Article
Chemistry, Medicinal
Michael G. Thomas, Kate McGonagle, Paul Rowland, David A. Robinson, Peter G. Dodd, Isabel Camino-Diaz, Lorna Campbell, Juan Cantizani, Pablo Castaneda, Daniel Conn, Peter D. Craggs, Darren Edwards, Liam Ferguson, Andrew Fosberry, Laura Frame, Panchali Goswami, Xiao Hu, Justyna Korczynska, Lorna MacLean, Julio Martin, Nicole Mutter, Maria Osuna-Cabello, Christy Paterson, Imanol Pena, Erika G. Pinto, Caterina Pont, Jennifer Riley, Yoko Shishikura, Frederick R. C. Simeons, Laste Stojanovski, John Thomas, Karolina Wrobel, Robert J. Young, Filip Zmuda, Fabio Zuccotto, Kevin D. Read, Ian H. Gilbert, Maria Marco, Timothy J. Miles, Pilar Manzano, Manu De Rycker
Summary: There is an urgent need for new treatments for Chagas disease. The discovery of a preclinical candidate for visceral leishmaniasis prompted the investigation of alternative proteasome inhibitors for Trypanosoma cruzi, the parasite causing Chagas disease. A selective pyridazinone compound was identified and optimized for efficacy studies, showing potential as a new treatment for Chagas disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
G. Cesar, M. A. Natale, M. C. Albareda, M. G. Alvarez, B. Lococo, A. M. De Rissio, M. Fernandez, M. D. Castro Eiro, G. Bertocchi, B. E. White, F. Zabaleta, R. Viotti, R. L. Tarleton, S. A. Laucella
Summary: Participants with Trypanosoma cruzi-specific plasmablasts in circulation before treatment and early changes in these B cells after treatment are likely to have a positive serological outcome.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Jose Ismael F. de Araujo, Natalia L. Aires, Francisco W. Q. Almeida-Neto, Marcia M. Marinho, Emanuelle M. Marinho, Emanuel Paula Magalhaes, Ramon R. P. P. B. de Menezes, Tiago L. Sampaio, Alice Maria Costa Martins, Edson H. Teixeira, Ana Rafaela Freitas Dotto, Wanderlei do Amaral, Alexandre Magno R. Teixeira, Pedro De Lima-Neto, Emmanuel S. Marinho, Helcio S. dos Santos
Summary: The study found that the triterpene CLF-1 has a good inhibitory effect on Trypanosoma cruzi and is well-absorbed in the intestine with low toxicity, making it a potential candidate for new Chagas disease treatments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Infectious Diseases
Steven Van den Broucke, Maxim Van Herreweghe, Annelies Breynaert, Marjan Van Esbroeck, Carine Truyens, Tess De Bruyne, Nina Hermans, Ralph Huits
Summary: This study investigated the effects of antioxidant supplementation on the treatment of chronic indeterminate Chagas' disease with benznidazole. The results showed that antioxidant supplementation effectively mitigated the adverse drug reactions caused by benznidazole. The study suggested that oxidative stress is the key mechanism of benznidazole-associated toxicity, rather than hypersensitivity.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Priscila Silva Grijo Farani, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Igor C. Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira
Summary: Research explored the immune response-related gene expression changes in heart tissues of C57BL/6 mice chronically infected with T. cruzi and treated with benznidazole (Bz) or Bz+pentoxifylline (PTX). The study found that treatment could mitigate the Th1-driven response in cardiac remodeling processes of CCC patients by restoring the expression of genes related to inflammatory response, cellular development, growth, proliferation, and tissue development pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucas A. M. Franco, Carlos H. V. Moreira, Lewis F. Buss, Lea C. Oliveira, Roberta C. R. Martins, Erika R. Manuli, Jose A. L. Lindoso, Michael P. Busch, Alexandre C. Pereira, Ester C. Sabino
Summary: Chagas disease is a major social and public health issue in Latin America, with adverse reactions to benznidazole (BZN) treatment potentially genetically determined. Genetic and transcriptomic analyses identified chromosome 16 gene region associations and enriched signaling pathways related to BZN adverse reactions. These findings suggest potential for patient risk stratification before initiating BZN treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
A. C. A. Azevedo, M. V. L. Barros, L. G. Klaboe, T. Edvardsen, H. S. Costa, G. M. M. Paixao, O. R. Santos Junior, M. C. P. Nunes, M. O. C. Rocha
Summary: The study confirms the association between myocardial mechanical dispersion (MD) and ventricular arrhythmogenicity in patients with Chagas cardiomyopathy (CCM). Increased MD is linked to higher density and complexity of ventricular extrasystoles (VES) in CCM patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Biyi Chen, Nastaran Daneshgar, Hsiang-Chun Lee, Long-Sheng Song, Dao-Fu Dai
Summary: Mitochondrial oxidative stress plays a role in aging and various cardiovascular diseases. Its involvement in bradyarrhythmia is less understood. In a mouse model of Leigh Syndrome (LS), mitochondrial antioxidant treatment improved bradyarrhythmia and extended lifespan. Increased reactive oxygen species (ROS) in the LS heart were observed and abolished by mitochondrial antioxidant treatment. This study suggests the direct mechanistic roles of mitochondrial ROS in bradyarrhythmia and highlights the potential clinical application of mitochondrial-targeted antioxidants in LS patients.
Article
Microbiology
Isabela Ribeiro, Bethania Blum, Jayme Fernandes, Glaucia Santina, Makoto Asada, Michael Everson, Edgar Schuck, Ethel Feleder, Eric Evene, Virginie Gualano
Summary: The study evaluated the pharmacokinetics and safety interactions of BNZ and E1224 in healthy volunteers. The results showed changes in RVZ concentration parameters when both compounds were coadministered, but both compounds were well tolerated and no clinically relevant safety interactions were observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Luis Antonio Rodriguez Carnero, Andreia Kuramoto, Lea Campos de Oliveira, Jhonatas Sirino Monteiro, Joao Carlos Setubal, Edecio Cunha-Neto, Ester Cerdeira Sabino, Ricardo Jose Giordano
Summary: This study used the gPhage platform to compare antigens and antibodies before and after treatment in 20 patients with chronic Chagas disease. The results showed a decrease in antibody levels and recognition of specific antigens after treatment. The gPhage data correlated with patient PCR-status and could predict patient response to treatment. In conclusion, the use of the gPhage platform contributes to the development of novel diagnostic tools for Chagas disease.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Review
Biochemistry & Molecular Biology
Maria F. Torre, Maria Martinez-Ferran, Nestor Vallecillo, Sergio L. Jimenez, Carlos Romero-Morales, Helios Pareja-Galeano
Summary: There is insufficient evidence to confirm that antioxidant vitamins intake can minimize delayed-onset muscle soreness after eccentric exercise. Although some studies show the beneficial effects of chronic supplementation with vitamins C and E on muscle soreness, further research is needed to confirm their effectiveness in this context.
Article
Immunology
Juliana Magalhaes Chaves Barbosa, Yasmin Pedra-Rezende, Luiza Dantas Pereira, Tatiana Galvao de Melo, Helene Santos Barbosa, Joseli Lannes-Vieira, Solange Lisboa de Castro, Anissa Daliry, Kelly Salomao
Summary: The combination treatment of Bz + AMD can attenuate the damage caused by T. cruzi infection in cardiac cells and have a certain control effect on parasite replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maykon Tavares de Oliveira, Andre Schmidt, Maria Claudia da Silva, Eduardo Antonio Donadi, Joao Santana da Silva, Jose Antonio Marin-Neto
Summary: The study revealed that the blood parasite load in patients with CCC is highly variable and appears to be directly linked to the reduction of LVEF, an important prognostic indicator in CCC patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chao Wang, Tracey A. Gaspari, Dorota Ferens, Iresha Spizzo, Barbara K. Kemp-Harper, Chrishan S. Samuel
Summary: This study showed that targeting oxidative stress and fibrosis simultaneously is crucial in treating cardiomyopathy-induced heart failure. The combination therapy of NAC and RLX had better effects in preventing disease progression and restoring cardiac function compared to either treatment alone.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jose Francisco Taty Zau, Rodrigo Costa Zeferino, Nadia Sandrine Mota, Gerez Fernandes Martins, Salvador Manoel Serra, Therezil Bonates da Cunha, Daniel Medeiros Lima, Basilio de Braganca Pereira, Emilia Matos do Nascimento, Danilo Wilhelm Filho, Rozangela Curi Pedrosa, Roberto Coury Pedrosa
Article
Statistics & Probability
Cachimo Combo Assane, Basilio de Braganca Pereira, Carlos Alberto de Braganca Pereira
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2019)
Article
Environmental Sciences
Vanessa Santana Vieira Santos, Edgar Silveira, Boscolli Barbosa Pereira
Article
Environmental Sciences
Vanessa Santana Vieira Santos, Carlos Eduardo Silva, Cynthia Martins Oliveira, Cassio Resende de Morais, Jean Ezequiel Limongi, Boscolli Barbosa Pereira
Article
Environmental Sciences
Cassio Resende de Morais, Boscolli Barbosa Pereira, Patricia Cristina Almeida Sousa, Vanessa Santana Vieira Santos, Carlos Fernando Campos, Stephan Malfitano Carvalho, Mario Antonio Spano, Alexandre Azenha Alves de Rezende, Ana Maria Bonetti
Article
Environmental Sciences
Vanessa Santana Vieira Santos, Jean Ezequiel Limongi, Boscolli Barbosa Pereira
Review
Environmental Sciences
Boscolli Barbosa Pereira
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2020)
Review
Environmental Sciences
Vanessa Santana Vieira Santos, Boscolli Barbosa Pereira
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2020)
Review
Environmental Sciences
Elida Cristina Monteiro De Oliveira, Evelyn Siqueira Caixeta, Vanessa Santana Vieira Santos, Boscolli Barbosa Pereira
Summary: Arsenic is naturally occurring but can also contaminate groundwater due to mining, agricultural, and industrial processes. Human exposure to arsenic from contaminated water can lead to acute toxicity and chronic effects, including skin lesions and cancer. Strategies to diminish arsenic in water include physicochemical treatment systems, bioremediation using cyanobacteria and algae, and nanotechnology applications.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2021)
Article
Environmental Sciences
Evelyn Siqueira Caixeta, Joao Vitor Meza Bravo, Boscolli Barbosa Pereira
Summary: Several studies have shown that effluent discharges can contaminate waterways. However, the impact of chemical pollutants on sediment, especially from an ecotoxicological perspective, is not well understood. This study compared water-sediment samples from high-anthropogenic urban areas and low-anthropogenic peri-urban areas. The results suggest chronic toxicity effects in the samples collected from the high-anthropogenic urban area, while no acute toxicity was observed in both areas.
Article
Environmental Sciences
Carine de Mendonca Francisco, Luiz Alfredo Pavanin, Sandra Morelli, Joao Vitor M. Bravo, Boscolli Barbosa Pereira
Summary: Worldwide water quality has worsened due to continuous pollution by agrochemicals, especially heavy metals. Fish genotoxicity biomarkers are important for evaluating the environmental risk of pollutants. In this study, Cichlasoma paranaense fish were used as a model to assess the genotoxic effects of water pollution in Brazilian rivers. Samples from different river sites showed contamination by metals, with the highest concentrations of Cu in areas with forest fragmentation caused by intensive agriculture. The fish exposed to samples from agricultural areas exhibited significantly higher genotoxic effects. The results suggest that C. paranaense fish can serve as a reliable model for detecting genotoxic effects of agrochemicals.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Elida Cristina Monteiro de Oliveira, Luis Paulo Pires, Vanessa Santana Vieira Santos, Evelyn Siqueira Caixeta, Joao Vitor M. Bravo, Boscolli Barbosa Pereira
Summary: The direct impact of mining activities on physicochemical and biological parameters in aquatic ecosystems increases the ecotoxicological risk of exposure to contaminants and pollutants. This study used a native and adapted floating aquatic macrophyte as a model organism to assess the environmental risk and its potential application in bioremediation of heavy metals in a gold mining area. The results showed significant bioconcentration of Cr, Pb, Cu, and Zn in the roots of the macrophyte, confirming its suitability for use in rhizofiltration. H. ranunculoides also demonstrated high potential for phytoextraction of arsenic, an essential requirement for plants in bioremediation programs.
Article
Green & Sustainable Science & Technology
Luis Paulo Pires, Boscolli Barbosa Pereira
Summary: The performance of Brazilian higher education institutions in green metrics has improved, with an increasing number of universities participating in sustainable actions. However, their focus on sustainable development is primarily limited to traditional teaching and research methods, leaving room for improvement.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Environmental Sciences
Carlos Fernando Campos, Matheus Campos Cunha, Vanessa Santana Vieira Santos, Edimar Olegario de Campos Junior, Ana Maria Bonetti, Boscolli Barbosa Pereira