期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 14, 页码 3845-3853出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b06723
关键词
oleocanthal; inflammation; rheumatic diseases; neurodegenerative diseases
资金
- ISCIII
- FEDER
- (RIER: Red de Investigacion en Inflamacion y Enfermedades Reumaticas) via Instituto de Salud Carlos III (ISCIII) [RD16/0012/0014]
- Instituto de Salud Carlos III [PI17/00409, PI15/00681, CB16/11/00226]
- Research Executive Agency of the European Union [734899 Olive-Net]
- (RIER: Red de Investigacion en Inflamacion y Enfermedades Reumaticas) via FEDER [RD16/0012/0014]
Extra virgin olive oil (EVOO) is the main source of fat in the Mediterranean diet. Phenolic compounds of EVOO, in particular, secoiridoids, are minor components that have generated special interest due to their positive effects on human health, supported by several clinical trials. This review summarizes the most recent findings on the pharmacological properties and action's mechanisms of secoiridoid oleocanthal, focusing attention on inflammation, oxidative stress, cancer, neurodegenerative processes, and rheumatic diseases. Being of relevance to the clinical effects of EVOO intake, the bioavailability and biotransformation of EVOO polyphenols are addressed. Moreover, this review summarizes the factors that may influence the oleocanthal concentration in EVOO. With the growing incidence of age- and lifestyle-related diseases, the current data indicated that the administration of EVOO rich in secoiridoids may be helpful in the prevention or treatment of different pathologies with an inflammatory component. Although promising, the future raises several questions and challenges, which are discussed here. The real beneficial effects of olive oil phenols on human health need to be clarified in new, well designed clinical studies.
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