sheep through modulation of the ram effect. However, supplementation before ram introduction does not improve ovulation rate and frequency of short cycles.
Review
Veterinary Sciences
Sarah A. Robertson, Graeme B. Martin
Summary: The classical view of pheromones is challenged by camelids, which have discovered that a nerve growth factor in seminal plasma can trigger ovulation. Further research has found that certain molecules in seminal fluid can enhance the female reproductive tract's receptivity to embryos, increasing the likelihood of pregnancy. This phenomenon has significant implications in the field of reproductive biology.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Shamshad Ul Hassan, Eng Guan Chua, Parwinder Kaur, Erwin A. Paz, Chin Yen Tay, Johan C. Greeff, Shimin Liu, Graeme B. Martin
Summary: Gastrointestinal helminths are a global health issue. This study found that inflammation in the ileum is related to the development and severity of diarrhoea. Through transcriptome analysis, differentially expressed genes were identified between susceptible and resistant sheep, with up-regulated genes in susceptible sheep associated with inflammatory immune response and down-regulated genes related to ion transport and pathways preventing inflammation.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Endocrinology & Metabolism
Bronwyn G. A. Stuckey, James D. Nolan, David M. Hurley, Graeme B. Martin
Summary: This article reports a case of a patient with Kallmann syndrome who received pulsatile GnRH treatment during infancy, resulting in a rapid and successful response to gonadotrophin therapy in adulthood. The authors propose that pulsatile GnRH treatment in infancy induces minipuberty and can benefit fertility treatment later in life.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2023)
Article
Microbiology
Erwin A. Paz, Eng Guan Chua, Shamshad Ul Hassan, Johan C. Greeff, Dieter G. Palmer, Shimin Liu, Binit Lamichhane, Nestor Sepulveda, Junhua Liu, Chin Yen Tay, Graeme B. Martin
Summary: This study compared the gastrointestinal microbiota composition between highly helminth-susceptible and highly helminth-resistant sheep and found significant differences between the two. Different gastrointestinal sections support different bacterial compositions, with the duodenum of helminth-resistant sheep having the most diverse microbial population, which may help restrict the development of parasites.
Review
Agriculture, Dairy & Animal Science
Z. Durmic, J. L. Black, G. B. Martin, P. E. Vercoe
Summary: This review highlights the utilization of plant bioactivity to reduce enteric methane emissions from Australian ruminant production systems. Potential strategies include low methanogenic forage species, plant-based agricultural by-products, and plant extracts that offer exciting opportunities, but further research is needed to confirm effectiveness and determine optimal doses for in vivo application.
ANIMAL PRODUCTION SCIENCE
(2022)
Review
Developmental Biology
Jennifer L. Juengel, Robert A. Cushman, Joelle Dupont, Stephane Fabre, Richard G. Lea, Graeme B. Martin, Francesca Mossa, Janet L. Pitman, Christopher A. Price, Peter Smith
Summary: This review presents a consensus view of critical advances over the past decade in understanding follicle function in ruminants, covering concepts such as the value of major genes, fetal ovarian development dynamics, ovarian follicle reserve, theca cells, follicular fluid, 'adipokinome', and the contribution of follicle development to conception success. These concepts are crucial for reproductive efficiency and productivity in sheep and cattle, and are also important in improving methane efficiency in livestock enterprises.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2021)
Article
Agriculture, Dairy & Animal Science
J. C. Greeff, E. A. Paz, K. Munyard, A. C. Schlink, J. Smith, L. J. E. Karlsson, G. B. Martin, D. Groth
Summary: The study found no significant association between microbial differences on the skin of sheep and susceptibility to breech strike. The research focused on Merino sheep and compared the microbial populations in the skin around the breech area using 16S rRNA gene sequence analysis.
ANIMAL PRODUCTION SCIENCE
(2021)
Article
Developmental Biology
Graciela Pedrana, Camila Larranaga, Alejandra Diaz, Helen Viotti, Paula Lombide, Daniel Cavestany, Mark H. Vickers, Graeme B. Martin, Deborah M. Sloboda
Summary: The study showed that maternal undernutrition during pregnancy and lactation may disrupt the balance between proliferation and apoptosis in germ cells, leading to increased germ cell production and potentially exceeding the support capacity of Sertoli cells. Furthermore, changes in meiosis and spermiogenesis mediated by germ cell HSP90 and HSP70 could further compromise fertility.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2021)