期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 67, 期 10, 页码 2818-2830出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b06444
关键词
ampelopsin A; ampelopsin C; MDA-MB-231; AxL; FYN
资金
- Ministry of Science and Technology, Taiwan [MOST 106-2320-B-007-003, MOST 107-2320-B-007-001]
- Yen Tjing Ling Medical Foundation [CI-108-25]
Ampelopsins A and C are resveratrol oligostilbenes whose role in cancer development remains unknown. This study evaluated the antimetastatic and apoptosis-inducing properties of ampelopsins A and C in MDA-MB-231 cells. The IC50 values of ampelopsins A and C against MDA-MB-231 cells at 72 h were 38.75 +/- 4.61 and 2.71 +/- 0.21 mu M, respectively. However, at 24 h, ampelopsins A and C decreased cell metastasis significantly. Among the 71 proteins present on the human phosphoreceptor tyrosin kinase array, ampelopsin C decreased the phosphorylated protein level of AXL, Dtk (TYRO3), EphA2, EphA6, Fyn, Hck, and SRMS. Additionally, antiproliferation effects of ampelopsin C were enhanced when combined with luteolin and chrysin compared to either two or a single agent in MDA-MB-231 cells. Overall, ampelopsins A and C extracted from Vitis thunbergii are both novel antimetastatic agents and potential therapeutic targets in patients with breast cancer.
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