Article
Pharmacology & Pharmacy
Touba Khaliq, Muhammad Sohail, Muhammad Usman Minhas, Arshad Mahmood, Abubakar Munir, Aya Hamid Mohammad Qalawlus, Nazish Jabeen, Mubeen Kousar, Zobia Anwar
Summary: The study aims to develop a new multifunctional biopolymer-based hydrogel membrane dressing that can release cefotaxime sodium at the wound site. Sodium alginate enhances collagen production in the skin, while hyaluronic acid plays a significant role in the wound healing cascade. These biopolymers are essential ingredients for the fabrication of hydrogel membranes. The developed membranes showed suitable characteristics for wound healing of diabetic wounds, with rapid re-epithelization and decreased inflammation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Gizem Ceylan Turkoglu, Merih Sariisik, Sinem Yaprak Karavana, Fadime Aydin Koseme
Summary: A composite wound dressing with reduced swelling and more stable fluid handling properties, containing 1% WGO which significantly improved NIH/3T3 cell proliferation. In addition, the proposed product demonstrated air and water vapor permeability of 8.05 cm3/cm2/s and 541.37 g/m2/day respectively.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Weiqun Tan, Zhengfa Ma, Lijie Zhang, Mei Zhang, Tiantian Yu, Yunru Zhang, Tiantao Zhao
Summary: In this study, a polyvinyl alcohol/polymalic acid hydrogel dressing incorporated with curcumin was prepared. The hydrogel exhibited good swelling properties and slow release of curcumin. It was non-toxic to cells and promoted wound healing in animal experiments. The hydrogel also reduced inflammation and enhanced angiogenesis and epithelial tissue regeneration.
Article
Biochemistry & Molecular Biology
Pathum Chandika, Fazlurrahman Khan, Seong-Yong Heo, Tae -Hee Kim, Young-Mog Kim, Myunggi Yi, Won-Kyo Jung
Summary: In this study, chitooligosaccharide/sinapic acid conjugate and photo cross-linkable hyaluronic acid were successfully synthesized and encapsulated in dual cross-linked polyvinyl alcohol/methacrylated hyaluronic acid composite hydrogel for full-thickness wound healing application. The composite hydrogel exhibited excellent physical and mechanical properties, and the introduction of the conjugate significantly enhanced its biocompatibility, antioxidant, and antimicrobial properties, thereby promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Umar, Azeem Ullah, Hifza Nawaz, Tanzeel Areeb, Motahira Hashmi, Davood Kharaghani, Kyu Oh Kim, Ick Soo Kim
Summary: The study developed bi-component alginate-hyaluronic acid (AHA) fibers with improved mechanical performance and high liquid absorption. The controlled release of hyaluronic acid, high biocompatibility towards cell lines, and suitable MVTR values make the fibers appropriate for promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Lijie Zhang, Mei Zhang, Weiqun Tan, Zhengfa Ma, Tiantian Yu, Tiantao Zhao
Summary: A novel composite hydrogel consisting of polyvinyl alcohol (PVA) and sodium alginate (SA) was prepared as a drug carrier for trauma treatment. The hydrogel showed excellent liquid absorption and permeation capabilities, and exhibited superior anti-inflammatory, antioxidant, and antibacterial properties. It effectively prevented bacterial infiltration and promoted wound healing.
Article
Engineering, Biomedical
Yan Hu, Bangrui Yu, Yuanbo Jia, Meng Lei, Zhijie Li, Hao Liu, Haishui Huang, Feng Xu, Jing Li, Zhao Wei
Summary: A bioadhesive and injectable ECM-mimicking hydrogel dressing with antibacterial capacity has been developed for burn injury therapy. The HG/Doxy hydrogel dressing exhibits biocompatibility and antibacterial activity against both Gram-positive and Gram-negative bacteria. In a rat model of burn wound, the HG/Doxy hydrogel dressing significantly accelerates wound closure and promotes skin structure regeneration, demonstrating its potential for clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Paper & Wood
Faheem Ahmad, Bushra Mushtaq, Faaz Ahmed Butt, Abher Rasheed, Sheraz Ahmad
Summary: A novel biodegradable composite of sodium alginate hydrogel with wool needle-punched nonwoven fabric was developed for wound dressing, showing increased wound exudate absorbing capacity, enhanced tensile strength, and improved moisture management properties. The unique combination provides a moist environment and promotes cell proliferation during the wound healing process.
Article
Polymer Science
Bin Jeremiah D. Barba, Tomoko G. Oyama, Mitsumasa Taguchi
Summary: The study successfully developed a bilayer hydrogel with dual functions of wound dressing and antiadhesion, using gelatin and PVA crosslinked with gamma-rays. Cell culture and enzymatic degradation tests showed good cell activity and stability, indicating the potential of the developed bilayer hydrogel as a novel medical material.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Biochemistry & Molecular Biology
Niloofar Khandan-Nasab, Elahe Mahdipour, Saeede Askarian, Mahmoud Reza Kalantari, Navid Ramezanian, Reza Kazemi Oskuee
Summary: Recently, there has been a focus on developing skin equivalents to accelerate wound healing and restore skin. This study aimed to design and characterize a novel hydrogel scaffold using alginate, pullulan, and hyaluronic acid polymers to deliver Adipose-derived mesenchymal Stem Cells (ASC) and promote wound healing in an animal model. The synthesized hydrogel was characterized using various techniques, and in vitro studies demonstrated the attachment, viability, and migration of cells in the scaffold. The cell-seeded hydrogel treatment improved wound healing and closure in an animal model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Qiushi Tang, Jiwen Hu, Shi Li, Shudong Lin, Yuanyuan Tu, Xuefeng Gui
Summary: A colorimetric pH-sensitive hydrogel indicator integrated with the smartphone was developed for real-time and visual food spoilage monitoring. The hydrogel indicators show sensitive and stable properties, proving to be promising materials for the monitoring of beef, fish, chicken, and pork.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Bialik-Was, Klaudia Pluta, Dagmara Malina, Mateusz Barczewski, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz
Summary: The study demonstrates that increasing glycerin content significantly decreases gel fraction and thermal resistance, while also reducing water absorption capacity. However, it does not affect cytotoxicity and elongation properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Dwi Ratna Ningrum, Wildan Hanif, Deby Fajar Mardhian, Lia A. T. W. Asri
Summary: Hydrogel-based wound dressings containing Moringa oleifera leaf extract and graphene oxide were developed for healing diabetic foot ulcers. The hydrogels showed high water content, swelling ratio, and antibacterial activity. They also exhibited appropriate cytocompatibility with fibroblast cells.
Article
Nanoscience & Nanotechnology
Yi-Ming Gao, Zi-Yuan Li, Xiao-Jie Zhang, Junji Zhang, Qing-Feng Li, Shuang-Bai Zhou
Summary: Inventions of materials with biocompatibility, bioadhesion, and easy manufacturing are urgently needed for wound healing in clinical treatment. This study reports the fabrication of a hybrid double-network polydopamine-HA (PDA-HA) hydrogel with enhanced adhesiveness compared to HA hydrogel. The PDA-HA hydrogel can be vacuum-dried to form a patch for convenient storage and distribution. When applied on wounds, the PDA-HA patch quickly rehydrates and tightly adheres to the wound, promoting wound healing and increasing healing rates.
ACS APPLIED MATERIALS & INTERFACES
(2023)
