Review
Immunology
Vanitha Sampath, Juan Aguilera, Mary Prunicki, Kari C. Nadeau
Summary: Climate change is the main driver of various extreme weather events, which have direct and indirect impacts on human health, especially in terms of allergic diseases and asthma. This review examines the immune mechanisms behind the health risks associated with climate change events and explores the molecular and cellular processes involved in mediating these effects.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Environmental Sciences
Shilu Tong, Yong Yin, Yixiao Bao
Summary: Asthma, affecting over 300 million people globally, is a significant burden, leading to premature death and reduced quality of life. Environmental changes are believed to be the main cause of the rising trend of asthma and other allergic diseases. Therefore, environmental modification plays a crucial role in the treatment and management of asthma, and further research and efforts are needed in this emerging field.
ENVIRONMENTAL RESEARCH
(2022)
Review
Pediatrics
Gennaro D'Amato, Maria D'Amato
Summary: Respiratory allergy is closely related to air pollution and climate change. Climate change leads to an increase in trigger factors such as pollens and moulds in the atmosphere, causing rhinitis and asthma in sensitized patients. Pollen allergy is often used to study the relationship between air pollution and allergic respiratory diseases. Recent studies have shown that environmental pollution and climate change have significant negative impacts on human health, particularly on the respiratory system.
CURRENT OPINION IN PEDIATRICS
(2023)
Review
Respiratory System
Kira Morgan Hughes, Dwan Price, Cenk Suphioglu
Summary: Australia has a high rate of allergic rhinitis, also known as hay fever, which affects up to 30% of the population. The increase in atmospheric concentration of airborne allergens due to climate change has led to more frequent extreme weather events and epidemic thunderstorm asthma, posing a potential threat to susceptible populations. The underlying factors influencing these epidemics are still unknown.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Khaiwal Ravindra, Akshi Goyal, Suman Mor
Summary: Pollen allergy is a significant public health issue that affects patients' quality of life. Climate change and air pollutants can impact the pollen number, morphology, and distribution, which in turn influence the prevalence and severity of allergic diseases. It is crucial to strengthen preventive and adaptive strategies to mitigate the risk of pollen-related illnesses, especially in lower and middle-income countries.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Review
Environmental Sciences
Gennaro D'Amato, Isabella Annesi-Maesano, Benedetta Biagioni, Andrea Lancia, Lorenzo Cecchi, Maria Concetta D'Ovidio, Maria D'Amato
Summary: In recent years, the impacts of climate change on the environment have become increasingly evident. Changes in climate influence extreme weather events and alter precipitation and wind patterns. Climate change can negatively affect respiratory health, leading to the emergence of asthma and allergic respiratory illnesses. Pollen, a major component of atmospheric bioaerosols, can induce allergic symptoms. Climate change affects the timing, duration, and severity of the pollen season, leading to increased pollen allergies. Higher levels of carbon dioxide can enhance photosynthesis and increase pollen production. Pollen grains can also interact with air pollutants and be affected by extreme events, exacerbating respiratory diseases such as allergic rhinitis and asthma. Climate change may also facilitate the spread of pandemics like COVID-19.
Article
Environmental Sciences
Paul J. Beggs
Summary: Climate change has a significant impact on aeroallergens and allergic respiratory diseases, with research in this field rapidly advancing in recent years. The importance of addressing the impacts of climate change on environmental monitoring and exposure through the concept of the aeroexposome is increasingly recognized. Further research is needed to fill knowledge gaps and explore the effects of climate change on indoor aeroallergens.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Allergy
Kyung Suk Lee, Kyunghoon Kim, Young-Jin Choi, Seung Yang, Chang-Ryul Kim, Jin-Hwa Moon, Kyu Rang Kim, Yung-Seop Lee, Jae-Won Oh
Summary: This study investigated the relationship between allergenic pollen sensitization rates in children living in the Seoul metropolitan area and changes in pollination associated with weather changes. Results showed that the sensitization rates to oak, hazel, and alder pollen increased annually, especially in younger age groups. The duration of the pollen season and increasing temperatures were found to be positively correlated with sensitization rates to tree pollens.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Alessandro Di Menno di Bucchianico, Raffaela Gaddi, Maria Antonia Brighetti, Denise De Franco, Annarosa Miraglia, Alessandro Travaglini
Summary: Today, excessive air pollution is affecting a significant portion of the European population, surpassing the standards recommended by the World Health Organization. This pollution, along with the seasonal release of allergenic pollen, poses a significant health risk and can cause severe allergic reactions, especially during peak pollen periods. Unlike pollutants from human activities, pollen sources have fluctuating trends, with high concentrations during the flowering season and negligible levels throughout the rest of the year. Therefore, defining data coverage standards for major allergenic taxa is crucial.
Article
Environmental Sciences
Martha Cabrera, Javier Subiza, Enrique Fernandez-Caldas, Belen Garzon Garcia, Stella Moreno-Grau, Jose Luis Subiza
Summary: This study compared airborne levels of Phl p 1 and Phl p 5 inside and outside of the pollen season, and evaluated their association with symptoms in grass allergic patients. The findings suggest that climate and pollution may have contributed to the higher seasonal allergic rhinitis symptom score recorded in 2009.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Engineering, Chemical
Marie Choel, Anastasia Ivanovsky, Antoine Roose, Mona Hamze, Anne-Marie Blanchenet, Nicolas Visez
Summary: The coagulation of airborne particles on the surface of allergenic pollen grains is not well understood. This study quantitatively assessed the particulate deposition on allergenic pollen surfaces by sampling birch pollen grains (BPGs) during pollination. It was found that, on average, polluted BPGs carried 2 +/- 1 particles, representing an average surface coverage of 0.95%. The main coagulation process was hypothesized to be particle deposition by gravitational settling, although the effects of electric charges carried by pollen remain unknown. The presence of particle-polluted allergenic pollens appears to be common in the urban atmosphere, even under low air pollution conditions.
JOURNAL OF AEROSOL SCIENCE
(2022)
Article
Oncology
Wei Han, Yi Su, Binglin Liu, Wenjing Zhu, Xinjuan Yu, Xiaohui Sun, Xuefei Qi, Xiaopei Lin, Syed A. A. Rizvi, Woo-Jung Song, Ji-Hyang Lee, Yasuo Shimizu, Ziguang Li, Qinghai Li
Summary: This study explored the effect of weather factors on increased hospitalization due to worsening of asthma symptoms in Qingdao, China. The study found that the high rate of hospitalization during the spring of 2019 might be associated with unfavorable weather conditions and atmospheric circulation.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Allergy
Magnus Lindqvist, Katja Biering Leth-Moller, Allan Linneberg, Inger Kull, Anna Bergstrom, Antonios Georgellis, Magnus P. Borres, Agneta Ekebom, Marianne van Hage, Erik Melen, Marit Westman
Summary: Patients with pollen-induced allergic rhinitis face a high risk of persistent disease for at least 20 years, with childhood to adolescence being the most critical period for disease progression. The study findings underscore the close relationship between sensitization, allergic rhinitis, and asthma.
Review
Medicine, General & Internal
Paul J. Beggs, Bernard Clot, Mikhail Sofiev, Fay H. Johnston
Summary: One of the adverse impacts of climate change on human health is the increase in allergic respiratory diseases. This is caused by the effects of increased atmospheric carbon dioxide concentration and air temperature on airborne allergens such as pollen and fungal spores. This review discusses these effects and explores three translational mitigation approaches for improved health outcomes.
Review
Environmental Sciences
Maria -Viola Martikainen, Tarleena Tossavainen, Noora Hannukka, Marjut Roponen
Summary: In recent years, there has been increasing evidence of the synergistic effects of pollen and viruses on respiratory health. While pollen exposure is a known risk factor for respiratory viral infections, recent studies suggest that it may also have inhibitory or weakening effects on these infections. However, a comprehensive summary and consensus on the synergistic health effects have not been reached.
ENVIRONMENTAL RESEARCH
(2023)
Review
Allergy
Jonathan A. Bernstein, Andrew A. White, Joseph K. Han, David M. Lang, David Elkayam, Fuad M. Baroody
Summary: This study aimed to analyze published reports on the efficacy and safety of corticosteroid irrigation (CSI) in chronic rhinosinusitis (CRS) with nasal polyps and evaluate its clinical implications. CSI is commonly used for the treatment of CRS, but it is not approved by the FDA.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Dermatology
Jorge Sanchez, Iris-Selva Ale, Maria Valeria Angles, Guillermo Guidos Fogelbach, Angela Marie Jansen, Roberto Takaoka, Arturo Borzutzky
Summary: Atopic dermatitis is a chronic, pruritic skin disease with a complex etiology. In Latin America, the prevalence of AD is high in children and adults. Most patients experience remission in adolescence and adulthood, but there are still a significant number of patients who continue to have symptoms. Access to healthcare services is limited for some patients, leading to healthcare disparities. Recognizing and resolving these disparities is crucial for improving the treatment and quality of life of individuals with AD.
DERMATOLOGY AND THERAPY
(2023)
Article
Allergy
Marek Jutel, Giselle S. Mosnaim, Jonathan A. Bernstein, Stefano del Giacco, David A. Khan, Kari C. Nadeau, Isabella Pali-Schoell, Maria J. Torres, Magdalena Zemelka-Wiacek, Ioana Agache
Summary: The One Health approach is a collaborative and interdisciplinary strategy that focuses on the interconnections between human, animal, and environmental health. It can advance the management of allergic diseases and asthma by addressing their complex and multifactorial nature. The impacts of allergens, infectious agents, and irritants on allergic diseases and asthma are influenced by environmental health intertwined with animal health. A coordinated response across sectors such as public health, veterinary medicine, and environmental science is needed, along with activities like monitoring and surveillance, targeted interventions, and research on underlying mechanisms.
Editorial Material
Allergy
Jonathan A. Bernstein
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Immunology
Diti H. H. Patel, Lauren M. M. Fine, Jonathan A. A. Bernstein
Summary: Progestogen Hypersensitivity (PH) is characterized by recurrent cutaneous eruptions and systemic symptoms, caused by increased sensitivity to progestogens. The prevalence of PH is expected to increase due to the widespread use of oral contraceptives and hormonal treatments. A better understanding of the underlying mechanisms and the development of accurate diagnostic tests are needed for improved recognition and management of the condition.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Matthew Greenhawt, Timothy E. Dribin, Elissa M. Abrams, Marcus Shaker, Derek K. Chu, David B. K. Golden, Cem Akin, Akterini Anagnostou, Faisal Almuhizi, Waleed Alqurashi, Peter Arkwright, James L. Baldwin, Aleena Banerji, Philippe Begin, Moshe Ben-Shoshan, Jonathan Bernstein, Theresa A. Bingemann, Carsten Bindslev-Jensen, Kim Blumenthal, Aideen Byrne, Julia Cahill, Scott Cameron, Dianne Campbell, Ronna Campbell, Michael Cavender, Edmond S. Chan, Sharon Chinthrajah, Pasquale Comberiati, Jacqueline J. Eastman, Anne K. Ellis, David M. Fleischer, Adam Fox, Pamela A. Frischmeyer-Guerrerio, Remi Gagnon, Lene H. Garvey, Mitchell H. Grayson, Ghislaine Annie Clarisse Isabwe, Nicholas Hartog, David Hendron, Caroline C. Horner, Johnathan O'B Hourihane, Edward Iglesia, Manstein Kan, Blanka Kaplan, Constance H. Katelaris, Harold Kim, John M. Kelso, David A. Khan, David Lang, Dennis Ledford, Michael Levin, Jay A. Lieberman, Richard Loh, Douglas P. Mack, Bruce Mazer, Ketan Mody, Gisele Mosnaim, Daniel Munblit, S. Shahzad Mustafa, Anil Nanda, Richard Nathan, John Oppenheimer, Iris M. Otani, Miguel Park, Ruby Pawankar, Kirsten P. Perrett, Jonny Peter, Elizabeth J. Phillips, Matthieu Picard, Mitchell Pitlick, Allison Ramsey, Trine Holm Rasmussen, Melinda M. Rathkopf, Hari Reddy, Kara Robertson, Pablo Rodriguez del Rio, Stephen Sample, Ajay Sheshadri, Javed Sheik, Sayantani B. Sindher, Jonathan M. Spergel, Cosby A. Stone, David Stukus, Mimi L. K. Tang, James M. Tracy, Paul J. Turner, Timothy K. Vander Leek, Dana V. Wallace, Julie Wang, Susan Wasserman, David Weldon, Anna R. Wolfson, Margitta Worm, Mona-Rita Yacoub
Summary: This guidance provides updates on immediate allergic reactions following COVID-19 vaccines, including recommendations for revaccinating individuals with first-dose allergic reactions and conducting allergy testing. The recommendations were formed by an international panel of experts and are based on recent meta-analyses and diagnostic accuracy studies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Samuel Adabla, Laura A. Nabors, Olutosin Sanyaolu, Afolakemi Olaniyan, Jonathan A. Bernstein
Summary: This study reviewed research on interventions aimed at improving asthma management among children by educating parents and other professionals. Stakeholders developed programs that resulted in improvements in asthma symptoms, knowledge of asthma management, perceptions of health care, and decreased emergency health care visits. Successful interventions involved education about asthma management, providing medications, and partnerships with school staff, healthcare teams, and community members.
Review
Allergy
Wasuchon Chaichan, Chidchanok Ruengorn, Kednapa Thavorn, Brian Hutton, Jacek C. Szepietowski, Jonathan A. Bernstein, Mati Chuamanochan, Surapon Nochaiwong
Summary: A systematic review and network meta-analysis were conducted to compare the safety profiles of different second-generation H1-antihistamines in patients with chronic urticaria. The study found variations in safety profiles, with mizolastine, emedastine, and cetirizine associated with unfavorable safety profiles.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Jonathan A. Bernstein, Ana Gimenez-Arnau, Marcus Maurer, Petra Staubach, Nathalie Barbier, Eva Hua, Thomas Severin, Pedro A. Laires, Maria-Magdalena Balp
Summary: This study investigated the association between urticaria activity and health-related quality of life. The results showed that chronic spontaneous urticaria significantly impacted the patients' HRQoL. Patients with complete response to treatment had no impairments on health-related quality of life and improved work capacities compared to those with minimal disease activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jonathan A. Bernstein, Jean-Pierre Llanos, Gillian Hunter, Neil Martin, Christopher S. Ambrose
Summary: This study describes the reduction of annualized asthma exacerbation rate (AAER) from randomized controlled trials (RCTs) in patients with allergic severe asthma. The study found that the efficacy of biologics varied considerably overall and by baseline blood eosinophil count (BEC), with tezepelumab consistently demonstrating the greatest reduction in AAER across all subgroups.
ADVANCES IN THERAPY
(2023)
Article
Allergy
P. J. de Kam, S. Zielen, J. A. Bernstein, U. Berger, M. Berger, M. Cuevas, D. Cypcar, A. Fuhr-Horst, W. A. Greisner, M. Jandl, S. Lassmann, M. Worm, J. Matz, E. Sher, C. Smith, G. C. Steven, R. Moesges, M. H. Shamji, L. DuBuske, F. Borghese, K. Oluwayi, T. Zwingers, M. Seybold, O. Armfield, M. D. Heath, S. J. Hewings, M. F. Kramer, M. A. Skinner
Summary: The study evaluated the efficacy and safety of a modified grass allergen subcutaneous immunotherapy for grass-pollen allergic rhinitis/rhinoconjunctivitis. The results showed clinically relevant and statistically significant improvements in symptom and medication scores, as well as a good safety profile.
Editorial Material
Allergy
Raagini Suresh Yedidi, Jonathan A. Bernstein
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Allergy
Hannah Hardin, Wenhai Shao, Jonathan A. Bernstein
Summary: This article provides an updated review on the diagnosis, management, and treatment of pediatric autoimmune neuropsychiatric disorder associated with streptococcus and pediatric autoimmune neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis (IAE). The study outlines current knowledge on IAE pathophysiology, clinical manifestations, and epidemiology, as well as diagnostic recommendations and treatment guidelines. The article emphasizes the need for interdisciplinary collaboration and further research to improve the recognition and acceptance of this condition.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Respiratory System
Denislava Nedeva, Krzysztof Kowal, Stefan Mihaicuta, Guillermo Guidos Fogelbach, Paschalis Steiropoulos, Herberto Jose Chong-Neto, Angelica Tiotiu
Summary: This article reviews the role of TSLP, IL-33, IL-25, and HMGB1 in the pathogenesis of asthma, COPD, idiopathic pulmonary fibrosis, and cystic fibrosis. It also summarizes the current evidence on the efficacy of anti-alarmin therapies in chronic respiratory diseases.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Allergy
Remy S. Petersen, Laura Bordone, Marc A. Riedl, Raffi Tachdjian, Timothy J. Craig, William R. Lumry, Michael E. Manning, Jonathan A. Bernstein, Jason Raasch, Bruce L. Zuraw, Yiwen Deng, Kenneth B. Newman, Veronica J. Alexander, Cindy Lui, Eugene Schneider, Danny M. Cohn
Summary: The 2-year interim results of this phase 2 open-label extension study of donidalorsen in patients with HAE demonstrated no new safety signals. Donidalorsen was well tolerated with durable efficacy, resulting in a 96% reduction in HAE attacks.